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市场调查报告书
商品编码
1887156
前列腺癌激素治疗市场规模、占有率、成长及全球产业分析:按类型、应用和地区划分的洞察与预测(2024-2032 年)Prostate Cancer Hormone Therapy Market Size, Share, Growth and Global Industry Analysis By Type & Application, Regional Insights and Forecast to 2024-2032 |
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随着前列腺癌发生率的持续上升和治疗创新技术的快速发展,全球前列腺癌激素治疗市场呈现强劲增长势头。根据最新的产业预测,该市场预计在 2024 年达到 160.7 亿美元,并在 2025 年达到 204.4 亿美元。预计到 2032 年,该市场规模将飙升至 799.3 亿美元,显示全球医疗保健系统对基于荷尔蒙疗法的治疗方案有着强劲的需求。 2024 年,北美地区凭藉先进的医疗保健基础设施、完善的报销政策以及对早期癌症诊断的高度重视,以 51.71% 的市场占有率占主导地位。
荷尔蒙疗法仍是前列腺癌治疗的基石。这种疗法也称为雄性激素剥夺疗法 (ADT),它能降低驱动肿瘤生长的荷尔蒙水平,广泛用于转移性和晚期疾病的治疗。随着全球癌症负担的加重——2022 年全球癌症研究联盟 (GLOBOCAN 2022) 记录了 147 万例前列腺癌病例,使其成为第四大癌症发病原因——人们对荷尔蒙疗法作为核心治疗方法的依赖性日益增强。
市场驱动因素
先进荷尔蒙疗法的研发是推动市场发展的关键因素。各大製药公司正在推出新的雄性激素受体抑制剂和新一代基于促性腺激素释放激素 (GnRH) 的疗法,以克服抗药性并改善患者预后。 2023 年 11 月,安斯泰来製药和辉瑞的 XTANDI 获得 FDA 批准用于治疗非转移性去势敏感性前列腺癌,扩大了治疗选择的范围。
强大的研发管线和不断增加的临床试验持续加速治疗创新。 除了全球前列腺癌发生率不断上升外,已开发国家先进治疗手段的普及也支撑着市场的持续成长。
市场限制因子
一个主要的限制因素是对传统雄性激素剥夺疗法(ADT)抗药性的日益增强。随着时间的推移,前列腺癌细胞可能会发生突变,持续产生雄激素,从而降低治疗效果。例如,西尔维斯特综合癌症中心于2024年1月发表的一项研究表明,即使在激素抑制疗法期间,3β-羟基类固醇脱氢酶1(3BHSD1)也能使肿瘤再生雄激素,加速疾病进展。这种抗药性对治疗效果构成挑战,并限制了长期治疗的实施。
市场挑战
接受荷尔蒙治疗的患者常常会出现严重的副作用,这可能导致治疗顺从性下降。勃起功能障碍和性慾减退是常见的併发症。 2020 年 Elsevier 的一项研究发现,82% 的 ADT 患者出现勃起功能障碍,64% 的患者报告性慾下降,对生活品质有负面影响。这些不良反应仍然是治疗持续性的重大障碍。
市场机会
联合疗法具有巨大的未来潜力。製药公司正在积极探索 PARP 抑制剂与 ADT 的联合应用,以克服抗药性并延长存活期。 2025 年 2 月,TALAPRO-2 试验表明,他拉唑帕尼(Tarzena)和恩扎卢胺(Xtandi)的联合用药可使 HRR 缺陷型转移性前列腺癌患者的总生存期延长 14 个月,死亡风险降低 38%。 这些结果凸显了联合疗法在塑造未来治疗格局方面的巨大潜力。
依药物类别
2024年,GnRH激动剂凭藉其强大的睪固酮抑製作用占了最大的市场占有率。 CAMCEVI等产品的监管批准持续巩固了这个细分市场。由于多项新药核准和临床适应症的扩大,GnRH受体拮抗剂和雄激素受体抑制剂预计将显着成长。
依疾病类型
2024年,转移性去势抵抗性前列腺癌(mCRPC)细分市场引领市场,这主要得益于发病率的上升和获批标靶疗法数量的增加。 随着各公司扩大适应症范围,非转移性去势抵抗性前列腺癌 (CRPC) 市场预计将显着成长。
依给药途径
口服给药途径占最大占有率,这主要得益于其给药方便以及仿製药的普及(例如,Amneal 公司获得 FDA 批准的醋酸阿比特龙仿製药)。由于新的注射剂型正在研发中,肠外给药途径的市占率也持续成长。
按分销管道
医院药房占主导地位,这得益于医院拥有专业的癌症治疗中心,并且治疗过程由医生监督。 同时,随着药物可近性的提高,零售药局和线上药局也在稳定成长。
北美
由于前列腺癌的高发病率和先进疗法的广泛应用,预计到2024年,北美市场规模将达到83.1亿美元。强大的研发基础和FDA的批准是该地区主导的重要因素。
欧洲
欧洲拥有第二大市场占有率,这得益于监管机构的批准。 2024年,NICE(英国国家卫生与临床优化研究所)推荐ORGOVYX作为经济有效的治疗选择。
亚太地区
由于人口老化和治疗药物核准数量的增加,预计亚太地区将实现最快成长。 2024年7月,中国国家药品监督管理局(NMPA)核准Estandi用于治疗转移性疾病。
拉丁美洲、中东和非洲
预计在合作不断扩大和前列腺癌治疗可及性逐步提高的推动下,该地区将实现温和增长。
The global prostate cancer hormone therapy market is witnessing robust growth as prostate cancer prevalence continues to rise and treatment innovations advance rapidly. According to the latest industry estimates, the market was valued at USD 16.07 billion in 2024, is expected to reach USD 20.44 billion in 2025, and is projected to surge to USD 79.93 billion by 2032, demonstrating the strong demand for hormone-based treatment options across global healthcare systems. In 2024, North America dominated the market with a 51.71% share, supported by advanced healthcare infrastructure, strong reimbursement policies, and high awareness of early cancer diagnosis.
Hormone therapy remains a cornerstone of prostate cancer management. Also known as Androgen Deprivation Therapy (ADT), this treatment reduces hormone levels that fuel tumor growth and is widely used in metastatic and advanced-stage cancers. With global cancer burden intensifying-GLOBOCAN 2022 recorded 1.47 million prostate cancer cases, making it the 4th most common cancer-there is rising dependence on hormone therapy as a core treatment approach.
Market Drivers
The development of advanced hormonal therapies is a major market driver. Leading pharmaceutical companies are introducing new androgen receptor inhibitors and next-generation GnRH-based therapies to overcome resistance and improve patient outcomes. In November 2023, Astellas Pharma and Pfizer received FDA approval for XTANDI for non-metastatic Castration-Sensitive Prostate Cancer, enabling broader treatment use.
Strong R&D pipelines and increasing clinical trials continue to accelerate therapeutic innovation. The rising global incidence of prostate cancer, coupled with expanding access to advanced therapies in developed nations, also supports continuous market growth.
Market Restraints
A significant restraint is the growing resistance to conventional ADT. Over time, prostate cancer cells may mutate and continue producing androgens, diminishing therapeutic effectiveness. For instance, research in January 2024 by Sylvester Comprehensive Cancer Center revealed that the enzyme 3BHSD1 enables tumors to regenerate androgens even during hormone suppression therapy, accelerating disease progression. This resistance challenges treatment efficacy and limits long-term therapy adoption.
Market Challenges
Patients undergoing hormonal therapy often experience substantial side effects, making treatment adherence challenging. Erectile dysfunction and libido loss are common complications. A study published by Elsevier in 2020 reported that 82% of ADT patients experienced erectile problems, while 64% reported loss of sexual desire, negatively affecting quality of life. Such adverse effects remain a major barrier to therapy continuation.
Market Opportunities
Combination therapies offer significant future opportunities. Pharmaceutical companies are increasingly exploring combinations of PARP inhibitors with ADT to address resistance and extend survival. In February 2025, the TALAPRO-2 trial demonstrated that combining talazoparib (Talzenna) with enzalutamide (Xtandi) provided a 14-month improvement in overall survival for HRR-deficient metastatic prostate cancer patients, with a 38% reduction in mortality risk. These outcomes highlight the strong potential of combination therapy in shaping the future treatment landscape.
By Drug Class
In 2024, GnRH agonists held the leading share due to high effectiveness in testosterone suppression. Regulatory approvals for products like CAMCEVI continue strengthening this segment. GnRH receptor antagonists and androgen receptor inhibitors are expected to grow substantially due to multiple new approvals and expanded clinical indications.
By Disease State
The metastatic castration-resistant prostate cancer (mCRPC) segment dominated in 2024, driven by rising incidence and increased approvals of targeted therapies. The non-metastatic CRPC segment is set for strong growth as companies broaden their indications.
By Route of Administration
The oral segment held the largest share due to ease of administration and growing generic launches, such as Amneal's FDA-approved generic Abiraterone Acetate. The parenteral segment continues to expand with new injectable formulations under trial.
By Distribution Channel
Hospital pharmacies lead due to specialized cancer treatment centers and physician-supervised therapy administration. Retail and online pharmacies are growing steadily due to improved drug accessibility.
North America
The market reached USD 8.31 billion in 2024, driven by high prostate cancer incidence and advanced therapeutic adoption. Strong R&D presence and FDA approvals contribute to regional dominance.
Europe
Europe holds the second-largest share, supported by healthcare authority endorsements. In 2024, NICE recommended ORGOVYX as a cost-effective treatment option.
Asia Pacific
Expected to be the fastest-growing region due to rising aging populations and increasing therapy approvals. In July 2024, China's NMPA approved XTANDI for metastatic disease.
Latin America & Middle East/Africa
Moderate growth is expected, driven by rising collaborations and gradual improvements in prostate cancer treatment access.
Conclusion
The global prostate cancer hormone therapy market is on a strong growth trajectory, rising from USD 16.07 billion in 2024 to USD 20.44 billion in 2025, and projected to reach USD 79.93 billion by 2032. With expanding treatment innovations, increasing approvals, and strong R&D momentum, hormone therapy remains central to the future of prostate cancer care.
Segmentation By Drug Class
By Route of Administration
By Disease State
By Distribution Channel
By Region
Figure 57: Global Prostate Cancer Hormone Therapy Market Share (%), By Company, 2024