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市场调查报告书
商品编码
1722423
2025 年至 2033 年高通量筛选市场报告(按技术、产品和服务、应用、最终用户和地区划分)High-throughput Screening Market Report by Technology, Products and Services, Applications, End User, and Region 2025-2033 |
2024年全球高通量筛选市场规模达271亿美元。展望未来, IMARC Group预计到2033年市场规模将达到507亿美元,2025-2033年期间的成长率(CAGR)为7.2%。 3D 细胞培养模型的采用率不断提高、个人化医疗筛选检测的需求不断增长以及基于 CRISPR 的筛选技术的应用日益增多是推动市场成长的一些关键因素。
主要市场驱动因素:越来越多地利用 HTS 来最大限度地缩短製造药物所需的时间,这主要推动了市场的成长。此外,治疗各种危及生命的疾病的新药的开发也催化了对 HTS 技术的需求。
主要市场趋势:将人工智慧 (AI) 和机器学习 (ML) 等先进技术与高通量筛选相结合,以促进自动化和快速资料处理,这是促进市场成长的重要趋势之一。
地理格局:高通量筛选市场预测报告提供了基于地区的市场详细细分和分析。其中包括北美、亚太地区、欧洲、拉丁美洲以及中东和非洲。由于高通量筛选的日益普及、研发支出的增加以及组合化学和基因组学领域的不断进步等因素,预计北美将在高通量筛选市场中占据相当大的市场份额。
竞争格局:一些领先的高通量筛选市场公司包括安捷伦科技公司、Aurora Biomed 公司、Axxam SpA、贝克曼库尔特公司(丹纳赫公司)、Bio-RAD Laboratories 公司、Charles River Laboratories International 公司、康宁公司、Luminex 公司(DiaSorin)、Perkinelmerature 公司、Sywise Group。
挑战与机会:高通量筛选市场的挑战包括资料管理的复杂性和对更多生理相关检测模型的需求,而机会则在于自动化、人工智慧和器官晶片系统等先进技术,以实现更有效率和更具预测性的筛选过程。
不断增加的HTS设施数量
治疗各种危及生命的疾病的新药的开发是推动市场成长的主要动力。此外,HTS 利用率的提高,最大限度地缩短了药品製造所需的时间,也促进了市场的成长。除此之外,高通量筛选(HTS)设施数量的不断增加也催化了高通量筛选市场的近期价格。这些中心的显着优势之一是研究人员、科学家、研究人员等之间的知识分享。例如,哥伦比亚基因组中心为整个哥伦比亚大学研究界的研究人员提供高品质的分子筛选服务。此外,美国国立卫生研究院 (NIH) 计画的欧洲对应计画 EU-open-screen 也为所有从事化学生物学的欧洲公司提供开放取用。高通量筛选(HTS)中心的联合旨在提供有关药物或标靶或整个过程的有用资讯。因此,开放取用为知识共享提供了更好的平台,有助于加速药物开发过程,这可能会推动未来几年高通量筛选市场份额的成长。
新分子的不断开发
各种传染病的盛行率不断上升,促使新型分子和疫苗的开发,这反过来又为高通量筛选市场创造了积极的前景。此外,在药物製造过程中对各种药物和分子进行精确和快速筛选的需求不断增加,导致自动化高通量筛选技术的应用日益广泛。此外,各种製药和生物公司越来越多地采用高通量筛选方法,因为它们具有高灵敏度、自动化、样品最小化以及检测低背景讯号的能力等各种优势,这增强了高通量筛选市场的需求。根据美国国会预算办公室 2021 年发布的资料,全球製药业在 2020 年的研发支出接近 2,000 亿美元,而 2019 年为 8,300 万美元。同样,丹纳赫公司在 2021 年的研发投资为 17.42 亿美元,而 2020 年为 13.48 亿美元。此外,Bio-Rad Laboratories Inc. 在 2021 年的投资为 8.796 亿美元,而 2020 年为 8.003 亿美元。因此,公司在研发方面不断增加的投资进一步提高了它们在高通量筛选检测中采用创新技术的能力,从而增加了市场成长。
技术进步
近年来,高通量筛选 (HTS) 技术取得了重大进展,这得益于机器人、自动化、资料分析和小型化领域的持续创新。此外,自动化和机器人技术的进步正在大大提高 HTS 工作流程的速度和效率。自动化液体处理系统、读板器和机器人平台现在可以高精度、高通量地执行重复性任务,从而减少了人工干预的需要。此外,各领先的生物技术公司也在投资研发活动,以引入改进的 HTS 方法,预计这将推动高通量筛选市场收入的成长。例如,2024 年 2 月,生命科学分析技术的全球领导者 SCIEX 在 SLAS 2024 上推出了 Echo MS+ 系统。该系统将专有的声学喷射质谱技术和开放端口介面 (OPI) 采样与 SCIEX ZenoTOF 7600 或 Triple Quad 6500+ 系统的功能相结合,透过扩展的强大高通量筛选工作流程提供精确的定性和定量结果。
高通量筛选市场概况表明,基于细胞的分析正越来越多地被各种製药和生物技术公司使用。高通量筛选中的细胞分析利用活细胞作为化合物测试的生物读数,能够以高通量的方式评估候选药物对细胞功能、活力和表型的影响,通常用于药物发现和毒性筛选。萤光成像板读数仪检测因其可见的结果和以最小体积进行测试的能力,已成为最常用的基于细胞的检测方法。除此之外,超高通量筛选是最新技术,可在更短的时间内提高产量。大多数公司正处于从 2D 细胞培养到 3D 细胞培养的过渡阶段,因为 3D 细胞在自然环境和其他细胞相关操作中进行测试时表现出更逼真的特性,有助于药物设计和发现。
高通量筛选市场报告根据产品和服务提供了详细的市场细分和分析。其中包括仪器、试剂和试剂盒以及服务。
高通量筛选依赖专门的仪器,例如自动液体处理器、平板读取器和机器人平台。这些仪器能够快速处理、分配和分析微孔板形式的样品,从而提高筛选实验的效率和吞吐量。而高通量筛选所使用的试剂和试剂盒则包括化合物库、生化检测试剂、萤光探针或酵素底物等检测试剂。这些针对与自动化系统和微型化分析格式的兼容性进行了最佳化,从而可以针对特定的生物靶点或途径筛选大型化合物库。
目标识别和验证涉及识别和验证与疾病或生物过程有关的分子目标(例如蛋白质、基因或细胞通路)。透过基因组学、蛋白质组学和生物资讯学等各种方法,可以识别潜在目标并进行验证,以确保其与进一步研究的相关性和可追溯性。而在初级和二级筛选中,会针对特定目标或生物测定对大量化合物库进行测试,以识别出显示出活性或调节作用的初始化合物。该方法涉及对命中化合物进行更详细的表征,以确认其活性、选择性和效力。初步筛选和二次筛选通常包括剂量反应研究、反筛选和二次分析,以验证命中结果并确定其优先顺序以进行先导化合物优化和临床前开发。
根据 IMARC 的高通量筛选市场统计数据,製药公司和政府组织在研发 (R&D) 上的支出最近一直在增加,预计这将在预测期内推动市场成长。例如,全球领先的生命科学和诊断创新者丹纳赫公司 (Danaher Corporation) 在 2021 年的研发投资为 17.42 亿美元,而 2020 年为 13.48 亿美元。此外,Bio-Rad Laboratories Inc. 在 2021 年的投资为 8.796 亿美元,而 2020 年为 8.003 亿美元。因此,製药公司、生技公司和政府机构的巨额投资将继续推动市场成长。
市场研究报告也对所有主要区域市场进行了全面分析,包括北美(美国和加拿大);欧洲(德国、法国、英国、义大利、西班牙、俄罗斯等);亚太地区(中国、日本、印度、韩国、澳洲、印尼等);拉丁美洲(巴西、墨西哥等);以及中东和非洲。
由于高通量筛选的日益普及、研发支出的增加以及组合化学和基因组学领域的不断进步等多种因素,预计北美将在高通量筛选市场中占据相当大的市场份额。除此之外,该地区知名市场参与者的存在也对高通量筛选市场前景产生了正面影响。例如,2021年8月,碧迪公司推出了一款全新的全自动高通量诊断系统,该系统采用机器人技术和样本管理软体演算法,为美国核心实验室和其他中心实验室的传染病分子检测自动化树立了新标准。此次发布使得 BD Onclarity HPV 检测试剂盒(具有扩展基因分型功能)可用于 BD COR 系统,供高通量实验室用于处理美国大多数持续感染人类乳突病毒 (HPV) 的子宫颈癌筛检样本。
市场研究报告对竞争格局进行了全面的分析。也提供了所有主要公司的详细资料。市场中的一些主要参与者包括:
(请注意,这只是关键参与者的部分列表,完整列表在报告中提供。)
2024 年 4 月:Gordian Biotechnology 推出高通量体内筛选平台,以发现治疗方法并更好地预测与年龄相关的疾病的人类结果。
2024 年 4 月:Metrion Biosciences Limited 和 Enamine Ltd. 宣布,Metrion 已增强其高通量筛选 (HTS) 服务,并增加了对 Enamine 化合物库的存取权限。
2024 年 2 月:生命科学分析技术的全球领导者 SCIEX 在 SLAS 2024 上推出了 Echo MS+ 系统。该系统将专有的声学喷射质谱技术和开放端口介面 (OPI) 采样与 SCIEX ZenoTOF 7600 或 Triple Quad 6500+ 系统的功能相结合,透过扩展的强大高通量筛选工作流程提供精确的定性和定量结果。
The global high-throughput screening market size reached USD 27.1 Billion in 2024. Looking forward, IMARC Group expects the market to reach USD 50.7 Billion by 2033, exhibiting a growth rate (CAGR) of 7.2% during 2025-2033. The increased adoption of 3D cell culture models, growing demand for personalized medicine screening assays, and rising application of CRISPR-based screening techniques are some of the key factors driving the market growth.
Major Market Drivers: The increasing utilization of HTS for minimizing the time required for manufacturing a drug is primarily driving the growth of the market. Furthermore, the development of new medicines for treating various life-threatening diseases is also catalyzing the demand for HTS techniques.
Key Market Trends: Integration of advanced technologies, such as artificial intelligence (AI) and machine learning (ML) with high-throughput screening to facilitate automation and fast data processing is one of the significant trends, augmenting the growth of the market.
Geographical Landscape: The high-throughput screening market forecast report has provided a detailed breakup and analysis of the market based on the region. This includes North America, Asia Pacific, Europe, Latin America, and Middle East and Africa. North America is expected to hold a significant market share in the high-throughput screening market owing to factors such as the increasing adoption of high-throughput screening, rising research and development expenditure, and the growing advances in combinatorial chemistry and the field of genomics.
Competitive Landscape: Some of the leading high-throughput screening market companies include Agilent Technologies Inc., Aurora Biomed Inc., Axxam S.p.A, Beckman Coulter Inc. (Danaher Corporation), Bio-RAD Laboratories Inc., Charles River Laboratories International Inc. Corning Incorporated, Luminex Corporation (DiaSorin), Perkinelmer Inc., Sygnature Discovery, Tecan Group Ltd., and Thermo Fisher Scientific, among many others.
Challenges and Opportunities: Challenges in the high-throughput screening market include data management complexities and the need for more physiologically relevant assay models, while opportunities lie in advancing technologies like automation, artificial intelligence, and organ-on-a-chip systems for more efficient and predictive screening processes.
Increasing Number of HTS Facilities
The development of new medicines for treating various life-threatening diseases is primarily driving the growth of the market. Furthermore, the rise in the utilization of HTS for minimizing the time required for manufacturing a drug is also contributing to the market growth. In addition to this, the escalating number of high-throughput screening (HTS) facilities is also catalyzing the high-throughput screening market's recent prices. One of the significant advantages of these centers is knowledge sharing among investigators, scientists, researchers, etc. For instance, the Columbia Genome Center offers high-quality molecular screening services for investigators throughout the Columbia University research community. Also, the European counterpart of the National Institutes of Health (NIH) program, known as EU-open-screen, provides open access to all European companies engaged in chemical biology. The association of high-throughput screening (HTS) centers is intended to provide useful information about the drug or target or the entire process. Thus, open access provides a better platform for knowledge sharing and can help accelerate the drug development process, which may drive the high-throughput screening market share in the coming years.
Rising Development of Novel Molecules
The rising prevalence of various infectious diseases is prompting the development of novel molecules and vaccines, which in turn is creating a positive outlook for the high-throughput screening market. Moreover, the escalating need for precise and quick screening of various drugs and molecules during the manufacturing of a drug is resulting in an increased adoption of automated high-throughput screening techniques. Furthermore, various pharmaceutical and biologic firms are increasingly adopting high-throughput screening methods on account of their various advantages, such as high sensitivity, automation, minimization of the sample, and the ability to detect low background signals, which is bolstering the high-throughput screening market demand. According to the data published by the Congressional Budget Office, in 2021, it was observed that pharmaceutical industries spent nearly US$ 200 Billion on research and development in 2020 globally, compared to US$ 83 Million in 2019. Similarly, Danaher Corporation invested US$ 1,742 Million in its research and development in 2021, as compared to US$ 1,348 Million in 2020. In addition, Bio-Rad Laboratories Inc. invested US$ 879.6 Million in 2021 as compared to US$ 800.3 Million in 2020. Thus, the increasing investment in research and development by the companies further increases their capabilities to adopt innovative technologies in high throughput screening assays, thereby increasing the market growth.
Technological Advancements
High-throughput screening (HTS) techniques have seen significant advancements in recent years, driven by the continuous innovations in robotics, automation, data analysis, and miniaturization. Moreover, advances in automation and robotics are extensively increasing the speed and efficiency of HTS workflows. Automated liquid handling systems, plate readers, and robotic platforms can now perform repetitive tasks with high precision and throughput, reducing the need for manual intervention. Additionally, various leading biotech companies are also investing in research and development activities to introduce improved HTS methods which are anticipated to propel the high-throughput screening market revenue. For instance, in February 2024, SCIEX, a global leader in life science analytical technologies, launched the Echo MS+ system at SLAS 2024. The system couples proprietary Acoustic Ejection Mass Spectrometry technology and Open Port Interface (OPI) sampling with the capabilities of either the SCIEX ZenoTOF 7600 or Triple Quad 6500+ system to deliver precise qualitative and quantitative results through an expanded panel of robust high-throughput screening workflows.
The high-throughput screening market overview indicates that cell-based assays are increasingly being used by various pharmaceutical and biotech companies. Cell-based assays in high-throughput screening utilize live cells as the biological readout for compound testing, enabling the evaluation of drug candidates' effects on cellular function, viability, and phenotype in a high-throughput manner, often employed in drug discovery and toxicity screening. Fluorometric imaging plate reader assays have become the most used cell-based assays owing to visible results and their ability to test with the smallest of volumes. Besides this, ultra-high-throughput screening is the latest technology and is used for increased output in less time. A majority of companies are in a transition phase from 2D-cell cultures to 3D-cell cultures as 3D cells show more lifelike properties while testing in the natural environment and other cell-related manipulations, aided for drug design and discovery.
The high-throughput screening market report has provided a detailed breakup and analysis of the market based on the products and services. This includes instruments, reagents and kits, and services.
High-throughput screening relies on specialized instruments, such as automated liquid handlers, plate readers, and robotic platforms. These instruments enable the rapid handling, dispensing, and analysis of samples in microplate formats, thereby increasing the efficiency and throughput of screening experiments. Whereas reagents and kits that are used in high-throughput screening include compound libraries, biochemical assays, and detection reagents such as fluorescent probes or enzyme substrates. These are optimized for compatibility with automated systems and miniaturized assay formats, allowing for the screening of large compound libraries against specific biological targets or pathways.
Target identification and validation involves identifying and validating molecular targets (such as proteins, genes, or cellular pathways) that are implicated in a disease or biological process. Through various methods, including genomics, proteomics, and bioinformatics, potential targets are identified and then validated to ensure their relevance and draggability for further investigation. Whereas in primary and secondary screening large libraries of compounds are tested against a specific target or biological assay to identify initial hits that show activity or modulation. This method involves a more detailed characterization of hit compounds to confirm their activity, selectivity, and potency. Primary and secondary screening typically includes dose-response studies, counter-screens, and secondary assays to validate hits and prioritize them for lead optimization and preclinical development.
According to high-throughput screening market statistics by IMARC, the spending on research and development (R&D) by both pharmaceutical companies and government organizations has been increasing recently, which is anticipated to drive market growth over the forecast period. For instance, Danaher Corporation, a leading global life sciences and diagnostics innovator, invested US$ 1,742 Million in its research and development in 2021, as compared to US$ 1,348 Million in 2020. In addition, Bio-Rad Laboratories Inc. invested US$ 879.6 Million in 2021 as compared to US$ 800.3 Million in 2020. Thus, the huge investment by pharmaceuticals, biotech firms, and government institutions will continue to drive the market growth.
The market research report has also provided a comprehensive analysis of all the major regional markets, which include North America (the United States and Canada); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Latin America (Brazil, Mexico, and others); and the Middle East and Africa.
North America is expected to hold a significant market share in the high-throughput screening market owing to various factors such as the increasing adoption of high-throughput screening, rising research and development expenditure, and the growing advances in combinatorial chemistry and the field of genomics. In addition to this, the presence of prominent market players in the region is also positively impacting the high-throughput screening market outlook. For instance, in August 2021, Becton, Dickinson, and Company launched a new, fully automated high-throughput diagnostic system using robotics and sample management software algorithms to set a new standard in automation for infectious disease molecular testing in core laboratories and other centralized laboratories in the United States. This launch made BD Onclarity HPV Assay with extended genotyping for the BD COR System available to the high-throughput labs for processing most cervical cancer screening specimens in the United States with persistent infection with human papillomavirus (HPV).
The market research report has provided a comprehensive analysis of the competitive landscape. Detailed profiles of all major companies have also been provided. Some of the key players in the market include:
(Please note that this is only a partial list of the key players, and the complete list is provided in the report.)
April 2024: Gordian Biotechnology introduced a high-throughput in vivo screening platform to discover therapies and better predict human outcomes for age-related diseases.
April 2024: Metrion Biosciences Limited and Enamine Ltd., announced that Metrion has enhanced its High Throughput Screening (HTS) services with the addition of access to Enamine's compound libraries.
February 2024: SCIEX, a global leader in life science analytical technologies, launched the Echo MS+ system at SLAS 2024. The system couples proprietary Acoustic Ejection Mass Spectrometry technology and Open Port Interface (OPI) sampling with the capabilities of either the SCIEX ZenoTOF 7600 or Triple Quad 6500+ system to deliver precise qualitative and quantitative results, through an expanded panel of robust high-throughput screening workflows.