市场调查报告书
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1276458
多发性骨髓瘤全球市场规模,份额,行业趋势分析:按最终用户,按疾病(症状性多发性骨髓瘤,冒烟(无症状)多发性骨髓瘤)药物类型,地区展望和预测,2023-2029Global Multiple Myeloma Market Size, Share & Industry Trends Analysis Report By End User, By Disease Type (Active Multiple Myeloma and Smoldering Multiple Myeloma), By Drug Type, By Regional Outlook and Forecast, 2023 - 2029 |
多发性骨髓瘤市场规模预计到 2029 年将达到 375 亿美元,预测期内復合年增长率为 9.8%。
多发性骨髓瘤是一个术语,用于描述已发展成恶性肿瘤的浆细胞不受控制的生长。 单克隆免疫球蛋白,或 M 蛋白、M 刺突蛋白和副蛋白,是由浆细胞产生的异常蛋白质(抗体)。 健康的浆细胞产生的免疫球蛋白可有效对抗感染,因为它们可以识别和消除细菌。
然而,癌性浆细胞在多发性骨髓瘤患者的骨髓中积聚并破坏健康的血细胞。 因此,身体会产生一种称为副蛋白的异常蛋白质,它会积聚并损害组织和器官。 多发性骨髓瘤有多种副作用,包括频繁感染、贫血、骨痛和肾臟问题。 治疗选择包括靶向治疗、化学疗法、放射疗法和干细胞移植。
COVID-19 影响分析
由于大流行严重扰乱了研发工作,多发性骨髓瘤的新药和□□治疗方法的开发也被大大推迟。 此外,根据 2021 年 12 月的 Blood Cancer Journal,与 2019 年相比,2020 年新确诊的多发性骨髓瘤病例将减少,这些病例的存活率也在下降。 多发性骨髓瘤患者在 2020 年死亡和感染 COVID-19 的风险增加。 因此,大流行对多发性骨髓瘤市场产生了不利影响。
市场增长因素
全球范围内政府支持计划的增加
在医疗实践的同时,政府和组织还应解决当前与医疗保健提供者关係中出现的其他问题(费用结构和报销、医疗保健设施、药物输送路线、政治和其他网络问题)。正在扩大。 这些问题已通过接受以患者护理为导向的医疗设施得到解决,初级保健医生在这些设施中与专家和其他专家协调护理,并在商业和医疗保险/医疗补助领域建立负担得起的肿瘤中心。我们正在推动实践更多的是付款人和提供者的联合倡议。 因此,预计政府支持的增加将增加对多发性骨髓瘤治疗和药物的需求,从而刺激市场扩张。
全球多发性骨髓瘤病例增加
包括多发性骨髓瘤在内的几种血液系统恶性肿瘤的发病率不断上升,是推动市场发展的关键因素之一。 儘管多发性骨髓瘤被认为是一种罕见的癌症,但全世界有大量癌症患者,这增加了对有效、尖端治疗的需求。 有效的尖端治疗可为患者带来更好的临床结果。 这一点非常重要,因为 MM 的流行在全球呈上升趋势。 此外,研究和开发导致治疗取得进展,需要更复杂的药物来改善结果。
市场製约因素
没有永久的解决办法,许多现有的治疗方法都有副作用
Kyprolis 的常见副作用包括疲劳、低血液和血小板计数、腹泻、便秘、噁心、气短、发烧、四肢肿胀、上呼吸道感染、支气管炎和肺炎。 此外,某些副作用包括低血钾、高血糖、低血钙、肌肉痉挛、四肢麻木或麻痹以及高血压。 放射治疗还会导致疲劳、皮肤刺激、噁心、腹泻、治疗部位脱髮、不育、感染风险增加、食慾不振、后续癌症风险增加以及治疗部位附近器官受损。有副作用比如伤害。
药物类型展望
按药物类型划分,多发性骨髓瘤市场分为化学疗法、蛋白□抑製剂、单克隆抗体等。 2022年,单克隆抗体领域在多发性骨髓瘤市场取得了大幅增长。 随着最近引入的单克隆抗体 (mAb),多发性骨髓瘤的治疗选择发生了根本性的变化。 elotuzumab 和 daratumumab 在復发/难治性患者中的疗效引起了人们对该疾病的 mAb 的极大兴趣。
最终用户视角
根据最终用户,多发性骨髓瘤市场被细分为医院、诊所等。 2022 年,医院部门在多发性骨髓瘤市场占据了最大的收入份额。 由于患者入院人数增加、多发性骨髓瘤患病率上升以及这些设施拥有合格的医务人员可以改善患者服务等因素,医院部门正在增长。 用于治疗的药物通常在医院开处方和给药,这一事实是该细分市场占据主导地位的重要组成部分。
按疾病类型划分的前景
多发性骨髓瘤市场按疾病类型分为症状性多发性骨髓瘤和冒烟(无症状)多发性骨髓瘤。 在 2022 年的多发性骨髓瘤市场中,冒烟(无症状)多发性骨髓瘤细分市场实现了显着的增长。 该细分市场的增长归因于人们对这种疾病的认识不断提高。 冒烟型(无症状)多发性骨髓瘤可能需要数年才能变得活跃。 因此,一些患有这种综合征的人不会经历有症状的 MM。 医疗保健专业人员通过观察症状转变为症状性多发性骨髓瘤来控制 SMM。
区域展望
按地区分析了北美、欧洲、亚太地区和 LAMEA 的多发性骨髓瘤市场。 到 2022 年,北美部分将在多发性骨髓瘤市场获得最高的收入份额。 由于主要竞争对手的强大存在以及多发性骨髓瘤药物发布和产品批准的增加,预计北美多发性骨髓瘤市场在预测期内将显着扩大。 此外,由于多发性骨髓瘤的患病率上升,市场有望发展。 例如,美国癌症协会预测,到 2023 年,美国将发现 35,730 例多发性骨髓瘤病例。
市场进入者采取的主要策略是收购。 根据基数矩阵中的分析,Novartis AG、Johnson &Johnson、Pfizer, Inc.是多发性骨髓瘤市场的先驱。 Amgen, Inc.、Sanofi S.A. 和 Bristol Myers Squibb Company 等公司是多发性骨髓瘤市场的领先创新者。
The Global Multiple Myeloma Market size is expected to reach $37.5 billion by 2029, rising at a market growth of 9.8% CAGR during the forecast period.
Multiple myeloma or plasma cell cancer is a disease. The immune system is significantly dependent on healthy plasma cells, which are located in the bone marrow. In order to combat infections and other diseases, the immune system is composed of various cell types. T cells and B cells are two of the most common types of lymphocytes (lymph cells) in the immune system. The lymph nodes, bone marrow, intestines, and circulation are just a few of the organs where lymphocytes can be found.
B cells develop into plasma cells due to the immune system's response to an infection. Antibodies, also known as immunoglobulins, are produced by plasma cells and aid the body's defense against pathogens. Bone marrow contains the majority of plasma cells. Soft tissue found inside bones is called bone marrow. Other blood cells, including red, white, and platelets, are also found in the normal bone marrow and plasma cells.
Multiple myeloma is the term used to describe plasma cells that have developed malignancy and are growing uncontrollably. Monoclonal immunoglobulin, or M-protein, M-spike, or paraprotein, is an aberrant protein (antibody) produced by plasma cells. Immunoglobulins made by healthy plasma cells can recognize and eliminate germs, which is helpful in the fight against infections.
However, cancerous plasma cells gather in the bone marrow of patients with multiple myeloma and destroy healthy blood cells. As a result, the body produces paraproteins, aberrant proteins that can accumulate and harm tissues and organs. Multiple myeloma has several side effects, including frequent infections, anemia, bone pain, and renal problems. Targeted therapy, chemotherapy, radiation therapy, and stem cell transplantation are available as alternatives for treatment.
COVID-19 Impact Analysis
Since R&D operations were substantially hampered by the pandemic, developing novel medicines and treatments for multiple myeloma also slowed considerably. Moreover, the Blood Cancer Journal reported in December 2021 that fewer new instances of multiple myeloma were identified in 2020 in comparison with 2019 and that the survival rate for those cases declined concurrently. Patients with multiple myeloma had a higher mortality rate and COVID-19 infection risk in 2020. Therefore, the pandemic had a detrimental effect on the multiple myeloma market.
Market Growth Factors
Increasing government support initiatives worldwide
Along with care practices, governments and organizations are also extending support for other current problems in provider relations include fee schedules & reimbursement, sites of care, route of drug administration, and politics as well as other network issues. These problems are pushing oncology practices into more payer-provider collaborative initiatives, including accepting patient-care medical homes, where primary care doctors coordinate care with experts and other specialists and creating affordable oncology healthcare institutions in both the commercial and Medicare/Medicaid spaces. Hence, the increasing support of governments is projected to increase demand for treatments or medications for multiple myeloma, thereby fueling market expansion.
Rising cases of multiple myeloma worldwide
The rising incidence of several types of blood malignancies, including multiple myeloma, is one of the major market-driving factors. Although MM is regarded as a more uncommon cancer kind, there are a sizable number of cases of cancer worldwide, and the demand for effective and cutting-edge therapies is rising. Patients frequently experience better and more favorable clinical results when effective and cutting-edge therapies are administered. This is crucial because current trends point to an increase in the prevalence of MM around the globe. In addition, as a result of ongoing R&D, treatment has advanced, necessitating more complex medicines to improve prognosis.
Market Restraining Factors
Lack of permanent solutions and side effects of many existing treatments
Common side effects of Kyprolis include fatigue, a low blood cell count and blood platelet levels, diarrhea, constipation, nausea, shortness of breath, fever, swelling of the extremities, upper respiratory tract infection, bronchitis, and pneumonia. Additionally, certain side effects of the drug include low blood potassium, high blood sugar, low blood calcium, muscle spasms, numbness and tingling in the extremities, and high blood pressure. In addition, radiation therapy can cause adverse effects such as fatigue, irritation of the skin, nausea, diarrhea, loss of hair in the treatment area, infertility, higher risk of infection, loss of appetite, increased risk of subsequent cancer, and harm to organs located near the treatment area.
Drug Type Outlook
Based on drug type, the multiple myeloma market is categorized into chemotherapy, protease inhibitors, monoclonal antibody, and others. The monoclonal antibodies segment procured a considerable growth rate in the multiple myeloma market in 2022. The therapeutic options for multiple myeloma have radically changed due to the recent introduction of monoclonal antibodies (mAbs). The effectiveness of elotuzumab and daratumumab in relapsed/refractory patients has sparked much interest in mAbs for this condition.
End User Outlook
On the basis of end user, the multiple myeloma market is divided into hospitals, clinics, and others. The hospitals segment acquired the largest revenue share in the multiple myeloma market in 2022. The hospital segment is growing due to factors including an increase in patient admissions, a rise in the prevalence of multiple myeloma, and the availability of qualified medical staff in these facilities that enable improved patient services. The fact that the medications used in treatment can be routinely prescribed and given in hospital settings accounts for a significant portion of this segment's dominance.
Disease Type Outlook
Based on disease type, the multiple myeloma market is segmented into active multiple myeloma and smoldering multiple myeloma. The smoldering multiple myeloma segment garnered a remarkable growth rate in the multiple myeloma market in 2022. The growth of the segment is owed to the increasing awareness of the disease. It may take years for smoldering multiple myeloma to develop into an active form. As a result, some individuals with this syndrome never experience active MM. Healthcare professionals' control SMM by watching for symptoms that it's turning into active multiple myeloma.
Regional Outlook
On the basis of region, the multiple myeloma market is analyzed across North America, Europe, Asia Pacific, and LAMEA. The North America segment procured the highest revenue share in the multiple myeloma market in 2022. Due to the strong presence of key competitors and the rise in multiple myeloma drug launches and product approvals, the North American multiple myeloma market is predicted to expand considerably over the forecast period. Moreover, the market is anticipated to develop because of the rising prevalence of multiple myeloma. For instance, the American Cancer Society forecasted that by 2023, 35,730 incidences of multiple myeloma would have been discovered in the United States.
The major strategies followed by the market participants are Acquisitions. Based on the Analysis presented in the Cardinal matrix; Novartis AG, Johnson & Johnson, and Pfizer, Inc. are the forerunners in the Multiple Myeloma Market. Companies such as Amgen, Inc., Sanofi S.A., and Bristol Myers Squibb Company are some of the key innovators in Multiple Myeloma Market.
The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include Novartis AG, Bristol Myers Squibb Company, Amgen, Inc., AbbVie, Inc., Sanofi S.A., Johnson & Johnson, Baxter International, Inc., Takeda Pharmaceutical Company Limited, Teva Pharmaceuticals Industries Ltd., and Pfizer, Inc.
Recent Strategies Deployed in Multiple Myeloma Market
Partnerships, Collaborations and Agreements:
Mar-2022: Sanofi came into collaboration with Blackstone Life Sciences, a US-based private equity firm focused on investing in pharmaceutical, life science, and medical research companies. The collaboration involves the private equity firm contributing up to 300 million euros to advance studies and clinical development programs for the development and delivery of the anti-CD38 antibody Sarclisa focused on treating patients with multiple myeloma.
Jan-2020: Sanofi partnered with Sebia, a France-based provider of clinical protein electrophoresis equipment. The partnership focuses on co-developing treatment for multiple myeloma. The agreement includes, Sebia developing in vitro diagnostic (IVD) tests and acting as its supplier.
Acquisitions and Mergers:
Dec-2022: Johnson & Johnson took over Abiomed, a US-based medical device technology company. The addition of Abiomed advances the acquiring company's MedTech business division, by providing innovational medical technologies. Further, the acquisition broadens Johnson & Johnson's cardiovascular product offerings.
Dec-2021: Baxter acquired Hillrom, a US-based medical device company. The acquisition advances the company's mission to transform healthcare and patient care.
Nov-2021: Pfizer acquired Trillium Therapeutics, a Canada-based clinical-stage immuno-oncology company. The acquisition strengthens the acquiring company's devotion to seeking scientific breakthroughs. Further, the addition of Trillium expands Pfizer's hematology product offerings.
Oct-2021: Amgen completed the acquisition of Teneobio, a US-based biotechnology company. The acquisition of Teneobio broadens the acquiring company's skills and further accelerates its aim to design, build and bring innovations to the markets to better serve their patients. Further, the addition of Teneobio's proprietary bispecific and multispecific antibody technologies perfectly complements Amgen's BiTE platform and its already existing antibody capabilities.
Product Launches and Expansions:
Mar-2023: Teva and Natco together launched extra strengths for the generic version of Revlimid. The medicine is intended to use by adult patients for the cure of multiple myeloma, specific myelodysplastic syndromes, and mantle cell lymphoma. The added strengths reflect the company's devotion to making generic drugs accessible to patients who need them.
Feb-2022: Sandoz, part of Novartis introduced lenalidomide, a generic oncology medicine. The medicine is intended for various haemato-oncology conditions and is available in the form of hard capsules. Lenalidomide is a cost-saving treatment, thereby increasing the treatment's accessibility amongst patients.
Dec-2021: Novartis introduced T-Charge, a CAR-T platform that would act as a base for multiple investigational CAR-T cell therapies. The T-Charge eradicates the need for extended culture time outside the body (ex-vivo), as it primarily happens within a patient's body.
Trials and Approvals:
Oct-2022: The US FDA issued clearance for Johnson & Johnson's Tecvayli, a BCMA-targeted bispecific drug intended for treating patients with refractory or relapsed multiple myeloma. The conditions to be met to use the recently approved drug, patients must have undergone a minimum of four lines of therapy.
Jan-2022: Bristol Myers Squibb received approval for Abecma in Japan. Abecma is a CAR T therapy intended for adult patients with refractory or relapsed (R/R) multiple myeloma. The adult patient should have already received a minimum of three therapies and should have experienced disease progression on the last therapy. Further, the approval demonstrates the company's devotion to catering to the unmet medical needs in Japan.
Dec-2021: U.S. Food and Drug Administration (FDA) approved Amgen's expansion of KYPROLIS to use it in combination with DARZALEX FASPRO, and dexamethasone. The new combination is intended for adult patients with refractory or relapsed multiple myeloma, who have undergone one to three lines of therapy. Further, the combination provides enhanced flexibility and easiness to the patients.
Mar-2020: Sanofi announced FDA approved the use of Sarclisa in combination with dexamethasone and pomalidomide. The combination is intended for the treatment of adults with relapsed refractory multiple myeloma (RRMM), who have already received two therapies. The approval provides patients with hard-to-treat multiple myeloma with a new treatment option.
Market Segments covered in the Report:
By End User
By Disease Type
By Drug Type
By Geography
Companies Profiled
Unique Offerings from KBV Research
List of Figures