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市场调查报告书
商品编码
1445546
移植物抗宿主疾病(GvHD)市场评估:按疾病类型、药物类别、给药途径、最终用户和地区划分的机会和预测(2017-2031)Graft versus Host Disease Assessment, By Disease Type, By Drug Class, By Route of Administration, By End-user, By Region, Opportunities and Forecast, 2017-2031F |
全球移植物抗宿主疾病 (GvHD) 市场规模将从 2023 年的 29.9 亿美元增至 2031 年的 61 亿美元,2024-2031 年预测期间复合年增长率为 9.51%。预计将增长至9000万美元。
由于器官移植和干细胞移植等移植需求的增加、技术进步、政府举措以及人工智慧的整合等因素,GvHD 市场正在不断增长。 移植需求的不断增加正在推动 GvHD 的流行,并加速对治疗方案的需求。 患者正在寻找更可靠、无麻烦和一流的方法来管理移植后症状。 此外,政府也大力投资研发,将最好的技术推向市场。 许多新进展正在帮助接受移植手术的患者恢復得更快、更好。
GvHD 盛行率增加
由于干细胞移植的增加,GvHD 市场正在显着扩大。 干细胞移植是治疗多种免疫学和血液学问题的一种强大的新方法。 然而,随着移植手术的增多,GvHD的盛行率也在增加。 干细胞移植已成为多种疾病的常见治疗方法。 有使用病人干细胞的自体移植和使用捐赠者干细胞的同种异体移植。 再生障碍性贫血和严重复合型免疫缺陷(SCID)等非恶性疾病以及白血病、淋巴瘤和骨髓瘤等血液恶性肿瘤的治疗都受益于这些疗法。 随着越来越多人接受干细胞移植,发生 GvHD 的风险也会增加。 除了传统用途之外,医生和研究人员正在研究支持实体器官移植、自体免疫疾病移植和再生医学的应用。 随着移植手术的多样化,面临 GvHD 风险的患者数量不断增加,对有效 GvHD 治疗的需求进一步增加。
政府措施
对 GvHD 治疗的生产和批准的持续监管支持是市场成长的关键驱动力之一。 GvHD 研究、临床研究和有前景药物的商业化得到了政府和私营部门的大力资助。 政府已采取主动与该领域的研究中心、医疗专业人员和研究机构合作。
技术进步
GvHD 治疗技术正在以惊人的速度发展,这主要归功于医疗技术的进步。 由于医疗技术的进步,诊断GvHD的能力已大大提高。 利用基因组定序、生物标记识别和高解析度成像,医疗保健专业人员可以高精度检测 GvHD。 医疗技术的进步使得专门针对 GvHD 患者的需求而设计的针对性治疗成为可能。 GvHD 有前景的治疗方法包括免疫调节药物、生物製剂和单株抗体。 基于这些免疫学特征的精确定製药物提供了危害较小、更好的疾病控制方法。
本报告调查了全球移植物抗宿主疾病(GvHD) 市场,并提供了市场定义和概述、市场规模趋势和预测、各个细分市场和地区的详细分析、产业结构和市场成长。它总结了以下分析:影响因素、案例研究、竞争格局、主要公司概况。
Global graft versus host disease market is projected to witness a CAGR of 9.51% during the forecast period 2024-2031, growing from USD 2.99 billion in 2023 to USD 6.19 billion in 2031. The graft versus host disease (GvHD) market is experiencing growth due to factors such as rising demand for transplants, such as organ transplants or stem cell transplants, advancements in technology, government initiatives, and the integration of AI. Increasing demand for transplantations has boosted the prevalence of GvHD, which, in turn, has accelerated the demand for treatment options. Patients are looking for a more reliable, hassle-free, and best possible approach to deal with the symptoms that come after the transplantations. Furthermore, the government is also spending significant amounts on research and development to bring out the best possible techniques in the market. Many new advancements are helping faster and better recovery of patients after undergoing transplantation procedures.
Results from a phase 2 study (NCT02867384) presented during the 2023 ASH Annual Meeting showed that using obinutuzumab (Gazyva) to enhance B-cell depletion significantly reduced the need for corticosteroids and increased relapse-free survival in patients with steroid-requiring chronic GvHD undergoing well-matched hematopoietic stem cell transplant.
Rising Prevalence of GvHD
The market for GvHD is expanding significantly due to the rising use of stem cell transplants. A potent new technique for treating several immunological and hematological problems is stem cell transplantation. However, the prevalence of GvHD has increased in tandem with the growth in transplant procedures. Stem cell transplants have become a common therapy option for a variety of illnesses. They can be performed autologously, using the patient's stem cells, or allogeneically, using donor stem cells. Treatments for non-malignant conditions, including aplastic anemia and severe combined immunodeficiency (SCID), as well as hematological malignancies like leukemia, lymphoma, and myeloma, are both benefiting from this rising use. There is a growing risk of developing GvHD as more individuals receive stem cell transplantation. Beyond the conventional applications, physicians and researchers are investigating solid organ transplant support, autoimmune disease transplantation, and regenerative medicine applications. The demand for efficient GvHD treatments is being further driven by the expansion of the patient pool at risk of developing GvHD due to the diversity of transplant procedures.
In the United States, 42% of patients had developed chronic (cGvHD) within three years following allogenic HCT; 66% of those impacted by cGvHD had acute GvHD prior, per an Elsevier paper from June 2021.
Government Initiatives
Ongoing support by regulatory bodies toward the production and approval of GvHD medicines is acting as one of the main market drivers of flourishing growth. Research, clinical studies, and the commercialization of promising medicines related to GvHD are receiving significant funding from the government and private sectors. The government is taking initiatives to collaborate with research centers, healthcare professionals, and institutes that deal with this sector. According to the Australian government's Department of Health and Aged Care, new medications are now available for treating esophageal cancer, chronic rhinosinusitis, and GvHD. The new and upgraded medications, which will be covered under the Pharmaceutical Benefits Scheme (PBS), include Opdivo (nivolumab), Jakavi (ruxolitinib), and Nucala (mepolizumab).
Technological Advancements
The treatment techniques for GvHD are expanding at an impressive rate, mostly due to the ongoing progress in medical technology. The ability to diagnose GvHD has greatly improved due to developments in healthcare technologies. Using genome sequencing, biomarker identification, and high-resolution imaging, medical professionals can detect GvHD with high accuracy. Early detection is essential because it enables timely action, which may stop the illness from getting worse. Targeted therapies that are specifically designed to meet the needs of patients with GvHD are now possible due to advancements in medical technology. Promising therapies for GvHD include immunomodulatory medications, biologics, and monoclonal antibodies. These precisely tailored immunological profile-based medicines provide a less harmful and more successful means of controlling the illness.
The development of cellular and gene treatments is one of the biggest developments in the treatment of GvHD. GvHD may be treated with chimeric antigen receptor T-cell (CAR-T) therapy, which targets the immune cells that cause the illness. CRISPR-Cas9 and other gene editing methods show promise for precisely modifying immune cells to prevent or treat GvHD. Innovative medical technology makes these state-of-the-art treatments possible. Treatment has been transformed by the combination of telemedicine and remote monitoring technology, especially when it comes to GvHD. Improved GvHD management and patient outcomes are a result of this accessibility, which also improves patient compliance and overall quality of care. Big data analytics and artificial intelligence (Al) are being utilized to help with GvHD early detection and prevention. Large-scale datasets can be analyzed by machine learning algorithms, which can then spot patterns and risk factors that human clinicians could miss. With the use of this technology, medical professionals can anticipate future GvHD consequences, personalize treatment regimens, and make better decisions.
Research studies from Michigan Medicine, the Children's Hospital of Philadelphia, and Penn Medicine are paving the road for novel gene therapy treatments for blood disorders like sickle cell anemia. A patient still needs chemotherapy and the transplantation of their own corrected cells even after gene therapy corrects the mutation in their cells. However, it is possible to genetically modify blood stem cells in the bone marrow during a single therapy.
Corticosteroids are Dominating the Global Market
Tyrosine kinase inhibitors, corticosteroids, monoclonal antibodies, and other pharmaceuticals make up the product segment of this market. Due to the increasing number of research studies and the rising prevalence of the target disease, the corticosteroid segment retained the biggest share in 2023. Furthermore, the corticosteroid segment is anticipated to grow over the forecast period due to increased research and development efforts focused on corticosteroids and their combinations for the treatment of GvHD in patients undergoing hematopoietic cell transplantation (HCT). Corticosteroids help in managing the immune system and can also limit the activity of donated T-cells in the host's body. It even helps to reduce inflammation caused after the transplant, which regulates the blood pressure well. As of June 2022, an open-label, multicenter, two-arm randomized trial was conducted to evaluate the efficacy of corticosteroids alone or in combination with Ruxolitinib for newly identified high-risk acute gene therapy-related heart failure or dysfunction. It has been observed that roughly 50% of instances of acute graft-versus-host disease (aGvHD) respond to corticosteroid first-line therapy.
North America to Dominate GvHD Market
The North American region is expected to hold a significant market size due to its well-established healthcare infrastructure, ongoing research and development activities, and a growing number of transplant procedures. An increasing number of transplants performed in North America is accelerating market opportunities in the region. Between January 2022 and June 2022, 20,663 transplant procedures were performed in the United States, according to statistics provided by the Organ Procurement and Transplantation Network, which is supervised by the US Department of Health and Human Services and updated in July 2022. Due to the immunological-mediated reactions that take place between the recipients' and donors' adaptive immune systems, the rise in transplant cases may raise demand for therapies for GvHD, which would ultimately spur market demand.
Future Market Scenario (2024 - 2031F)
The growing need to address a variety of symptoms that occur post transplantation processes can fuel the market of GvHD. Increasing number of organ transplantations and the use of new types of inhibitors are also driving market expansion.
The advent of new and improved technologies, well researched drugs, gene editing techniques, and the integration of AI have enabled high accuracy and precision, which, in turn, is anticipated to increase market share in the upcoming years.
Personalised treatment strategies that target genetic alterations and pathways are becoming more and more popular as precision medicine gains traction. AI has also enhanced early detection for any possible indications that further helps the treatment as well as ensure market expansion.
Global regulatory bodies are building frameworks to speed up the development of specialized transplantation departments, which is also driving the expansion of the GvHD market worldwide.
Key Players Landscape and Outlook
There are several significant players in the competitive graft versus host disease market. Currently, the market is dominated by a few dominant players, such as Merck & Co., Inc, Novartis AG, Astellas Pharma Inc., Astra Zeneca PLC, Bayer AG, Boehringer Ingelheim International Gmbh, Abott Inc., Bristol Myers Squibb, Pfizer Inc., F. Hoffmann-La Roche Ltd, Novartis AG, Elli Lilly and Company, etc. These companies are governing the market share because of their consistent efforts toward R&D, technological advancements, and reliable quality.
Jakavi (ruxolitinib), approved by the European Commission (EC) in May 2022, is intended to treat individuals with acute or chronic GvHD who are 12 years of age or older and do not respond well to corticosteroids or other systemic therapy.
The EQUATOR project, a major Phase III clinical trial of itolizumab in patients with aGvHD, was started by Equillium Inc. in March 2022. When used in conjunction with corticosteroids, itolizumab versus placebo will be evaluated for both safety and efficacy as first-line therapy for aGvHD in this randomized, double-blind study.
All segments will be provided for all regions and countries covered
Companies mentioned above DO NOT hold any order as per market share and can be changed as per information available during research work.