市场调查报告书
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1466258
DNA 定序市场:按产品和服务、技术、工作流程、应用划分 - 2024-2030 年全球预测DNA Sequencing Market by Product & Services (Consumables, Instruments, Services), Technology (Next-Generation Sequencing, Sanger Sequencing, Third Generation DNA Sequencing), Workflow, Application - Global Forecast 2024-2030 |
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DNA定序市场规模预估2023年为603.9亿美元,2024年达719.8亿美元,预计2030年将达2,103.4亿美元,复合年增长率为19.51%。
DNA 定序是一种实验室技术,可确定单一 DNA 分子内的核苷酸或碱基序列。 DNA 碱基序列包含细胞用来发育和发挥功能的编码生物讯息。 DNA 序列可用于多种目的,包括诊断和疾病治疗、医学研究和法医分析。医疗专业人员可以使用定序来识别某些疾病的基因变化或突变。对遗传疾病和癌症的研究数量不断增加,以及对个人化医疗的需求不断增长,主要推动了 DNA 定序的研究和发展。此外,与 DNA 定序相关的技术限制和定序平台的高成本也限制了 DNA 定序市场的成长。此外,复杂的资料分析和标准化通讯协定的缺乏导致 DNA 定序结果的变异性。此外,DNA定序在临床和研究应用中的日益普及以及包括下一代定序在内的新定序技术的采用预计将为市场成长创造利润丰厚的机会。基因组研究投资的增加正在促进市场成长。
主要市场统计 | |
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基准年[2023] | 603.9亿美元 |
预测年份 [2024] | 719.8亿美元 |
预测年份 [2030] | 2103.4亿美元 |
复合年增长率(%) | 19.51% |
产品/服务:随着生物资讯学和计算生物学的进步,整体服务的演变
耗材对于 DNA 定序至关重要,包括定序过程中使用的所有必需试剂、套件和化学物质。包括DNA製备套件、文库製备套件、定序试剂等。耗材的品质和类型直接影响定序工作的准确性、效率和成本效益。耗材的持续创新对于提高定序性能、降低每个样本的成本并使 DNA 定序可用于更广泛的应用至关重要。仪器是 DNA 测序中使用的核心硬件,从能够同时处理数千个基因组的高通量测序仪到专为快速现场分析而设计的小型可携式仪器。设备选择取决于所需序列的规模、所需的详细程度和可用预算。该领域的创新着重于提高速度、降低成本以及提高定序结果的解析度和保真度。用户友好的介面和更紧凑的设计的开拓也在新市场和应用中采用测序技术方面发挥关键作用。 DNA 定序服务涵盖广泛的服务,从服务到资料分析和咨询。这些服务对于需要内部基础设施或专业知识来执行定序的营业单位尤其重要。服务供应商描述复杂资料的定序以及有价值的分析和解释,以提供可行的见解。随着生物资讯学和计算生物学的进步扩大了从序列资料中获得的见解的范围和质量,这一领域正在迅速发展。
技术:次世代定序仪(NGS) 日益普及,可实现超高通量
新一代定序 (NGS) 技术是一种快速对 DNA 样本中的碱基对进行定序的高通量方法。 NGS 可以同时对多条 DNA 链进行定序,从而显着减少基因组研究的时间和成本。标靶定序和重定序着重于对基因组内的特定感兴趣区域进行定序,例如包含致病突变的区域。这提供了一种经济高效的方法来分析目标区域的遗传变异。全EXOME定序涉及对基因组中基因的所有蛋白质转录区进行定序。这些区域被称为外显子,约占人类基因组的 1% 至 2%,包含约 85% 的已知与疾病相关的基因突变。全基因组定序(WGS)透过对整个基因组进行定序来概述生物体的整个基因组成,使研究人员能够识别编码和非编码区域,并了解它们的潜在突变和变异。Sanger定序被认为是第一代定序技术,是一种确定DNA碱基序列的方法。它在 DNA 定序技术的发展中发挥了关键作用,并且仍然是小规模 DNA 定序计划的黄金标准。第三代 DNA 定序,也称为长读长定序,可以对单分子 DNA 进行即时定序。这项技术透过产生更长的读数超越了先前的限制,这对于理解复杂的基因组区域至关重要。奈米定序是第三代定序仪的一种型态,可让单条 DNA 链通过奈米尺寸的孔。碱基序列是利用 DNA 通过时电导率的变化来确定的。此方法可以即时分析长 DNA 或 RNA 片段。单分子即时 (SMRT) 定序的特点是能够高精度读取单分子 DNA。此方法有利于检测表观遗传修饰,并提供高品质的长读长,从而可以全面了解基因组、转录组和表观基因。
工作流程:越来越偏好满足准确性要求的定序方法
预测序阶段是 DNA 定序工作流程中关键的第一步,收集样本、评估其品质并为定序过程做好准备。此步骤包括从样本中提取 DNA,对其进行定量以确定存在多少 DNA,并可能将 DNA 打碎以将其分解成更小的片段。在此阶段确保 DNA 的完整性和纯度对于成功的定序结果至关重要。定序阶段涉及 DNA 序列的实际确定。这可以透过多种技术来完成,包括短 DNA 链的Sanger定序和用于全面、大规模基因组研究的下一代定序 (NGS)。 NGS 技术允许对数百万个 DNA 片段进行平行序列测定,并描述了一种高通量的基因组序列测定方法。在这个阶段,会产生大量的原始序列资料,分析需要大量的计算工作。资料分析阶段将原始序列资料转换为可解释的格式。这个过程通常被称为生物资讯学,包括序列与参考基因组的比对、突变/突变的识别以及基因组特征的註释等任务。采用先进的计算工具和演算法来处理复杂的资料,使得从序列资讯中得出生物学结论成为可能。最终目标是深入了解序列测定基因组的遗传结构、功能和变异。
应用:扩大DNA定序在临床研究的应用,以准确诊断与了解遗传疾病
农业基因组学利用基因组学见解来提高作物产量、抗病性和对环境变化的适应性,从而增强粮食安全和农业实践。在法医学领域,DNA定序有助于刑事调查、灾难受害者身分识别、遗产鑑定等中的个人识别,大大提高了法医分析的准确性。临床试验中的 DNA 定序可以实现对遗传疾病的准确诊断、治疗和理解。透过对个别基因组进行定序,医疗专业人员可以检测致病突变,指导个人化治疗计划,预测疾病感受性,并彻底改变患者照护和预防医学。消费者基因体学是 DNA 定序中成长最快的部分,可以深入了解个人的基因组成、血统、性状和某些健康状况的倾向。基因组资讯的民主化将促进采取知情和主动的方法来保护消费者的健康和保健。 HLA型检测(DNA 序列中的人类白血球抗原分型)对于免疫系统监测至关重要,特别是在器官移植适宜性、疾病相关研究和药物超敏反应方面。此应用确保了供体和受体之间的兼容性,降低了移植排斥的风险,并促进了标靶治疗。总体基因体学和流行病学透过分析复杂微生物群落的遗传物质,描述了微生物在生物多样性、微生物生态学和人类健康中的作用的见解。这些知识有助于追踪疾病爆发、了解病原体的传播以及开发药物。在药物开发中,DNA 定序加速了新治疗标靶和机制的发现,提高了新药的功效和安全性。在肿瘤学领域,DNA定序能够识别与癌症相关的基因突变,促进标靶治疗和个人化医疗方法的开发,并透过更有效和毒性更低的治疗来改善癌症患者的生活,其好处包括提高生存率和品质。
区域洞察
由于主要企业的持续技术进步、高额研发投资以及技术先进的医疗基础设施的可用性,美洲在 DNA 定序市场中占据关键地位,从而在预测期内带来良好的市场成长。在美国和加拿大,政府支持药物开发和癌症治疗研究的倡议正在推动北美市场的强劲成长。在欧洲,由于实验室中 DNA 定序的使用增加、研发活性化以及 DNA 定序技术的进步,该地区正在经历显着的发展。由于国际公司的策略性倡议,亚太地区的 DNA 定序市场规模正在扩大。
FPNV定位矩阵
FPNV定位矩阵对于评估DNA定序市场至关重要。我们检视与业务策略和产品满意度相关的关键指标,以对供应商进行全面评估。这种深入的分析使用户能够根据自己的要求做出明智的决策。根据评估,供应商被分为四个成功程度不同的像限。最前线 (F)、探路者 (P)、利基 (N) 和重要 (V)。
市场占有率分析
市场占有率分析是一种综合工具,可对 DNA 定序市场中供应商的现况进行深入而详细的研究。全面比较和分析供应商在整体收益、基本客群和其他关键指标方面的贡献,以便更好地了解公司的绩效及其在争夺市场占有率时面临的挑战。此外,该分析还提供了对该细分市场竞争特征的宝贵见解,包括在研究基准年观察到的累积、碎片化主导地位和合併特征等因素。这种详细程度的提高使供应商能够做出更明智的决策并制定有效的策略,从而在市场上获得竞争优势。
1. 市场渗透率:提供有关主要企业所服务的市场的全面资讯。
2. 市场开拓:我们深入研究利润丰厚的新兴市场,并分析其在成熟细分市场的渗透率。
3. 市场多元化:包括新产品发布、开拓地区、最新发展和投资的详细资讯。
4. 竞争评估和情报:对主要企业的市场占有率、策略、产品、认证、监管状况、专利状况和製造能力进行全面评估。
5. 产品开发与创新:包括对未来技术、研发活动和突破性产品开发的见解。
1.DNA定序市场的市场规模与预测是多少?
2.在DNA定序市场的预测期间内,我们应该考虑投资哪些产品和应用?
3.DNA定序市场的技术趋势和法规结构是什么?
4.DNA定序市场主要厂商的市场占有率是多少?
5.进入DNA定序市场的合适型态和策略手段是什么?
[185 Pages Report] The DNA Sequencing Market size was estimated at USD 60.39 billion in 2023 and expected to reach USD 71.98 billion in 2024, at a CAGR 19.51% to reach USD 210.34 billion by 2030.
DNA sequencing is the laboratory technique determining the sequence of nucleotides or bases in a single DNA molecule. DNA base sequence contains the encoded biological information that cells use to develop and function. DNA sequencing is used for various purposes, including diagnosis & disease treatment, medical research, and forensic analysis. Healthcare professionals can use sequencing to identify gene alterations or mutations of a specific disease condition. Rising cases of genetic disorders & cancer and growing demand for personalized medicine primarily boosting the research & development for DNA sequencing. Furthermore, technical limitations associated with DNA sequencing and the high cost of the sequencing platform limit the DNA sequencing market growth. In addition, complex data analysis & lack of standardized protocols lead to variability in the results of DNA sequencing. Moreover, the increasing adoption of DNA sequencing in clinical and research applications and the adoption of novel sequencing technologies, including next-generation sequencing, are expected to create lucrative opportunities for market growth. The rising investments in genomics research contribute to market growth.
KEY MARKET STATISTICS | |
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Base Year [2023] | USD 60.39 billion |
Estimated Year [2024] | USD 71.98 billion |
Forecast Year [2030] | USD 210.34 billion |
CAGR (%) | 19.51% |
Product & Services: Evolution across services with advances in bioinformatics and computational biology
Consumables are integral to DNA sequencing, encompassing all the necessary reagents, kits, and chemicals used during sequencing. These include DNA preparation kits, library preparation kits, and sequencing reagents. The quality and type of consumables directly impact the sequencing operation's accuracy, efficiency, and cost-effectiveness. Continuous innovation in consumables is critical for enhancing sequencing performance and reducing the per-sample cost, thereby making DNA sequencing more accessible for a broader range of applications. Instruments are the core hardware used in DNA sequencing, which ranges from high-throughput sequencers capable of processing thousands of genomes simultaneously to smaller, more portable devices designed for rapid and on-site analysis. The choice of instrument depends on the scale of sequencing needed, the level of detail required, and the available budget. Innovations in this segment focus on improving speed, reducing costs, and enhancing the resolution and fidelity of the sequencing results. Developing user-friendly interfaces and more compact designs also plays a significant role in adopting sequencing technology in new markets and applications. Services in DNA sequencing encompass a wide array of offerings, from sequencing-as-a-service to data analysis and consulting. These services are particularly important for entities needing more in-house infrastructure or expertise to perform sequencing. Service providers offer sequencing and valuable analysis and interpretation of complex data to provide actionable insights. This segment is evolving rapidly, with advances in bioinformatics and computational biology enhancing the scope and quality of the insights that can be derived from sequencing data, thereby offering tailored solutions to meet the diverse needs of customers.
Technology: Growing popularity of next-generation sequencing (NGS) for ultra-high throughput
Next-generation sequencing (NGS) technology represents a high-throughput approach that helps rapidly sequence the base pairs in DNA samples. NGS allows for the sequencing of multiple DNA strands simultaneously, drastically reducing the time and cost of genomic research. Targeted sequencing & resequencing focuses on sequencing specific areas of interest within a genome, such as regions containing mutations contributing to disease. This provides a cost-effective way to analyze genetic variation in targeted regions. Whole exome sequencing involves sequencing all the protein-coding regions of genes in a genome. These regions, known as exons, comprise about 1%-2% of the human genome and contain about 85% of known genetic mutations linked to diseases. Whole Genome Sequencing (WGS) involves sequencing the entire genome that provides an overview of the entire genetic makeup of an organism, allowing researchers to understand both coding and non-coding regions and their potential mutations or variations. Sanger sequencing is regarded as the first-generation sequencing technique and is a method for determining DNA nucleotide sequences. It has been pivotal in the development of DNA sequencing technologies and remains a gold standard for small-scale DNA sequencing projects. Third-generation DNA sequencing, also known as long-read sequencing, allows for the sequencing of single molecules of DNA in real-time. This technology surpasses previous limitations by generating longer reads, critical for understanding complex genomic regions. Nanopore sequencing is a form of third-generation sequencing that involves threading single DNA strands through nanoscopic pores. As the DNA passes through, changes in the electrical conductivity are used to identify the base sequence; this method allows for real-time analysis of long DNA or RNA fragments. Single-molecule real-time (SMRT) sequencing is characterized by its ability to read single molecules of DNA with high accuracy. This method provides advantages in detecting epigenetic modifications and offers high-quality long reads, enabling comprehensive views of genomes, transcriptomes, and epigenomes.
Workflow: Rising preference for sequencing methods to meet accuracy requirements
The pre-sequencing phase is a critical first step in the DNA sequencing workflow, where samples are collected, assessed for quality, and prepared for the sequencing process. This stage involves DNA extraction from the sample material, quantification to determine the amount of DNA present, and sometimes fragmentation, where the DNA is broken down into smaller pieces. Ensuring the integrity and purity of the DNA at this stage is paramount for successful sequencing outcomes. During the sequencing phase, the actual determination of the DNA sequence takes place. This can be performed using various technologies, such as Sanger sequencing for shorter DNA strands or Next-Generation Sequencing (NGS) for comprehensive, large-scale genomic studies. NGS techniques allow for the parallel sequencing of millions of DNA fragments, providing a high-throughput approach to genome sequencing. This stage generates vast raw sequence data, requiring significant computational effort to analyze. The data analysis phase involves converting the raw sequencing data into an interpretable format. This process, often referred to as bioinformatics, includes tasks such as aligning the sequences against reference genomes, identifying variations/mutations, and annotating genomic features. Advanced computational tools and algorithms are employed to handle the complex data, making drawing biological conclusions from the sequence information possible. The end goal is to provide insights into the sequenced genome's genetic structure, function, and variations.
Application: Expanding application of DNA sequencing in clinical investigation for precise diagnosis and understanding of genetic disorders
Agrigenomics uses genomic insights to improve crop yield, disease resistance, and adaptability to environmental changes for enhanced food security and agricultural practices. In forensics, DNA sequencing facilitates the identification of individuals in criminal investigations, disaster victim identification, and heritage testing, significantly improving the accuracy of forensic analysis. DNA sequencing in clinical investigations enables precise diagnosis, treatment, and understanding of genetic disorders. By sequencing an individual's genome, healthcare professionals detect mutations responsible for diseases, guide personalized treatment plans, and predict disease susceptibility, revolutionizing patient care and preventive medicine. Consumer genomics, a burgeoning segment of DNA sequencing, gives individuals insights into their genetic makeup, ancestry, traits, and predispositions to certain health conditions. This democratization of genomic information fosters an informed and proactive approach to health and wellness among consumers. HLA typing, or human leukocyte antigen typing in DNA sequencing, is pivotal in immune system monitoring, particularly for organ transplantation suitability, disease association studies, and drug hypersensitivity reactions. This application ensures the compatibility between donors and recipients, mitigating the risk of transplant rejection and facilitating targeted therapies. Metagenomics and epidemiology involve the analysis of genetic material from complex microbial communities, offering insights into biodiversity, microbial ecology, and the role of microbes in human health. This knowledge is instrumental in tracking disease outbreaks, understanding pathogen spread, and developing drugs. In drug development, DNA sequencing accelerates the discovery of novel therapeutic targets and mechanisms, enhancing the efficacy and safety of new drugs. Oncology benefits significantly from DNA sequencing by enabling the identification of genetic mutations associated with cancer, which facilitates the development of targeted therapy and personalized medicine approaches, improving cancer patients' survival rates and quality of life through more effective and less toxic treatments.
Regional Insights
The Americas has a significant landscape in the DNA sequencing market owing to continuous technological developments by key players, high research and development investment, and availability of technologically advanced healthcare infrastructure, resulting in lucrative market growth in the forecasted period. Government initiatives in the U.S. and Canada supporting research in drug development and treatment of cancer have created significant market growth in North America. In Europe, the growing usage of DNA sequencing in laboratories, rising R&D, and increasing advancements in DNA sequencing technologies have created significant regional development. Asia-Pacific has a growing market in DNA sequencing due to strategic initiatives undertaken by international firms to expand their presence owing to the high customer base, which is expected to create market growth in the region.
FPNV Positioning Matrix
The FPNV Positioning Matrix is pivotal in evaluating the DNA Sequencing Market. It offers a comprehensive assessment of vendors, examining key metrics related to Business Strategy and Product Satisfaction. This in-depth analysis empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success: Forefront (F), Pathfinder (P), Niche (N), or Vital (V).
Market Share Analysis
The Market Share Analysis is a comprehensive tool that provides an insightful and in-depth examination of the current state of vendors in the DNA Sequencing Market. By meticulously comparing and analyzing vendor contributions in terms of overall revenue, customer base, and other key metrics, we can offer companies a greater understanding of their performance and the challenges they face when competing for market share. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With this expanded level of detail, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.
Key Company Profiles
The report delves into recent significant developments in the DNA Sequencing Market, highlighting leading vendors and their innovative profiles. These include 10x Genomics, Inc., Abbott Laboratories, AbbVie Inc., Agilent Technologies, Inc., Azenta, Inc., Becton, Dickinson and Company, BGI Genomics Co., Ltd., Bio-Rad Laboratories, Inc., BioChain Institute Inc., Charles River Laboratories International, Inc., Danaher Corporation, Dante Labs Inc., Eppendorf SE, Eurofins Scientific SE, F. Hoffmann-La Roche Ltd., Genomics England, Genscript Biotech Corporation, Illumina, Inc., Johnson & Johnson Services, Inc., Konica Minolta, Inc., Laboratory Corporation of America Holdings, Macrogen Inc., Merck KGaA, Novartis AG, Novogene Co, Ltd., Oxford Nanopore Technologies PLC, Pacific Biosciences of California, Inc., PerkinElmer, Inc., QIAGEN N.V., Sartorius AG, Shimadzu Corporation, SOPHiA GENETICS SA, Thermo Fisher Scientific Inc., Twist Bioscience Corporation, and Veritas Genetics Inc. by LetsGetChecked.
Market Segmentation & Coverage
1. Market Penetration: It presents comprehensive information on the market provided by key players.
2. Market Development: It delves deep into lucrative emerging markets and analyzes the penetration across mature market segments.
3. Market Diversification: It provides detailed information on new product launches, untapped geographic regions, recent developments, and investments.
4. Competitive Assessment & Intelligence: It conducts an exhaustive assessment of market shares, strategies, products, certifications, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players.
5. Product Development & Innovation: It offers intelligent insights on future technologies, R&D activities, and breakthrough product developments.
1. What is the market size and forecast of the DNA Sequencing Market?
2. Which products, segments, applications, and areas should one consider investing in over the forecast period in the DNA Sequencing Market?
3. What are the technology trends and regulatory frameworks in the DNA Sequencing Market?
4. What is the market share of the leading vendors in the DNA Sequencing Market?
5. Which modes and strategic moves are suitable for entering the DNA Sequencing Market?