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市场调查报告书
商品编码
1495975

全球微载体市场 - 2024 年至 2029 年预测

Global Microcarrier Market - Forecasts from 2024 to 2029
出版日期: | 出版商: Knowledge Sourcing Intelligence | 英文 140 Pages | 商品交期: 最快1-2个工作天内

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简介目录

预计微载体市场在预测期内将以 11.55% 的复合年增长率成长，从 2022 年的 925,914,000 美元达到 2029 年的 1,989,084,000 美元。

微载体是用于组织培养的微小珠子或球体，可增加贴壁依赖性细胞附着和产量的表面积，并作为支持基质使贴壁细胞在反应器中生长。微载体广泛用于在生技药品和疫苗的大规模商业生产中繁殖产生病毒和产生蛋白质的贴壁细胞群。微载体市场的成长可归因于生技药品和生物相似药产业的快速成长。

对细胞疫苗的需求不断增长以及技术进步预计将对微载体市场产生积极影响。然而，细胞生技药品和细胞疗法的高成本可能会阻碍指定预测期内的市场成长。此外，高密度微载体培养的成长限制也预计将抑制预测期内微载体市场的成长。此外，微载体市场分为产品、应用、最终用户和地区。

市场驱动因素：

  • 由于对细胞疫苗的需求不断增加，微载体市场将会成长。

流感、猴痘、伊波拉出血热和COVID-19等新病毒感染疾病的增加增加了全球对疫苗的需求，导致市场对微载体的需求增加，我们支持在预测期内对微载体的需求增加。市场的成长。例如，世界卫生组织（WHO）的疾病爆发新闻（DONs）为潜在关注的事件提供了已确认的急性公共卫生事件，以及2022年9月刚果民主共和国爆发的伊波拉病毒疫情。

刚果民主共和国卫生署在 RT-PCR 实验室检测证实北基伍省贝尼卫生区出现一例死亡病例后宣布爆发疫情。同时，乌干达截至9月25日，已确诊18例由苏丹病毒引起的伊波拉出血热病例。此类感染疾病患者数量的增加和大流行风险的增加是全球疫苗需求的关键因素。此外，许多组织正在重点开发针对日益增多的感染疾病的疫苗。例如，美国疾病管制与预防中心 (CDC) 在 2022 年 9 月更新的疫苗考量摘要中指出，JYNNEOS 疫苗已被核准用于预防猴痘和天花疾病。

此外，CDC 指出，ACAM2,000 疫苗已被核准用于天花疫苗接种，根据扩大使用临床实验新药通讯协定也可用于猴痘疫苗。北美地区预计将占据微载体市场的很大份额。由于研发活动、基因治疗以及生技药品和技术进步的兴起，美国等国家正在增加对细胞研究的投资。

此外，老牌製药公司的普及扩大了其地理范围并继续促进其疫苗的广泛营销，预计将推动该地区的市场扩张。此外，随着感染疾病和癌症盛行率的上升，增加了疫情期间疫苗接种的需求，预计该地区的规模将会成长。

另一方面，由于市场领先企业的增加和技术创新利用率的提高，欧洲在预期期间在微载体市场中占据第二大份额。由于研发投入的增加，预计该地区将推动产品开发和市场需求。

主要发展

  • 2023 年 10 月 - Thermo Fisher Scientific 推出 Gibco CTS Detachable Dynabeads，这是一个用于细胞疗法製造的具有主动释放机制的平台。儘管 Gibco CTS Detachable Dynabeads CD3/CD28 试剂盒提供一步式分离和激活，但 CTS Dynabeads 磁珠可以在此过程中的任何时刻从目标细胞中释放。该套件包含包装在与 CTS DynaCellect 磁分离系统相容的生物製程容器中的活性释放缓衝液，可在分离和磁分离后透过竞争性结合机制将目标细胞主动从磁珠上分离。
  • 2023 年 10 月 - 可乐丽有限公司开发出用于再生医学细胞培养的 PVA 水凝胶微载体。这种支架材料是一种安全的材料，不易受到损坏，不会产生碎片，并且可以进行有效的细胞培养。当PVA水凝胶微载体被引入反应器并大量培养时，细胞会黏附并增殖，从而实现有效的分离和恢復。它也被证实是安全的并且表现出更高的细胞培养效率。
  • 2023 年 6 月，Teijin Frontier 开发了一种不织布微载体，可实现高效、大规模的细胞培养。这种支架材料促进各种细胞类型的3D黏附和增殖。这种不织布将帝人Frontier独特的纤维加工技术和不织布设计技术与福井大学前沿科学学院藤田聪教授掌握的纤维生物医学领域知识相结合。
  • 2023年3月，大日本印刷公司和Hyperion Drug Discovery开发了用于再生医学细胞培养的可溶性微载体。这些微载体在基于细胞和基因的产品、胞外体、生物製药和培养肉的细胞培养过程中充当支架剂。与传统的 2D 培养相比，这种方法减少了工作步骤，并实现了高效的大规模细胞培养。

公司产品

  • SoloHill(R) 微载体入门套件- Sartorius AG 的 SoloHill(R) 微载体入门套件是一个 10 克的套件，包含六种类型的 SoloHill(R) 微载体（蛋白质包被的和无涂布的），适用于特定的细胞类型。这种低成本解决方案可加速微载体评估，并允许为特定应用选择最佳微载体类型，确保最佳的细胞附着和增殖。
  • HarvestainerTM 微载体分离系统 - Thermo Fisher Scientific 提供 HarvestainerTM 微载体分离系统，这是贴壁细胞培养生产过程中分离微载体珠的理想解决方案。该系统非常适合小型和大规模线上微载体分离应用。与传统程序相比，该系统有助于提高产品产量，同时减少就地清洁、就地蒸汽和注入水的需求。
  • Corning® 微载体 康宁提供用于生物製程放大的 Corning® 微载体，旨在简化放大过程。微载体以封闭式系统包装提供，是无菌的，并准备用于反应器。微载体经过进一步的表面处理，以改善细胞黏附并增加细胞产量和活力。

目录

第一章简介

  • 市场概况
  • 市场定义
  • 调查范围
  • 市场区隔
  • 货币
  • 先决条件
  • 基准年和预测年时间表
  • 相关利益者的主要利益

第二章调查方法

  • 研究设计
  • 调查过程

第三章执行概述

  • 主要发现

第四章市场动态

  • 市场驱动因素
  • 市场限制因素
  • 波特五力分析
  • 产业价值链分析
  • 分析师观点

第五章全球微载体市场：依产品类型

  • 介绍
  • 装置
  • 消耗品
  • 试剂
  • 微载体珠
  • 其他的

第六章微载体的全球市场：依应用分类

  • 介绍
  • 生物製药製造
  • 细胞和基因治疗
  • 其他的

第七章 全球微载体市场：依最终用户分类

  • 介绍
  • 製药和生物技术公司
  • 研究机构
  • 合约研究组织

第八章全球微载体市场：按地区

  • 介绍
  • 北美洲
  • 南美洲
  • 欧洲
  • 中东/非洲
  • 亚太地区

第九章竞争环境及分析

  • 主要企业及策略分析
  • 市场占有率分析
  • 合併、收购、协议和合作
  • 竞争对手仪表板

第十章 公司简介

  • Thermo Fisher Scientific
  • Corning Incorporated
  • Sartorius AG
  • Pall Corporation
  • Batavia Biosciences BV
  • Primorigen Biosciences
  • Cytiva
  • Nucleus Biologics, LLC.
  • Merck KGaA
  • Entegris
简介目录
Product Code: KSI061611920

The microcarrier market is projected to grow at a CAGR of 11.55% during the forecast period to reach US$1,989.084 million by 2029, up from US$925.914 million in 2022.

Microcarriers are microscopic beads or spheres used to increase the surface area in tissue culture for the attachment and yield of anchorage-dependent cells and act as a support matrix, which allows the growth of adherent cells in bioreactors. Microcarriers are extensively used in the large-scale commercial production of biologics and vaccines to grow virus-generating or protein-producing adherent cell populations. The growth in the microcarriers market may be attributed to the rapid growth in the biologics and biosimilar industries.

Rising demand for cell-based vaccines, along with technological advancements, will positively impact the market for microcarriers. However, the high cost of cell biologics and cell-based therapies might hamper the market growth during the given forecast period. Growth limitations of high-density microcarrier cultures will also restrain the microcarrier's market growth during the anticipated period. Further, the microcarrier market is segmented into product, application, end-user, and geography.

Market Drivers:

  • The Microcarriers market will grow due to the rising demand for cell-based vaccines.

Due to the growing number of new virus outbreaks such as influenza, monkeypox, Ebola, and COVID-19, among others, the demand for vaccines is increasing globally, consequently increasing the demand for microcarriers in the market and supporting the microcarrier market growth during the forecast period. For instance, the World Health Organization's Disease Outbreak News (DONs), which provided confirmed acute public health events of potential events of concern, reported an Ebola virus outbreak in the Democratic Republic of the Congo in September 2022.

The Ministry of Health of the Democratic Republic of the Congo declared the outbreak following the confirmed laboratory test via RT-PCR in a fatal case in Beni Health Zone, North Kivu Province. During the same period, Uganda also witnessed a confirmed 18 cases as of 25th September 2022 Ebola virus, which were caused by the Sudan Virus. Such increasing cases of infectious diseases and the growing risk of pandemics are the prime factors driving the demand for vaccines worldwide. Further, many organizations are putting efforts into developing vaccines for the rising disease. For instance, the Centers for Disease Control and Prevention (CDC) mentions in its Vaccine Considerations summary, updated in September 2022, that the JYNNEOS vaccine is approved for the prevention of monkeypox and smallpox diseases.

Further, the ACAM2000 Vaccines has been approved for immunization against smallpox which is made available for use against monkeypox under Expanded Access Investigational New Drug protocol, mentions the CDC. The microcarrier market is expected to be dominated by the North American region, which is expected to hold a significant share of the Microcarrier market. The rising research and development activities, gene therapies, and biologics, coupled with technological advancement and investment in cell-based research in countries like the US.

Additionally, the prevalence of established pharmaceutical companies, who continually work to expand their geographic reach and promote the widespread marketing of their vaccines, is anticipated to spur market expansion in this region. Moreover, this region will grow due to the increased need for immunizations during pandemics. due to the rise in the prevalence of infectious and cancerous illnesses.

On the other hand, Europe holds the second largest share of the microcarrier market during the anticipated period owing to the increasing number of leading firms in the market and growing usage of technical innovations. It is anticipated that increased R&D utilization will enhance product development and market demand in this region.

Key Developments:

  • October 2023- Thermo Fisher Scientific introduced the Gibco CTS Detachable Dynabeads, a platform with an active release mechanism for cell therapy manufacturing. The Gibco CTS Detachable Dynabeads CD3/CD28 Kit offers one-step isolation and activation but allows for the release of CTS Dynabeads magnetic beads from target cells at any point in the process. The kit contains an active release buffer enclosed in a CTS DynaCellect Magnetic Separation System-compatible bioprocess container, allowing for the active detachment of target cells from the beads through a competitive binding mechanism after isolation and magnetic separation.
  • October 2023- Kuraray Co., Ltd. developed PVA hydrogel microcarriers for cell cultures in regenerative medicine. These scaffolding materials are damage-resistant, debris-free, and safe for efficient cell culturing. When PVA hydrogel microcarriers are introduced into bioreactors for mass cell culture, these microcarriers allow cells to adhere and proliferate, facilitating efficient detachment and recovery. They are also safe, have been verified, and exhibit higher cell culture efficiency.
  • June 2023- Teijin Frontier developed new nonwoven microcarriers for efficient and large-scale cell culture. These scaffolding materials facilitate adherence and growth in three dimensions for various cell types. The nonwoven microcarriers combine Teijin Frontier's proprietary fiber process and nonwoven design technology with fiber-related bio-medical expertise from Professor Satoshi Fujita at the University of Fukui's Department of Frontier Fiber Technology and Science.
  • March 2023- Dai Nippon Printing Co. and Hyperion Drug Discovery developed soluble microcarriers for cell culture in regenerative medicine. These microcarriers serve as scaffolding agents in cell culture processes, including cell and gene-based products, exosomes, biopharmaceuticals, and cultured meat. This approach reduces the number of work processes and allows for efficient large-scale cell culture compared to traditional two-dimensional cultures.

Company Products:

  • SoloHill(R) Microcarrier Starter Kit- Sartorius AG's SoloHill(R) Microcarrier Starter Kit is a 10-gram kit containing six different types of SoloHill(R) microcarriers, both protein-coated and non-coated, for specific cell types. This low-cost solution accelerates microcarrier evaluation, allowing for the selection of the optimal microcarrier type for specific applications, ensuring optimal cell attachment and growth.
  • HarvestainerTM Microcarrier Separation system- Thermo Fisher Scientific offers the HarvestainerTM Microcarrier Separation system, which is an ideal solution for the separation of microcarrier beads during adherent cell culture production. It is an ideal system for smaller-scale as well as larger-scale applications for in-line microcarrier separation. In comparison to conventional procedures, the system helps to boost product yields while lowering the need for clean-in-place, steam-in-place, and water for injection.
  • Corning(R) Microcarriers- Corning incorporated offers Corning(R) Microcarriers for Bioprocess scale-up that are designed to simplify the scale-up processes. The microcarriers are provided in closed systems packaging, are sterile, and are prepared for use with bioreactors. The microcarriers are additionally surface-treated to improve cell adhesion and increase cell production and survival.

Market Segments:

By Product Type

  • Equipment
  • Consumables
  • Reagents
  • Microcarrier Beads
  • Others

By Application

  • Biopharmaceutical Production
  • Cell and gene therapy
  • Others

By End-Users

  • Pharmaceuticals & Biotechnology Companies
  • Research Institutes
  • Contract Research Organizations

By Geography

  • North America
  • USA
  • Canada
  • Mexico
  • South America
  • Brazil
  • Argentina
  • Others
  • Europe
  • United Kingdom
  • Germany
  • France
  • Spain
  • Others
  • Middle East and Africa
  • Saudi Arabia
  • UAE
  • Israel
  • Others
  • Asia Pacific
  • China
  • India
  • Japan
  • South Korea
  • Indonesia
  • Others

TABLE OF CONTENTS

1. INTRODUCTION

  • 1.1. Market Overview
  • 1.2. Market Definition
  • 1.3. Scope of the Study
  • 1.4. Market Segmentation
  • 1.5. Currency
  • 1.6. Assumptions
  • 1.7. Base and Forecast Years Timeline
  • 1.8. Key Benefits to the Stakeholder

2. RESEARCH METHODOLOGY

  • 2.1. Research Design
  • 2.2. Research Processes

3. EXECUTIVE SUMMARY

  • 3.1. Key Findings

4. MARKET DYNAMICS

  • 4.1. Market Drivers
  • 4.2. Market Restraints
  • 4.3. Porter's Five Forces Analysis
    • 4.3.1. Bargaining Power of Suppliers
    • 4.3.2. Bargaining Power of Buyers
    • 4.3.3. Threat of New Entrants
    • 4.3.4. Threat of Substitutes
    • 4.3.5. Competitive Rivalry in the Industry
  • 4.4. Industry Value Chain Analysis
  • 4.5. Analyst View

5. GLOBAL MICROCARRIERS MARKET BY PRODUCT TYPE

  • 5.1. Introduction
  • 5.2. Equipment
    • 5.2.1. Market Opportunities and Trends
    • 5.2.2. Growth Prospects
    • 5.2.3. Geographic Lucrativeness
  • 5.3. Consumables
    • 5.3.1. Market Opportunities and Trends
    • 5.3.2. Growth Prospects
    • 5.3.3. Geographic Lucrativeness
  • 5.4. Reagents
    • 5.4.1. Market Opportunities and Trends
    • 5.4.2. Growth Prospects
    • 5.4.3. Geographic Lucrativeness
  • 5.5. Microcarrier Beads
    • 5.5.1. Market Opportunities and Trends
    • 5.5.2. Growth Prospects
    • 5.5.3. Geographic Lucrativeness
  • 5.6. Others
    • 5.6.1. Market Opportunities and Trends
    • 5.6.2. Growth Prospects
    • 5.6.3. Geographic Lucrativeness

6. GLOBAL MICROCARRIERS MARKET BY APPLICATION

  • 6.1. Introduction
  • 6.2. Biopharmaceutical Production
    • 6.2.1. Market Opportunities and Trends
    • 6.2.2. Growth Prospects
    • 6.2.3. Geographic Lucrativeness
  • 6.3. Cell and gene therapy
    • 6.3.1. Market Opportunities and Trends
    • 6.3.2. Growth Prospects
    • 6.3.3. Geographic Lucrativeness
  • 6.4. Others
    • 6.4.1. Market Opportunities and Trends
    • 6.4.2. Growth Prospects
    • 6.4.3. Geographic Lucrativeness

7. GLOBAL MICROCARRIERS MARKET BY END-USERS

  • 7.1. Introduction
  • 7.2. Pharmaceuticals & Biotechnology Companies
    • 7.2.1. Market Opportunities and Trends
    • 7.2.2. Growth Prospects
    • 7.2.3. Geographic Lucrativeness
  • 7.3. Research Institutes
    • 7.3.1. Market Opportunities and Trends
    • 7.3.2. Growth Prospects
    • 7.3.3. Geographic Lucrativeness
  • 7.4. Contract Research Organizations
    • 7.4.1. Market Opportunities and Trends
    • 7.4.2. Growth Prospects
    • 7.4.3. Geographic Lucrativeness

8. GLOBAL MICROCARRIERS MARKET BY GEOGRAPHY

  • 8.1. Introduction
  • 8.2. North America
    • 8.2.1. By Product Type
    • 8.2.2. By Application
    • 8.2.3. By End Users
    • 8.2.4. By Country
      • 8.2.4.1. USA
        • 8.2.4.1.1. Market Opportunities and Trends
        • 8.2.4.1.2. Growth Prospects
      • 8.2.4.2. Canada
        • 8.2.4.2.1. Market Opportunities and Trends
        • 8.2.4.2.2. Growth Prospects
      • 8.2.4.3. Mexico
        • 8.2.4.3.1. Market Opportunities and Trends
        • 8.2.4.3.2. Growth Prospects
  • 8.3. South America
    • 8.3.1. By Product Type
    • 8.3.2. By Application
    • 8.3.3. By End Users
    • 8.3.4. By Country
      • 8.3.4.1. Brazil
        • 8.3.4.1.1. Market Opportunities and Trends
        • 8.3.4.1.2. Growth Prospects
      • 8.3.4.2. Argentina
        • 8.3.4.2.1. Market Opportunities and Trends
        • 8.3.4.2.2. Growth Prospects
      • 8.3.4.3. Others
        • 8.3.4.3.1. Market Opportunities and Trends
        • 8.3.4.3.2. Growth Prospects
  • 8.4. Europe
    • 8.4.1. By Product Type
    • 8.4.2. By Application
    • 8.4.3. By End Users
    • 8.4.4. By Country
      • 8.4.4.1. United Kingdom
        • 8.4.4.1.1. Market Opportunities and Trends
        • 8.4.4.1.2. Growth Prospects
      • 8.4.4.2. Germany
        • 8.4.4.2.1. Market Opportunities and Trends
        • 8.4.4.2.2. Growth Prospects
      • 8.4.4.3. France
        • 8.4.4.3.1. Market Opportunities and Trends
        • 8.4.4.3.2. Growth Prospects
      • 8.4.4.4. Spain
        • 8.4.4.4.1. Market Opportunities and Trends
        • 8.4.4.4.2. Growth Prospects
      • 8.4.4.5. Others
        • 8.4.4.5.1. Market Opportunities and Trends
        • 8.4.4.5.2. Growth Prospects
  • 8.5. Middle East and Africa
    • 8.5.1. By Product Type
    • 8.5.2. By Application
    • 8.5.3. By End Users
    • 8.5.4. By Country
      • 8.5.4.1. Saudi Arabia
        • 8.5.4.1.1. Market Opportunities and Trends
        • 8.5.4.1.2. Growth Prospects
      • 8.5.4.2. UAE
        • 8.5.4.2.1. Market Opportunities and Trends
        • 8.5.4.2.2. Growth Prospects
      • 8.5.4.3. Israel
        • 8.5.4.3.1. Market Opportunities and Trends
        • 8.5.4.3.2. Growth Prospects
      • 8.5.4.4. Others
        • 8.5.4.4.1. Market Opportunities and Trends
        • 8.5.4.4.2. Growth Prospects
  • 8.6. Asia Pacific
    • 8.6.1. By Product Type
    • 8.6.2. By Application
    • 8.6.3. By End Users
    • 8.6.4. By Country
      • 8.6.4.1. China
        • 8.6.4.1.1. Market Opportunities and Trends
        • 8.6.4.1.2. Growth Prospects
      • 8.6.4.2. India
        • 8.6.4.2.1. Market Opportunities and Trends
        • 8.6.4.2.2. Growth Prospects
      • 8.6.4.3. Japan
        • 8.6.4.3.1. Market Opportunities and Trends
        • 8.6.4.3.2. Growth Prospects
      • 8.6.4.4. South Korea
        • 8.6.4.4.1. Market Opportunities and Trends
        • 8.6.4.4.2. Growth Prospects
      • 8.6.4.5. Indonesia
        • 8.6.4.5.1. Market Opportunities and Trends
        • 8.6.4.5.2. Growth Prospects
      • 8.6.4.6. Others
        • 8.6.4.6.1. Market Opportunities and Trends
        • 8.6.4.6.2. Growth Prospects

9. COMPETITIVE ENVIRONMENT AND ANALYSIS

  • 9.1. Major Players and Strategy Analysis
  • 9.2. Market Share Analysis
  • 9.3. Mergers, Acquisitions, Agreements, and Collaborations
  • 9.4. Competitive Dashboard

10. COMPANY PROFILES

  • 10.1. Thermo Fisher Scientific
  • 10.2. Corning Incorporated
  • 10.3. Sartorius AG
  • 10.4. Pall Corporation
  • 10.5. Batavia Biosciences B.V.
  • 10.6. Primorigen Biosciences
  • 10.7. Cytiva
  • 10.8. Nucleus Biologics, LLC.
  • 10.9. Merck KGaA
  • 10.10. Entegris