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基因合成市场:副产品、方法、基因型、应用和最终用途 - 2024-2030 年全球预测Gene Synthesis Market by Product (Hardware, Services, Software), Method (Chip-Based Synthesis, PCR-Based Enzyme Synthesis, Solid-Phase Synthesis), Gene Type, Application, End-use - Global Forecast 2024-2030 |
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预计2023年基因合成市场规模为42.4亿美元,2024年达46.8亿美元,2030年预计将达87亿美元,复合年增长率为10.82%。
基因合成市场包括与研究、医学、农业和生物技术等各行业透过化学方法人工创建 DNA 序列相关的技术、产品和服务。典型的最终用户包括学术机构、製药和生物技术公司、政府机构和委外研发机构(CRO)。全球人口中慢性病盛行率的不断上升、对个人化药物的需求不断增加,以及基因组研究的进步正在推动这一市场的发展。此外,基因合成相对于传统方法的优势正在推动市场成长。然而,诸如规范基因改造作物开发和商业化的严格法规以及对合成基因的大小和复杂性的限制等技术挑战限制了基因合成市场的成长。提高效率和精度的基因合成新技术以及基因合成在能源和农业领域的广泛应用正在为市场创造巨大的成长机会。
主要市场统计 | |
---|---|
基准年[2023] | 42.4亿美元 |
预测年份 [2024] | 46.8亿美元 |
预测年份 [2030] | 87亿美元 |
复合年增长率(%) | 10.82% |
扩大支持产品合成基因精确设计的软体的使用
基因合成硬件,包括寡核苷酸合成器,是合成 DNA 和 RNA 短片段(称为寡核苷酸)的专用设备。这些合成器在基因合成的早期阶段至关重要,可以创建组装成更长基因序列的构建块。基因定序仪对于此目的至关重要,它提供高通量和准确的定序能力,以确保合成基因符合预期设计。自动液体处理系统用于在移液、稀释和混合组装和扩增步骤所需的试剂和寡核苷酸期间减少错误并提高通量。基因合成服务涉及生产可自订的合成 DNA 序列,以满足特定的研究或工业要求。这些服务对于蛋白质生产、抗体工程、疫苗开发和生质燃料研究等各种应用至关重要。对自订基因的需求不断增长,导致越来越多的服务供应商提供基因合成的端到端解决方案。该软体解决方案专为合成基因设计和模拟而设计。这些工具使研究人员和生物技术人员能够透过优化密码子使用偏差、RNA 二级结构预测、GC 含量和限制性内切酶位点避免等因素来简化他们的工作流程。此外,基因合成软体可降低 DNA 从头合成过程中出现错误的风险,有助于提高研究效率并最大限度地降低成本。
方法 提高大型计划中基于晶片的合成的利用率
基于晶片的合成使用微阵列或生物晶片在小玻片上同时合成数千种寡核苷酸。这种高通量方法适用于需要多个基因的大型计划或当成本效率很重要时。基于 PCR 的酵素合成使用 DNA聚合酵素等酶,透过连续几轮的 PCR 扩增将短寡核苷酸组装成全长基因。这种方法提供快速的周转时间,非常适合专注于单一基因或基因变异的小型计划。固相合成将核苷酸依序付加固定在撑体上的不断生长的 DNA 链中。此方法保真度高,并且可以产生比其他方法错误更少的长 DNA 序列。基于晶片的综合非常适合需要成本效率的大型计划。基于 PCR 的酶合成非常适合专注于单基因或基因变异的小型计划,其中快速週转时间至关重要,而固相合成需要高保真度和长 DNA 序列时则首选。
基因型表现基因合成具有越来越大的潜力,为时间敏感的计划提供快速获取短基因的途径。
复杂基因合成专注于创建包含挑战性序列的合成基因,例如高 GC 含量、串联重复序列和同聚物区域。疫苗开发、途径工程和酵素优化等治疗应用的高级研究需要这些基因。 Express Gene Synthesis 适合需要快速週转时间进行小型计划和概念验证研究的科学家。与其他类型的基因合成相比,合成基因的长度短,传递时间短。标准基因合成使用多种技术,包括寡核苷酸组装和纠错,来合成高品质、无错误的 DNA 序列。此产品类型最常用于常规分子生物学计划,包括克隆、表达分析和重组蛋白生产。
最终用途生物技术和製药公司越来越关注创新药物发现和治疗方法开发。
学术机构和政府研究机构由于专注于基础研究、治疗开发和基因工程的进步,对基因合成市场的需求做出了重大贡献。这些研究机构使用基因合成服务来产生自订DNA 序列、设计生物途径和目标基因修饰。生物技术和製药公司严重依赖基因合成服务来推进药物发现、治疗方法开发和精准医疗。自订基因促进蛋白质表现研究、新药物标靶的鑑定以及疾病特异性动物模型的开发。受託研究机构已成为基因合成服务的重要最终用户,为生物製药和学术客户提供基因库建设、自订克隆和蛋白质表现优化方面的支援。生物技术和製药公司由于专注于创新药物发现和治疗开发而占据最大份额。学术和政府研究机构也纷纷效仿,并专注于基因工程的基础研究和进展。透过提供满足各行业不同客户需求的全面基因组学解决方案,CRO 正经历快速成长。
基因型:越来越多的机会表达针对特定宿主生物体中高水平表达而优化的基因。
复杂基因的特征是其核苷酸序列复杂,通常含有高GC含量、重复序列和容易产生二级结构的序列。这种复杂性可能会给合成过程和随后的克隆带来挑战。具有长均聚物运作或编码剪接位点的基因也可以被认为是复杂的。合成复杂的基因需要先进的技术和精心的设计,以确保最终产品的保真度和功能性。表达基因是指经优化以在特定宿主生物体中高水平表达的合成产生的DNA序列。这些基因变体通常会经历密码子优化,即更改密码子以匹配表达系统的首选用途,并导致 mRNA 更有效地翻译为蛋白质。此外,可以将强启动子、增强子和其他调控元件付加到表达的基因中,以促进研究或工业酵素应用的蛋白质生产。标准基因是合成的 DNA 序列,是基因合成服务的基本产品。该基因不具有复杂基因中的复杂性,且未针对涉及表达基因的过度表现进行最佳化。相反,标准基因为研究人员提供了一种准确、可靠且经济高效的方法来获取反映天然 DNA 序列或包含微小修饰的 DNA 序列,以用于克隆和功能分析。标准基因是许多基因工程计划的支柱,广泛应用于生命科学的各个领域。
区域洞察
由于发达的医疗保健部门和支持性政府计划的存在,美洲的基因合成市场高度发展。这是由于研发设施的改善、可支配收入的增加和经济状况的快速发展。此外,联邦机构和当局还推出了多项倡议、计划和计划,以鼓励该地区的基因治疗研究,形成美洲基因合成的平台。印度、中国、新加坡和马来西亚等新兴国家由于医疗保健标准的提高而具有市场扩张的潜力。国内基因合成製造商在这些经济体中占有重要地位,有助于大型跨国企业快速渗透市场。慢性病的流行、技术的进步和医疗基础设施的改善是推动欧洲、中东和非洲基因合成市场的关键原因。该地区各国政府继续投资基因治疗,从而扩大了各种基因合成的使用。 2022年2月,荷兰政府投资5,504万美元建造一座新的国家试点工厂,以推进有前景的细胞和基因疗法的开发和製造。荷兰政府的投资预计将为细胞和基因治疗公司提供巨大的机会。
FPNV定位矩阵
FPNV定位矩阵对于评估基因合成市场至关重要。我们检视与业务策略和产品满意度相关的关键指标,以对供应商进行全面评估。这种深入的分析使用户能够根据自己的要求做出明智的决策。根据评估,供应商被分为四个成功程度不同的像限:前沿(F)、探路者(P)、利基(N)和重要(V)。
市场占有率分析
市场占有率分析是一种综合工具,可以对基因合成市场供应商的现状进行深入而深入的研究。全面比较和分析供应商在整体收益、基本客群和其他关键指标方面的贡献,以便更好地了解公司的绩效及其在争夺市场占有率时面临的挑战。此外,该分析还提供了对该行业竞争特征的宝贵见解,包括在研究基准年观察到的累积、分散主导地位和合併特征等因素。详细程度的提高使供应商能够做出更明智的决策并制定有效的策略,从而在市场上获得竞争优势。
1. 市场渗透率:提供有关主要企业所服务的市场的全面资讯。
2. 市场开拓:我们深入研究利润丰厚的新兴市场,并分析其在成熟细分市场的渗透率。
3. 市场多元化:提供有关新产品发布、开拓地区、最新发展和投资的详细资讯。
4. 竞争评估和情报:对主要企业的市场占有率、策略、产品、认证、监管状况、专利状况和製造能力进行全面评估。
5. 产品开发与创新:提供对未来技术、研发活动和突破性产品开发的见解。
1. 基因合成市场的市场规模与预测是多少?
2.在基因合成市场的预测期间内,有哪些产品、细分市场、应用和领域需要考虑投资?
3.基因合成市场的技术趋势与法规结构是什么?
4.基因合成市场主要厂商的市场占有率是多少?
5. 进入基因合成市场的合适型态和策略手段是什么?
[181 Pages Report] The Gene Synthesis Market size was estimated at USD 4.24 billion in 2023 and expected to reach USD 4.68 billion in 2024, at a CAGR 10.82% to reach USD 8.70 billion by 2030.
The gene synthesis market comprises technologies, products, and services related to the artificial creation of DNA sequences through chemical methods in various industries such as research, medicine, agriculture, and biotechnology. Key end-users include academic institutions, pharmaceutical and biotechnology companies, government agencies, and contract research organizations (CROs). The growing prevalence of chronic conditions among the global population and rising demand for personalized medicines, along with advancements in genomics research, are driving this market. Moreover, the advantage of gene synthesis over traditional methods is fueling market growth. However, strict regulations governing the development and commercialization of GMOs and technical challenges such as limitations in size and complexity of synthetic genes limit the growth of the gene synthesis market. Emerging technologies in gene synthesis for efficiency and accuracy and the growing utilization of gene synthesis in energy and agriculture industries are creating significant growth opportunities in the market.
KEY MARKET STATISTICS | |
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Base Year [2023] | USD 4.24 billion |
Estimated Year [2024] | USD 4.68 billion |
Forecast Year [2030] | USD 8.70 billion |
CAGR (%) | 10.82% |
Product: Expanding usage of software that helps design synthetic genes accurately
Gene synthesis hardware, including oligonucleotide synthesizers, are specialized instruments used for the synthesis of short DNA or RNA fragments called oligonucleotides. These synthesizers are essential in the initial steps of gene synthesis, creating the building blocks that will be assembled into longer gene sequences. Gene sequencers are critical for this purpose, providing high-throughput and accurate sequencing capabilities to ensure the synthetic genes match the intended design. Automated liquid handling systems are employed to reduce errors and increase throughput during the pipetting, dilution, and mixing of reagents and oligonucleotides necessary for assembly and amplification steps. Gene synthesis services involve the production of synthetic DNA sequences that can be customized to cater to specific research or industrial requirements. These services are essential for various applications such as protein production, antibody engineering, vaccine development, and biofuel research. The growing demand for custom-made genes has led to an increase in service providers offering end-to-end solutions in gene synthesis. Software solutions are designed specifically for designing and simulating synthetic genes. These tools allow researchers and biotechnologists to streamline their workflow by optimizing factors such as codon usage bias, RNA secondary structure prediction, GC content, and restriction enzyme site avoidance. Moreover, gene synthesis software helps reduce the risk of errors during de novo DNA synthesis, thereby improving research efficiency and minimizing costs.
Method: Rising utilization of chip-based synthesis for large-scale projects
Chip-based synthesis uses microarrays or biochips to synthesize thousands of oligonucleotides simultaneously on a small glass slide. This high-throughput method is suitable for large-scale projects requiring multiple genes or when cost-efficiency is crucial. PCR-based enzyme synthesis involves using enzymes such as DNA polymerase to assemble short overlapping oligonucleotides into full-length genes through consecutive rounds of PCR amplification. This method offers quick turnaround times and is ideal for small-scale projects focusing on single genes or gene variants. Solid-phase synthesis involves sequentially adding nucleotides to a growing DNA chain immobilized on a solid support. This method offers high fidelity and can generate long DNA sequences with fewer errors than other methods. Chip-based synthesis is best suited for large-scale projects requiring cost efficiency. PCR-based enzyme synthesis is ideal when rapid turnaround times are essential for small-scale projects focusing on single genes or gene variants, while solid-phase synthesis is preferred when high fidelity and longer DNA sequences are required.
Gene Type: Growing potential for express gene synthesis that provides quick access to shorter genes for time-sensitive projects
Complex gene synthesis focuses on creating synthetic genes that contain challenging sequences, such as high GC content, tandem repeats, and homopolymeric regions. Scientists often require these genes for advanced research in therapeutic applications such as vaccine development, pathway engineering, and enzymatic optimization. Express gene synthesis caters to scientists who require fast turnaround times for small-scale projects or proof-of-concept studies. These synthesized genes are shorter in length and have a quicker turnaround time compared to other types of gene synthesis. Standard gene synthesis involves the synthesis of high-quality, error-free DNA sequences using a variety of techniques, including oligonucleotide assembly and error correction. This type is most commonly used in routine molecular biology projects involving cloning, expression analysis, and recombinant protein production.
End-use: Increasing focus on innovative drug discovery and therapeutic development across biotechnology and pharmaceutical companies
Academic and government research institutes significantly contribute to gene synthesis market demand because they focus on basic research, therapeutic development, and genetic engineering advancements. These institutes utilize gene synthesis services to generate custom DNA sequences, design biological pathways, and perform targeted gene modifications. Biotechnology and pharmaceutical companies rely heavily on gene synthesis services for drug discovery, therapeutic development, and precision medicine advancements. Custom genes facilitate protein expression studies, identification of novel drug targets, and development of disease-specific animal models. Contract research organizations have emerged as vital end-users of gene synthesis services, supporting biopharmaceutical and academic clients in gene library construction, custom cloning, and protein expression optimization. Biotechnology and pharmaceutical companies command the largest share due to their focus on innovative drug discovery and therapeutic development. Academic government research institutes follow closely, emphasizing fundamental research and genetic engineering advancements. CROs are experiencing rapid growth by offering comprehensive genomics solutions that cater to diverse client demands across industries.
Gene Type: Growing potential of express genes that are optimized for high levels of expression in specific host organisms
Complex genes are characterized by their intricate nucleotide sequences, which often include high GC content, repeated sequences, or sequences prone to secondary structures. Such complexities can pose challenges during the synthesis process and subsequent cloning. Genes with long homopolymeric runs or cryptic splice sites are also considered complex. Synthesizing complex genes requires advanced techniques and careful design to ensure the fidelity and functionality of the final product. Express genes refer to synthetically manufactured DNA sequences optimized for high levels of expression in specific host organisms. These gene variants usually undergo codon optimization, where codons are modified to match the preferred usage of the expression system, leading to more efficient translation of the mRNA into proteins. Additionally, express genes can be outfitted with strong promoters, enhancers, and other regulatory elements to boost protein production for research or industrial enzyme applications. Standard genes are synthetic DNA sequences that represent the basic offering in gene synthesis services. The genes do not possess the complexities found in complex genes and are not optimized for overexpression, including express genes. Instead, standard genes provide researchers with accurate, reliable, and cost-effective means to obtain DNA sequences that are reflective of the native DNA sequence or include slight modifications for cloning or functional analysis. Standard genes are the backbone of many genetic engineering projects and are widely used across different domains of life sciences.
Regional Insights
The gene synthesis market in the Americas is highly developing owing to the presence of a developed healthcare sector and supportive government programs, which has resulted in considerable product development and the commercialization of gene synthesis technologies in the United States and Canada. This is attributed to growing improvements in R&D facilities, available disposable income, and rapidly developing economic conditions. Moreover, federal agencies and authorities have launched several initiatives, programs, and schemes to encourage gene therapy research in the region, creating a platform for gene synthesis in the Americas. Emerging economies such as India, China, Singapore, and Malaysia are potential markets for market expansion due to improved healthcare standards. These economies have a considerable presence of domestic manufacturers of gene synthesis, which contributes to an upsurge in the market penetration of multinational giants. The growing prevalence of chronic diseases, increasing technological advancements, and improved healthcare infrastructure are the primary reasons driving the gene synthesis market in EMEA. Governments across the region have been continuously investing in gene therapies, thereby expanding the utilization of various gene syntheses. In February 2022, the Dutch government invested USD 55.04 million to build a new national pilot factory to advance the development and manufacturing of promising cell and gene therapies. The investment by the Dutch government is expected to provide excellent opportunities for cell and gene therapy companies.
FPNV Positioning Matrix
The FPNV Positioning Matrix is pivotal in evaluating the Gene Synthesis Market. It offers a comprehensive assessment of vendors, examining key metrics related to Business Strategy and Product Satisfaction. This in-depth analysis empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success: Forefront (F), Pathfinder (P), Niche (N), or Vital (V).
Market Share Analysis
The Market Share Analysis is a comprehensive tool that provides an insightful and in-depth examination of the current state of vendors in the Gene Synthesis Market. By meticulously comparing and analyzing vendor contributions in terms of overall revenue, customer base, and other key metrics, we can offer companies a greater understanding of their performance and the challenges they face when competing for market share. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With this expanded level of detail, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.
Key Company Profiles
The report delves into recent significant developments in the Gene Synthesis Market, highlighting leading vendors and their innovative profiles. These include Agilent Technologies, Inc., Ansa Biotechnologies, Inc., Applied Biological Materials Inc., AstraZeneca PLC, Azenta, Inc., Barcode Biosciences Private Limited, BGI Genomics by BGI Group, BioCat GmbH by AddLife AB, Biomatik Corporation, Bioneer Corporation, Biotage AB, Biotech Desk Pvt. Ltd., Boster Biological Technology, Brooks Automation Inc., Camena Bioscience, Charles River Laboratories International, Inc., Constructive Bio Ltd, Creative Biogene, Danaher Corporation, DNA TwoPointO Inc., Elabscience Biotechnology Inc., Elegen Corp., Eurofins Scientific SE, Evonetix Ltd., GenCefe Biotech Limited, Gene Universal, Inc., General Biosystems, Inc., GenScript Biotech Corporation, Ginkgo Bioworks Holdings, Inc., Macrogen, Inc., Merck KGaA, NZYTech, Lda., OriGene Technologies, Inc., ProMab Biotechnologies, Inc., ProteoGenix SAS, QIAGEN N.V., Synbio Technologies LLC, Telesis Bio Inc., Thermo Fisher Scientific Inc., and Twist Bioscience Corporation.
Market Segmentation & Coverage
1. Market Penetration: It presents comprehensive information on the market provided by key players.
2. Market Development: It delves deep into lucrative emerging markets and analyzes the penetration across mature market segments.
3. Market Diversification: It provides detailed information on new product launches, untapped geographic regions, recent developments, and investments.
4. Competitive Assessment & Intelligence: It conducts an exhaustive assessment of market shares, strategies, products, certifications, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players.
5. Product Development & Innovation: It offers intelligent insights on future technologies, R&D activities, and breakthrough product developments.
1. What is the market size and forecast of the Gene Synthesis Market?
2. Which products, segments, applications, and areas should one consider investing in over the forecast period in the Gene Synthesis Market?
3. What are the technology trends and regulatory frameworks in the Gene Synthesis Market?
4. What is the market share of the leading vendors in the Gene Synthesis Market?
5. Which modes and strategic moves are suitable for entering the Gene Synthesis Market?