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市场调查报告书
商品编码
1800881
萤光原位杂交探针市场报告(按类型、探针类型、技术、应用、最终用户和地区)2025-2033Fluorescent in Situ Hybridization Probe Market Report by Type, Probe Type, Technology, Application, End-User, and Region 2025-2033 |
2024年,全球萤光原位杂交 (FISH) 探针市场规模达9.262亿美元。展望未来, IMARC Group预计到2033年,该市场规模将达到15.796亿美元,2025-2033年期间的复合年增长率 (CAGR) 为5.81%。遗传性疾病盛行率的不断上升、对早期疾病检测和筛检的日益重视以及广泛的研发活动是推动市场发展的主要因素。
萤光原位杂交 (FISH) 探针是一种分子生物学技术,用于可视化和定位细胞和组织内特定的脱氧核糖核酸 (DNA) 或核糖核酸 (RNA) 序列。它们由各种材料组成,例如寡核苷酸、萤光团、连接子和间隔子、封闭剂和杂交缓衝液。 FISH 探针广泛应用于染色体异常检测、基因拷贝数变异分析、肿瘤学研究、微生物鑑定、基因表现分析和产前诊断。它们具有高灵敏度和分辨率,甚至可以检测低拷贝数的目标序列。
个人化医疗需求的不断增长促进了 FISH 探针的应用,因为它们能够提供关于个别患者基因图谱的宝贵信息,从而根据患者特定的基因变异制定个性化治疗策略。此外,临床医生和研究人员广泛使用 FISH 探针来获取关于基因异常的高分辨率可视化和定量信息,这为市场增长提供了动力。此外,多国政府推出的支持性政策,为患者报销高级诊断检测费用并提供高品质的医疗服务,也正在增强市场成长。其他因素,包括老年人口的成长、医疗保健行业的快速扩张、广泛的研发 (R&D) 活动、对标靶治疗的日益关注以及对高级 FISH 探针开发投资的增加,预计将推动市场成长。
遗传疾病的盛行率不断上升
FISH探针广泛用于检测与遗传疾病相关的结构异常,例如缺失、重复、倒位和易位。此外,它们在诊断标准显微镜下极难检测到的微缺失和微重复症候群方面发挥着至关重要的作用。此外,FISH探针能够检测重复扩增,有助于识别亨廷顿氏舞蹈症、脆性X症候群和强直性肌肉营养不良症。此外,它们还可以评估基因拷贝数变化,从而帮助医疗保健专业人员进行疾病分类、预测治疗反应并指导个人化治疗决策,从而促进市场成长。此外,FISH探针还可以提供有关携带者状态的信息,使个人能够做出明智的生育决策并获得适当的遗传咨询。
越来越重视早期疾病检测和筛检
FISH 探针在早期癌症检测和诊断中发挥着至关重要的作用,因为它们可以针对各种癌症中常见的特定基因变异,包括基因扩增、缺失、易位和染色体重排。此外,它们还可用于早期诊断由寄生虫、细菌或病毒引起的传染病。此外,FISH 探针也广泛用于及时检测遗传疾病,例如唐氏症、特纳氏症或杜氏肌肉营养不良症。此外,它们还广泛用于产前诊断,以检测发育中胎儿的染色体异常,帮助父母就怀孕和潜在的医疗干预做出明智的决定。
广泛的研发活动
多重 FISH 探针的引入,使得研究人员和临床医生能够在单一样本中同时检测多个基因靶点,从而节省时间和资源,对市场成长产生了积极影响。此外,近期开发的近距离 FISH 探针能够检测细胞或组织样本中两个或多个基因靶点之间的空间接近度,从而提供有关细胞内空间相互作用、基因聚集和染色质组织的宝贵信息,这也促进了市场增长。此外,FISH 探针资料的快速数位化,使得资料共享和影像分析、储存和远端存取自动化,也为市场成长提供了支援。
The global fluorescent in situ hybridization (FISH) probe market size reached USD 926.2 Million in 2024. Looking forward, IMARC Group expects the market to reach USD 1,579.6 Million by 2033, exhibiting a growth rate (CAGR) of 5.81% during 2025-2033. The increasing prevalence of genetic disorders, growing emphasis on early disease detection and screening, and extensive research and development (R&D) activities are some of the major factors propelling the market.
Fluorescent in situ hybridization (FISH) probe is a molecular biology technique used to visualize and map specific deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) sequences within cells and tissues. They are composed of various materials, such as oligonucleotides, fluorophores, linkers and spacers, blocking reagents, and hybridization buffers. FISH probes are widely used in chromosomal abnormality detection, gene copy number variation analysis, oncology research, microbial identification, gene expression analysis, and prenatal diagnosis. They offer high sensitivity and resolution, allowing for the detection of even low-copy-number target sequences.
The increasing demand for personalized medicine is facilitating the adoption of FISH probes, as they provide valuable insights into individual patients' genetic profiles, enabling tailored treatment strategies based on their specific genetic alterations. Furthermore, the widespread utilization of FISH probes by clinicians and researchers to provide high-resolution visual and quantitative information about genetic abnormalities is providing an impetus to the market growth. Additionally, the implementation of supportive policies by several governments to reimburse patients for advanced diagnostic tests and provide access to high-quality healthcare facilities is strengthening the market growth. Other factors, including the rising geriatric population, the rapid expansion of the healthcare industry, extensive research and development (R&D) activities, rising focus on targeted therapies and increasing investment in the development of advanced FISH probes, are anticipated to drive the market growth.
The increasing prevalence of genetic disorders
FISH probes are extensively used to detect structural abnormalities associated with genetic disorders, such as deletions, duplications, inversions, and translocations. Furthermore, they play a crucial role in the diagnosis of microdeletion and microduplication syndromes that are extremely difficult to detect under a standard microscope. Moreover, FISH probes enable the detection of repeat expansions, which aids in identifying Huntington's disease, fragile X syndrome, and myotonic dystrophy. Apart from this, they allow the assessment of gene copy number changes, thus aiding healthcare professionals in disease classification, predicting treatment response, and guiding personalized therapy decisions, which in turn is contributing to the market growth. Additionally, FISH probes provide information about carrier status, which allow individuals to make informed reproductive decisions and receive appropriate genetic counseling.
The growing emphasis on early disease detection and screening
FISH probes play a critical role in early cancer detection and diagnosis, as they can target specific genetic alterations commonly found in various cancers, including gene amplifications, deletions, translocations, and chromosomal rearrangements. Apart from this, they find applications in early diagnosis of infectious diseases caused by parasites, bacteria, or viruses. Moreover, FISH probes are extensively used in the timely detection of genetic conditions, such as Down syndrome, Turner syndrome, or Duchenne muscular dystrophy. Additionally, they are widely employed in prenatal diagnosis to detect chromosomal abnormalities in developing fetuses, which allows parents to make informed decisions about pregnancy and potential medical interventions.
Extensive research and development (R&D) activities
The introduction of multiplex FISH Probes, which allows the simultaneous detection of multiple genetic targets within a single sample, enabling researchers and clinicians to analyze multiple genomic regions in a single experiment, thus saving time and resources, is positively influencing the market growth. Furthermore, the recent development of proximity-FISH probes that enables the detection of spatial proximity between two or more genetic targets within a cell or tissue sample, thus providing valuable information about spatial interactions, gene clustering, and chromatin organization within cells, is contributing to the market growth. Moreover, the rapid digitalization of FISH Probe data, allowing for enhanced data sharing and automated image analysis, storage, and remote access, is supporting the market growth.
RNA dominates the market
RNA is dominating the market, as RNA FISH probes enable researchers to investigate gene expression patterns at the single-cell level, which provides valuable insights into cellular heterogeneity, developmental processes, and disease mechanisms. Furthermore, they enable the detection and visualization of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs), which aids in improving the understanding of the functions and regulatory networks of these important RNA molecules. Apart from this, RNA FISH Probes facilitate the real-time observation and tracking of RNA dynamics, such as RNA synthesis, degradation, and turnover rates, thus enabling researchers to study RNA biology and cellular response. Moreover, they offer high sensitivity and specificity in detecting RNA molecules by reducing background noise and false-positive signals.
Locus specific probes hold the largest share in the market
Locus-specific probes are designed to hybridize to specific genetic loci or regions of interest in the genome, which allows researchers and clinicians to focus on specific genes and chromosomal abnormalities associated with particular diseases and conditions. They also offer high diagnostic accuracy and precision by enabling the detection of specific genetic abnormalities with great specificity. Apart from this, Locus-specific probes are extensively used to detect and characterize genetic variations in patients, including chromosomal aberrations, microdeletions, and gene mutations.
Flow FISH dominates the market
Flow FISH is dominating the market as it allows for rapid processing of a large number of cells, thus offering more data in a shorter amount of time compared to traditional FISH methods. Furthermore, it is known for its high sensitivity, which makes it ideal for detecting even low-abundance targets in medical diagnostics and research. In addition, flow FISH can be easily integrated with automation technologies to reduce manual errors and increase the throughput. Besides this, it provides quantitative data, which is crucial in fields such as healthcare, where precise measurements are required for diagnosis and treatment plans. Moreover, the cost per sample in flow FISH is less than traditional FISH methods, especially when analyzing large samples, making it highly appealing for both research and clinical settings.
Cancer dominates the market
FISH probes are widely used in cancer treatment as they help to detect specific genetic abnormalities. It also enables healthcare professionals to identify and classify cancer cells, which further assist in diagnosis, prognosis, and treatment decision-making. Furthermore, they offer high specificity and sensitivity in detecting genetic aberrations and chromosomal rearrangements that are characteristic of various types of cancer. Apart from this, FISH probes aid oncologists in selecting the most appropriate targeted therapies and monitoring treatment response. They also assist in cancer research by improving the understanding of the underlying mechanism associated with cancer. Additionally, FISH probes are widely used in liquid biopsies to offer a non-invasive approach for cancer detection, monitoring, and treatment response assessment.
FISH probes are widely used in research organizations to enable the visualization and detection of specific DNA or RNA sequences within cells or tissues. They are used in gene mapping and chromosomal analysis, which aids in studying cancer genetics and identifying chromosomal rearrangements associated with specific malignancies. Furthermore, the FISH probe is extensively utilized in developmental biology and neurobiology to provide valuable insights into gene regulation, cellular development, and disease mechanisms.
Diagnostic centers extensively utilize FISH probes to identify genetic alterations in patient samples, which aids in diagnosing cancer, determining prognosis, and guiding treatment decisions. They also assist in genetic disease screening by detecting specific genetic abnormalities, such as aneuploidies and microdeletion syndromes. Apart from this, FISH probes are widely used in prenatal testing to screen for chromosomal abnormalities in developing fetuses.
North America exhibits a clear dominance in the market, accounting for the largest fluorescent in situ hybridization (FISH) probe market share
The report has also provided a comprehensive analysis of all the major regional markets, which includes North America (the United States and Canada); Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Latin America (Brazil, Mexico, and others); and the Middle East and Africa. According to the report, North America represented the largest market segment.
North America is dominating the FISH probe market owing to the strong focus on biomedical research in the region aimed at developing new diagnostic tools and molecular technologies. Additionally, the presence of a robust healthcare infrastructure comprising well-established hospitals, clinical laboratories, and diagnostic facilities is favoring the market growth. Moreover, the growing incidences of genetic disorders and cancer are facilitating the demand for accurate and reliable molecular diagnostic tools, such as FISH probes. Furthermore, the implementation of strict policies by regional governments to maintain the safety, efficacy, and quality of medical products and instruments is contributing to the market growth. Along with this, the presence of key players in the region that are equipped with resources and expertise to drive product development, marketing, and sales is positively influencing the market growth.
The top companies in the FISH probe market are actively engaged in developing new products by incorporating advanced technologies to improve the accuracy and reliability of results. In line with this, the significant investment in research and development (R&D) projects to expand their portfolio, gain competitive advantages, and meet rising consumer demand is favoring the market growth. Furthermore, several key players are adopting targeted marketing strategies by designing customized products that meet the unique requirements of users. Additionally, the increasing collaboration between leading companies, research institutions, and academic centers to jointly develop new FISH probe technologies, validate products through clinical studies, and strengthen market presence is contributing to the market growth. Moreover, several product manufacturers are establishing distribution channels, partnerships, and subsidiaries across the globe to expand their business and attract a new customer base.