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市场调查报告书
商品编码
1885393
全球成人史蒂尔病市场:按治疗方法和地区分類的分析和预测(2025-2035 年)Adult-Onset Still Disease Market - A Global and Regional Analysis: Focus on Therapy and Region - Analysis and Forecast, 2025-2035 |
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全球成人史蒂尔病市场规模预计将从 2024 年的 3.231 亿美元大幅成长至 2035 年的 4.552 亿美元,2025 年至 2035 年的复合年增长率将达到 3.30%。
| 关键市场统计数据 | |
|---|---|
| 预测期 | 2025-2035 |
| 2025 年评估 | 3.29亿美元 |
| 2035 年预测 | 4.552亿美元 |
| 复合年增长率 | 3.3% |
成人斯蒂尔病市场正经历稳步增长,主要驱动因素包括临床上对该疾病认识的提高、免疫发病机制研究的进展以及靶向关键炎症通路生物疗法的广泛应用。成人史蒂尔氏症是一种罕见的全身性自体发炎性疾病,其特征是反覆发烧、关节炎和皮疹。由于诊断标准的改进以及风湿症医师和免疫学家对该疾病的认知提高,其诊断率正在上升。此疾病的多种临床表现常常导致诊断延迟,凸显了对更有效、更特异性的生物标记和标靶治疗的持续需求。
对这种疾病的细胞激素驱动机制,特别是白细胞介素(IL)-1、IL-6 和 IL-18 的作用机制的深入了解,激发了人们对靶向这些细胞因子的生物疗法的兴趣。 IL-1 和 IL-6 拮抗剂等细胞激素抑制剂的引入,透过改善症状控制和减轻对传统糖皮质激素和非类固醇消炎剂(NSAIDs) 无效患者的全身性炎症,彻底改变了疾病的治疗方式。目前正在进行的评估新型药物(包括 IL-18结合蛋白质和 Janus 激酶 (JAK) 抑制剂)的临床研究,预计在未来几年将进一步丰富治疗选择。
按治疗方法,生物製药主导。
按治疗方法类型划分,生物製药在全球市场占据主导地位,预计2024年市占率将达到70.39%。此领域对于治疗难治性成人史蒂尔氏症至关重要,抑制IL-1、IL-6和IL-18等关键细胞激素是实现缓解和预防巨噬细胞活化症候群等併发症的关键。应用最广泛的生物製药包括IL-1抑制剂(如阿那白滞素和卡那单抗)以及IL-6抑制剂(如托珠单抗),这两种药物对于快速控制全身性发炎至关重要。阿那白滞素可在急性发作期每日给药以发挥阻断作用,而卡那单抗则允许延长给药间隔,并被指南强烈推荐。随着对精准自体发炎性疾病治疗需求的不断增长,这些生物製药对于复杂的全身性疾病至关重要,在重症病例中展现出优于非类固醇消炎剂(NSAIDs)和糖皮质激素的疗效。生物製药的日益普及反映了其在重塑成人斯蒂尔病治疗和推动市场持续扩张方面的核心作用。
按地区划分,预计北美将录得最高的成长率
北美地区在全球成人史蒂尔病市场中主导,预计2024年将占据约37%的市场。同时,亚太地区在预测期(2025-2035年)内预计将以5.36%的复合年增长率增长,这主要得益于医疗基础设施的不断完善、疾病认知度的提高以及对生物製药疗法投资的增加。亚太地区拥有多元化且快速发展的医疗体系,在成人斯蒂尔病的治疗方面取得了显着进展,尤其是在中国、日本、印度和韩国等国家,各国政府和私营机构都优先考虑罕见疾病研究和孤儿药的取得。该地区庞大的人口规模,加上自体发炎性疾病盛行率的不断上升,推动了对创新细胞激素抑制剂(如IL-1和IL-6抑制剂)的需求。此外,先进的诊断技术和生物相似药的日益普及,提高了治疗的可及性,预计也将推动成人斯蒂尔病市场的快速成长。
本报告检视了全球成人史蒂尔病市场,并总结了关键趋势、市场影响因素分析、法律制度、研发管线分析、市场规模趋势和预测、按各个细分市场、地区/主要国家进行的详细分析、竞争格局以及主要企业的概况。
范围和定义
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Introduction of the Adult-Onset Still Disease Market
The global adult-onset still disease market, initially valued at $323.1 million in 2024, is projected to witness substantial growth, surging to $455.2 million by 2035, marking a remarkable compound annual growth rate (CAGR) of 3.30% over the period from 2025 to 2035.
| KEY MARKET STATISTICS | |
|---|---|
| Forecast Period | 2025 - 2035 |
| 2025 Evaluation | $329.0 Million |
| 2035 Forecast | $455.2 Million |
| CAGR | 3.3% |
The adult-onset still disease market has been witnessing gradual evolution, largely driven by growing clinical recognition of the condition, advances in immunopathogenesis research, and the expanding use of biologic therapies targeting key inflammatory pathways. Adult-onset still disease, a rare systemic autoinflammatory disorder characterized by recurrent fevers, arthritis, and skin rash, is increasingly being identified through improved diagnostic criteria and greater awareness among rheumatologists and immunologists. The disease's heterogeneous presentation often leads to diagnostic delays, which continue to underscore the need for more effective and specific biomarkers as well as targeted treatment options.
Rising understanding of the disease's underlying cytokine-driven mechanisms, particularly the roles of interleukin (IL)-1, IL-6, and IL-18, has catalyzed interest in targeted biologic therapies. The introduction of cytokine inhibitors such as IL-1 and IL-6 antagonists has transformed disease management, offering improved symptom control and reduction in systemic inflammation for patients refractory to conventional corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs). Ongoing clinical investigations evaluating newer agents, including IL-18 binding proteins and Janus kinase (JAK) inhibitors, are expected to further diversify the therapeutic landscape over the coming years.
Market Introduction
The adult-onset still disease market has been undergoing steady transformation, propelled by advances in cytokine-targeted biologics and strengthened clinical guidelines for early intervention. Companies and researchers are prioritizing interleukin (IL)-1 and IL-6 inhibitors, alongside emerging IL-18 blockers, to address refractory cases and achieve sustained remission. Key developments include the FDA approval of canakinumab (Ilaris) for active still's disease encompassing adult-onset still's disease and tadekinig alfa's orphan drug status. These innovations underscore a shift toward first-line biologic therapy, reducing reliance on glucocorticoids and enhancing outcomes in this rare autoinflammatory condition. As focus intensifies on molecular diagnostics and combination regimens, adult-onset still's disease treatments are set to expand access and efficacy across global rheumatology practices.
Industrial Impact
The adult-onset still disease market has been experiencing a significant shift, driven by the increasing demand for cytokine-targeted biologics and the growing focus on early intervention in autoinflammatory disorders. Key players such as Novartis AG, F. Hoffmann-La Roche Ltd, and Swedish Orphan Biovitrum AB have been playing a central role in advancing adult-onset still's disease therapies, supporting the development of novel IL-1, IL-6, and IL-18 inhibitors beyond traditional corticosteroids. These innovations are crucial for managing refractory cases, systemic inflammation, and complications, including macrophage activation syndrome, enabling more efficient, targeted disease control with improved remission rates. By enhancing the speed and precision of therapeutic response, reducing glucocorticoid dependency, and facilitating global clinical collaborations, adult-onset still's disease treatment advancements are contributing to more effective, streamlined management. The market's impact is further amplified by its alignment with the global shift toward precision medicine, positioning biologics as a cornerstone of adult-onset still disease care.
Market Segmentation:
Segmentation 1: By Therapy
Biologics to Dominate the Adult-Onset Still Disease Market (by Therapy)
Based on the method, the global adult-onset still disease market was led by biologics, which held a 70.39% share in 2024. This segment is essential in managing refractory adult-onset still disease cases, where blocking key cytokines such as IL-1, IL-6, and IL-18 is critical for achieving remission and preventing complications such as macrophage activation syndrome. Among the most widely adopted biologics are IL-1 inhibitors, including anakinra and canakinumab, alongside IL-6 blockers, including tocilizumab, both of which are pivotal in rapidly controlling systemic inflammation. Anakinra provides daily blockade for acute flares, while canakinumab enables extended dosing intervals with strong guideline endorsement. As demand for precision autoinflammatory therapies grows, these biologics are crucial for complex systemic disorders, outpacing NSAIDs and corticosteroids in efficacy for severe presentations. The rising adoption of biologics reflects their central role in reshaping adult-onset still's disease treatment and driving sustained market expansion.
Segmentation 2: By Region
North America to Witness the Highest Growth in the Adult-Onset Still Disease Market (by Region)
The adult-onset still disease market in North America dominates globally, accounting for approximately 37% share in 2024. Meanwhile, the Asia-Pacific region is expected to witness a growth rate of 5.36% during the forecast period 2025-2035, driven by expanding healthcare infrastructure, rising disease awareness, and increased investments in biologic therapies. Asia-Pacific, with its diverse and rapidly evolving healthcare systems, is witnessing notable advancements in adult-onset still's disease management, particularly in countries including China, Japan, India, and South Korea, where governments and private entities are prioritizing rare disease research and orphan drug access. The region's large population, coupled with a growing burden of autoinflammatory conditions, has heightened demand for innovative cytokine inhibitors such as IL-1 and IL-6 blockers. Furthermore, increasing adoption of advanced diagnostics and biosimilars is enhancing treatment accessibility, positioning Asia-Pacific for accelerated expansion in the adult-onset still disease market.
Recent Developments in the Adult-Onset Still Disease Market
Demand - Drivers, Challenges, and Opportunities
Market Drivers:
Expansion of Diagnostic Capabilities: The advancement of diagnostic tools for adult-onset still's disease has played a crucial role in propelling market expansion by enabling earlier detection, precise differentiation from similar conditions, and personalized treatment strategies. Key biomarkers such as glycosylated ferritin and elevated serum ferritin levels (>500 ng/mL) are pivotal in distinguishing adult-onset still's disease from other inflammatory disorders. These developments, integrated into clinical guidelines in certain countries, including Japan, facilitate rapid initiation of targeted biologics such as IL-1 and IL-6 inhibitors, reducing misdiagnosis and improving patient outcomes in this rare autoinflammatory condition. Additionally, emerging AI and machine learning applications in systems biology models are optimizing therapy selection, validating early biologic intervention over conventional treatments, and supporting sustained remission. As diagnostic precision evolves alongside biomarker-driven monitoring and flare prediction, these innovations are addressing critical unmet needs, positioning advanced diagnostics as a cornerstone for adult-onset still disease market growth and enhanced disease management.
Market Challenges:
High Costs of Biologic Treatments: The high costs associated with biologic therapies for adult-onset still's disease present a significant challenge to market growth, limiting patient access and straining healthcare systems. Biologics such as anakinra (Kineret), tocilizumab (Actemra), and canakinumab (Ilaris), essential for managing refractory cases, require substantial investment in complex manufacturing, specialized facilities, and rigorous quality control, resulting in annual treatment expenses. The elevated prices, far exceeding traditional therapies, restrict affordability, particularly in low- and middle-income countries and among uninsured patients. Additionally, stringent eligibility for such financial aid programs leaves many underinsured individuals facing high out-of-pocket burdens, hindering widespread adoption. Overcoming these financial barriers through biosimilars, expanded insurance coverage, and enhanced access initiatives will be crucial for broadening adult-onset still's disease treatment reach and ensuring equitable care across diverse healthcare settings.
Market Opportunities:
Regulatory Incentives and Designations: Regulatory incentives, particularly Orphan Drug Designation and Breakthrough Therapy Designation, present a significant growth opportunity for the adult-onset still disease market, accelerating development timelines and providing essential financial and market exclusivity benefits. These designations, including FDA tax credits covering up to 50% of clinical trial costs, fee waivers, and seven years of U.S. market exclusivity alongside EMA's ten-year protection, are driving investment into rare disease therapies such as canakinumab and tadekinig alfa. In regions such as North America and Europe with robust regulatory frameworks, these incentives facilitate expedited approvals through intensive FDA guidance, rolling reviews, and priority evaluations. Additionally, collaborations between biopharma developers and regulatory bodies are enhancing adult-onset still's disease therapy pipelines, positioning these incentives as a cornerstone for broader market expansion and improved patient access.
How can this report add value to an organization?
Product/Innovation Strategy: The global adult-onset still disease market has been extensively segmented based on various categories, such as therapy and region. This can help readers get a clear overview of which segments account for the largest share and which ones are well-positioned to grow in the coming years.
Growth/Marketing Strategy: Regulatory approval has accounted for the majority of key developments, comprising nearly 85% of the total developments in the global adult-onset still disease market between January 2021 and October 2025.
Competitive Strategy: The global adult-onset still disease market has numerous established players with product portfolios. Key players in the global adult-onset still disease market, analyzed and profiled in the study, include established players offering therapies for adult-onset still's disease.
Methodology
Key Considerations and Assumptions in Market Engineering and Validation
Primary Research
The primary sources involve industry experts in adult-onset still's disease, including the market players offering therapies. Resources such as CEOs, vice presidents, marketing directors, and medical directors have been interviewed to obtain and verify both qualitative and quantitative aspects of this research study.
The key data points taken from the primary sources include:
Secondary Research
Open Sources
The key data points taken from the secondary sources include:
Key Market Players and Competition Synopsis
The companies profiled have been selected based on inputs gathered from an analysis of company coverage, product portfolio, and market penetration.
Some prominent names established in this market are:
Scope and Definition