半乳糖凝集素抑制剂的世界市场趋势,临床试验的考察(2023年)
市场调查报告书
商品编码
1258030

半乳糖凝集素抑制剂的世界市场趋势,临床试验的考察(2023年)

Global Galectin Inhibitors Market Trends & Clinical Trials Insight 2023

出版日期: | 出版商: KuicK Research | 英文 72 Pages | 商品交期: 最快1-2个工作天内

价格

本报告提供全球半乳糖凝集素抑制剂市场相关调查分析,市场动态,临床试验的形势,未来的机会预测,竞争情形等资讯。

目录

第1章 半乳糖凝集素抑制剂的简介

  • 概要
  • 半乳糖凝集素与其抑制剂的发现

第2章 半乳糖凝集素抑制剂所扮演的角色和作用机制:各适应症

  • 癌症
  • 病毒感染
  • 肝疾病
  • 神经退化性疾病
  • 心血管疾病

第3章 全球半乳糖凝集素抑制剂的临床试验的形势

  • 各企业
  • 各国
  • 各适应症
  • 各阶段
  • 各患者市场区隔

第4章 全球半乳糖凝集素抑制剂的临床实验平台:各企业、适应症、阶段

  • 研究
  • 前临床
  • I/II期
  • II期
  • II期/III

第5章 全球半乳糖凝集素抑制剂的市场动态

  • 有利的要素与机会
  • 课题与阻碍因素

第6章 全球半乳糖凝集素抑制剂市场机会预测

第7章 竞争情形

  • BioXyTran
  • G3 Pharmaceuticals
  • Galectin Therapeutics
  • Galecto
  • GlycoMimetics
  • HiFiBiO
  • PureTech Health
  • TrueBinding
  • University Medical Center Groningen
  • University Of Michigan Medical School

“Global Galectin Inhibitors Market Trends & Clinical Trials Insight 2023” Report Highlights:

  • Global Galectin Inhibitors Clinical Pipeline By Company, Indication & Phase
  • Insight On All 16 Galectin Inhibitors In Clinical Pipeline
  • Clinical Study Initiation & Completion Timeline By Key Drugs
  • Global Galectin Inhibitors Market Dynamics
  • Insight On Top 10 Companies Involved In Development Of Galectin Inhibitors Drugs
  • Galectin Inhibitors Market Future Opportunity Outlook

Some of the most recent proteins to be exploited as therapeutic targets in various indications are those that regulate and participate in signaling pathways. A related class of proteins known as the galectin family is implicated in numerous disorders that account for the majority of the world's sick population. The member of the galectin family that has drawn the most attention and developed into the best understood is galectin-3. Galectins have been targeted as potential therapeutic targets because of their functions in a variety of diseases, including cancer, autoimmune disorders, and liver ailments.

Many medications that target the galectins have been created to far, including OTX008 and LLS30, however only a select few have been successful in reaching clinical trials. Even then, numerous applicants had their trials halted or withdrew for a variety of reasons. These kinds of factors significantly hurt the pharmaceutical sector. Nevertheless, a few new businesses have emerged with a primary focus on the creation of medications and treatments that target the various galectins; some of these have already started clinical trials. Biotechnology companies with the support of specialists with years of experience and knowledge about the functioning and pathology of galectins in various disorders predominate the market for these medications.

Around 15 therapeutic candidates have been created for various indications and are in various stages of development and clinical review, demonstrating that the functions of galectins are not only limited to a small number of disorders. The most well-known and likely to succeed of the candidates created to date is GR-MD-O2, the lead candidate of Galectin Therapeutics. The fact that GR-MD-O2 was granted fast track status by the US FDA in 2013 for the treatment of non-alcoholic steatohepatitis (NASH) with hepatic fibrosis, also known as fatty liver disease with advanced fibrosis, supports this conclusion.

Galectin-3 inhibitor GR-MD-O2, also known as belapectin, is being tested for both cancer and non-cancer indications, while non-cancer indications studies were initiated sooner. In order to determine the effectiveness and safety of GR-MD-O2 in treating cirrhosis brought on by non-alcoholic steatohepatitis (NASH), patients with esophageal varices are participating in a phase 2/3 randomized multinational trial. Further, the investigational new drug medication application for the evaluation of GR-MD-O2 in patients with advanced or metastatic head and neck cancer in combination with a checkpoint inhibitor received FDA clearance in the third quarter of 2022. In response, Galectin began a phase 1 dose escalation research to examine the outcomes of GR-MD-O2 and pembrolizumab in patients with advanced melanoma, non-small cell lung cancer, and head and neck squamous cell cancer.

However, ProLectin M, a galectin-3 inhibitor, is the candidate that has advanced the furthest in clinical studies for the treatment of COVID-19 patients at various stages of infection. For treating COVID-19 patients with an early and severe infection, the medication has been developed in different formulations that are a chewable tablet and an intravenous infusion. Its developer Bioxytran is conducting preclinical research or has submitted the IND application for the medicine to be assessed in viral infections such COVID-19, influenza, monkeypox, and Ebola, as well as in pulmonary fibrosis and other fibrotic disorders.

Other companies are also striving to create viable candidates for blocking galectins to treat various ailments. Some companies, like MandalMed, developed candidates with unique modes of action. MandalMed's candidate MM-003 was a human protein inhibitor of galectin-3 developed to stop and treat harmful remodeling during myocardial infarction. Preclinical investigations on the candidate were being conducted until the project was abandoned by the company. Yet, this raises hope for the introduction of additional innovative modalities with greater efficacies in the upcoming years.

Galectin inhibitors are still in their infancy on the market, but some companies are working to develop them by accelerating research and development efforts to take advantage of the untapped potential of galectins as a medical treatment. The involvement of galectins in a variety of pathways gives hope for the possibility of one inhibitor to be used for more than one disease, which might help the company grow its patient base. As companies performing preclinical and clinical investigations release their findings, the market is predicted to grow in the coming years.

Table of Contents

1. Introduction to Galectin Inhibitors

  • 1.1. Overview
  • 1.2. Discovery of Galectins & Their Inhibitors

2. Role of Galectin Inhibitors & Mechanism of Action by Indication

  • 2.1. Cancer
  • 2.2. Viral Infection
  • 2.3. Liver Diseases
  • 2.4. Neurodegenerative Disease
  • 2.5. Cardiovascular Diseases

3. Global Galectin Inhibitors Clinical Trials Landscape

  • 3.1. By Company
  • 3.2. By Country
  • 3.3. By Indication
  • 3.4. By Phase
  • 3.5. By Patient Segment

4. Global Galectin Inhibitors Clinical Pipeline By Company, Indication & Phase

  • 4.1. Research
  • 4.2. Preclinical
  • 4.3. Phase-I/II
  • 4.4. Phase-II
  • 4.5. Phase-II/III

5. Global Galectin Inhibitors Market Dynamics

  • 5.1. Favorable Factors & Opportunities
  • 5.2. Challenges & Restraints

6. Global Galectin Inhibitors Market Opportunity Outlook

7. Competitive Landscape

  • 7.1. BioXyTran
  • 7.2. G3 Pharmaceuticals
  • 7.3. Galectin Therapeutics
  • 7.4. Galecto
  • 7.5. GlycoMimetics
  • 7.6. HiFiBiO
  • 7.7. PureTech Health
  • 7.8. TrueBinding
  • 7.9. University Medical Center Groningen
  • 7.10. University Of Michigan Medical School

List of Figures

  • Figure 1-1: Timeline of Discovery of Galectin Inhibitors
  • Figure 2-1: Roles of Galectins in Cancer
  • Figure 2-2: LYT-200 Phase I/II Study - Initiation & Completion Years
  • Figure 2-3: GR-MD-02 Phase I Study - Initiation & Completion Years
  • Figure 2-4: GB1211 Phase I/II Study - Initiation & Completion Years
  • Figure 2-5: Roles of Galectins in Viral Infections
  • Figure 2-6: ProLectin M Phase III PROTECT Study - Initiation & Completion Years
  • Figure 2-7: ProLectin-M Phase II Study - Initiation & Completion Years
  • Figure 2-8: Roles of Galectins in Liver Diseases
  • Figure 2-9: Belapectin Phase II/III NAVIGATE Study - Initiation & Completion Years
  • Figure 2-10: GB1211 Phase I/II GULLIVER-2 Study - Initiation & Completion Years
  • Figure 2-11: Roles of Galectins in Neurodegenerative Disease
  • Figure 2-12: Roles of Galectins in Cardiovascular Diseases
  • Figure 3-1: Global - Galectin Inhibitors Drugs In Clinical Pipeline By Company (Numbers), 2023
  • Figure 3-2: Global - Galectin Inhibitors Drugs In Clinical Pipeline By Country (Numbers), 2023
  • Figure 3-3: Global - Galectin Inhibitors Drugs In Clinical Pipeline By Indication (Numbers), 2023
  • Figure 3-4: Global - Galectin Inhibitors Drugs In Clinical Pipeline By Phase (Numbers), 2023
  • Figure 3-5: Global - Galectin Inhibitors Drugs In Clinical Pipeline By Patient Segment (Numbers), 2023
  • Figure 5-1: Factors Driving Galectin Inhibitors Market
  • Figure 5-2: Factors Limiting Galectin Inhibitors Market

List of Tables

  • Table 2-1: Galectins & Their Disease Implications