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2023-2030 年细胞培养蛋白表面涂层的全球市场Global Cell Culture Protein Surface Coating Market - 2023-2030 |
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细胞培养蛋白表面涂层的全球市场规模预计到 2022 年将达到 8.434 亿美元,到 2030 年将达到 18.105 亿美元,在预测期内(2023-2030 年)增长 10.3%。预计将增长复合年增长率。 主要参与者增加产品发布将有助于在预测期内促进细胞培养蛋白表面涂层市场的增长。 例如,2020年6月,康宁公司推出了包括Matrigel matrix-3D板在内的新产品。
作为附加表面处理的涂层是指为增强细胞粘附而进行的任何附加修改,以及製造商对所有细胞培养塑料进行的标准等离子或电晕处理。 涂层通常用蛋白质或□完成。 细胞培养的一个缺点是它需要高度熟练的人员,动物细胞比许多常见的污染物(细菌、病毒和真菌)生长得慢,并且必须在严格的无菌技术下进行。
3D 细胞培养的额外维度是影响细胞反应的关键特征。 这不仅会影响与周围细胞相互作用的细胞表面受体的空间组织,还会对细胞施加物理限制。
3D 培养的这些空间和物理方面从外到内影响细胞信号,最终影响基因表达和细胞行为。 与 2D 培养相比,3D 培养中的细胞反应已被证明可以更接近地模拟体内行为。
细胞培养需要持续监测以防止污染,同时要避免细胞培养蛋白表面涂层的浪费,它本身也很昂贵,影响了市场增长。
此外,组织组成是可变的和异质的。 来自同一样本的副本具有不同的成分。 必须通过连续传代多次操作细胞系才能重现实验结果。
例如,任何文化都会与原本不同,其构成也不统一。 为了解决这个问题,复製品在每一代随机混合,生长条件的选择压力倾向于产生最佳显性表型。 这些缺点将阻碍细胞培养蛋白表面涂层市场的增长。
根据 2022 年 7 月发表在《临床病毒学杂誌》上的一份报告,在培养物中分离出 SARS-CoV-2 的概率、出现症状的天数更少以及 RT-PCR 循环阈值更低之间存在显着差异。存在显着的正相关。
因此,在 COVID-19 中,细胞培养被用于正确诊断,这有望推动细胞培养蛋白表面涂层市场的增长。 病毒研究仍在进行中,因此预计将在未来产生重大影响。
俄罗斯和乌克兰之间的衝突中断了文化中使用的某些设备的供应链,增加了消费者的成本,并使他们更难获得所需的设备。 这些因素对细胞培养蛋白表面涂层市场产生了重大影响。
The global cell culture protein surface coating market size was valued at US$ 843.4 million in 2022 and is estimated to reach US$ 1,810.5 million by 2030, growing at a CAGR of 10.3% during the forecast period (2023-2030). An increase in the product launches by major key players helps to boost cell culture protein surface coating market growth over the forecast period. For instance, in June 2020, Corning Incorporated launched new products, including Matrigel matrix-3D plates.
Coating as an additional surface treatment stands for all additional modifications made to increase cell adhesion and the standard plasma or corona treatment performed on all cell culture plastic by the manufacturer. Usually, a coating is done with proteins or peptides. The disadvantages of cell culture are: highly skilled personnel, techniques must be performed using strict asepsis techniques because animal cells grow slower than many of the common contaminants (bacteria, viruses, and fungi).
The additional dimensionality of 3D cell cultures is the crucial feature leading to the differences in cellular responses. It not only influences the spatial organization of the cell surface receptors engaged in interactions with surrounding cells, but it also induces physical constraints on cells.
These spatial and physical aspects in 3D cultures affect the signal transduction from the outside to the inside of cells and ultimately influence gene expression and cellular behavior. It has been demonstrated that cell responses in 3D cultures are more similar to in vivo behavior compared to 2D cultures.
Cell cultures should be constantly monitored to prevent contamination and avoid wastage of protein surface coating of the cell cultures, which can be expensive in nature, thereby impacting the growth of the market.
In addition, tissue composition is variable and heterogeneous. Replicas from the same sample have various constituents. To replicate an experimental result, cell lines must be manipulated many times in serial passages.
For instance, every culture will be different from the original and less uniform in its constitution. The replicas are randomly mixed in each passage to resolve this issue, and the selective pressure of growing conditions tends to produce an optimal prevalent phenotype. These disadvantages will hamper the cell culture protein surface coating market growth.
As per the report published by the Journal of Clinical Virology in July 2022, there was a significant positive correlation between the probability of isolating SARS-CoV-2 in culture, fewer days of symptoms, and a lower RT-PCR cycle threshold value.
Hence, the cell culture was used during COVID-19 for proper diagnosis and was expected to drive the growth of the cell culture protein surface coatings market. As viral studies are still ongoing, it is expected to have a significant impact in the coming future.
The conflict between Russia and Ukraine has caused a disruption of the supply chain for some of the equipment used in culture, increasing costs for consumers and making it more difficult for them to access the necessary equipment. These factors have had a significant impact on the cell culture protein surface coating market.
The global cell culture protein surface coating market is segmented based on coating type, protein source, and region.
In coating type segment, the precoating segment accounted for the highest cell culture protein surface coating market size of around 3/5th in 2022. Depending on the quality and quantity control of the plasma treatment surface of the flask, petri dish or microwell plates are activated for adhesion either homogeneously or artefacts, and it may be inserted, as regions like edges are not treated or parts in the middle area or over or under activated.
Another important part of choosing a cell culture consumable supplier is the construction design. Multiwell plates and petri dishes are strongly influenced by adhesion.
One of the secrets that allow Canada to punch above its weight in the biomanufacturing economy is the tradition of collaboration between academia, industry, non-profits, and government support. In British Columbia, both the University of Victoria and the University of British Columbia have strong undergraduate programs in biomedical engineering that provide an important supply of talent to feed the growing biomanufacturing ecosystems and address challenges in regenerative medicine.
The Canadian government has already invested 1.2 billion dollars into a national biomanufacturing strategy that they continue to support. The Canadian government also supports research and development through its national funding agency - the Natural Sciences and Engineering Research Council.
The major global players include Thermo Fisher Scientific, Corning, Merck, PerkinElmer, Greiner Bio-One International GmbH, Agilent Technologies, BRAND GMBH + CO KG, Kollodis BioSciences, DenovoMATRIX, and faCellitate among others.
The global cell culture protein surface coating market report would provide approximately 92 tables, 108 figures and 195 Pages.
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