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市场调查报告书
商品编码
1712496
全球骨坏死治疗市场 - 2025-2033Global Osteonecrosis Treatment Market - 2025-2033 |
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2024年全球骨坏死治疗市场规模达2.5322亿美元,预计到2033年将达到4.0301亿美元,在2025-2033年的预测期内复合年增长率为5.9%。
骨坏死,也称为缺血性坏死、无菌性坏死或缺血性骨坏死,是一种因骨软骨下区域血流中断而导致骨细胞死亡的退化性骨病变。这种疾病最常影响承重关节处长骨的骨骺,在严重的情况下,会破坏软骨下骨或导致整个关节塌陷。
股骨头、膝关节、距骨和肱骨头是骨坏死最常见的部位,而髋关节是最常受影响的关节。不太常见的是,它可以发生在其他骨骼中,例如腕骨或下颚骨。早期发现和介入对于有效治疗骨坏死至关重要。这项活动探讨了该疾病背后的原因和机制以及最常见受影响区域的表现和治疗方案。
驾驶员和约束装置
骨坏死发生率上升
骨坏死发生率的不断上升是全球骨坏死治疗市场扩张的重要驱动力。随着越来越多的人被诊断出患有这种疾病,对有效治疗方案的需求也随之增加,推动了市场的成长。全球人口老化是导致骨坏死病例增加的主要因素。老年人罹患骨坏死的风险更高,尤其是髋关节。根据世界卫生组织(WHO)的数据,到2030年,每6人中就有1人年龄在60岁或以上,到2050年,60岁以上人口数将达到21亿人。
骨坏死最常见于 60 岁及以上的人,其中髋关节最容易受到影响。创伤性损伤,尤其是道路交通事故造成的创伤,是导致骨坏死增加的主要原因,尤其是在年轻人身上。根据世界卫生组织(WHO)2023年12月的资料,每年约有119万人死于道路交通事故。道路交通伤害是5至29岁儿童和年轻人死亡的主要原因。随着外伤数量的增加,骨坏死病例的数量也会增加。这增加了对关节保护手术、截骨术和关节成形术等治疗方案的需求。
骨坏死最常影响髋部,但也可发生在肱骨、膝盖和距骨。这种症状在腕部较小的骨头(如月骨)中较不常见。虽然它也会影响下颚,但本综述重点关注骨科医生看到的更常见的形式。根据美国国家生物技术资讯中心 (NCBI) 2023 年 8 月的资料,在美国,10% 的全髋关节置换术是由于缺血性坏死 (AVN) 进行的,通常影响 30 至 65 岁的个人。
由于使用皮质类固醇、生活方式疾病、创伤和人口老化,骨坏死发生率不断上升,对全球骨坏死治疗市场产生了重大影响。这种日益加重的负担推动了药物和外科治疗的创新,使骨坏死管理成为骨科和再生医学行业中一个不断增长的领域。
与治疗相关的不良副作用
多种因素会增加双磷酸盐相关颚骨坏死(BRONJ)的风险,这可能会对全球骨坏死治疗市场造成限制。根据美国国家生物技术资讯中心(NCBI)2023年7月的资料,拔牙、牙周治疗、口腔植牙、使用假牙等牙科手术会加速骨转换,增加骨坏死的风险。癌症、化疗、低血红蛋白、糖尿病、肾透析、高血压、高脂血症和高胆固醇血症等疾病进一步增加了 BRONJ 的风险。
皮质类固醇、H2 阻断剂、抗血管生成剂(例如舒尼替尼、贝伐单抗)、促红血球生成素和环磷酰胺疗法等药物会影响骨骼代谢和免疫反应,从而增加 BRONJ 的风险。某些遗传因素,例如法呢基焦磷酸合成酶或 CYP2C8 的多态性,可能使个体易患双磷酸盐相关的骨坏死,尤其是在多发性骨髓瘤患者中。年龄、饮酒和吸烟会进一步增加骨坏死的可能性,使治疗选择变得复杂。
The global osteonecrosis treatment market reached US$ 253.22 million in 2024 and is expected to reach US$ 403.01 million by 2033, growing at a CAGR of 5.9 % during the forecast period of 2025-2033.
Osteonecrosis, also referred to as avascular necrosis, aseptic necrosis, or ischemic bone necrosis, is a degenerative bone condition caused by the interruption of blood flow to the bone's subchondral area, leading to the death of bone cells. This condition most commonly affects the epiphysis of long bones at weight-bearing joints and, in severe cases, can destroy the subchondral bone or cause the collapse of an entire joint.
The femoral head, knee, talus, and humeral head are the most frequent sites for osteonecrosis, with the hip being the most commonly affected joint. Less commonly, it can occur in other bones such as the carpus or jaw. Early detection and intervention are crucial for the effective management of osteonecrosis. This activity explores the causes and mechanisms behind the disease and the presentation and treatment options for the most commonly affected areas.
Market Dynamics: Drivers & Restraints
Rising Incidence of Osteonecrosis
The growing incidence of osteonecrosis is a significant driver for expanding the global osteonecrosis treatment market. As more individuals are diagnosed with this condition, the demand for effective treatment options increases, fueling market growth. The aging global population is a major factor contributing to the rising number of osteonecrosis cases. Older individuals are at a higher risk of developing osteonecrosis, particularly in the hip joint. According to the World Health Organization (WHO), by 2030, 1 in 6 people will be aged 60 or older, and by 2050, the number of people aged 60 and above will reach 2.1 billion.
Osteonecrosis is most common in individuals aged 60 and above, with the hip joint being the most frequently affected. Traumatic injuries, particularly from road accidents, are key contributors to the rise in osteonecrosis, especially in younger individuals. As per World Health Organization (WHO) data in December 2023, around 1.19 million people die annually due to road traffic accidents. Road traffic injuries are the leading cause of death among children and young adults aged 5 to 29 years. As the number of traumatic injuries increases, so will the number of osteonecrosis cases. This increases the demand for treatment options like joint preservation surgery, osteotomy, and arthroplasty.
Osteonecrosis most commonly affects the hip but can also occur in the humerus, knee, and talus. It is less frequently seen in the smaller bones of the wrist, like the lunate. While it can also impact the jaw, this review focuses on the more common forms seen by orthopedic surgeons. According to the National Center for Biotechnology Information (NCBI) data in August 2023, in the United States, 10% of total hip arthroplasties are performed due to avascular necrosis (AVN), typically affecting individuals aged 30 to 65.
The increasing incidence of osteonecrosis, driven by corticosteroid use, lifestyle diseases, trauma, and an aging population, is significantly impacting the global osteonecrosis treatment market. This rising burden is pushing forward innovations in both pharmacological and surgical treatments, making osteonecrosis management a growing segment within the orthopedic and regenerative medicine industries.
Adverse Side Effects Associated with Treatment
Several factors increase the risk of developing bisphosphonate-related osteonecrosis of the jaw (BRONJ), which can act as a restraint in the global osteonecrosis treatment market. According to the National Center for Biotechnology Information (NCBI) data in July 2023, dental surgeries such as tooth extractions, periodontal treatments, oral implants, and the use of dentures can heighten bone turnover and increase the risk of osteonecrosis. Conditions like cancer, chemotherapy, low hemoglobin, diabetes, renal dialysis, hypertension, hyperlipidemia, and hypercholesterolemia further elevate the risk of developing BRONJ.
Drugs such as corticosteroids, H2 blockers, antiangiogenic agents (e.g., sunitinib, bevacizumab), erythropoietin, and cyclophosphamide therapy can increase the risk of BRONJ by affecting bone metabolism and immune response. Certain genetic factors, such as polymorphisms in farnesyl pyrophosphate synthase or CYP2C8, may predispose individuals to bisphosphonate-associated osteonecrosis, particularly in patients with multiple myeloma. Age, alcohol consumption, and tobacco use can further increase the likelihood of developing osteonecrosis, complicating treatment options.
The global osteonecrosis treatment market is segmented based on type, treatment, route of administration, and region.
The non-steroidal anti-inflammatory drugs segment in treatment is expected to dominate the global osteonecrosis treatment market with the highest market share
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used as a first-line treatment to manage pain and inflammation associated with osteonecrosis, a condition characterized by the death of bone tissue due to reduced blood supply. NSAIDs work by inhibiting cyclooxygenase (COX) enzymes, reducing the production of prostaglandins, which are responsible for inflammation and pain. In osteonecrosis, NSAIDs are primarily prescribed to provide symptomatic relief and to manage associated conditions such as arthritis.
The increasing prevalence of osteonecrosis due to factors such as prolonged corticosteroid use, alcohol consumption, trauma, and autoimmune diseases is driving demand for NSAIDs.Due to concerns over opioid addiction, many healthcare providers prefer NSAIDs as a safer alternative for pain management.NSAIDs are available in oral, topical, and injectable forms, offering flexibility in administration for different patient needs. With an aging population prone to bone-related conditions like osteoporosis and osteonecrosis, NSAID demand is expected to grow. These factors have solidified the segment's position in the global osteonecrosis treatment market.
North America is expected to hold a significant position in the global osteonecrosis treatment market, with the highest market share
Osteonecrosis is a significant cause of hip arthroplasties in the U.S., affecting individuals primarily between the ages of 30 and 65. Around 10% of total hip replacements are due to avascular necrosis, indicating a strong demand for treatment solutions. The increasing number of elderly individuals in North America contributes to the demand for osteonecrosis treatments. In the U.S., 17% of the population was 65 or older in 2022, and this demographic is at a higher risk of developing osteonecrosis, further driving market growth.
The development of innovative treatment options, such as ozone injections for medication-related osteonecrosis of the jaw (MRONJ), is expected to boost the market. These treatments provide effective alternatives to surgical intervention for complex cases. The market has seen several approvals for osteonecrosis-related medications. For instance, in June 2022, Strides Pharma received FDA approval for its Ibuprofen suspension. The U.S. market for this product is estimated to be approximately $41 million, and it will be produced at the company's facility in Bengaluru. Thus, the above factors are consolidating the region's position as a dominant force in the global osteonecrosis treatment market.
The major global players in the osteonecrosis treatment market include Pfizer Inc., Haleon Group of Companies, BASF Corporation, Johnson & Johnson, Bayer AG, Sanofi, Upsher-Smith Laboratories, LLC., Merck & Co., Inc., Procter & Gamble Pharmaceuticals, Inc., Novartis AG, Eugia US, Dr. Reddy's Laboratories, and Amgen Inc. among others.
The global osteonecrosis treatment market report delivers a detailed analysis with 71 key tables, more than 56 visually impactful figures, and 176 pages of expert insights, providing a complete view of the market landscape.
Target Audience 2024
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