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总体基因体学市场:2023年至2028年预测Metagenomics Market - Forecasts from 2023 to 2028 |
总体基因体学市场预计在预测期内将以 13.26% 的复合年增长率成长。
总体基因体学是指透过定序直接从环境或临床样本中获得的遗传物质的科学研究。总体基因体学在多个领域都有应用,包括环境研究、临床诊断、药物研发、生物技术、食品和营养研究以及其他专业领域。总体基因体学产业的成长主要是由该领域持续的技术进步以及药物研发和临床诊断的改进所推动的。
总体基因体学用于药物研发发现,因为它能够识别新的微生物基因和可能成为潜在候选药物的天然产物。总体基因体学透过分析不同环境中的不同微生物群落,能够发现具有治疗特性的生物活性化合物。鼓励探索开拓的微生物生物多样性的有利政府倡议和投资正在推动人们对透过总体基因体学进行药物研发发现的兴趣。例如,2023 年 3 月,加拿大政府向加拿大关键药物倡议拨款 8,050 万加元(5,900 万美元),以加强亚伯达的药物研究、商业化和製造。
随着定序技术和生物资讯学工具的不断进步使总体基因体学研究更加高效和更具成本效益,总体基因体学行业正在经历显着增长。研究人员和工业界现在可以利用这些尖端工具更深入地研究复杂的微生物群落。例如,2023 年 2 月,Tecan Group 和 Oxford Nanopore Technologies 建立了联合伙伴关係,透过简化高通量、自动化工作流程的流程来增强奈米孔文库的製备。 LSK114 代表了传统定序平台的重大进步,因为它能够对天然长 DNA 片段进行定序。
总体基因体学在临床诊断中发挥着重要作用,因为它能够全面了解人体中存在的微生物群落。总体基因体学有助于了解这些微生物与宿主健康之间的相互作用,从而改善疾病识别、治疗策略和个人化医疗。临床诊断领域正在经历快速成长,製药公司和政府的投资增加加速了对总体基因体学的需求。例如,2021 年 11 月,美国卫生与公众服务部 (HHS) 宣布投资 6.5 亿美元用于快速诊断检测,以扩大 COVID-19 检测的范围。
由于亚太地区高度重视药物研发和相关投资,预计将占据很大的市场份额。例如,2023年6月,一项新的国家药物研发化学倡议MedChem Australia将启动医学研究未来基金(MRFF),该基金旨在加速药物研发进展并增强国家在药物研发化学方面的能力,接受975万美元。此外,2022年5月,韩国卫生福利部宣布向製药业投资8,778亿韩元(6.93亿美元),以加强新药研发工作并加强製药业的劳动力。
宏基因组研究需要使用最先进的研究设备、先进的定序技术和复杂的资料分析方法,这不可避免地需要大量的资金。对于小型研究机构和公司来说,这些高昂的成本可能是采用总体基因体学作为研究方法的主要障碍。例如,仅全基因组定序的成本就约为 25,000 卢比(338 美元)至 50,000 卢比(676 美元),这进一步增加了科学界更广泛采用的挑战。
The metagenomics market is estimated to grow at a CAGR of 13.26% during the forecast period.
Metagenomics refers to the scientific investigation of genetic material obtained directly from environmental or clinical samples via sequencing. Metagenomics finds diverse applications across various fields, including environmental research, clinical diagnostics, drug discovery, biotechnology, food and nutrition studies, and other specialized areas. Metagenomics industry growth is primarily driven by improved drug discovery and clinical diagnostics, alongside continuous technological advancements in the field.
Metagenomics is used in drug discovery due to its ability to identify novel microbial genes and natural products that can serve as potential drug candidates. By analyzing diverse microbial communities in various environments, metagenomics enables the discovery of bioactive compounds with therapeutic properties. Favorable government initiative and investments to encourage the exploration of untapped microbial biodiversity has fuelled the interest in drug discovery through metagenomics. For instance, in March 2023, to bolster drug research, commercialization, and manufacturing in the Alberta province, the Canadian government allocated 80.5 million Canadian dollars ($59 million) to the Canadian Critical Drug Initiative.
The metagenomics industry has experienced significant growth owing to continuous advancements in sequencing technologies, and bioinformatics tools which have enhanced the efficiency and cost-effectiveness of metagenomics studies. Researchers and industries can now harness these cutting-edge tools to delve deeper into complex microbial communities. For instance, in February 2023, Tecan Group and Oxford Nanopore Technologies formed a collaborative partnership to enhance nanopore library preparation by streamlining the process for high-throughput and automated workflows. The LSK114 represents a significant advancement over conventional sequencing platforms as it enables the sequencing of native, long fragments of DNA.
Metagenomics plays a crucial role in clinical diagnostics due to its ability to provide comprehensive insights into the microbial communities present in the human body. Metagenomics aids in understanding the interplay between these microorganisms and the host's health, leading to improved disease identification, treatment strategies, and personalized medicine. The field of clinical diagnostics is experiencing rapid growth, driven by increased investments from pharmaceutical companies, and the government which is accelerating metagenomics demand. For instance, in November 2021, an investment of $650 million in rapid diagnostic testing was announced by the US Department of Health and Human Services (HHS) to expand access to COVID-19 tests.
The Asia Pacific will account for a significant share of the market due to the region's significant focus on drug discovery and the accompanying investments. For instance, in June 2023, MedChem Australia, a new national medicinal chemistry initiative, received $9.75 million from the Medical Research Future Fund (MRFF), which aims to foster advancements in drug discovery and strengthen the country's capabilities in the field of medicinal chemistry. Also, in May 2022, the Korean Ministry of Health and Welfare announced an investment of 877.8 billion won ($693 million) in the pharmaceutical industry, aimed at bolstering research and development efforts for new drugs and strengthening the workforce in the sector.
Metagenomic research demands the utilization of cutting-edge laboratory equipment, highly advanced sequencing technologies, and intricate data analysis methodologies, which inevitably results in significant financial outlays. For smaller research institutions and companies, these substantial expenses can pose a major obstacle to embracing metagenomics as a research approach. As an illustration, the cost of whole genome sequencing alone can range from approximately 25,000 Rs (USD 338) to 50,000 Rs (USD 676), further contributing to the challenge of broader adoption in the scientific community.