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市场调查报告书
商品编码
1801268
2025 年至 2033 年蛋白质治疗市场报告(依产品、治疗领域、功能、地区划分)及预测Protein Therapeutics Market Report by Product, Therapy Area, Function, Region and Forecast 2025-2033 |
2024 年全球蛋白质治疗市场规模为 3,670 亿美元。展望未来, IMARC Group估计到 2033 年市场规模将达到 6,175 亿美元,2025-2033 年期间的复合年增长率为 6%。北美目前占据市场主导地位,2024 年市占率将超过 45%。癌症、糖尿病、心血管疾病 (CVD) 和自体免疫疾病等慢性疾病的盛行率不断上升,蛋白质工程技术的快速进步,生物製药行业的不断扩张,以及产品在不同治疗领域的广泛应用,都是推动市场发展的一些因素。在北美,由于拥有先进的医疗基础设施、高盛行率以及对研发 (R&D) 的持续投入,市场正在蓬勃发展。
癌症、糖尿病和自体免疫疾病等慢性疾病的日益普及是全球蛋白质治疗市场的主要驱动力。根据世界卫生组织 (WHO) 统计,每年约有 4,100 万人死于慢性疾病。其中,心血管疾病是主要杀手,每年造成 1,790 万人死亡,其次是癌症(930 万人)、慢性呼吸道疾病(410 万人)和糖尿病(200 万人,包括糖尿病引起的肾臟疾病导致的所有死亡)。这些疾病通常是慢性的,需要针对性强且复杂的治疗策略,而蛋白质治疗正是理想的选择。单株抗体是一种重要的蛋白质产品,旨在与疾病中的特定分子相互作用,提供更精准的治疗且副作用更少,从而促进蛋白质治疗市场的成长。
在美国,蛋白质治疗市场正在不断扩大,这得益于多种因素,包括慢性病的高发病率、强大的研发基础设施以及支持性的医疗保健法规。该国癌症、糖尿病、自体免疫疾病和其他疾病的发生率很高,因此需要先进的治疗方法。根据可靠来源估计,该国人口中至少有 1.29 亿人患有至少一种主要慢性病;4,200 万人患有两种或两种以上的慢性病;1,200 万人患有五种或五种以上的慢性病。越来越多的患者批准使用新型生物药物,例如单株抗体、胰岛素类似物和酵素替代疗法。此外,美国食品药物管理局 (FDA) 最近简化了生物製剂和生物相似药的准入和竞争,提高了这些产品的可及性和成本,从而加强了蛋白质治疗市场的份额。
生物製药研发投资不断成长
产业和研究机构越来越关註生物製药和基于蛋白质的药物,主要是因为它们具有高度选择性、有效性和针对性。全球对生物製药行业研发支出的关注正在促进蛋白质疗法的发展。这些投资资助了包括蛋白质工程、药物发现和配方优化在内的活动,从而促进了新型和增强型蛋白质治疗产品的开发。例如,全球生物製药公司在2021年在研发流程上投入了2,760亿美元。这项投资涵盖了全球4,191家公司,反映出人们对加强该产业创新的日益重视。此外,大量的研发资金投入使研究人员能够寻找更多的治疗靶点,对分子进行微调以获得更好的功能,并进行大量的体外、体内和临床试验。这些努力也有助于市场的成长,因为针对不同疾病的新疗法正在不断涌现。此外,研发支出的增加也促进了蛋白质治疗产品生产流程的商业化,使其价格更实惠。这有利于蛋白质类药物的进一步商业利用和市场拓展。
生物相似药的扩张
生物相似药市场的成长是市场成长的重要因素。生物相似药是指与已核准的参考蛋白药物高度相似的生物製品。由于多种畅销生物製剂的专利到期,生物相似药市场正在蓬勃发展。生物相似药的出现为昂贵的蛋白疗法提供了经济高效的替代方案,使患者和医疗保健系统更容易获得。它提高了患者治疗的可负担性,间接推动了市场的成长。此外,生物相似药的存在有助于创造市场竞争。竞争导致价格下降,从而扩大了市场,并为生物仿製药製造商以及参考蛋白疗法公司提供了创新和改进的空间。例如,2022年2月,Biocon 的子公司 Biocon Biologics Ltd. 签署了一项最终商业协议,收购 Viatris Inc. 的生物相似药业务。有鑑于此,该交易的价格定为 33 亿美元。然而,近年来,生物相似药的监管和指导方针不断发展完善,为生物相似药的开发和批准制定了明确的路线。这增强了医疗界的信心,从而提高了生物相似药的利用率。随着生物相似药市场的扩张,也刺激了蛋白质疗法的进一步研发。製造商致力于开发更先进、更具差异化的生物相似药,从而为蛋白质疗法市场带来了积极的前景。
人口老化加剧
由于老龄人口的增长,市场正在显着增长。随着全球人口老化,与年龄相关的疾病(例如阿兹海默症、帕金森氏症、黄斑部病变和骨质疏鬆症)的发生率也随之上升。据估计,全球约有32.9%的成年人患有至少两种慢性疾病。老龄化人口面临的这些特殊健康挑战促进了蛋白质疗法的开发和应用。此外,蛋白质疗法可直接有效治疗与年龄相关的疾病,并且在疗效和副作用方面比传统疗法更具优势。它们也作用于选择性分子受体,并专注于这些疾病的分子过程,从而提高治疗水平和人们的生活品质。此外,随着人口老化,对这些产品的需求也随之激增。此外,大型製药公司和研究机构正在寻求符合这一人群需求的新型蛋白质疗法。此外,老龄化人口的不断增长为蛋白质疗法带来了更高的市场潜力,促使製造商拓宽产品范围并提高产量。这增加了蛋白质疗法的供应,并进一步促进了市场的扩张。
The global Protein Therapeutics market size was valued at USD 367.0 Billion in 2024. Looking forward, IMARC Group estimates the market to reach USD 617.5 Billion by 2033, exhibiting a CAGR of 6% during 2025-2033. North America currently dominates the market, holding a significant market share of over 45% in 2024. The increasing prevalence of chronic diseases such as cancer, diabetes, cardiovascular diseases (CVDs), and autoimmune disorders, rapid technological advancements in protein engineering, the expanding biopharmaceutical industry, and the widespread product applications in diverse therapeutic areas are some factors propelling the market. In North America, the market is thriving due to the presence of advanced healthcare infrastructure, high disease prevalence, and ongoing investment in research and development (R&D)..
The escalating prevalence of chronic diseases such as cancer, diabetes, and autoimmune disorders is a key driver for the global protein therapeutics market. According to the World Health Organization (WHO), about 41 million people die from chronic diseases every year. Of this total, cardiovascular diseases are the biggest killers or 17.9 million people per year, cancers (9.3 million), chronic respiratory diseases (4.1 million), and diabetes (2.0 million including all deaths caused by kidney diseases due to diabetes). These conditions are frequently chronic and need specific and complex treatment strategies, which are ideal for protein treatments. A large and important type of protein product, monoclonal antibodies, are designed to interact with specific molecules involved in diseases, offered more accurate treatments with less side effects, thus contributing to the protein therapeutics market growth.
In the United States, the protein therapeutics market is expanding due to several factors, including a high prevalence of chronic diseases, a strong R&D infrastructure, and supportive healthcare regulations. The country has a high prevalence of diseases and illnesses such as cancer, diabetes, auto immune and other illnesses therefore the need for advanced treatments. It is estimated from reliable sources that at least 129 million people in the country's population have at least one major chronic disease; 42 million people, two or more chronic diseases; and 12 million people, five or more chronic diseases. There is a growing approval of patients with new biologic drugs like the monoclonal antibodies, insulin analogs and enzyme replacement therapy. Furthermore, the U.S. Food and Drug Administration (FDA) has recently simplified the entry and competition for biologics and biosimilars, which improves access and costs of these products, thereby strengthening the protein therapeutics market share.
Growing biopharmaceutical research and development investments
Industry and research organizations are paying more attention to bio-pharmaceuticals and drugs based on proteins basically because they are highly selective, effective, and targeted. The global attention on R&D spending in the biopharmaceutical industry is facilitating the development of protein therapeutics. These investments finance activities that include protein engineering, drug discovery, and formulation optimization hence the development of new and enhanced protein therapeutic products. For example, worldwide biopharmaceutical corporations spent $276 billion on R&D processes in the year 2021. This investment spread over 4191 firms globally and reflected the increasing focus on enhancing innovation in the sector. In addition, a large amount of money going into R & D allows researchers to search for additional therapeutic targets, fine-tune the molecule for better function, and perform numerous in vitro in vivo, and clinical trials. The efforts also help in the growth of the market due to the development of new treatments for different diseases. Also, the rise in spending on R&D enhances the commercialization of production procedures of protein therapeutic products making them affordable. This facilitates further commercial utilization and market expansion of protein-based drugs.
Expansion of biosimilars
The growth of the biosimilar market is a significant contributor to the market. Biosimilars are biological products that are highly similar to an already approved reference protein medicinal product. Because of the expiration of patents on several high-selling biologics, the market for biosimilars is emerging significantly. The availability of biosimilars offers cost-effective alternatives to expensive protein therapeutics, thus making them more accessible to patients and healthcare systems. It increases the affordability of treatments to patients, thus indirectly driving the market into growth. Also, the existence of biosimilars helps create competition in the market. Competition makes prices reduce, hence expanding the market and giving room to innovate and improve among biosimilar manufacturers and also in the case of reference protein therapeutics companies. For instance, in February 2022, Biocon Biologics Ltd., a Biocon subsidiary, signed a definitive business agreement to acquire the biosimilars business of Viatris Inc. With such merit, the deal was set at US$ 3.3 Billion. However, regulation and guidance on biosimilars have evolved and have improved in recent years, creating a definite line of biosimilar development and approval. This has strengthened the healthcare community's confidence and hence increased biosimilar utilization. As the biosimilar market expands, it stimulates further R&D efforts in protein therapeutics. Manufacturers strive to develop more advanced and differentiated biosimilars, creating a positive protein therapeutics market outlook.
Rising aging population
The market is significantly growing due to the increase in population of the aging people. While the global population ages it is accompanied by increased occurrences of age-related illnesses and diseases like Alzheimer's, Parkinson's, macular degeneration, and osteoporosis. It was estimated that about 32.9% of adults globally suffer from at least two multiple chronic diseases. These specific health challenges that the aging population face, promote the development and application of protein therapeutics. In addition, protein therapeutics are directly effective in treating age-related diseases and have better advantages than traditional therapies in terms of efficiency and fewer side effects. They also act on selective molecular receptors and focus on the molecular processes of these diseases, which should elevate the standard of treatment and the quality of people's lives. Furthermore, the surging demand for these products increases with the aging population. Besides this, major pharmaceutical companies and research institutions are seeking new protein therapeutics that align with the needs of this group of people. Apart from this, the rising aging population provides a higher market potential for protein therapeutics, encouraging manufacturers to broaden product ranges and produce more. This results in increased availability of protein therapeutics and influences the expansion of the market further.
Monoclonal Antibodies (mAbs) products stand as the largest product in 2024, holding over 49% of the market. mAbs are widely applied to cancer therapy, autoimmune disorders, and inflammatory diseases. These diseases are on the rise and with enhancement in the technologies for the development of antibodies, the rising demand for mAbs is contributing to the market expansion.
However, human insulin is an essential protein medicine required for the treatment of diabetes. The growth of incidence of diabetes across the world increases the demand for insulin and insulin analogs, which drives the growth of the market in this segment. Also, erythropoietin more commonly referred to as EPO is one of the most common therapeutic proteins utilized to raise red blood cells' levels in the body. It is used for anemia especially for patients with chronic kidney disease and patients under chemotherapy. Furthermore, with a higher patient population requiring the indication for EPO therapy, this segment is growing steadily.
Apart from this, clotting factors are proteins which are involved in blood clotting. They are utilized for the control of various types of bleeding disorders such as hemophilia. Consequently, the demand for clotting factors increases with the rise in the awareness, diagnosis and treatment of hemophilia. In addition, chimeric proteins wherein two or more functional protein domains have been joined together have received enormous interest in the development of new therapeutic agents. They offer specific methods of cure of different diseases such as cancer and autoimmune diseases, which is driving the growth of this segment.
Metabolic disorders lead the market, holding the largest market share. Metabolic disorders encompass conditions such as diabetes, obesity, and hypercholesterolemia. Protein therapeutics and drugs like insulin for diabetes are vital in managing these diseases and conditions. The increase in the incidence of metabolic diseases and the need for effective therapies and targeted medications contribute to the growth of the segment.
Immunological disorders, auto-immune diseases, and inflammatory diseases are also some other large therapy areas for protein therapeutics. Small molecules like nitroglycerin operate on the immune system and engage in disease pathways. Some of the drugs classified as monoclonal antibodies, and other protein-based drugs also operate on the immune system and involve the disease pathway. Immunological diseases are on the rise, and the number of protein drugs for these diseases is also on the rise, so it is also driving the market.
Furthermore, cancer continues to be one of the major forces boosting the market growth. While protein and antibody-based medicines are amongst the first-line therapies, they are revolutionizing cancer treatment through monoclonal antibodies, antibody-drug conjugates, and immune checkpoint inhibitors. Global cancer cases are increasing along with the cure such as targeted therapy and immunotherapy, boosting the market in oncology.
Protein therapeutics with enzymatic and regulatory activity are vital in modulating biological processes and metabolic pathways. These proteins act as enzymes, receptors, or signaling molecules, offering therapeutic benefits in various diseases. The development of novel protein therapeutics with specific enzymatic or regulatory functions drives market growth in this segment.
Special targeting activity refers to protein therapeutics targeting certain cells, tissues, or molecular targets. Monoclonal antibodies and antibody-drug conjugates are examples of protein therapeutics with special targeting activity. They can selectively acknowledge and adhere to particular molecules or cells, offering tailored treatments. The development of targeted therapies in diseases such as cancer as well as autoimmune diseases has boosted the growth of protein therapeutics in this segment.
Vaccines are another significant segment in the market. Protein-substance vaccines are based on proteins or peptides that produce an immune response and protect against infections. The rising concern for vaccination programs throughout the world, the development of new infectious diseases, and the need for new and better types of vaccines are bolstering the market demand.
Protein diagnostics involves using proteins or protein-based assays for diagnostic purposes. These diagnostics can identify certain proteins or biomarkers that are linked to diseases, and can help in the early diagnosis, disease management or even in tailoring the treatment. The need for better diagnostic tools in ever increasing and as such, protein diagnostics are on the rise which helps support the market.
In 2024, North America accounted for the largest market share of over 45%. The region is endowed with well-developed healthcare system, a large number of bioscience and biopharmaceutical firms, and high levels of research and development. The availability of prominent companies and high investments in protein therapeutics research has boosted the growth of the market in North America. Besides, the increased incidence of chronic diseases, a vast number of aging patients, and reasonable compensation policies also strengthen the market in the region.
Asia Pacific is in the process of becoming a rather fast-developing market. This region holds a large population base, higher healthcare spending and growing incidences of chronic diseases. There is an increasingly growing pace of biopharmaceutical industry development and innovation within the Asian nations including China, Japan and India. However, the increasing perception of the existence of personalized medicine and the increasing need for affordable treatment is contributing to the growth of the market in the region.
North America Protein Therapeutics Market Analysis
The protein therapeutics market in North America is witnessing robust growth due to a combination of advanced healthcare infrastructure, high disease prevalence, and significant investment in research and development (R&D). The region has one of the highest incidences of chronic diseases, including cancer, diabetes, and autoimmune disorders, which necessitate innovative and effective treatment options. With a well-established biotechnology sector, North America is a global leader in developing and commercializing protein-based therapeutics, including monoclonal antibodies and fusion proteins. Favorable regulatory frameworks, such as expedited drug approvals by the U.S. FDA, further accelerate the market growth. Additionally, the region benefits from a strong focus on personalized medicine, where protein therapeutics play a critical role in offering targeted therapies with improved patient outcomes.
United States Protein Therapeutics Market Analysis
The United States accounts for 75% share of the market in North America. The high prevalence of chronic diseases, such as diabetes, autoimmune disorders, and cancer, is driving the market for protein therapies in the country. With more than 37 million Americans living with diabetes as of 2023, there is a high need for insulin and other protein-based treatments. The need for cutting-edge biologics to treat age-related disorders is further fueled by the aging population, which is predicted to reach more than 78 million by 2040. The development of next-generation protein therapies, such as fusion proteins and antibody-drug conjugates, is being streamlined by technological developments like recombinant DNA technology and the manufacture of monoclonal antibodies.
Innovation has been aided by regulatory support, such as the FDA's accelerated approval processes for innovative biologics. Biopharmaceutical firms are making significant investments in research and development; in 2023, the United States will still be the world's largest market, generating about 60% of biopharmaceutical innovation. Furthermore, the manufacture of protein therapies is now more scalable due to the availability of a strong infrastructure for manufacturing and clinical trials. The industry is anticipated to be further supported by the rise of customized medicine and the launch of biosimilars, which provide affordable substitutes for pricy biologics without sacrificing efficacy or safety.
Europe Protein Therapeutics Market Analysis
Growing chronic illness rates and a strong focus on healthcare innovation in the region are driving the market for protein therapies in Europe. The European Medicines Agency (EMA) recommended 77 medicines for marketing authorization in 2023, demonstrating the region's dedication to cutting-edge protein-based therapies. Since cancer accounts for 2.7 million new cases in Europe each year, there is a great need for targeted therapy using protein medicines like interferons and monoclonal antibodies. European governments and health institutions are making significant investments in biotechnology and personalized medicine, with programs such as Horizon Europe offering major financing for research and development. The market is led by nations with strong healthcare systems and high patient awareness, such as Germany, France, and the UK. Furthermore, the EU's cost-cutting measures are encouraging the growing acceptance of biosimilars, which is increasing market penetration by making protein-based medications more accessible.
Asia Pacific Protein Therapeutics Market Analysis
The market for protein therapies in Asia-Pacific is expanding quickly as a result of rising healthcare costs, an increase in the number of chronic illnesses, and the use of cutting-edge medical technology. Insulin and other protein-based therapies are essential in tackling this expanding healthcare issue in China and India, which have the highest diabetes populations in the world. Leaders in biopharmaceutical innovation, South Korea and Japan have made large expenditures in the development of biosimilars and monoclonal antibodies.
Demand is being increased by the burgeoning middle class and rising knowledge of sophisticated biologics in emerging economies. To lessen reliance on imports, the governments in the area are encouraging domestic manufacturing and research and development. China's "Healthy China 2030" policy, for instance, promotes the creation of innovative biopharmaceuticals, such as protein therapies. Furthermore, collaborations between regional and international pharmaceutical firms are augmenting the introduction of reasonably priced protein therapies throughout Asia-Pacific.
Latin America Protein Therapeutics Market Analysis
The rising incidence of chronic illnesses and the development of better healthcare facilities are driving the market for protein therapies in Latin America. To improve patient outcomes, nations with high incidences of diabetes and cancer, such as Brazil and Mexico, are implementing cutting-edge biologics. Government healthcare initiatives and increased investments in biopharmaceutical R&D are boosting the manufacturing and marketing of protein therapies. Additionally, the emergence of biosimilars, which provide affordable substitutes, is opening up more therapy possibilities in the area.
Middle East and Africa Protein Therapeutics Market Analysis
The rising prevalence of chronic illnesses and a growing emphasis on expanding access to healthcare are driving the market for protein therapies. In line with their goal of modernizing healthcare systems, nations in the Middle East like as Saudi Arabia and the United Arab Emirates are making significant investments in biopharmaceuticals. Access to protein therapies, especially for conditions like diabetes and cancer, is being improved in Africa thanks to international partnerships and funding programs run by agencies like the WHO. Furthermore, local production facilities and awareness campaigns are progressively extending the reach of these cutting-edge remedies throughout the region.
Top companies are now investing heavily in scientific research with the aim of identifying new therapeutic targets and creating protein-based drugs with enhanced efficacy and safety profiles. They can use their skills in protein engineering, molecular biology, and biotechnology to create and optimize therapeutic proteins. Additionally, top companies form strategic collaborations with academic institutions, research organizations, and other pharmaceutical companies in order to acquire new technologies and expand their pipeline while accelerating the development process. Collaborations allow the parties to share knowledge, resources, and expertise with each other for innovation and for driving the market. Also, successful commercialization strategies play an important role in promoting market growth. These companies implement strong marketing and sales activities in order to offer their products to healthcare providers and patients worldwide. They perform detailed clinical trials, develop significant clinical data, and gain regulatory approval to access the market. The top companies also invest continually in manufacturing capabilities and quality control systems to be able to produce a consistent supply of their products to meet growing demand. These efforts at excellence in manufacturing thus help them in meeting the requirements of patients, healthcare providers, and payers, further driving the market.