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市场调查报告书
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1198142

蛋白质稳定性分析市场 - COVID-19 的增长、趋势、影响和预测 (2023-28)

Protein Stability Analysis Market - Growth, Trends, and Forecasts (2023-28)
出版日期: | 出版商: Mordor Intelligence | 英文 114 Pages | 商品交期: 2-3个工作天内

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简介目录

在预测期内，蛋白质稳定性分析市场预计将以 3.5% 的复合年增长率增长。

COVID-19 在其早期阶段对蛋白质稳定性分析市场产生了重大影响，因为已经进行了蛋白质稳定性研究以极大地评估 COVID-19 病毒的结构和特性，这将有助于更好地帮助获得理解并支持开发有效和高效的疗法。 例如，2022 年 9 月在斯坦福大学医学杂誌上发表的一篇论文发现，医院 COVID-19 患者血液中病毒水平升高预示着呼吸道症状恶化，并继续暗示病毒复製。 在测试过程中，在患者血液中测量了来自导致 COVID-19 的病毒的蛋白质。 因此，蛋白质分析显示与 COVID-19 相关的并发症可能会促进市场增长。

在后大流行时代出现了不同的 COVID-19 变体，并且仍在研究中。 自大流行开始以来，世卫组织描述了八个关注领域 (VOI)，即 Epsilon、Zeta、Eta、Theta、Iota、Kappa、Lambda 和 Mu。 目前正在进行研究以确定 omicron 变体是否会影响病毒特性、传播速度、相关疾病的严重程度、疫苗性能或其他公共卫生和社会措施。因此，对蛋白质分析产品的需求预计会增加。 另一个要考虑的因素是 Sars-COV-2 库存，预计在预测期内对市场产生积极影响。

製药和生物製药公司研发支出的增加、蛋白质组学和基因组学研究活动的增加以及重组蛋白疗法和生物製品的增加等因素都是有助于蛋白质稳定性以证明研究成果的因素。由于根据评估的需要，预计将在预测期内推动市场增长。

例如，根据 EFPIA 2022 报告，2021 年欧洲将在药物研发方面投入约 415 亿欧元（约合 351.09 亿美元）。 因此，巨大的研发投资将在预测期内推动蛋白质稳定性分析市场的增长。 此外，随着研究人员寻求蛋白质稳定性研究的机会，预计基因组研究活动的投资和融资将推动市场发展。 例如，2022 年 9 月，隶属于 NIH 的 NHGRI 将在五年内投资 335 万美元启动基因组学研究体验，以吸引研究人员参与其基因组学增加多样性 (GREAT) 计划。计划投资于 此外，2022 年 9 月，西澳大利亚大学与 Proteomics International 的合资企业获得了 200 万美元的资金，该公司是一家在蛋白质医学、环境和农业测试方面提供基本服务的公司。 这笔资金将使 WA Proteomics Facility 能够升级其自动化工具和员工，并将其输出能力提高到数百个样本。

由于製药和生物製药公司研发支出的增加以及蛋白质组学和基因组学研究活动的增加，预计蛋白质稳定性分析市场在预测期内将会增长。 然而，蛋白质稳定性分析系统的高成本预计将在一定程度上抑制该市场的增长。

蛋白质稳定性分析的市场趋势

差示扫描量热法 (DSC) 预计在预测期内将占很大份额

差示扫描量热法通过测量某些生物分子（如蛋白质）变性所需的热量，已广泛用于评估天然形式的蛋白质稳定性。稻田。 通过这种技术，具有较高中点热转变的分子被确定为比具有较低热转变中点的分子更稳定。 该技术广泛用于研发和药物发现。 由于 DSC 可用于观察材料转变的简便性和速度等广泛优势，预计 DSC 领域将在预测期内增长。 由于这些原因，DSC 优于其他蛋白质扫描和鑑定技术。

使用差示扫描量热法在蛋白质稳定性领域的研发正在推动市场增长，因为它证明了 DSC 在研究中的简便性和速度。 根据 2022 年 6 月发表在《生物传感器》杂誌上的一篇文章，有一项研究展示了使用基于微机电系统 (MEMS) 的新型差示扫描量热仪 (DSC) 对蛋白质样品进行直接热表征。 这种 MEMS 量热仪可以根据许多治疗性蛋白质的转变温度以高通量筛选其构象稳定性。 因此，与蛋白质分析相关的 DSC 的这种进步可能会在预测期内推动市场增长。 该行业的累计研发支出证明了研发 (R&D) 在製药行业的重要性。 研发支出每年都在增加，据观察，一些製药和生物技术公司专注于加强其研发设施，这最终促进了市场的增长。 美国最近看到各种製药公司和政府组织增加了研发支出，预计这将在预测期内推动市场增长。 例如，根据 EFPIA 的 2022 年报告，2021 年北美将占全球药品销售额的 49.1%，而欧洲为 23.4%。 研发支出和销售增长预计将增加对 DSC 等蛋白质稳定性分析技术的需求，从而推动市场增长。

北美有望在预测期内主导市场

在该地区，知名研发机构的存在及其高额投资将在预测期内推动市场增长，因为研究计划预计将利用蛋白质稳定性研究来获得准确的结果。 例如，根据加拿大统计局 2022 年 6 月的一份报告，2021 年内部研发支出预计将增长 3.5%，达到 234 亿美元。 公司预计 2022 年内部研发支出增长将放缓，总研发支出预计将增长 1.7% 至 238 亿美元。

此外，政府和私营公司对基因组学和蛋白□□质组学研究的投资预计将推动北美地区的市场增长。 例如，2021 年 2 月，总部位于西雅图的 Nautilus Biotechnology 将通过合併进入股票市场，获得 3.5 亿美元，用于加速开髮用于药物发现和诊断应用的蛋白质分析技术。 此外，斯坦福大学质谱蛋白质组学种子基金将于 2022 年 9 月向寻求新质谱项目和新方法的研究人员提供 10,000 美元的研究资助，以利用最近增加的研究仪器的功能。

此外，北美地区的基因组学和蛋白□□质组学研究将推动市场增长，因为它认识到蛋白质稳定性研究的必要性，并利用与稳定性研究相关的试剂和仪器。 例如，MDPI 在墨西哥国家呼吸疾病研究所 Ismael Cosio Villegas 的支持下于 2022 年 5 月发表的一篇论文发现，蛋白质组学能够识别可用于血清学诊断的新型过敏原，1 研究结果已经宣布，它现在可以在一次分析中分析数千种蛋白质。

蛋白质稳定性分析市场竞争者分析

由于多家公司在全球和区域运营，蛋白质稳定性分析市场在本质上是分散的。 竞争格局包括对具有市场份额的几家知名国际和地区公司的分析。 其中包括 Agilent Technologies Inc、NanoTemper Technologies、Shimadzu Corporation、Thermo Fisher Scientific 和 Spectris PLC (Malvern Panalytical Ltd)。

其他福利。

  • Excel 格式的市场预测 (ME) 表
  • 3 个月的分析师支持

内容

第一章介绍

  • 研究假设和市场定义
  • 调查范围

第二章研究方法论

第 3 章执行摘要

第四章市场动态

  • 市场概览
  • 市场驱动力
    • 製药和生物製药公司的研发支出增加
    • 增加蛋白质组学和基因组学方面的研究活动
    • 重组蛋白疗法和生物製剂的数量增加
  • 市场製约因素
    • 蛋白质稳定性分析仪成本高
  • 波特的五力分析
    • 供应商的议价能力
    • 买方/消费者议价能力
    • 新进入者的威胁
    • 替代品的威胁
    • 竞争公司之间的敌对关係

第 5 章市场细分（基于价值的市场规模：100 万美元）

  • 按产品分类
    • 试剂和检测试剂盒
    • 乐器
    • 耗材/配件
    • 其他产品
  • 按技术
    • 色谱法
    • 光谱学
    • 表面等离子体共振
    • 差示扫描量热仪
    • 差示扫描荧光法
    • 其他技术
  • 最终用户
    • 製药和生物技术公司
    • 学术和研究机构
  • 按地区
    • 北美
      • 美国
      • 加拿大
      • 墨西哥
    • 欧洲
      • 德国
      • 英国
      • 法国
      • 意大利
      • 西班牙
      • 其他欧洲地区
    • 亚太地区
      • 中国
      • 日本
      • 印度
      • 澳大利亚
      • 韩国
      • 其他亚太地区
    • 中东
      • 海湾合作委员会
      • 南非
      • 其他中东地区
    • 南美洲地区
      • 巴西
      • 阿根廷
      • 其他南美洲

第六章竞争格局

  • 公司简介
    • Agilent Technologies, Inc.
    • NanoTemper Technologies
    • Horiba, Ltd
    • Perkinelmer, Inc.
    • Setaram Instrumentation
    • Shimadzu Corporation
    • Spectris PLC
    • Thermo Fisher Scientific
    • Unchained Labs
    • Danaher Corporation（Molecular Devices）
    • Spectris PLC（Malvern Panalytical Ltd）
    • Bruker Corporation

第七章市场机会与未来趋势

简介目录
Product Code: 67630

The protein stability analysis market is expected to register a CAGR of 3.5% during the forecast period.

COVID-19 had a significant impact on the protein stability analysis market in the initial phase since protein stability studies were conducted to assess the structure and nature of the COVID-19 virus to a great extent which helps gain a better understanding of the virus and supports the development of effective and efficient therapeutics. For instance, as per the article published in September 2022 in Stanford Medicine, elevated virus levels in the blood of COVID-19 patients in hospitals predicted the worsening of respiratory symptoms and suggest ongoing viral replication in advanced disease stages. A protein of the virus that causes COVID-19 was measured in the patient's blood during the test. Hence, such analysis showing the complications associated with COVID-19 through protein analysis will likely boost the market growth.

In the post-pandemic era, studies are still being conducted due to the emergence of different COVID-19 mutants. Since the beginning of the pandemic, the WHO has described eight variants of interest (VOIs), namely Epsilon, Zeta, Eta, Theta, Iota, Kappa, Lambda, and Mu. Currently, studies are being conducted to determine whether mutants of Omicron variants affect the virus's properties, speed of spreading, the severity of the associated disease, the performance of vaccines, or other public health and social measures and hence, the demand for protein analysis products is expected to increase. Another factor to account for are the Sars-COV-2 strains which are expected to have a positive impact on the market over the forecast period.

Factors such as rising research and development expenditure of pharmaceutical and biopharmaceutical companies, increasing proteomics and genomics research activities, and an increasing number of recombinant protein therapeutics and biologics are expected to drive the market growth over the forecast period since research studies require protein stability assessments to substantiate the results.

For instance, as per the EFPIA 2022 report, in 2021, Europe invested an estimated EUR 41,500 million (about USD 35,109 million) in pharmaceutical R&D. Thus, huge investments in R&D drive the growth of the protein stability analysis market during the forecast period. Furthermore, investments and financing in genomic research activities are projected to fuel the market as researchers seek opportunities in protein stability studies. For instance, in September 2022 NHGRI, part of the NIH, planned to fund USD 3.35 million over five years to launch the Genome Research Experiences to attract researchers into the Genomics Field to Enhance Diversity (GREAT) program. Moreover, in September 2022, a joint venture by the University of Western Australia and Proteomics International, which conducts vital work in medical, environmental, and agricultural testing of proteins received a funding of USD 2 million . The money is likely to enable the WA Proteomics Facility to upgrade its automated tools and staff, increasing output capacity to hundreds of samples.

As a result of the increase in pharmaceutical and biopharmaceutical companies' R&D expenditures, as well as the increase in the number of proteomics and genomics research activities, the protein stability analysis market is anticipated to witness growth over the forecast period. However, the high cost of protein stability analysis systems is expected to restrain the growth of this market to a certain extent.

Protein Stability Analysis Market Trends

Differential Scanning Calorimetry (DSC) is Expected to Hold a Significant Share Over the Forecast Period

The differential scanning calorimetry technique has been widely used in characterizing the stability of proteins in their native form by measuring the heat required to denature a particular biomolecule, like a protein. This technique determines molecules with higher thermal transition midpoints, which are considered more stable than those with lower transition midpoints. This technique is widely used in research & development and drug discovery. The DSC segment is likely to witness growth over the forecast period due to the wide advantages of DSC such as the ease and speed with which it can be used to see transitions in materials. Due to this reason, DSC is preferred over other techniques to scan and identify proteins.

The research and development in the field of protein stability using differential scanning calorimetry are driving the market growth as it showcases the ease and speed of DSC for research. According to an article published in June 2022 in the Biosensors journal, a study demonstrated the direct thermal characterization of protein samples using a new micro-electromechanical system (MEMS)-based differential scanning calorimeter (DSC). With high throughput, the MEMS calorimeter could screen many therapeutic proteins for conformational stability based on transition temperature. Hence, such advancements in DSC associated with protein analysis are likely to boost market growth over the forecast period. The importance of research and development (R&D) for the pharmaceutical industry is evidenced by the cumulative R&D expenditure in the sector. It has been observed that R&D spending is increasing each year and several pharma and biotech companies are focusing on strengthening their R&D facilities which are ultimately driving the growth of the market studied. The spending on research and development (R&D) by various pharmaceutical companies and government organizations has been increasing recently in the United States, which is anticipated to drive market growth over the forecast period. For instance, as per the 2022 report from EFPIA, in 2021 North America accounted for 49.1% of world pharmaceutical sales compared with 23.4% for Europe. As the R&D expenditure and sales increase, the demand for protein stability analysis techniques like DSC is expected to increase thereby boosting the market growth.

North America is Expected to Dominate the Market During the Forecast Period

The presence of well-established research and development institutions and their high investment in the region is driving market growth over the forecast period since the research initiatives are likely to utilize protein stability studies for accurate results. For instance, as per the Statistics Canada June 2022 report, in-house spending on R&D in 2021 was expected to grow by 3.5%, reaching USD 23.4 billion. Companies expect more modest growth in their in-house R&D spending in 2022, with total R&D spending anticipated to increase by 1.7% to USD 23.8 billion.

Furthermore, investments by the government and private companies in genomic and proteomic research are likely to drive market growth in the North American region. For instance, in February 2021, through a merger, Seattle-based Nautilus Biotechnology entered the public market and received USD 350 million to accelerate the development of its protein analysis technology for drug discovery and diagnostic applications. Moreover, in September 2022, Stanford University Mass Spectrometry Proteomics Seed Grants provided a research grant of USD 10,000 to researchers aiming for new mass spectrometry projects and new methodologies taking advantage of the capabilities of recently added research instrumentation.

Additionally, genomic as well as proteomic research works in the North American region promote market growth since they identify the need for protein stability study and utilize the reagents and equipment associated with stability studies. For instance, as per the article published in May 2022 by MDPI which was supported by the National Institute of Respiratory Diseases "Ismael Cosio Villegas," Mexico, a study showed that proteomics has enabled the identification of novel allergens that can be used in serodiagnosis and has made it possible to analyze thousands of proteins in a single analysis.

Protein Stability Analysis Market Competitor Analysis

The protein stability analysis market is fragmented in nature due to the presence of several companies operating globally as well as regionally. The competitive landscape includes an analysis of a few international and local companies that hold market shares and are well-known. These include Agilent Technologies Inc, NanoTemper Technologies, Shimadzu Corporation, Thermo Fisher Scientific, and Spectris PLC (Malvern Panalytical Ltd).

Additional Benefits:

  • The market estimate (ME) sheet in Excel format
  • 3 months of analyst support

TABLE OF CONTENTS

1 INTRODUCTION

  • 1.1 Study Assumptions and Market Definition
  • 1.2 Scope of the Study

2 RESEARCH METHODOLOGY

3 EXECUTIVE SUMMARY

4 MARKET DYNAMICS

  • 4.1 Market Overview
  • 4.2 Market Drivers
    • 4.2.1 Rising Research and Development Expenditure of Pharmaceutical and Biopharmaceutical Companies
    • 4.2.2 Increasing Proteomics and Genomics Research Activities
    • 4.2.3 Increasing Number of Recombinant Protein Therapeutics and Biologics
  • 4.3 Market Restraints
    • 4.3.1 High Cost of Protein Stability Analysis Instruments
  • 4.4 Porter's Five Forces Analysis
    • 4.4.1 Bargaining Power of Suppliers
    • 4.4.2 Bargaining Power of Buyers/Consumers
    • 4.4.3 Threat of New Entrants
    • 4.4.4 Threat of Substitute Products
    • 4.4.5 Intensity of Competitive Rivalry

5 MARKET SEGMENTATION (Market Size by Value - USD Million)

  • 5.1 By Product
    • 5.1.1 Reagents and Assay Kits
    • 5.1.2 Instruments
    • 5.1.3 Consumables and Accessories
    • 5.1.4 Other Products
  • 5.2 By Technique
    • 5.2.1 Chromatography
    • 5.2.2 Spectroscopy
    • 5.2.3 Surface Plasmon Resonance
    • 5.2.4 Differential Scanning Calorimetry
    • 5.2.5 Differential Scanning Fluorimetry
    • 5.2.6 Other Techniques
  • 5.3 By End-User
    • 5.3.1 Pharmaceutical & Biotechnology Companies
    • 5.3.2 Academic and Research Organizations
  • 5.4 Geography
    • 5.4.1 North America
      • 5.4.1.1 United States
      • 5.4.1.2 Canada
      • 5.4.1.3 Mexico
    • 5.4.2 Europe
      • 5.4.2.1 Germany
      • 5.4.2.2 United Kingdom
      • 5.4.2.3 France
      • 5.4.2.4 Italy
      • 5.4.2.5 Spain
      • 5.4.2.6 Rest of Europe
    • 5.4.3 Asia-Pacific
      • 5.4.3.1 China
      • 5.4.3.2 Japan
      • 5.4.3.3 India
      • 5.4.3.4 Australia
      • 5.4.3.5 South Korea
      • 5.4.3.6 Rest of Asia-Pacific
    • 5.4.4 Middle East
      • 5.4.4.1 GCC
      • 5.4.4.2 South Africa
      • 5.4.4.3 Rest of Middle East
    • 5.4.5 South America
      • 5.4.5.1 Brazil
      • 5.4.5.2 Argentina
      • 5.4.5.3 Rest of South America

6 COMPETITIVE LANDSCAPE

  • 6.1 Company Profiles
    • 6.1.1 Agilent Technologies, Inc.
    • 6.1.2 NanoTemper Technologies
    • 6.1.3 Horiba, Ltd
    • 6.1.4 Perkinelmer, Inc.
    • 6.1.5 Setaram Instrumentation
    • 6.1.6 Shimadzu Corporation
    • 6.1.7 Spectris PLC
    • 6.1.8 Thermo Fisher Scientific
    • 6.1.9 Unchained Labs
    • 6.1.10 Danaher Corporation (Molecular Devices)
    • 6.1.11 Spectris PLC (Malvern Panalytical Ltd)
    • 6.1.12 Bruker Corporation

7 MARKET OPPORTUNITIES AND FUTURE TRENDS