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市场调查报告书
商品编码
1950895

分子胶-竞争格局(2026 年)

Molecular Glues - Competitive landscape, 2026

出版日期: | 出版商: DelveInsight | 英文 280 Pages | 商品交期: 2-10个工作天内

价格

报告要点

  • 2025年8月,Plexium在最近一轮资金筹措中筹集了6,010万美元,这对该公司而言,这是重组后的一个重要里程碑。此次融资将协助Plexium持续开发其创新蛋白质降解剂产品线。这笔6010万美元的资金为公司提供了重要的财务支持。
  • 2025年8月,Seed Therapeutics公司宣布,美国食品药物管理局(FDA)已核准其新药临床实验申请(IND),用于治疗进行性固体癌和骨髓恶性肿瘤。此核准允许启动ST-01156的首次人体临床试验(I期)。试验将优先考虑多种具有强有力的临床前证据支持RBM39依赖性的癌症类型。预计首批患者将于2026年第一季开始给药。
  • 2025 年 8 月,Zennova 宣布与美国生技公司 Rapafusyn Pharmaceuticals 建立策略伙伴关係,共同开发创新的不可降解分子胶药物。
  • 2025年6月,Revolution Medicines宣布与Royalty Pharma达成20亿美元的灵活资金筹措合作协议,以支持公司独立的全球研发和商业化策略及业务营运。 Revolution Medicines将继续保持对其RAS(ON)抑制剂产品组合在美国和国际市场的研发和商业化的全面策略和营运控制权。
  • 2025 年 6 月,Revolution Medicines 宣布其 RAS(ON) 多选择性抑制剂 daraxonrasib 获得美国食品药物管理局(FDA) 的创新药物疗法认定,用于治疗携带 KRAS G12 突变的先前接受过治疗的转移性胰腺导管癌 (PDAC) 患者。
  • 2025年5月,Captor Therapeutics宣布启动一项临床试验,该试验可望彻底改变肝细胞癌(HCC)的治疗方式。这项I期临床试验已在西班牙、德国和法国的19个欧洲研究中心展开,并与全球知名公司ICON合作进行。候选药物CT-01的首剂给药已在着名的巴塞隆纳肝癌诊所(BCLC)完成。
  • 2025 年 5 月,Erasca 公司宣布其临床实验新药核准(IND) 已获得美国食品药物管理局(FDA) 的批准,该药物为 ERAS-0015,是一种可能为 RAS 突变 (RASm) 实体瘤患者提供的最佳泛 RAS 分子固体癌。
  • 2025年1月,Salarius Pharmaceuticals, Inc.和Decoy Therapeutics宣布签署最终合併协议。根据该最终协议,在满足协议中规定的交割条件后​​,Decoy Therapeutics将与Salarius Pharmaceuticals, Inc.的完全子公司合併。合併后的新公司将沿用Decoy Therapeutics的名称。
  • 2024 年 7 月,MindRank 宣布其分子胶计划MRANK-103(旨在靶向 MYC 信号通路并调节真核翻译和转录因子)已完成临床前候选药物筛选 (PCC),并启动了 IND 准备研究。
  • 2024年5月,Gluetacs Therapeutics宣布完成A轮资金筹措,由黄埔生物製药基金主导,高通投资、南湾百奥和Synlinx参投。这笔资金将主要用于推动公司在产品平臺GT919和GT929的I期临床试验,以及进行临床前计划。
  • 2024 年 5 月,Erasca 宣布已就两项临床前阶段的 RAS 项目达成独家许可协议:ERAS-0015,一种潜在的同类最佳RAS 分子胶;以及 ERAS-4001,一种潜在的First-in-ClassKRAS授权合约。
  • 2024 年 3 月,Gluetacs Therapeutics核准进行 GT919 与地塞米松合併用药的 1 期临床试验。

本报告全面深入分析了分子胶的竞争格局,涵盖 80 多家公司和 90 多种药物,按产品类型、阶段、给药途径和分子类型对治疗药物进行评估,并重点介绍了暂停中的在研发线产品。

目录

介绍

执行摘要

分子胶:概述

  • 介绍
  • 分子胶的发展历程与临床里程碑
  • 作用机制
  • 分子胶和靶向蛋白质降解
  • 分子胶分解剂的发展策略
  • 分子胶的应用

分子胶-分析观点:深入的商业性评估

  • 公司对分子胶合作关係的分析

竞争格局

  • 治疗方法、研发阶段和技术对公司进行比较评估

治疗方法评估

  • 按产品类型评分
  • 评级:按等级和产品类型
  • 评估:透过给药途径
  • 评估:按给药阶段和途径
  • 评估:按分子类型
  • 评估:依阶段和分子类型

分子胶:公司和产品简介(已上市治疗方法)

百时美施贵宝

  • 公司概况

波马利斯特

  • 产品描述
  • 研究与开发活动
  • 产品开发活动

分子胶:公司与产品简介(在研治疗方法)

后期产品(III期)

  • 比较分析

Revolution Medicines, Inc.

  • 公司概况

达拉西布

  • 产品描述
  • 研究与开发活动
  • 产品开发活动

中期产品(II期)

  • 比较分析

卫材株式会社

  • 公司概况

E 7820

  • 产品描述
  • 研究与开发活动
  • 产品开发活动

早期产品(I期)

  • 比较分析

Captor Therapeutics

  • 公司概况

CT-01

  • 产品描述
  • 研究与开发活动
  • 产品开发活动

临床前/探索阶段产品

  • 比较分析

SEED Therapeutics, Inc.

  • 公司概况

ST-00937

  • 产品描述
  • 研究与开发活动
  • 产品开发活动

暂停中产品

  • 比较分析

分子胶-未被满足的需求

分子胶-市场驱动因素与障碍

Product Code: DICL0049

DelveInsight's, "Molecular Glues - Competitive landscape, 2026," report provides comprehensive insights about 80+ companies and 90+ drugs in Molecular Glues Competitive landscape. It covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered:

  • Global coverage

Molecular Glues: Understanding

Molecular Glues: Overview

Molecular glues (MGs) are a distinct class of small, typically monovalent molecules that modulate protein-protein interactions by stabilizing or inducing novel complexes between proteins. Most notably, they function by recruiting target proteins often previously considered "undruggable" to E3 ubiquitin ligases, leading to their ubiquitination and subsequent degradation via the proteasome. Unlike traditional inhibitors that block enzymatic function, MGs act through proximity-induced mechanisms, enabling the modulation of non-enzymatic or scaffolding proteins and reshaping cellular protein networks.

Initially discovered in plants, MGs have since been repurposed for therapeutic use across oncology, neurodegeneration, immunology, and antiviral applications. Clinically validated examples, such as thalidomide and its derivatives (lenalidomide, pomalidomide), reprogram the CRBN E3 ligase to degrade transcription factors like IKZF1/3 in multiple myeloma, showcasing their therapeutic potential. Their small size and ligand efficiency allow them to cross the blood-brain barrier and achieve favorable pharmacokinetics, making them particularly attractive for central nervous system (CNS) disorders.

MGs can target a single protein via multiple scaffolds or, conversely, influence multiple targets with a single compound, offering high mechanistic versatility. Structural studies have revealed that MGs bind shallow pockets or induce conformational changes that enable new protein-protein interactions. This often involves cooperative binding, where interaction with one protein enhances affinity for the second, significantly increasing complex stability, potency, and selectivity. Beyond degradation, MGs can also inactivate, stabilize, or sequester proteins, depending on the nature of the ternary complex formed. Their modularity and ability to target disease-specific proteins position them as key tools in precision medicine, particularly for stratified patient populations defined by genetic mutations or biomarkers. They are also valuable in research settings as probes to dissect protein function and interaction networks.

While challenges remain, such as off-target effects, limited diversity of E3 ligases, and a discovery process still largely driven by serendipity, advances in high-throughput screening, DNA-encoded libraries, structural biology, and AI-based modeling are accelerating MGD discovery and optimization. As a result, molecular glues represent a transformative modality within the targeted protein degradation (TPD) field, poised to reshape drug discovery and expand the therapeutic landscape for complex and refractory diseases.

Report Highlights:

  • In August 2025, Plexium has raised USD 60.1 million in a recent funding round, marking a significant milestone for the company following a period of restructuring. This cash infusion comes as Plexium continues to advance its pipeline of innovative protein degraders. The USD 60.1 million raised by Plexium provides a crucial financial boost for the company.
  • In August 2025, Seed Therapeutics, Inc. announced that the US Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for ST-01156. The clearance enabled initiation of a first-in-human Phase 1 clinical trial in patients with advanced solid tumor and hematological malignances, prioritizing multiple cancers with convincing preclinical evidence of RBM39 dependency. First patient dosing is expected in the first quarter of 2026.
  • In August 2025, Zennova announced a strategic collaboration with Rapafusyn Pharmaceuticals, a US-based biotech company, to jointly advance the development of innovative non-degrading molecular glue medicines.
  • In June 2025, Revolution Medicines, announced that it has partnered with Royalty Pharma on USD 2 billion in flexible funding to support Revolution Medicines' independent global development and commercialization strategy and operations. Revolution Medicines retains full strategic and executional control of product development and commercialization for its portfolio of RAS(ON) inhibitors in the US and internationally.
  • In June 2025, Revolution Medicines, announced that the US Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation to Daraxonrasib, the company's RAS (ON) multi-selective inhibitor, for previously treated metastatic PDAC in patients with KRAS G12 mutations.
  • In May 2025, Captor Therapeutics S.A. announced that it has commenced a clinical trial that could revolutionize the treatment of hepatocellular carcinoma (HCC). The Phase I trial has begun in 19 European clinics across Spain, Germany, and France. It is being conducted in collaboration with the global company ICON. The first patient has been dosed with the CT-01 drug candidate at the renowned Barcelona Clinic Liver Cancer (BCLC).
  • In May 2025, Erasca, Inc. announced clearance of an investigational new drug (IND) application by the United States Food and Drug Administration (FDA) for ERAS-0015, a pan-RAS molecular glue with best-in-class potential for patients with RAS-mutant (RASm) solid tumors.
  • In January 2025, Salarius Pharmaceuticals, Inc. and Decoy Therapeutics, Inc., announced the signing of a definitive agreement under which Decoy Therapeutics will merge with a wholly-owned subsidiary of Salarius Pharmaceuticals, subject to the closing conditions set forth in the definitive agreement. The newly formed company will be named Decoy Therapeutics.
  • In July 2024, MindRank, announced that its molecular glue project, MRANK-103, targeting the MYC signaling pathway and designed to regulate eukaryotic translation and transcription factors, has completed the nomination of preclinical candidate (PCC) and begun the IND-Enabling studies.
  • In May 2024, Gluetacs Therapeutics announced that it has secured Series A Funding, led by Huangpu Biopharmaceutical Fund and followed by Gortune Investment, Nanwan Baiao, and Synlinx. This round of financing will be primarily used to advance the clinical Phase I trial of Gluetacs' product pipelines GT919 and GT929 and the development of pre-clinical projects.
  • In May 2024, Erasca, Inc. announced it has entered into exclusive license agreements for two preclinical RAS programs, a potential best-in-class pan-RAS molecular glue (ERAS-0015) and a potential first-in-class pan-KRAS inhibitor (ERAS-4001).
  • In March 2024, Gluetacs Therapeutics was approved to carry out Phase I clinical trial of GT919 combining with dexamethasone.

Molecular Glues: Company and Product Profiles (Marketed Therapies)

1. Company Overview: Bristol Myers Squibb

Bristol Myers Squibb is a global biopharmaceutical company that focuses on discovering, developing, and delivering innovative medicines to patients with serious diseases. Headquartered in New York City, the company specializes in areas such as oncology, immunology, cardiovascular diseases, and fibrosis. Through extensive research and development efforts, Bristol Myers Squibb aims to address unmet medical needs and improve the quality of life for patients around the world. The company collaborates with various partners and employs advanced scientific methods to advance its pipeline of therapeutics.

Product Description: POMALYST

POMALYST is a prescription medicine used to treat adults with Multiple myeloma, taken along with the medicine dexamethasone, in patients who have previously received at least 2 medicines to treat multiple myeloma, including a proteasome inhibitor and lenalidomide, and whose disease has become worse during treatment or within 60 days of finishing the last treatment. It is not known if POMALYST is safe and effective in children.

2. Company Overview: Bristol Myers Squibb

Bristol Myers Squibb is a global biopharmaceutical company that focuses on discovering, developing, and delivering innovative medicines to patients with serious diseases. Headquartered in New York City, the company specializes in areas such as oncology, immunology, cardiovascular diseases, and fibrosis. Through extensive research and development efforts, Bristol Myers Squibb aims to address unmet medical needs and improve the quality of life for patients around the world. The company collaborates with various partners and employs advanced scientific methods to advance its pipeline of therapeutics.

Product Description: REVLIMID

REVLIMID(R) (lenalidomide) is a prescription medicine, used to treat adults with multiple myeloma (MM) in combination with the medicine dexamethasone, or as maintenance treatment after autologous hematopoietic stem cell transplantation (a type of stem cell transplant that uses your own stem cells). REVLIMID should not be used to treat people who have chronic lymphocytic leukemia (CLL) unless they are participants in a controlled clinical trial. It is not known if REVLIMID is safe and effective in children. The therapy is also being approved for Follicular lymphoma, Mantle-cell lymphoma, Marginal zone B-cell lymphoma, Multiple myeloma, and Myelodysplastic syndromes.

Molecular Glues: Company and Product Profiles (Pipeline Therapies)

1. Company Overview: Revolution Medicines, Inc

Revolution Medicines is a clinical-stage oncology company dedicated to developing targeted therapies for cancers driven by RAS mutations, often referred to as RAS-addicted cancers. The company's research and development efforts focus on advancing a robust pipeline of RAS (ON) inhibitors, which are designed to directly suppress active RAS proteins across a broad spectrum of oncogenic variants. These include both multi-selective and mutation-specific approaches aimed at disrupting RAS signaling and halting tumor progression. In addition to its core RAS (ON) inhibitor programs, the company is also developing companion inhibitors to enhance therapeutic efficacy. Revolution Medicines is driven by a commitment to scientific excellence and innovation, challenging conventional approaches to cancer treatment.

Product Description: Daraxonrasib

Daraxonrasib (RMC-6236) is an investigational, oral RAS (ON) multi-selective inhibitor developed by Revolution Medicines. It is designed to target a broad range of oncogenic RAS mutations, including G12X, G13X, and Q61X. Unlike covalent inhibitors, RMC-6236 is non-covalent and works by blocking the interaction between active RAS and its downstream effectors. This suppression of RAS signaling may inhibit tumor growth in RAS-driven cancers. The therapy shows promise in treating pancreatic ductal adenocarcinoma (PDAC), non-small cell lung cancer (NSCLC), and advanced solid tumors. Daraxonrasib is currently being evaluated in a Phase III stage of clinical trial for the treatment of Pancreatic Ductal Adenocarcinoma.

2. Company Overview: Company Overview: Eisai Co., Ltd.

Eisai Co., Ltd. is a leading Japan-based global pharmaceutical company focused on oncology, neurology, and specialty care. The company is committed to its human health care (hhc) mission, emphasizing patient-centric innovation and access to medicines worldwide. Eisai has a strong portfolio that includes novel therapies for cancer, dementia-related diseases, and rare conditions, supported by robust R&D capabilities and strategic collaborations. With operations spanning more than 60 countries, Eisai maintains a significant global presence while continuing to expand its pipeline through research partnerships and in-house development.

Product Description: E 7820

E 7820 is an investigational small-molecule drug developed by Eisai Co., Ltd. that functions as an oral integrin a2 antagonist with anti-angiogenic and immunomodulatory properties. It is designed to inhibit tumor angiogenesis and modulate the tumor microenvironment, thereby suppressing cancer progression. E 7820 has been evaluated in clinical studies for solid tumors, including colorectal and non-small cell lung cancers, as part of Eisai's oncology pipeline. Currently, the drug is in Phase II stage of its clinical study for the treatment of Relapsed/Refractory Myeloid Malignancies.

3. Company Overview: Gluetacs Therapeutics

Gluetacs Therapeutics is the first biotech company incubated by ShanghaiTech University, specializing in the development of small molecule oral protein degraders. The company is led by a team of experienced scientists in the field of targeted protein degradation. Gluetacs owns proprietary platforms for molecular glue (GLUE) and bifunctional degrader (GLUETAC) development, with over 100 patents granted globally. Its fully integrated R&D infrastructure includes AI-driven virtual screening, in vitro and in vivo pharmacology, proteomics, and pharmacokinetics platforms. The GlueTacs(R) platform has successfully advanced two drug candidates into clinical trials. Gluetacs also serves as a training base for advanced degrees in collaboration with ShanghaiTech University and global academic partners. Guided by innovation and patient-centricity, the company is advancing a differentiated pipeline targeting unmet medical needs.

Product Description: GT919

GT919, a molecular glue, directly binds to the substrate receptor Cereblon (CRBN) in CRL4CRBN E3 ubiquitin ligase complex, and then recruits substrate proteins such as the transcription factors IKZF1 and IKZF3 to induce their ubiquitination and further degradation of the substrate proteins, driving to display anti-tumor effects and immune regulations. GT919 is a new generation of immunomodulatory drug in clinical trial, aiming to overcome resistance of existing drugs such as Lenalidomide and Pomalidomide. According to the company's pipeline, GT919 is currently being evaluated in a Phase II stage of clinical trial for the treatment of Relapsed or refractory multiple myeloma.

4. Company Overview: Captor Therapeutics

Captor Therapeutics is a biopharmaceutical company based in Basel, Switzerland and Wroclaw, Poland, dedicated to developing breakthrough therapeutics for severe and underserved diseases using Targeted Protein Degradation (TPD) technology. Leveraging its proprietary Optigrade(TM) discovery platform, which integrates protein engineering, structural biology, molecular modeling, CRISPR-based target validation, and proteomics, the company expedites the identification of both molecular glues and bifunctional degraders to address "undruggable" molecular targets across oncology and autoimmune conditions.

Product Description: CT-01

CT-01 is a first-in-class triple degrader that targets the proteins GSPT-1, NEK7, and SALL4, key drivers in cancer biology. Designed as a prodrug with enhanced tissue specificity for the liver and lungs, CT-01 has shown high efficacy in both cell line-derived and patient-derived xenograft models of hepatocellular carcinoma (HCC). In addition, it demonstrates strong synergy with everolimus, highlighting its potential as a novel therapeutic option for hard-to-treat liver and lung cancers. Currently, the drug is in Phase I stage of its clinical development for the treatment of Hepatocellular carcinoma, Lung cancer and NET tumors.

5. Company Overview: GluBio Therapeutics

GluBio Therapeutics, headquartered in San Diego, with research operations in both the US and Shanghai, specializes in discovering and developing innovative small-molecule therapies through Targeted Protein Degradation (TPD) technology. Combining deep expertise in drug development with a proprietary TPD discovery platform and advanced screening capabilities, the company is advancing a diverse pipeline of highly selective molecular glue and bifunctional degraders across therapeutic areas including oncology and immunology, with the goal of creating transformative treatments for patients with unmet medical needs.

Product Description: GLB-001

GLB-001 is an orally administered molecular glue degrader developed by GluBio Therapeutics that targets casein kinase 1 alpha (CK1a). By promoting the recruitment of CK1a to cellular E3 ubiquitin ligases, GLB-001 induces its ubiquitination and subsequent proteasomal degradation, effectively reducing CK1a protein levels. This mechanism is designed to disrupt oncogenic pathways in diseases such as acute myeloid leukemia and myelodysplastic syndromes. Currently, the drug is in Phase I stage of its clinical development for the treatment of Acute Myeloid Leukemia, Myelodysplastic Syndromes, Polycythemia Vera, and Myelofibrosis.

6. Company Overview: Nurix Therapeutics

Nurix Therapeutics is a clinical-stage biopharmaceutical company pioneering the discovery and development of targeted protein degradation therapies for cancer and inflammatory diseases. The company's wholly owned pipeline includes Bruton's tyrosine kinase (BTK) degraders and Casitas B-lineage lymphoma proto-oncogene B (CBL-B) inhibitors. Nurix is also advancing first- and best-in-class degraders and degrader antibody conjugates (DACs) in preclinical development. Its partnered pipeline features IRAK4 and STAT6 degraders and additional programs with Gilead Sciences, Sanofi, and Pfizer, with select rights for co-development and commercialization. Nurix leverages a fully AI-integrated discovery engine and deep expertise in E3 ligase biology to drive innovation. With a focus on translating cutting-edge science into impactful medicines, the company aims to redefine standards of care.

Product Description: Zelebrudomide

Zelebrudomide (NX-2127) is an oral dual degrader targeting both Bruton's tyrosine kinase (BTK) and cereblon neosubstrates IKZF1 (Ikaros) and IKZF3 (Aiolos), key regulators of B- and T-cell function. It is being evaluated in patients with B-cell malignancies, particularly aggressive non-Hodgkin lymphoma (NHL). By degrading BTK, zelebrudomide disrupts malignant B-cell signaling, while degradation of IKZF1/3 enhances immunomodulatory effects through T-cell activation. This dual mechanism addresses multiple oncogenic pathways, offering the potential for improved efficacy in resistant or relapsed disease. Zelebrudomide's combined anti-tumor and immune-enhancing activity supports its promise as a next-generation therapy. Zelebrudomide is currently being evaluated in a Phase I stage of clinical trial for the treatment of Relapsed/Refractory B-cell Malignancies.

7. Company Overview: Seed Therapeutics

Seed Therapeutics is a global research-focused biotech company and a subsidiary of BeyondSpring, Inc. The company specializes in creating molecular glue degraders to target disease-driving proteins deemed undruggable by traditional methods. Utilizing its proprietary RITE3(TM) platform, Seed leverages deep expertise in ubiquitin-proteasome biology to discover and engineer small molecules that induce targeted protein degradation across oncology, neurodegeneration, immunology, and infectious disease areas. It has built a growing pipeline of novel drug candidates and collaborates strategically with partners such as Eli Lilly and Eisai to advance its mission of developing transformative therapies.

Product Description: ST-00937

ST-00937 is an oral molecular glue degrader discovered by SEED Therapeutics that targets the RNA-binding protein RBM39, a pathogenic factor in various cancers. In preclinical studies, it drove RBM39 down to undetectable levels in Ewing sarcoma cells both in vitro and in vivo, producing complete regression of established tumors within two weeks, while also impairing homologous recombination DNA repair pathways. Currently, the drug is in Preclinical stage of its clinical development for the treatment of Ewing sarcoma.

8. Company Overview: MindRank

MindRank is a clinical stage AI powered drug discovery company founded in 2020 that focuses on hard to drug molecular targets. The company has developed three proprietary technology platforms, Molecule Pro, Molecule Dance, and the PharmKG biomedical knowledge graph, to accelerate small molecule drug design and optimization, spanning discovery through IND enabling stages.

Product Description: MRANK-103

MRANK-103 is a discovery-stage molecular glue degrader crafted using MindRank's AI-powered ProtaG(TM) design platform, targeting the MYC signaling pathway to modulate eukaryotic translation and transcription factors in oncology. This asset has advanced to the IND-enabling stage following nomination as a preclinical candidate. Preclinical data demonstrated nearly complete target degradation (close to 100% efficiency), picomolar-level DC50 potency, strong efficacy across cell models, excellent blood-brain barrier penetration, and promising pharmacokinetics and safety, particularly in MYC-high cancers such as breast, non-small cell lung, and small cell lung cancer, including brain metastases. Currently, the drug is in Preclinical stage of its clinical development for the treatment of breast cancer, colorectal cancer, lung cancer, and gastric cancer.

Molecular Glues Analytical Perspective by DelveInsight

  • In-depth Commercial Assessment: Molecular Glues Collaboration Analysis by Companies

The Report provides in-depth commercial assessment of drugs that have been included, which comprises collaboration, agreement, licensing and acquisition - deals values trends. The sub-segmentation is described in the report which provide company-company collaboration (licensing/partnering), company academic collaboration and acquisition analysis in tabulated form.

  • Molecular Glues Competitive Landscape

The report comprises of comparative assessment of Companies (by therapy, development stage, and technology).

Molecular Glues Report Assessment

  • Company Analysis
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions:

Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing Molecular Glues drugs?
  • How many Molecular Glues drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Molecular Glues?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Bispecific antibody therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Bispecific antibody and their status?
  • What are the key designations that have been granted to the emerging and approved drugs?

Key Players

  • Bristol Myers Squibb
  • Revolution Medicines, Inc.
  • Eisai Co Ltd
  • Gluetacs Therapeutics (Shanghai) Co., Ltd.
  • Captor Therapeutics
  • GluBio Therapeutics
  • Nurix Therapeutics, Inc.
  • SEED Therapeutics, Inc.
  • MindRank Ltd
  • Monte Rosa Therapeutics
  • Beijing InnoCare Pharma Tech Co., Ltd.
  • C4 Therapeutics, Inc.
  • Erasca, Inc.
  • Plexium, Inc.
  • Novartis AG
  • Salarius Pharmaceuticals, Inc
  • Orionis Biosciences
  • Rapafusyn Pharmaceuticals

Key Products

  • POMALYST
  • REVLIMID
  • Daraxonrasib
  • E 7820
  • GT919
  • CT-01
  • GLB-001
  • Zelebrudomide
  • ST-00937
  • MRANK-103
  • MRT-51443
  • ICP-490
  • Cemsidomide
  • ERAS-0015
  • PLX-4545
  • DKY709
  • SP-3164
  • ORB-PR3 MULTIPLE
  • IMM-001
  • ONC-006

Table of Contents

Introduction

Executive Summary

Molecular Glues: Overview

  • Introduction
  • Historical Development and Clinical Milestones of Molecular Glues
  • Mechanism of Action
  • Molecular Glues and Targeted Protein Degradation
  • Development Strategy of Molecular Glue Degraders
  • Applications of Molecular Glues

Molecular Glues -Analytical Perspective: In-depth Commercial Assessment

  • Molecular Glues Collaboration Analysis by Companies

Competitive Landscape

  • Comparative Assessment of Companies (by therapy, development stage, and technology)

Therapeutic Assessment

  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type

Molecular Glues: Company and Product Profiles (Marketed Therapies)

Bristol Myers Squibb

  • Company Overview

POMALYST

  • Product Description
  • Research and Development Activities
  • Product Developmental Activities

Molecular Glues: Company and Product Profiles (Pipeline Therapies)

Late Stage Products (Phase III)

  • Comparative Analysis

Revolution Medicines, Inc.

  • Company Overview

Daraxonrasib

  • Product Description
  • Research and Development Activities
  • Product Developmental Activities

Mid Stage Products (Phase II)

  • Comparative Analysis

Eisai Co Ltd

  • Company Overview

E 7820

  • Product Description
  • Research and Development Activities
  • Product Developmental Activities

Early Stage Products (Phase I)

  • Comparative Analysis

Captor Therapeutics

  • Company Overview

CT-01

  • Product Description
  • Research and Development Activities
  • Product Developmental Activities

Preclinical and Discovery Stage Products

  • Comparative Analysis

SEED Therapeutics, Inc.

  • Company Overview

ST-00937

  • Product Description
  • Research and Development Activities
  • Product Developmental Activities

Inactive Products

  • Comparative Analysis

Molecular Glues- Unmet needs

Molecular Glues - Market drivers and barriers

List of Tables

  • Table 1 Total Products for Molecular Glues
  • Table 2 Late Stage Products
  • Table 3 Mid Stage Products
  • Table 4 Early Stage Products
  • Table 5 Pre-clinical & Discovery Stage Products
  • Table 6 Assessment by Product Type
  • Table 7 Assessment by Stage and Product Type
  • Table 8 Assessment by Route of Administration
  • Table 9 Assessment by Stage and Route of Administration
  • Table 10 Assessment by Molecule Type
  • Table 11 Assessment by Stage and Molecule Type
  • Table 12 Inactive Products

List of Figures

  • Figure 1 Total Products for Molecular Glues
  • Figure 2 Late Stage Products
  • Figure 3 Mid Stage Products
  • Figure 4 Early Stage Products
  • Figure 5 Preclinical and Discovery Stage Products
  • Figure 6 Assessment by Product Type
  • Figure 7 Assessment by Stage and Product Type
  • Figure 8 Assessment by Route of Administration
  • Figure 9 Assessment by Stage and Route of Administration
  • Figure 10 Assessment by Molecule Type
  • Figure 11 Assessment by Stage and Molecule Type
  • Figure 12 Inactive Products