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Castleman氏病治疗市场:按疾病类型、适应症、治疗方法和应用分类 - 全球预测 2024-2030Castleman Disease Treatment Market by Disease Type, Indication, Treatment, Application - Global Forecast 2024-2030 |
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Castleman氏病治疗市场规模预计2023年为2.9433亿美元,2024年达到3.3415亿美元,预计2030年将达到7.1987亿美元,复合年增长率为13.62%。
Castleman氏病的治疗涉及专门的医疗治疗,以治疗一种称为Castleman氏病的罕见疾病。此疾病的特征是身体淋巴结中细胞过度生长,引起从发烧、疲劳到异常体重减轻等症状。近年来,包括Castleman氏病在内的罕见疾病的盛行率增加,因此需要增加治疗选择。多年来,我们对Castleman氏病的了解不断加深,从而促进了标靶治疗的发展。正在进行的研究重点是识别生物标记、了解潜在的病理学和发现新的治疗方法。Castleman氏病的几种治疗方法已获得孤儿药资格,这为製药公司开发罕见疾病的治疗方法提供了奖励。然而,药物开发成本高昂、治疗选择有限以及严格的监管合规性阻碍了治疗的扩展。医疗保健专业人员、研究人员和倡导团体正在全球范围内合作,以改善Castleman氏病的诊断、管理和治疗。
主要市场统计 | |
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基准年[2023] | 2.9433亿美元 |
预测年份 [2024] | 33415万美元 |
预测年份 [2030] | 71987万美元 |
复合年增长率(%) | 13.62% |
疾病类型:多中心Castleman氏病有可能导致全身器官衰竭,需要快速制定治疗策略。
多中心Castleman氏病(MCD) 是一种导致患者身体多个区域淋巴结肿大的疾病。多中心Castleman氏病有三种症状:多发性神经炎、器官肿大、内分泌疾病、M蛋白、皮肤改变(POEMS)相关的MCD、人类疱疹病毒8(HHV-8)相关的MCD和特发性MCD 。多中心Castleman氏病的治疗通常涉及药物和其他治疗方法来抑制细胞过度生长。特定治疗方法还取决于疾病的严重程度以及患者感染疾病感染疾病人类免疫力缺乏病毒 (HIV)、人类疱疹病毒 8 (HHV-8) 或两者。单中心Castleman氏病(UCD) 是一种影响一个淋巴结的疾病,通常位于胸部或腹部。单中心Castleman氏病可以透过手术切除受影响的淋巴结来治疗。
增加血管瘤肝血管瘤淋巴结病例的Castleman氏病治疗选择
肝血管瘤瘤样淋巴结增生与长期发烧、贫血、体重减轻、脾肿大和高丙种球蛋白血症有关。肝血管瘤淋巴球错构瘤或假性淋巴瘤最常见于乳房,常被误认为是伴随淋巴瘤样组织的胸腺肿瘤。这是一种罕见的疾病,经常使用免疫调节疗法。 Castleman 肿瘤是一种罕见的纵膈淋巴结增生,类似胸腺瘤。典型的组织学特征包括结节中淋巴球的洋葱皮样排列和具有明显毛细血管增殖的异常脉管系统。巨大良性淋巴瘤是发生在大肠中最常见的非上皮性良性肿瘤。通常在直肠中观察到单一圆形息肉,呈红紫色或灰色,直径从几毫米到 3 至 4 公分不等。巨大淋巴结增生是一种病因不明的非肿瘤性淋巴增生性疾病,通常发生在胸部。这种疾病的型态辨识是基于各种组织学特征的组合。淋巴结血管肌瘤性错构瘤(AMH-LN)是指平滑肌、血管、胶体基质和脂肪细胞的异常良性增生。
治疗方法化疗的进步正在增加Castleman氏病治疗方案的采用。
抗病毒药物用于针对有害病毒。抗病毒药物用于缓解疾病症状。化疗是指使用药物和化疗来杀死患者体内快速生长的癌细胞。低剂量单药化疗,例如每日口服Etoposide或间歇性Etoposide或长春花碱,已用于治疗 MCD。皮质类固醇是一种强效发炎药,可以缓解疾病症状。全身给予皮质类固醇可以缓解症状,但不能预测肿瘤缩小。免疫疗法利用人体的自然防御来对抗疾病。单株抗体是实验室製造的蛋白质,仅与一种致病抗原结合。利Rituximab治疗对 HHV-8 相关 MCD 非常有效。有些 HIV 感染者需要接受Rituximab抗逆转录病毒治疗 (ART)。放射线治疗是一种利用放射线杀死癌细胞并缩小肿瘤的癌症治疗方法。对于单中心Castleman氏病,放射线治疗是一种有效的治疗选择,且反应率较高。
门诊手术中心是提供最佳患者照护的首选
门诊手术中心 (ASC) 是一个现代化的医疗设施,旨在提供当天的手术治疗,包括诊断和预防程序。这些中心由于医疗效率高并且减少了治疗预约的等待时间,在Castleman氏病的治疗中越来越普及。由于疾病管理的复杂性与护理强度有关,医院部门仍然是Castleman氏病治疗的主要贡献者。
区域洞察
美洲,特别是美国和加拿大,拥有相对完善的诊断和治疗罕见疾病(包括Castleman氏病)的基础设施。有专门研究Castleman氏病的专门医疗中心和专家,患者倡导团体和研究组织为提高诊断和治疗的认识和进步做出了贡献。儘管与其他地区相比,亚洲Castleman氏病的治疗机会有限,但政府对医疗保健发展的投资极大地推动了针对这种罕见疾病的更有针对性的治疗方法。该地区的主要城市提供先进的诊断和治疗方案,而规模较小的学术机构正在中国、日本和印度大力投资研发活动。在欧洲,各国政府正在促进相关人员在医疗保健和研究工作方面的合作,以帮助治疗Castleman氏病。欧洲药品管理局正在努力审查和核准改进的药物,以改善该地区Castleman氏病者的治疗提供和获得机会。
FPNV定位矩阵
FPNV 定位矩阵对于评估Castleman氏病治疗市场至关重要。我们检视与业务策略和产品满意度相关的关键指标,以对供应商进行全面评估。这种深入的分析使用户能够根据自己的要求做出明智的决策。根据评估,供应商被分为四个成功程度不同的像限:前沿(F)、探路者(P)、利基(N)和重要(V)。
市场占有率分析
市场占有率分析是一种综合工具,可以对Castleman氏病治疗市场中供应商的现状进行深入而深入的研究。全面比较和分析供应商在整体收益、基本客群和其他关键指标方面的贡献,以便更好地了解公司的绩效及其在争夺市场占有率时面临的挑战。此外,该分析还提供了对该行业竞争特征的宝贵见解,包括在研究基准年观察到的累积、分散主导地位和合併特征等因素。详细程度的提高使供应商能够做出更明智的决策并制定有效的策略,从而在市场上获得竞争优势。
1. 市场渗透率:提供有关主要企业所服务的市场的全面资讯。
2. 市场开拓:我们深入研究利润丰厚的新兴市场,并分析其在成熟细分市场的渗透率。
3. 市场多元化:提供有关新产品发布、开拓地区、最新发展和投资的详细资讯。
4. 竞争评估和情报:对主要企业的市场占有率、策略、产品、认证、监管状况、专利状况和製造能力进行全面评估。
5. 产品开发与创新:提供对未来技术、研发活动和突破性产品开发的见解。
1.CastlemanCastleman氏病治疗市场的市场规模与预测为何?
Castleman氏病治疗市场预测期间需要考虑投资的产品、细分市场、应用和领域有哪些?
3.CastlemanCastleman氏病治疗市场的技术趋势和法规结构是什么?
4.CastlemanCastleman氏病治疗市场主要厂商的市场占有率是多少?
5. 进入Castleman氏病治疗市场的合适型态和策略手段是什么?
[196 Pages Report] The Castleman Disease Treatment Market size was estimated at USD 294.33 million in 2023 and expected to reach USD 334.15 million in 2024, at a CAGR 13.62% to reach USD 719.87 million by 2030.
Castleman disease treatment involves a specialized healthcare procedure to manage a rare illness called Castleman disease, which is characterized by the overgrowth of cells in the body's lymph nodes, causing a variety of symptoms from fever and fatigue to abnormal weight loss. Recent years have observed an increased prevalence of rare diseases, including Castleman disease, necessitating enhanced treatment options. The understanding of Castleman disease has advanced over the years, leading to the development of targeted therapies. Ongoing research focuses on identifying biomarkers, understanding the underlying pathophysiology, and discovering novel treatment options. Some treatments for Castleman disease have received orphan drug designation, which provides incentives for pharmaceutical companies to develop therapies for rare diseases. However, the high cost of drug development, limited treatment options, and strict regulatory compliance impede the expansion of treatment. Healthcare professionals, researchers, and advocacy groups are collaborating on a global scale to improve the diagnosis, management, and treatment of Castleman disease.
KEY MARKET STATISTICS | |
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Base Year [2023] | USD 294.33 million |
Estimated Year [2024] | USD 334.15 million |
Forecast Year [2030] | USD 719.87 million |
CAGR (%) | 13.62% |
Disease type: Need for rapid deployment of treatment strategies for multicentric Castleman's disease due to the chances of systemic organ failure
Multicentric Castleman's disease (MCD) refers to the disease condition that causes lymph node enlargement in multiple regions of the patient's body. There are three categories of MCD-Polyneuropathy, organomegaly, endocrinopathy, M proteins, and skin changes (POEMS)-associated MCD, human herpesvirus-8 (HHV-8)-associated MCD, and idiopathic MCD. Treatment for multicentric Castleman disease generally involves medicines and other therapies to control cell overgrowth. Specific treatment may also depend on the extent of the disease and whether the patient has human immunodeficiency virus infection (HIV), human herpesvirus-8 (HHV-8) infection, or both. Unicentric Castleman's disease (UCD) refers to a disorder that affects a single lymph node in the patient's body, usually in the chest or abdomen. Unicentric Castleman disease can be treated by surgically removing the diseased lymph node.
Indication: Rising adoption of Castlemann's disease treatment options for tackling angiomatous lymphoid cases
Angiofollicular lymph node hyperplasia is associated with prolonged fever, anemia, weight loss, splenomegaly, and hypergammaglobulinemia. Angiomatous lymphoid hamartomas or pseudolymphomas have been reported most commonly within the chest and are usually mistaken for thymic tumors of lymphomatous tissue. It is a rare manifestation where immunomodulatory treatment is often utilized. Castleman tumor is an unusual mediastinal lymph node hyperplasia that resembles thymoma. The characteristic histologic characteristics include an onion skin arrangement of the lymphocytes in nodules and an unusual vasculature with marked capillary proliferation. Giant benign lymphoma is the most common non-epithelial benign tumor occurring in the large intestine. It is usually observed in the rectum as a single reddish-purple or grey, rounded polyp varying in diameter from a few millimeters to 3-4 centimeters. Giant lymph node hyperplasia is a nonneoplastic lymphoproliferative disorder of unknown etiology that is usually observed in the chest. The morphological recognition of this disease is based on a combination of various histological features. Angiomyomatous hamartoma of lymph nodes (AMH-LN) refers to an unusual benign proliferation of smooth muscle, blood vessels, collagenous stroma, and adipocytes.
Treatment: Advancements in chemotherapy treatments leading to expanding adoption of Castleman disease treatment options
Antiviral medications are used to target harmful viruses. The antiviral drugs are used to ease disease symptoms. Chemotherapy refers to the practice of utilizing a drug or chemical treatment to kill fast-growing cancer cells in a patient's body. Low-dose single-agent chemotherapy treatment options, such as daily oral etoposide59 or intermittent etoposide or vinblastine, have been utilized for MCD. Corticosteroids are powerful anti-inflammatory drugs that can mitigate disease symptoms. Systemic corticosteroids can provide symptomatic relief but do not predictably reduce tumor size. Immunotherapy takes advantage of the body's natural defenses to fight the disease. Monoclonal antibodies refer to proteins made in a laboratory that bind to one pathogenic antigen only. In HHV-8-associated MCD, treatment with rituximab is highly effective. For some patients with HIV infection, antiretroviral therapy (ART) should be included with the rituximab. Radiation therapy refers to a cancer treatment that uses bursts of radiation to target and kill cancer cells and shrink tumors. In unicentric Castleman disease, radiotherapy radiation therapy is a viable treatment option because of its high response rates.
Application: Preference for ambulatory surgical centers due to provision of optimum patient care
Ambulatory surgical centers (ASCs) refer to modern medical facilities that aim to provide same-day surgical care, including diagnostic and preventive procedures. These centers have gradually become popular for the treatment of Castleman disease due to their perceived medical efficiency and the reduced waiting times involved in scheduling a treatment. The hospital segment continues to remain a significant contributor to Castleman disease treatment owing to the intensity of care that comes with the complex nature of disease management.
Regional Insights
The Americas, particularly the U.S. and Canada, has a relatively well-established infrastructure for rare disease diagnosis and treatment, including Castleman disease. There are specialized medical centers and experts focused on the condition, and patient advocacy groups and research institutes have contributed to the awareness and advancements in diagnosis and treatment. In Asia, access to castle treatment is limited when compared to the other regions; however, the government investment in healthcare development has significantly strived toward a more focused approach to rare diseases. Major cities in the region offer advanced diagnostic and treatment options, and small-scale academic institutes in China, Japan, and India are investing heavily in R&D activities. In Europe, the government promotes stakeholder cooperation in healthcare and research activities, benefiting the treatment of Castleman disease. The European Medicines Agency has been working on reviewing improved medications and approving them to elevate the provision and access to Castleman treatment to patients in the region.
FPNV Positioning Matrix
The FPNV Positioning Matrix is pivotal in evaluating the Castleman Disease Treatment Market. It offers a comprehensive assessment of vendors, examining key metrics related to Business Strategy and Product Satisfaction. This in-depth analysis empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success: Forefront (F), Pathfinder (P), Niche (N), or Vital (V).
Market Share Analysis
The Market Share Analysis is a comprehensive tool that provides an insightful and in-depth examination of the current state of vendors in the Castleman Disease Treatment Market. By meticulously comparing and analyzing vendor contributions in terms of overall revenue, customer base, and other key metrics, we can offer companies a greater understanding of their performance and the challenges they face when competing for market share. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With this expanded level of detail, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.
Key Company Profiles
The report delves into recent significant developments in the Castleman Disease Treatment Market, highlighting leading vendors and their innovative profiles. These include AbbVie Inc., Agilent Technologies, Inc., Amgen Inc., Artiva Biotherapeutics, Inc., Bayer AG, Bio-Rad Laboratories, Inc., Biogen Inc., Boehringer Ingelheim GmbH, Bristol-Myers Squibb Company, Cadila Pharmaceuticals Limited, Celltrion Healthcare Co.,Ltd., F. Hoffmann-La Roche AG, Gilead Sciences, Inc., GlaxoSmithKline PLC, Glenmark Pharmaceuticals S.A., Johnson & Johnson Services, Inc., LGM Pharma, Merck & Co., Inc., Novartis AG, Octapharma AG, Pfizer, Inc., Recordati Group Company, Recordati S.p.A., Sanofi S.A., Sartorius AG, Sun Pharmaceutical Industries Ltd., Takeda Pharmaceutical Company Limited, Teva Pharmaceutical Industries Ltd., Thermo Fisher Scientific Inc., and Viatris Inc..
Market Segmentation & Coverage
1. Market Penetration: It presents comprehensive information on the market provided by key players.
2. Market Development: It delves deep into lucrative emerging markets and analyzes the penetration across mature market segments.
3. Market Diversification: It provides detailed information on new product launches, untapped geographic regions, recent developments, and investments.
4. Competitive Assessment & Intelligence: It conducts an exhaustive assessment of market shares, strategies, products, certifications, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players.
5. Product Development & Innovation: It offers intelligent insights on future technologies, R&D activities, and breakthrough product developments.
1. What is the market size and forecast of the Castleman Disease Treatment Market?
2. Which products, segments, applications, and areas should one consider investing in over the forecast period in the Castleman Disease Treatment Market?
3. What are the technology trends and regulatory frameworks in the Castleman Disease Treatment Market?
4. What is the market share of the leading vendors in the Castleman Disease Treatment Market?
5. Which modes and strategic moves are suitable for entering the Castleman Disease Treatment Market?