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2024-2032 年萤光原位杂交探针市场报告(按类型、探针类型、技术、应用、最终用户和地区)Fluorescent in Situ Hybridization Probe Market Report by Type, Probe Type, Technology, Application, End-User, and Region 2024-2032 |
IMARC Group年,全球萤光原位杂交 (FISH) 探针市场规模达到 8.729 亿美元。 。遗传性疾病盛行率的增加、对早期疾病检测和筛检的日益重视以及广泛的研究和开发(R&D)活动是推动市场的一些主要因素。
萤光原位杂交 (FISH) 探针是一种分子生物学技术,用于可视化和绘製细胞和组织内特定脱氧核糖核酸 (DNA) 或核糖核酸 (RNA) 序列的图谱。它们由各种材料组成,例如寡核苷酸、萤光团、接头和间隔基、封闭试剂和杂交缓衝液。 FISH探针广泛应用于染色体异常检测、基因拷贝数变异分析、肿瘤学研究、微生物鑑定、基因表现分析及产前诊断。它们具有高灵敏度和分辨率,甚至可以检测低拷贝数的目标序列。
对个人化医疗的需求不断增长,促进了 FISH 探针的采用,因为它们为个别患者的基因图谱提供了宝贵的见解,从而能够根据其特定的基因改变制定客製化的治疗策略。此外,临床医生和研究人员广泛使用 FISH 探针来提供有关遗传异常的高解析度视觉和定量信息,这也推动了市场的成长。此外,多个政府实施支持性政策,为患者报销先进的诊断测试费用并提供高品质的医疗设施,这正在加强市场的成长。其他因素,包括老年人口的增加、医疗保健行业的快速扩张、广泛的研发 (R&D) 活动、对标靶治疗的日益关注以及对先进 FISH 探针开发的投资增加,预计将推动市场成长。
遗传性疾病盛行率不断增加
FISH 探针广泛用于检测与遗传性疾病相关的结构异常,例如缺失、重复、倒位和易位。此外,它们在微缺失和微重复综合征的诊断中发挥着至关重要的作用,而这些综合征在标准显微镜下极难检测到。此外,FISH 探针能够检测重复扩增,这有助于识别亨廷顿舞蹈症、脆性 X 症候群和强直性肌肉营养不良。除此之外,它们还可以评估基因拷贝数变化,从而帮助医疗保健专业人员进行疾病分类、预测治疗反应并指导个人化治疗决策,从而促进市场成长。此外,FISH 探针还提供有关携带者状态的信息,使个人能够做出明智的生殖决定并接受适当的遗传咨询。
人们越来越重视早期疾病检测和筛检
FISH 探针在早期癌症检测和诊断中发挥关键作用,因为它们可以针对各种癌症中常见的特定基因改变,包括基因扩增、缺失、易位和染色体重排。除此之外,它们还可以应用于寄生虫、细菌或病毒引起的传染病的早期诊断。此外,FISH 探针广泛用于及时检测遗传疾病,如唐氏症、特纳氏症或杜氏肌肉营养不良症。此外,它们还广泛用于产前诊断,以检测发育中胎儿的染色体异常,从而使父母能够就怀孕和潜在的医疗干预措施做出明智的决定。
广泛的研究与发展 (R&D) 活动
多重 FISH 探针的引入,可以同时检测单一样本中的多个遗传靶标,使研究人员和临床医生能够在单一实验中分析多个基因组区域,从而节省时间和资源,对市场成长产生积极影响。此外,最近开发的邻近FISH 探针能够检测细胞或组织样本内两个或多个遗传目标之间的空间邻近性,从而提供有关细胞内空间相互作用、基因聚类和染色质组织的有价值的信息,这有助于市场增长。此外,FISH 探针资料的快速数位化可以增强资料共享和自动图像分析、储存和远端访问,正在支援市场成长。
The global fluorescent in situ hybridization (FISH) probe market size reached US$ 872.9 Million in 2023. Looking forward, IMARC Group expects the market to reach US$ 1,512.7 Million by 2032, exhibiting a growth rate (CAGR) of 6.1% during 2024-2032. The increasing prevalence of genetic disorders, growing emphasis on early disease detection and screening, and extensive research and development (R&D) activities are some of the major factors propelling the market.
Fluorescent in situ hybridization (FISH) probe is a molecular biology technique used to visualize and map specific deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) sequences within cells and tissues. They are composed of various materials, such as oligonucleotides, fluorophores, linkers and spacers, blocking reagents, and hybridization buffers. FISH probes are widely used in chromosomal abnormality detection, gene copy number variation analysis, oncology research, microbial identification, gene expression analysis, and prenatal diagnosis. They offer high sensitivity and resolution, allowing for the detection of even low-copy-number target sequences.
The increasing demand for personalized medicine is facilitating the adoption of FISH probes, as they provide valuable insights into individual patients' genetic profiles, enabling tailored treatment strategies based on their specific genetic alterations. Furthermore, the widespread utilization of FISH probes by clinicians and researchers to provide high-resolution visual and quantitative information about genetic abnormalities is providing an impetus to the market growth. Additionally, the implementation of supportive policies by several governments to reimburse patients for advanced diagnostic tests and provide access to high-quality healthcare facilities is strengthening the market growth. Other factors, including the rising geriatric population, the rapid expansion of the healthcare industry, extensive research and development (R&D) activities, rising focus on targeted therapies and increasing investment in the development of advanced FISH probes, are anticipated to drive the market growth.
The increasing prevalence of genetic disorders
FISH probes are extensively used to detect structural abnormalities associated with genetic disorders, such as deletions, duplications, inversions, and translocations. Furthermore, they play a crucial role in the diagnosis of microdeletion and microduplication syndromes that are extremely difficult to detect under a standard microscope. Moreover, FISH probes enable the detection of repeat expansions, which aids in identifying Huntington's disease, fragile X syndrome, and myotonic dystrophy. Apart from this, they allow the assessment of gene copy number changes, thus aiding healthcare professionals in disease classification, predicting treatment response, and guiding personalized therapy decisions, which in turn is contributing to the market growth. Additionally, FISH probes provide information about carrier status, which allow individuals to make informed reproductive decisions and receive appropriate genetic counseling.
The growing emphasis on early disease detection and screening
FISH probes play a critical role in early cancer detection and diagnosis, as they can target specific genetic alterations commonly found in various cancers, including gene amplifications, deletions, translocations, and chromosomal rearrangements. Apart from this, they find applications in early diagnosis of infectious diseases caused by parasites, bacteria, or viruses. Moreover, FISH probes are extensively used in the timely detection of genetic conditions, such as Down syndrome, Turner syndrome, or Duchenne muscular dystrophy. Additionally, they are widely employed in prenatal diagnosis to detect chromosomal abnormalities in developing fetuses, which allows parents to make informed decisions about pregnancy and potential medical interventions.
Extensive research and development (R&D) activities
The introduction of multiplex FISH Probes, which allows the simultaneous detection of multiple genetic targets within a single sample, enabling researchers and clinicians to analyze multiple genomic regions in a single experiment, thus saving time and resources, is positively influencing the market growth. Furthermore, the recent development of proximity-FISH probes that enables the detection of spatial proximity between two or more genetic targets within a cell or tissue sample, thus providing valuable information about spatial interactions, gene clustering, and chromatin organization within cells, is contributing to the market growth. Moreover, the rapid digitalization of FISH Probe data, allowing for enhanced data sharing and automated image analysis, storage, and remote access, is supporting the market growth.
IMARC Group provides an analysis of the key trends in each segment of the global fluorescent in situ hybridization (FISH) probe market report, along with forecasts at the global, regional and country levels from 2024-2032. Our report has categorized the market based on type, probe type, technology, application, and end-user.
DNA
RNA
mRNA
miRNA
Others
RNA dominates the market
The report has provided a detailed breakup and analysis of the market based on the type. This includes DNA and RNA (mRNA, miRNA, and others). According to the report, RNA represented the largest market segment.
RNA is dominating the market, as RNA FISH probes enable researchers to investigate gene expression patterns at the single-cell level, which provides valuable insights into cellular heterogeneity, developmental processes, and disease mechanisms. Furthermore, they enable the detection and visualization of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs), which aids in improving the understanding of the functions and regulatory networks of these important RNA molecules. Apart from this, RNA FISH Probes facilitate the real-time observation and tracking of RNA dynamics, such as RNA synthesis, degradation, and turnover rates, thus enabling researchers to study RNA biology and cellular response. Moreover, they offer high sensitivity and specificity in detecting RNA molecules by reducing background noise and false-positive signals.
Locus Specific Probes
Alphoid/Centromeric Repeat Probes
Whole Chromosome Probes
Locus specific probes hold the largest share in the market
The report has provided a detailed breakup and analysis of the market based on the probe type. This includes locus specific probes, alphoid/centromeric repeat probes, and whole chromosome probes. According to the report, locus specific probes accounted for the largest market share.
Locus-specific probes are designed to hybridize to specific genetic loci or regions of interest in the genome, which allows researchers and clinicians to focus on specific genes and chromosomal abnormalities associated with particular diseases and conditions. They also offer high diagnostic accuracy and precision by enabling the detection of specific genetic abnormalities with great specificity. Apart from this, Locus-specific probes are extensively used to detect and characterize genetic variations in patients, including chromosomal aberrations, microdeletions, and gene mutations.
Flow FISH
Q FISH
Others
Flow FISH dominates the market
The report has provided a detailed breakup and analysis of the market based on the technology. This includes flow FISH, Q FISH, and others. According to the report, flow FISH represented the largest market segment.
Flow FISH is dominating the market as it allows for rapid processing of a large number of cells, thus offering more data in a shorter amount of time compared to traditional FISH methods. Furthermore, it is known for its high sensitivity, which makes it ideal for detecting even low-abundance targets in medical diagnostics and research. In addition, flow FISH can be easily integrated with automation technologies to reduce manual errors and increase the throughput. Besides this, it provides quantitative data, which is crucial in fields such as healthcare, where precise measurements are required for diagnosis and treatment plans. Moreover, the cost per sample in flow FISH is less than traditional FISH methods, especially when analyzing large samples, making it highly appealing for both research and clinical settings.
Cancer
Genetic Diseases
Others
Cancer dominates the market
The report has provided a detailed breakup and analysis of the market based on the application. This includes cancer, genetic diseases, and others. According to the report, cancer represented the largest market segment.
FISH probes are widely used in cancer treatment as they help to detect specific genetic abnormalities. It also enables healthcare professionals to identify and classify cancer cells, which further assist in diagnosis, prognosis, and treatment decision-making. Furthermore, they offer high specificity and sensitivity in detecting genetic aberrations and chromosomal rearrangements that are characteristic of various types of cancer. Apart from this, FISH probes aid oncologists in selecting the most appropriate targeted therapies and monitoring treatment response. They also assist in cancer research by improving the understanding of the underlying mechanism associated with cancer. Additionally, FISH probes are widely used in liquid biopsies to offer a non-invasive approach for cancer detection, monitoring, and treatment response assessment.
Research Organizations
Diagnostic Centers
Others
The report has provided a detailed breakup and analysis of the market based on the end-user. This includes flow research organizations, diagnostic centers, and others.
FISH probes are widely used in research organizations to enable the visualization and detection of specific DNA or RNA sequences within cells or tissues. They are used in gene mapping and chromosomal analysis, which aids in studying cancer genetics and identifying chromosomal rearrangements associated with specific malignancies. Furthermore, the FISH probe is extensively utilized in developmental biology and neurobiology to provide valuable insights into gene regulation, cellular development, and disease mechanisms.
Diagnostic centers extensively utilize FISH probes to identify genetic alterations in patient samples, which aids in diagnosing cancer, determining prognosis, and guiding treatment decisions. They also assist in genetic disease screening by detecting specific genetic abnormalities, such as aneuploidies and microdeletion syndromes. Apart from this, FISH probes are widely used in prenatal testing to screen for chromosomal abnormalities in developing fetuses.
North America
United States
Canada
Asia Pacific
China
Japan
India
South Korea
Australia
Indonesia
Others
Europe
Germany
France
United Kingdom
Italy
Spain
Russia
Others
Latin America
Brazil
Mexico
Others
Middle East and Africa
North America exhibits a clear dominance in the market, accounting for the largest fluorescent in situ hybridization (FISH) probe market share
The report has also provided a comprehensive analysis of all the major regional markets, which includes North America (the United States and Canada); Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Latin America (Brazil, Mexico, and others); and the Middle East and Africa. According to the report, North America represented the largest market segment.
North America is dominating the FISH probe market owing to the strong focus on biomedical research in the region aimed at developing new diagnostic tools and molecular technologies. Additionally, the presence of a robust healthcare infrastructure comprising well-established hospitals, clinical laboratories, and diagnostic facilities is favoring the market growth. Moreover, the growing incidences of genetic disorders and cancer are facilitating the demand for accurate and reliable molecular diagnostic tools, such as FISH probes. Furthermore, the implementation of strict policies by regional governments to maintain the safety, efficacy, and quality of medical products and instruments is contributing to the market growth. Along with this, the presence of key players in the region that are equipped with resources and expertise to drive product development, marketing, and sales is positively influencing the market growth.
The top companies in the FISH probe market are actively engaged in developing new products by incorporating advanced technologies to improve the accuracy and reliability of results. In line with this, the significant investment in research and development (R&D) projects to expand their portfolio, gain competitive advantages, and meet rising consumer demand is favoring the market growth. Furthermore, several key players are adopting targeted marketing strategies by designing customized products that meet the unique requirements of users. Additionally, the increasing collaboration between leading companies, research institutions, and academic centers to jointly develop new FISH probe technologies, validate products through clinical studies, and strengthen market presence is contributing to the market growth. Moreover, several product manufacturers are establishing distribution channels, partnerships, and subsidiaries across the globe to expand their business and attract a new customer base.
Abnova Corporation
Agilent Technologies Inc.
Biocare Medical LLC
Biosearch Technologies (LGC Ltd.)
Creative Biolabs
F. Hoffmann-La Roche Ltd. (Roche Holding AG)
Genemed Biotechnologies Inc. (Sakura Finetek USA Inc.)
Merck KGaA
Oxford Gene Technology (Sysmex Corporation)
PerkinElmer Inc.
ThermoFisher Scientific Inc.
In November 2022, Biocare Medical LLC announced the acquisition of Empire Genomics, a company that produces fluorescence in situ hybridization (FISH) probes designed and optimized for specific genes, diseases, or regions across the entire mouse and human genomes.
In March 2023, Oxford Gene Technology (Sysmex Corporation) announced that eight of its CytoCell FISH probes had been certified for clinical use in line with Europe's In Vitro Diagnostics Regulation (IVDR).
In April 2023, Agilent Technologies Inc. expanded its portfolio of SureFISH probes. This move was aimed at creating the largest offering of oligonucleotide-based fluorescent in situ hybridization (FISH) assays on the market.