市场调查报告书
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1394215
全球谷胱甘□树脂市场评估:依包装类型、应用、地区、机会、预测(2016-2030)Glutathione Resin Market Assessment, By Packaging Type [Less Than 50 ml, 50-100 ml, Greater Than 100 ml], By Application [Protein Purification, Laboratories Research, Others], By Region, Opportunities and Forecast, 2016-2030F |
全球谷胱甘□树脂市场规模预计将从 2022 年的 4.513 亿美元增至 2030 年的 7.929 亿美元,在 2023-2030 年预测期内复合年增长率为 7.3%。
针对具有成本效益的蛋白质纯化过程,一种经常探索的解决方案是将谷胱甘□化合物附着到具有适当数量的原子间隔基的琼脂糖珠上,以减少纯化过程中的阻碍效应。 开发此类具有成本效益的化合物的技术创新正在加速,各公司正在推进该领域的研究。 Thermo Fisher Scientific Inc. 成功开发了 Pierce 谷胱甘□,它透过 12 个原子间隔基将谷胱甘□化合物与琼脂糖珠连接起来,几乎最大限度地减少了空间位阻。
该公司提供采用预装色谱管柱的 Pierce 谷胱甘□琼脂糖产品,用于 FPLC 输送应用。 该产品为从细胞裂解物中亲和纯化 GST 标记的融合蛋白提供了高性能和能力。 Pierce 谷胱甘□树脂价格经济,可使用五次而不影响纯化性能和结合能力,使其成为高性价比产品。 该产品经过临床验证,可与该公司的细胞裂解试剂一起从哺乳动物和细菌细胞培养物中提取和纯化。
COVID-19的爆发严重影响了许多行业和人们的生活,使每个人都更容易感染传染病。 实验室关闭以及药物研究投资的减少导致经济稳定性恶化。 然而,开发有效药物来对抗COVID-19 的紧迫性为谷胱甘□树脂创造了多种机会,可以快速纯化谷胱甘□-S-转移□(GST) 标记的重组蛋白,同时减少破坏性影响。 疫情为市场拓展、企业融入服务创造了巨大潜力。
由于对先进和优化的蛋白质纯化製程的需求不断增加,谷胱甘□树脂市场正在稳步增长。 Cytiva 开发了 Glutathione Sepharose 4B 产品,这是一种亲和层析树脂,用于批量纯化谷胱甘□-S-转移□ (GST) 标记的蛋白质,实现高结合能力。 这种谷胱甘□树脂对所有常用的水性缓衝液具有化学稳定性,并广泛用于研究蛋白质-蛋白质相互作用。
本报告研究和分析了全球谷胱甘□树脂市场,提供市场规模和预测、市场动态、主要参与者的现状和前景等。
Global glutathione resin market size was valued at USD 451.3 million in 2022, which is expected to reach USD 792.9 million in 2030, with a CAGR of 7.3% for the forecast period between 2023 and 2030.
Protein purification processes are successively achieved using affinity chromatography, which offers high selectivity, resolution, and capacity in much less time. An effective design affinity chromatography, glutathione resin is a one-step purification process used for recombinant glutathione S-transferase (GST) fusion proteins and relevant binding proteins in insect cells, E. coli, and mammalian cells. Glutathione resin is widely considered an excellent compound for high-performance purifications, especially when high binding capacity is required for batch purification. Elevated glutathione (GSH) levels are significantly observed in several types of cancer cells that increase antioxidant capacity.
Glutathione affinity resins are designed to purify glutathione-S-transferase (GST)-tagged recombinant proteins rapidly. High binding capacity and yield of glutathione-S-transferase (GST) fusion proteins of 5-8 mg/ml settled resin is successfully developed by Merck KGaA, Darmstadt. Also, biological companies are successfully researching to develop cost-effective purification processes while reducing hinderance effect.
Glutathione is an essential compound that increases the immune system and provides a barrier to harmful diseases prone to humans. The rapid purification of glutathione-binding proteins from yeast, insect, bacteria, and glutathione-S-transferase (GST)-tagged recombinant proteins are accomplished by simply designing glutathione affinity resin.
The glutathione ligand is coupled to highly cross-linked 4% agarose beads to optimize and provide high binding capacity for GST-tagged proteins. Flow dependent characteristics is associated with binding of GST to glutathione and lower flow rates usually enhancing the binding capacity.
Merck KGaA, Darmstadt has introduced the trademark product GST. Bind Resins utilize a 14-atom spacer arm to covalently attach reduced glutathione by using sulfide linkage. The yield of glutathione-S-transferase (GST) fusion proteins of 5-8 mg/ml settled resin are achieved by a high degree substation of glutathione, ensuring high binding capacity. In November 2022, LTS Lohmann, a prominent producer of needle-free drug delivery systems, especially transdermal patches, had an investment of USD 14 million with the Global Health Investment Corporation. In addition to successive investment in June 2022, Evonik has partnered with the United States Government, by investing USD 220 million to build innovative drug delivery system for new lipid production facility for mRNA-based therapies.
The solution for a cost-effective purification process for proteins is frequently explored where the glutathione compound is linked to agarose beads with a suitable number of atom spacers that reduces the hindrance effect while undergoing purification. The innovation to develop such cost-effective compounds is accelerating and companies are conducting research in the field. Thermo Fisher Scientific Inc. has successfully developed pierce glutathione where the glutathione compound is linked to agarose beads through 12-atom spacer that substantially minimizes steric hinderance.
The company provides pierce glutathione agarose products in prepacked chromatography cartridges for delivering FPLC applications. The product delivers high performance and capacity properties for affinity purification of GST-tagged fusion proteins from cellular lysates. The pierce glutathione resin is economically priced and can be used five times without compromising purification performance and binding capacity which makes the product cost-effective. The product is clinically validated for its effective use with company's cell lysis reagents to extract and purify from mammalian or bacterial cell cultures.
Immune activity can be enhanced using nutritional or therapeutic composition while performing treatment of mammals. Glutathione precursor comprises of mixtures of glutamic acid, cystine, and glycine along with essential active ingredients like selenium. Selenium is a prominent trace metal found in various food compositions and is significantly incorporated in several non-toxic, water soluble organic or inorganic. Enhancement in cellular and tissue concentrations of glutathione improves resistance to infective agents by improving the immune system. Nutritional requirements are not fulfilled due to limited functionality of bacterial pathogens and commensals to metabolites. Hence, glutathione (GSH) is recognized as an abundant sulfur-content antioxidant present in mammalian tissues and is an incredible source of nutrient sulfur for human pathogens like staphylococcus aureus.
The data published by the Good Food Institute states that, in 2020 the United States market for plant-based foods is around USD 7.4 billion. Plant-based eggs are a modest category that is growing exponentially reaching around USD 39 million in 2021. The growing plant-based products are attracting various biological industries to improve nutritional characteristics which is subsequently creating market opportunities for glutathione resin market.
The outbreak of COVID-19 has severely impacted numerous sectors and human livelihood where every person was vulnerable to infectious disease. The shutdown of research laboratories accompanied by lower investment in pharmaceutical research has deteriorated the economic stability. But the urgency to develop effective drug to combat COVID-19 has created multiple opportunities for glutathione resin to incorporate rapid purification of glutathione-S-transferase (GST)-tagged recombinant proteins while reducing hinderance effect. The pandemic situation has created enormous potential for the market to expand and derive companies to incorporate services.
The glutathione resin market is successfully growing with the increasing demand for advanced and optimized protein purification process. Cytiva has developed Glutathione Sepharose 4B product which is an affinity chromatography resin for performing batch purification of glutathione-S-transferase (GST)-tagged proteins for attaining high binding capacity. The glutathione resin is chemically stable with all commonly used aqueous buffers and substantially used to study protein-protein interactions. Cytiva is successfully offering other life sciences solutions for undergoing purification GST fusion properties.
In October 2023, Cytiva and RoosterBio successively collaborated improving the exosome purification process for promising gene therapies and other significant modalities and manufacturing exosomes in mass quantities. The effective collaboration is developing prominent platform to provide cost-effective manufacturing solutions.
All segments will be provided for all regions and countries covered:
Companies mentioned above DO NOT hold any order as per market share and can be changed as per information available during research work.