市场调查报告书
商品编码
1447722
转移性大肠直肠癌市场评估:按治疗类型、诊断、最终用户和地区划分的机会和预测(2017-2031)Metastatic Colorectal Cancer Market Assessment, By Treatment Type, By Diagnosis, By End-user By Region, Opportunities and Forecast, 2017-2031F |
全球转移性大肠直肠癌市场规模将从2023年的39.1亿美元增长到2031年的51.8亿美元,2024-2031年预测期间复合年增长率为3.58%。预计将增长到2031年的51.8亿美元。美元。
由于蔬菜和水果摄取不足、过量饮酒、久坐的生活方式、吸烟、肥胖和加工肉类的大量消费,结直肠癌患病率不断上升,为市场提供了利润丰厚的增长机会。
转移性结直肠癌市场的发展得益于医疗领域支出的增加、世界各国政府的大力支持、研发活动的增加以及积极努力开发新的诊断技术和加强现有技术。多种因素,包括 意识的提高、人口老化、政府不断采取措施提供负担得起的治疗和诊断解决方案,以及有利的报销政策,也为市场提供了有利的成长机会。
此外,包括食品药物管理局 (FDA) 在内的各个监管机构越来越多地批准各种诊断和治疗解决方案,这进一步推动了市场扩张。 例如,2023年,Foundation Medicine的FoundationOne Liquid CDx被FDA批准为恩科拉非尼和西妥昔单抗联合治疗的伴随诊断。 FDA 批准此联合疗法用于治疗先前接受过 BRAF V600E 突变的转移性大肠直肠癌患者。
开发新诊断解决方案的研究活动支持市场发展
由于转移性结直肠癌的死亡率很高,早期检测对于改善患者预后至关重要,并且正在进行各种研究活动来筛选结直肠癌的转移性生物标誌物。我是。 例如,伊朗哈马丹医科大学的研究人员正在使用实验验证和机器学习方法来研究与转移性大肠直肠癌相关的生物标记。 这项研究的结果在机器学习演算法的帮助下,有望为转移性大肠直肠癌生物标记的鑑定提供新的见解,并为治疗该疾病的创新治疗策略奠定基础。
策略联盟支持市场拓展
策略联盟使製药公司能够测试和开发新药,满足所需的功效和安全标准,并加快药物开发过程。 此类合作加强了药品分销流程并支持药品的共同开发和商业化。
本报告调查了全球转移性结直肠癌市场,提供了市场定义和概述、市场规模趋势和预测、各个细分市场和地区的详细分析、行业结构以及影响市场成长的因素。分析、案例研究、竞争格局、以及主要公司的简介。
Global metastatic colorectal cancer market is projected to witness a CAGR of 3.58% during the forecast period 2024-2031, growing from USD 3.91 billion in 2023 to USD 5.18 billion in 2031F. The increasing prevalence of colorectal cancer due to low intake of fruits and vegetables, excessive alcohol consumption, sedentary lifestyle, smoking, obesity, and high intake of processed meats is providing lucrative growth opportunities to the market.
Growth of the metastatic colorectal cancer market is driven by various factors including increased spendings towards healthcare sector, rising support from various governments across the globe, growing research and development activities, and rising efforts towards development of novel diagnostic techniques and enhancement of existing techniques. Increasing awareness, ageing population, and rising government initiatives to provide affordable treatment and diagnostic solutions in combination with the presence of favorable reimbursement policies providing lucrative growth opportunities to the market.
Increasing approval for various diagnostic and treatment solutions by different regulatory bodies including the Food and Drug Administration (FDA) is further supporting the market expansion. For instance, in 2023, the FDA approved Foundation Medicine's FoundationOne Liquid CDx as a companion diagnostic for encorafenib combined with cetuximab. The combination therapy received FDA approval for patients with previously treated metastatic colorectal cancer with BRAF V600E alteration.
FoundationOne Liquid CDx became the first comprehensive genomic profiling test that was approved by the Food and Drug Administration for detecting BRAF V600E mutations in patients with metastatic colorectal cancer. The companion diagnostic indication provides oncologists with non-invasive and important genomic testing solutions for patients with metastatic cancers.
Research Activities for Development of Novel Diagnostic Solutions Support Market Growth
Due to the high fatality rate of metastatic colorectal cancer, early detection is essential for enhancing patient outcomes therefore, various research activities are underway for screening metastatic biomarkers in colorectal cancer. For instance, research is being conducted by the researchers of Hamadan University of Medical Sciences, Hamadan, Iran for the investigation of metastatic colorectal cancer related biomarkers by employing experimental validation and a machine learning approach. The findings of the research are expected to offer novel insights for the identification of biomarkers for metastatic colorectal cancer with the help of machine learning algorithms, laying the groundwork for innovative therapeutic strategies for disease treatment. Through machine learning algorithms 11 biomarkers were identified and 4 were experimentally validated. The joint applications of these genes can augment the development of innovative AI predictive models and can be considered as a diagnostic panel for metastatic assessment.
Strategic Collaborations Support Market Expansion
Strategic collaborations allow pharmaceutical companies to test and develop novel drugs, ensuring that they meet the required efficacy and safety standards, and fast-track the drug development process. Such collaborations bolster the drug distribution process and support the co-development and commercialization of drugs. For instance, Taiho Pharmaceutical, the company that manufactures Lonsurf (trifluridine and tipiracil) signed an exclusive license agreement for commercializing and co-developing the drug with Servier in Europe. In August 2023, Lonsurf received approval from the Food and Drug Administration for treating patients with metastatic colorectal cancer in combination with bevacizumab or as a single agent in patients who were previously treated with anti-epidermal Growth Factor Receptor (EGFR) antibodies, fluoropyrimidine, bevacizumab, oxaliplatin, and irinotecan have been diagnosed with RAS wild-type metastatic colorectal cancer.
North America Accounts for Significant Market Share
It is estimated that colorectal cancer is the fourth most diagnosed cancer among individuals aging 30 to 39 years in the United States. The increasing prevalence of colorectal cancer, presence of a well-established healthcare infrastructure, and increasing investments by leading research institutions and market players towards metastatic colorectal cancer are supporting the market expansion in North America. The high awareness among the regional population about diagnostic devices and testing coupled with government policies is further supporting the market expansion in the region. The rising investments of various market players and research institutions towards research and development activities are providing lucrative growth opportunities to the market.
For instance, the University of Florida is conducting a randomized interventional phase 2 study to investigate the utilization of the standard scan-based approach versus the Signatera ctDNA assay for guiding treatment in patients suffering from metastatic colorectal cancer. The main aim of the study is to compare and measure the best overall response, survival, and progression-free survival of the subjects whose treatment had been developed using these two approaches.
Chemotherapy Holds a Significant Market Share
Utilization of chemotherapy for the treatment of metastatic colorectal cancer relieves symptoms and prolongs the lifespan of the patients. Chemotherapy is used for destroying cancer cells and preventing them from multiplying, dividing, and growing. It is a form of systemic medication that travels through the bloodstream, reaching all the body parts. Doublet chemotherapy or triplet therapy should be offered to patients suffering from initially unresectable and previously untreated metastatic colorectal cancer. Chemotherapy in combination with other therapies and surgeries is recommended for treatment of metastatic colorectal cancer.
For instance, anti-epidermal growth factor receptor therapy and chemotherapy is recommended for proficient mismatch repair left-sided treatment-naive RAS wild-type metastatic colorectal cancer and for proficient mismatch repair RAS wild-type right-sided metastatic colorectal cancer. System chemotherapy plus cytoreductive surgery is often recommended for selected patients, with colorectal peritoneal metastases. Surgery alone or perioperative chemotherapy are offered to patients with metastatic colorectal cancer who are candidates for curative resection of liver metastases.
Advancements in In-vitro Diagnostic Solutions
The continuous advancements in the development of diagnostic solutions are offering lucrative growth opportunities to the market. The advancements are ensuring the provision of quality care to patients suffering from metastatic colorectal cancer and garnering approval from different regulatory bodies. For instance, in 2023, the Food and Drug Administration approved a RAS Mutation Detection Kit as a companion diagnostic for panitum. The kit is expected to increase access to RAS testing at the mid and small-sized laboratories by improving the turnaround time and simplifying the testing procedure while lowering the diagnostic costs. The molecular in-vitro diagnostic tool has been designed for detecting thirty-five variants of KRAS and NRAS exon 2, 3, and 4 somatic mutations in patients suffering from colorectal cancer via the extracted genomic DNA from paraffin-embedded, formalin-fixed embedded colorectal cancer tissue samples.
Future Market Scenario (2024 - 2031F)
Drug delivery systems using bacteria, cell manipulation techniques for immunotherapy, and nanotechnology promise viable and emerging therapeutic options for patients who are not benefitting from the treatment options that are currently available. Combining nanotechnology with immunotherapy and other targeted therapies as a means of delivering drugs that have systemic toxicity and are otherwise non-selective is expected to offer novel strategic venue for the treatment of metastatic colorectal cancer. Emerging technologies in pre-clinical phase studies including immunostimulatory cytokines, microbial therapies, and nanotechnology offer possibilities for therapeutic deliveries.
Key Players Landscape and Outlook
Key participants in the metastatic colorectal cancer market are Amgen, Inc., Sanofi S.A., F. Hoffmann-La Roche AG, Eli Lilly and Company, and Bristol-Myers Squibb Co. The market is expected to witness significant growth over the forecast period due to rising research and development activities by the leading market players.
In 2023, Amgen released data from their global Phase 3 CodeBreaK 300 trial that evaluated panitumumab in combination with two doses of sotorasib. The doses showed statistically significant superiority and the results were showcased during the European Society for Medical Oncology (ESMO) 2023. The data showed consistent efficacy across major subgroups and supports the combination of the two biomarker-directed therapies.
All segments will be provided for all regions and countries covered
Companies mentioned above DO NOT hold any order as per market share and can be changed as per information available during research work