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市场调查报告书
商品编码
1887170
镥-177 (Lu-177) 市场规模、占有率、成长及全球产业分析:依类型、应用和地区划分的洞察与预测 (2024-2032)Lutetium-177 Market Size, Share, Growth and Global Industry Analysis By Type & Application, Regional Insights and Forecast to 2024-2032 |
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随着标靶放射性核种疗法在癌症治疗中日益重要,全球镥-177 (Lu-177) 市场正在快速扩张。根据最新评估,预计2024年市场规模将达到21.5亿美元,2025年达到27.3亿美元,到2032年将达到108.4亿美元。这意味着2025年至2032年的复合年增长率(CAGR)为21.8%。这一快速增长主要受癌症发病率上升、标靶治疗的日益普及以及新一代Lu-177放射性药物供应量增加的推动。
市场概览
镥-177是一种β射线放射性同位素,用于标靶放射性核种治疗,特别适用于神经内分泌肿瘤(NETs)和摄护腺癌,这两种肿瘤的发生率在全球范围内均呈上升趋势。镥-177能够特异性地与肿瘤受体结合,例如NETs中的生长抑素受体和前列腺癌中的PSMA(前列腺特异性抗原受体),从而实现将辐射精准地输送到癌细胞,同时保护健康组织。主要市场参与者包括诺华製药(Novartis AG)、兰特斯控股公司(Lantheus Holdings, Inc.)、泰利克斯製药公司(Telix Pharmaceuticals, Inc.)和雷迪製药诊断公司(Radiopharm Theranostics, Inc.),这些公司都在积极拓展其镥-177 (Lu-177)。
全球精准肿瘤学的兴起也推动了市场发展,放射性配体疗法 (RLT) 已成为传统疗法无效患者的重要治疗选择。
主要地区市场规模及趋势
2024年,北美在全球市场占主导地位,市占率高达82.79%。这主要得益于该地区较高的癌症发生率、完善的医保报销系统以及先进的放射性药物生产设施。预计到 2024 年,该地区的收入将达到 17.8 亿美元,其中美国凭藉 SHINE Technologies 位于简斯维尔的 Lu-177 工厂(北美最大的 Lu-177 工厂)等关键设施,引领着生产市场。
欧洲在 2024 年占第二大市场占有率,这得益于其强大的临床基础设施和标靶疗法的日益普及。英国萨顿核医治疗中心的启用进一步增强了该地区提供 Lu-177 PSMA 疗法的能力。
亚太地区预计将成为成长最快的地区,这主要得益于癌症病例的增加、临床试验的扩展以及各项合作计画的支持。 Radiopharm Theranostics 与 ANSTO 达成协议,供应未掺杂的钌-177,这凸显了对先进放射性药物的持续投资。
市场驱动因素
前列腺癌、神经内分泌肿瘤和其他恶性肿瘤的发生率不断上升是推动市场成长的关键因素。仅在美国,预计到 2025 年将新增 313,780 例前列腺癌病例。镥-177 能够靶向输送 β 射线,使其成为晚期和难治性癌症的首选治疗方法。
标靶放射性核素治疗可减少副作用并改善治疗效果。 Lutathera(钌-177 多肽)和 Plavicto(钌-177 维匹博肽四环素)等产品的日益普及持续推动着市场成长。
市场限制因子
高额的治疗费用限制了中低收入国家的采用。单次注射 Pluvicto 的价格根据地区不同,从 5,000 美元到 12,000 美元不等,平均疗程需要六次注射。放射治疗基础设施的匮乏和不完善的报销体系进一步阻碍了其在全球的推广应用。
市场机会
推进临床研究带来了巨大的机会。在髓母细胞瘤、乳癌、胶质母细胞瘤和非小细胞肺癌 (NSCLC) 领域,使用镕-177 进行的临床试验数量不断增加,这正在扩大治疗范围。诸如 177Lu-omburtamab-DTPA 获得 RPDD(监管优先开发认定)等批准,正在拓展儿科肿瘤领域的治疗选择。
市场趋势
联合疗法
将钌-177与免疫疗法、DNA修復抑制剂和化疗合併应用正成为一大趋势。 Telix Pharmaceuticals 的 STARSTRUCK I 期临床试验(TLX250 与 peposertib 合併用药)代表治疗方案向协同增效方向的转变。
依药物分类
依年龄组
依应用领域
依最终使用者
The global Lutetium-177 (Lu-177) market is experiencing rapid expansion as targeted radionuclide therapy gains global prominence in cancer treatment. According to the latest assessment, the market was valued at USD 2.15 billion in 2024, is projected to rise to USD 2.73 billion in 2025, and is expected to reach USD 10.84 billion by 2032, registering a strong CAGR of 21.8% during 2025-2032. This accelerated growth is driven by increasing cancer prevalence, expanding adoption of targeted therapies, and the growing availability of next-generation Lu-177 radiopharmaceuticals.
Market Overview
Lutetium-177 is a beta-emitting radioisotope used in targeted radionuclide therapy, particularly for neuroendocrine tumors (NETs) and prostate cancer, two cancer types with rising global incidence. Its unique ability to bind to tumor receptors-such as somatostatin receptors in NETs and PSMA in prostate cancer-allows precise delivery of radiation directly to cancer cells while preserving healthy tissues. Key market players include Novartis AG, Lantheus Holdings, Inc., Telix Pharmaceuticals, and Radiopharm Theranostics, all actively expanding their Lu-177 portfolios and production capabilities.
The market is also supported by the global shift toward precision oncology, where radioligand therapy (RLT) is emerging as a vital treatment option for patients who fail conventional therapies.
Market Size & Key Regional Insights
North America dominated the global market in 2024, holding a substantial 82.79% share, driven by high cancer prevalence, strong reimbursement frameworks, and the presence of advanced radiopharmaceutical manufacturing facilities. Regional revenue reached USD 1.78 billion in 2024, with the U.S. leading production due to major facilities like SHINE Technologies' Lu-177 plant in Janesville, the largest in North America.
Europe accounted for the second-largest market share in 2024, supported by robust clinical infrastructure and rising adoption of targeted therapies. The launch of the Nuclear Medicine Therapy Centre in Sutton, U.K., further strengthened the region's capabilities in administering Lu-177 PSMA therapy.
Asia Pacific is projected to be the fastest-growing region, driven by rising cancer cases, expanding clinical trials, and supportive collaboration initiatives. Partnerships such as Radiopharm Theranostics' agreement with ANSTO to supply non-carrier-added Lu-177 highlight ongoing investments in advanced radiopharmaceuticals.
Market Drivers
The increasing incidence of prostate cancer, neuroendocrine tumors, and other malignancies is a primary growth driver. In the U.S. alone, 313,780 new prostate cancer cases are estimated for 2025. Lu-177's ability to deliver targeted beta radiation makes it a preferred therapy for advanced and treatment-resistant cancers.
Targeted radionuclide therapy reduces side effects and improves treatment outcomes. Increasing adoption of products like LUTATHERA (Lu-177 dotatate) and PLUVICTO (Lu-177 vipivotide tetraxetan) continues to fuel market expansion.
Market Restraints
High treatment costs restrict adoption in lower-middle-income countries. A single dose of Pluvicto can cost USD 5,000-12,000 depending on the region, with an average treatment regimen requiring six doses. Limited radiotherapy infrastructure and insufficient reimbursement policies further challenge global adoption.
Market Opportunities
Growing clinical research presents significant opportunities. Increasing numbers of clinical trials on Lu-177 for medulloblastoma, breast cancer, glioblastoma, and NSCLC are widening the therapeutic scope. Regulatory approvals-such as the RPDD for 177Lu-omburtamab-DTPA-are expanding treatment options into pediatric oncology.
Market Trends
Combination Therapy Integration
Combining Lu-177 with immunotherapy, DNA-repair inhibitors, and chemotherapy is emerging as a key trend. Telix Pharmaceuticals' STARSTRUCK Phase I trial combining TLX250 with peposertib exemplifies this shift toward synergistic treatment options.
By Drug
By Age Group
By Application
By End-User
Conclusion
With its market value rising from USD 2.15 billion in 2024 to USD 10.84 billion by 2032, the Lutetium-177 market is poised for transformational growth. Increasing cancer incidence, expanding radioligand therapy approvals, and strong regional production capabilities position Lu-177 as a cornerstone in the future of precision oncology.
Segmentation By Drug
By Age Group
By Application
By End-User
By Region
Figure 46: Global Lutetium-177 Market Share (%), By Company, 2024