市场调查报告书
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胃癌全球市场规模/份额/行业趋势分析报告:按给药途径(注射/口服)、治疗类型、疾病类型、分销渠道、药物类别、地区、展望/预测,2023-2029 年Global Gastric Cancer Market Size, Share & Industry Trends Analysis Report By Route of Administration (Injectable and Oral), By Treatment Type, By Disease Type, By Distribution Channel, By Drug Class, By Regional Outlook and Forecast, 2023 - 2029 |
胃癌市场规模预计到 2029 年将达到 69 亿美元,预测期内復合年增长率为 17.6%。
由于癌症在不同时间在胃的不同部位发展,因此症状和预后各不相同。 治疗的选择可能取决于癌症的起源。 例如,在胃食管交界处出现或开始于胃食管交界处的恶性肿瘤的分期和治疗通常与食管肿瘤相似。 胃的最内层粘膜含有引起这些恶性肿瘤的腺细胞。
胃腺癌有两种基本类型:肠型和瀰漫型。 癌细胞更有可能发生某些基因改变,从而更有可能进行靶向药物治疗。 扩散型通常传播得更快。 与肠型相比,它的发生频率较低,而且往往难以治疗。
COVID-19 影响分析
诊断和治疗的延误是 COVID-19 大流行对胃癌的主要影响。 癌症诊断和治疗的延误会对患者的预后产生重大影响。 癌症研究,尤其是测试胃癌新疗法的临床试验,也受到大流行的阻碍。 COVID-19 限制已推迟或暂停了许多临床试验,可能会延迟针对该疾病的新疗法的开发。 然而,在大流行期间,重症病例仍在接受治疗。 考虑到这些因素,我们发现胃癌市场受到了 COVID-19 的适度影响。
市场增长因素
扩大靶向治疗和免疫治疗的接受度,引入新药
随着对疾病分子基础的了解不断加深,越来越多的靶向和免疫治疗药物被开发并推向市场。 2010年以来,赫赛汀等抗HER-2药物陆续上市。 目前,EGFR和PD-1靶向治疗和免疫治疗正在开髮用于治疗胃癌。 此外,临床管道中药物的批准和后续上市预计将推动胃癌市场的增长。
胃癌患病率上升
胃癌是东亚地区最普遍的癌症类型。 到 2020 年,预计将有 110 万新发胃癌病例和 77 万胃癌相关死亡病例,男性患病率通常是女性的两倍。 在预测期内,由于胃癌患病率的增加,预计胃癌药物的需求将增加,这有望作为胃癌药物的市场趋势引起人们的关注。 在预测期内,这有望帮助胃癌市场增长。
市场製约因素
有限的治疗方案及其相关副作用的组合
可以使用化学疗法、放射疗法或两者结合手术来治疗癌症。 化学疗法中使用的药物通过攻击快速分裂的癌细胞起作用,但它们也会损害健康细胞,引起令人不快的副作用,例如噁心、呕吐和疲劳。。 我们预计这将成为未来几年市场需求的障碍。 此外,治疗成本上升和胃癌治疗药物相对有限等因素预计将阻碍预测期内胃癌市场的增长。
按疾病类型划分的前景
胃癌市场按疾病类型分为腺癌、淋巴瘤、胃肠道间质瘤、类癌等。 在 2022 年的胃癌市场中,淋巴瘤领域占据了相当大的收入份额。 免疫系统的淋巴细胞是这些肿瘤首先出现的地方。 一些淋巴瘤起源于胃壁,但大多数淋巴瘤起源于身体的其他部位。 根据淋巴瘤的类型和其他变量,这些肿瘤可以得到治疗并具有良好的预后。 预计淋巴瘤意识的增强将促进这一领域的扩张。
治疗类型的前景
按治疗类型划分,胃癌市场分为免疫疗法、靶向疗法、化学疗法和放射疗法/手术疗法。 到 2022 年,胃癌市场将由靶向治疗领域主导。 在靶向治疗中,癌症患者接受专门针对癌细胞中基因或蛋白质的药物治疗。 靶向癌症疗法有多种形式,包括激素剂、基因调节剂、血管生成抑製剂、细胞凋亡诱导剂和信号转导抑製剂。
药物类别展望
按照药物类别,胃癌市场分为 PD-1/PD-L1 抑製剂、抗 HER-2 药物、VEGFR2 抑製剂等。 2022年,PD-1/PD-L1抑製剂板块将以最大的收入份额主导胃癌市场。 程序性细胞死亡蛋白 1 (PD-1) 和 PD-L1 等免疫检查点蛋白通常有助于防止可能损害健康组织的过度免疫反应。 许多 PD-1/PD-L1 抑製剂,包括 nivolumab、pembrolizumab 和 atezolizumab,被批准用于治疗严重或转移性胃癌。 有几种药物已被证明可以延长晚期胃癌患者的生存期并减缓肿瘤生长。
管理路线展望
根据给药途径,胃癌市场分为口服药物和注射药物。 到 2022 年,注射剂将在胃癌市场占据最大的收入份额。 由于注射剂直接进入血液,因此它们可能比口服药物吸收得更快。 它可以帮助需要立即就医的晚期或转移性胃癌患者。 随着更多的药物到达靶位点,静脉内给药也提高了生物利用度。 这可以减少副作用并改善治疗结果。
销售渠道前景
按分销渠道,胃癌市场分为专业和零售药店、医院药店等。 预计到 2022 年,医院药房部门将在胃癌市场中占据显着的收入份额。 政府支持的医院药房的建立和优惠报销是医院药房部门增长的主要驱动力。 除了这些原因之外,政府还为癌症治疗提供了强有力的支持。 此外,由于患者数量增加、胃癌患病率增加以及癌症治疗设施数量增加,预计该领域将扩大。
区域展望
按地区划分,对北美、欧洲、亚太地区和 LAMEA(拉丁美洲、中东和非洲)的胃癌市场进行了分析。 到 2022 年,亚太地区将占据最大的收入份额,推动胃癌市场的发展。 亚太地区日益老龄化的人口推动了市场扩张。 胃癌诊断的需求是由胃肠道肿瘤和淋巴瘤的流行驱动的。 此外,亚太地区的胃癌患者正在增加,预计这将在预测期内推动亚太地区的市场增长。
合作伙伴关係是市场进入者采取的主要策略。 根据发表在 Cardinal Matrix 上的一项分析,辉瑞公司是胃癌市场的领先先驱。 默克公司、梯瓦製药工业有限公司、礼来公司是胃癌市场的领先创新者。
The Global Gastric Cancer Market size is expected to reach $6.9 billion by 2029, rising at a market growth of 17.6% CAGR during the forecast period.
The cells lining the stomach are where gastric cancer, also known as stomach cancer, first develops. Abdominal pain, vomiting, nausea, bloating, and weight loss can all be signs of gastric cancer. Surgery, radiation therapy, chemotherapy, or a combination of these treatments are all possible forms of treatment for gastric cancer.
Cancer develops when the body's cells start to proliferate out of control. Cancerous cells can develop in almost any body portion and spread to other organs. Usually, gastric cancers grow slowly over several decades. Precancerous alterations frequently appear in the inner mucosa of the stomach before genuine cancer develops. Since these early alterations rarely have symptoms, they may go unnoticed.
Different parts of the stomach can develop cancer at different times, which can result in a variety of symptoms and prognoses. Treatment choices may vary depending on the location of the cancer. For instance, malignancies that develop into or begin at the GE junction are often staged and treated similarly to esophageal tumors. The mucosa, the stomach's innermost lining, contains gland cells that give rise to these malignancies.
The intestinal type and diffuse type of stomach adenocarcinomas are the two basic forms. The likelihood of specific gene alterations in cancer cells increases the possibility that they can be treated with targeted medication therapy. The diffuse form typically spreads more rapidly. It is less frequent than the intestinal variety, and it is frequently more challenging to treat.
COVID-19 Impact Analysis
Delays in diagnosis & treatment have been the primary effects of the COVID-19 pandemic on gastric cancer. Delays in cancer diagnosis & treatment were the result, and they can significantly affect how patients turn out. Cancer research, particularly clinical trials looking at novel treatments for gastric cancer, has also been hampered by the pandemic. Due to COVID-19 limits, numerous clinical trials were postponed or suspended, which may be slowing down the creation of new treatments for the illness. However, the severe cases were being treated during the pandemic period. Considering these elements, the gastric cancer market witnessed a moderate impact due to COVID-19.
Market Growth Factors
Growing acceptance of targeted therapy and immunotherapy and introduction of new drugs
The number of targeted medications and immunotherapy treatments being developed and introduced into the market has increased due to a better understanding of the disease's molecular foundation. Since 2010, HER-2-specific medications, such as Herceptin, have been marketed. EGFR and PD-1 targeted therapy and immunotherapies are currently being created to treat gastric cancer. Furthermore, the market for gastric cancer is also anticipated to be driven by the approval and subsequent release of medications in the clinical pipeline aiding the gastric cancer market growth.
Rising Prevalence of Gastric Cancer
Gastric cancer is the most prevalent cancer type in Eastern Asia. 2020 saw an anticipated 1.1 million new cases of stomach cancer and 770 000 gastric cancer-related deaths, with male incidence rates often being twice as high as females. During the forecast period, it is anticipated that the rising prevalence of gastric carcinoma will increase demand for gastric cancer treatments and make them one of the most popular market trends for stomach cancer treatments. During the forecast period, this is expected to help the growth of the gastric cancer market.
Market Restraining Factors
Limited treatment option combined with their associated side effects
Treating cancer using chemotherapy, radiation therapy, or a combination of the two and with surgery is possible. The medications used in chemotherapy function by attacking rapidly dividing cancer cells; however, they can also harm healthy cells, resulting in unpleasant side effects such as nausea, vomiting, and exhaustion. In the next years, it is anticipated that this aspect will function as a barrier to the demand in the market. It is projected that factors such as high therapy costs and relatively limited availability of medications for the treatment of stomach cancer would work together to impede the growth of the gastric cancer market throughout the forecasted period.
Disease Type Outlook
Based on disease type, the gastric cancer market is characterized into adenocarcinoma, lymphoma, gastrointestinal stromal tumor, carcinoid tumor, and others. The lymphoma segment covered a considerable revenue share in the gastric cancer market in 2022. The immune system's lymphocytes are where these tumors develop in the first place. There are some lymphomas that can begin in the stomach wall, while most lymphomas begin in other areas of the body. Depending on the lymphoma type and other variables, these tumors can be treated and have good prognoses. The rising awareness of the lymphoma are predicted to support the segment's expansion.
Treatment Type Outlook
On the basis of treatment type, the gastric cancer market is classified into immunotherapy, targeted therapy, chemotherapy, and radiation therapy & surgery. The targeted therapy segment acquired a substantial revenue share in the gastric cancer market in 2022. With targeted therapy, cancer patients receive treatment by having pharmaceuticals that specifically target the genes or proteins that the cancer cells have. Targeted therapy for cancer comes in various forms, including hormonal treatments, gene expression regulators, angiogenesis inhibitors, apoptosis inducers, signal transduction inhibitors, and several more.
Drug Class Outlook
By drug class, the gastric cancer market is divided into PD-1/PD-L1 inhibitors, HER2 antagonists, VEGFR2 antagonists, and others. In 2022, the PD-1/PD-L1 inhibitors segment dominated the gastric cancer market with the maximum revenue share. Immune checkpoint proteins such as programmed cell death protein 1 (PD-1) and PD-L1 often aid in preventing overactive immune responses that may harm healthy tissues. For the treatment of severe or metastatic gastric cancer, a number of PD-1/PD-L1 inhibitors, such as nivolumab, pembrolizumab, and atezolizumab, have been licensed. In patients with advanced gastric cancer, several medications have demonstrated effectiveness in extending survival and slowing tumor growth
Route of Administration Outlook
Based on route of administration, the gastric cancer market is segmented into oral and injectable. In 2022, the injectable segment registered the maximum revenue share in the gastric cancer market. Since injectable pharmaceuticals are administered directly into the bloodstream, they can be absorbed faster than oral medicines. This helps individuals with advanced or metastatic stomach cancer, where quick action may be required. More of the drug can reach its target site when it is administered intravenously, which increases bioavailability. Less side effects and better therapeutic outcomes may arise from this.
Distribution Channel Outlook
On the basis of distribution channel, the gastric cancer market is classified into specialty & retail pharmacies, hospital pharmacies, and others. The hospital pharmacies segment projected a prominent revenue share in the gastric cancer market in 2022. The creation of government-sponsored hospitals pharmacies as well as advantageous reimbursement are the main causes of the hospital pharmacy segment's growth. These reasons together with the strong support the government has provided for cancer treatment. The segment is also predicted to expand as a result of the growing patient pool, growing prevalence of stomach cancer, and increasing number of cancer treatment facilities.
Regional Outlook
Region wise, the gastric cancer market is analyzed across North America, Europe, Asia Pacific, and LAMEA. In 2022, the Asia Pacific region led the gastric cancer market by generating the largest revenue share. The expansion of the market is being driven by the rise in the geriatric population in the Asia-Pacific region. The demand for gastric cancer diagnostics has been driven by the prevalence of gastrointestinal tumors and lymphomas. Furthermore, the rising case of gastric cancer in the region is anticipated to propel the market growth in the Asia Pacific during the projected period.
The major strategies followed by the market participants are Partnerships. Based on the Analysis presented in the Cardinal matrix; Pfizer, Inc. is the major forerunner in the Gastric Cancer Market. Companies such as Merck & Co., Inc., Teva Pharmaceutical Industries Ltd., Eli Lilly and Company are some of the key innovators in Gastric Cancer Market.
The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include Novartis AG, Pfizer, Inc., Viatris, Inc. (Mylan N.V.), F. Hoffmann-La Roche Ltd., Eli Lilly And Company, Merck & Co., Inc., Teva Pharmaceuticals Industries Ltd., Bristol Myers Squibb Company, Celltrion Healthcare Co., Ltd., and Samsung Biologics Co., Ltd. (Samsung Bioepis Co., Ltd.).
Strategies deployed in Gastric Cancer Market
Partnerships, Collaborations, and Agreements:
Feb-2023: Pfizer came into collaboration with Tempus, a technology company focused on advancing precision medicine through the practical application of artificial intelligence in healthcare. Following the collaboration, Pfizer would access Tempus' AI-based platform and multimodal data library, together with its clinical trial matching program and companion diagnostic development capabilities.
Jan-2023: Roche signed an agreement with CHEPLAPHARM, following which the latter company took the commercial rights from Roche for Xeloda (capecitabin) in China. Early in 2022, CHEPLAPHARM already had the rights for the extremely potent anti-cancer drug in every country except China and Japan. By incorporating China, CHEPLAPHARM improves its cancer product line and increases its market share in the world's second-largest pharmaceutical market. In 1997, Xeloda® received approval in China for use as a prescription drug. Shanghai Roche Pharmaceuticals got permission from China's State FDA in 2007 to treat advanced gastric cancer, metastatic breast cancer, and colorectal cancer.
Jan-2023: Roche extended its collaboration with CARsgen Therapeutics Holdings Limited, a manufacturer of innovative therapies for the treatment of solid tumors and hematologic malignancies. Following the expansion, the companies aim to evaluate CARsgen's investigational drug AB011, the first humanized monoclonal antibody against Claudin18.2 (CLDN18.2) that received IND clearance across the world, together with atezolizumab, Roche's PD-L1 checkpoint inhibitor, along with standard-of-care chemotherapy in patients with gastric or gastroesophageal junction carcinoma. In addition, Roche will be in charge of operating and conducting the research while both businesses would split the costs of the study's AB011 treatment arms.
Marr-2022: Celltrion Healthcare announced that they have got the tender in Brazil, from the Brazilian Federal Government to procure the world's first monoclonal antibody biosimilar Remsima (infliximab). Additionally, the company has won 12 State bids in Brazil to supply Remsima, including the largest state in Brazil Sao Paulo.
Mar-2022: Bristol Myers Squibb announced a clinical collaboration with Transcenta Holding Limited, a clinical-stage biopharmaceutical company, for the evaluation of the combination of TST001, an investigational humanized monoclonal antibody targeting Claudin18.2 created by Transcenta, with Opdivo® (nivolumab), Bristol Myers Squibb's anti-PD-1 therapy. This has been indicated for the treatment of unresectable locally advanced or metastatic gastric cancer or gastroesophageal junction cancer (GC/GEJ).
Feb-2022: Bristol Myers Squibb and Ono Pharmaceutical signed an agreement with Prime Research Institute for Medical RWD, Inc. for an industry-sponsored, large-scale, multi-institutional clinical research on gastric cancer patients treated with Opdivo together with chemotherapy. The study would utilize the PRiME-R's "CyberOncology®" data entry support system, which standardizes, organizes, manages, and integrates real-world data in routine cancer clinical practice.
Sep-2021: Roche Diagnostics International came into an agreement with Medical EarlySign, a company focused on developing ML-based decision support tools, for commercializing an AI tool that would detect cancer early. Following the agreement, the companies create the product, clinically validate it, and then market it. The companies would initially concentrate on the field of stomach cancer. EarlySign's software, which includes lab findings, EHR data, and other clinical care, is used in the clinical decision support tool.
Jun-2021: Eli Lilly and Company signed a clinical trial and supply agreement with ALX Oncology, a clinical-stage immuno-oncology company. Following the agreement, the companies aimed to evaluate the combination of Lilly's anti-VEGFR2 antibody, and ALX148, a next-generation CD47 blocker, for the treatment of HER2-positive gastric cancer or gastroesophageal junction cancer patients.
Feb-2021: Novartis Pharma announced a collaboration and license agreement with BeiGene, Ltd., a biotechnology company engaged in the development and commercialization of innovative medicines. The agreement was focused on developing, manufacturing, and commercializing BeiGene's anti-PD-1 antibody tislelizumab in the US, Mexico, Canada, and member countries of the European region, Norway, United Kingdom, Iceland, Switzerland, Russia, Liechtenstein, and Japan. Additionally, both businesses may perform clinical studies around the world to investigate pairings of tislelizumab with other cancer therapies, and BeiGene has the option to co-develop the medicine in North America with Novartis' financial support.
Product Launches and Product Expansions:
Aug-2020: Samsung Bioepis unveiled Ontruzant (trastuzumab), a biosimilar referencing Roche's Herceptin, in Brazil. Ontruzant (150 mg single-dose vials) has been authorized for the treatment of advanced gastric cancer, metastatic HER2-overexpressing breast cancer, and early HER2-overexpressing breast cancer by the Agencia Nacional de Vigilancia Sanitaria (ANVISA), the country's health regulatory body. It was launched in the United States in April 2020.
Mar-2020: Teva Pharmaceuticals USA, Inc., a division of Teva, together with Celltrion Healthcare, announced the availability of HERZUMA®1 (trastuzumab-pkrb) for Injection, a biosimilar to HERCEPTIN®1 in the United States. HERZUMA is approved in combination with cisplatin, capecitabine, or 5-fluorouracil for the treatment of patients with HER2-overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma who have not previously undergone treatment for metastatic disease.
Approvals & Trials:
Jun-2022: Eli Lilly and Company and Innovent Biologics, Inc., a biopharmaceutical company, received approval from the National Medical Products Administration (NMPA) of China for the supplemental New Drug Application (sNDA) for TYVYT® (sintilimab injection) together with fluorouracil and platinum-based chemotherapy for the first-line treatment of unresectable, locally advanced, recurrent or metastatic gastric or gastroesophageal junction adenocarcinoma.
Feb-2022: Samsung Bioepis got approval for ONTRUZANT® (also known as SB3), a biosimilar referencing Herceptin ®i (Trastuzumab) from Health Canada. This biosimilar is used for the treatment of Early Breast Cancer, metastatic gastric cancer (MGC), and Metastatic Breast Cancer (MBC), among adults.
Oct-2021: Bristol Myers Squibb got approval from European Commission for Opdivo (nivolumab) in combination with fluoropyrimidine- and platinum-based combination chemotherapy. This biosimilar is utilized for first-line treatment of adult patients with gastroesophageal junction (GEJ), HER2-negative advanced or metastatic gastric, or esophageal adenocarcinoma (EAC) whose tumors express PD-L1 with a combined positive score (CPS) ≥ 5.
Apr-2021: Bristol Myers Squibb received approval from the U.S. Food and Drug Administration (FDA) for Opdivo (nivolumab) (injection for intravenous use), in combination with fluoropyrimidine- and platinum-containing chemotherapy. This biosimilar is utilized for the treatment of patients with gastroesophageal junction cancer, advanced or metastatic gastric cancer, and esophageal adenocarcinoma, regardless of PD-L1 expression status.
Market Segments covered in the Report:
By Route of Administration
By Treatment Type
By Disease Type
By Distribution Channel
By Drug Class
By Geography
Companies Profiled
Unique Offerings from KBV Research
List of Figures