市场调查报告书
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1461247
盐酸去甲替林全球市场:依纯度、形式、应用和地区划分的机会和预测(2017-2031)Nortriptyline Hydrochloride Market Assessment, By Purity, By Form, By Application, By Region, Opportunities and Forecast, 2017-2031F |
全球盐酸去甲替林市场规模预计将从 2023 年的 2.397 亿美元成长到 2031 年的 2.8752 亿美元,在 2024-2031 年的预测期内复合年增长率为 2.3%。神经痛和忧郁症等情绪障碍盛行率的上升推动了市场的成长。
去甲替林抑制突触前神经元细胞膜对去甲肾上腺素和血清素的再摄取,增加突触内这些神经传导物质的浓度。去甲替林也抑制乙酰胆碱、组织胺和 5-羟色胺的活性。世界各地忧郁症盛行率上升是推动市场成长的主要市场趋势之一。例如,世界卫生组织 (WHO) 估计世界上大约 5% 的成年人患有忧郁症。女性忧郁症的发生率比男性高 50%。越来越多的忧郁症患者为市场提供了利润丰厚的成长机会,因为盐酸去甲替林(阿米替林的活性代谢物)可作为三环抗忧郁药,用于治疗重度忧郁症。
患有神经性疼痛的患者数量不断增加也是推动盐酸去甲替林全球市场规模的主要因素。去甲替林透过增加作用于背根神经节内非神经卫星细胞上表现的 B2 肾上腺素受体的去甲肾上腺素水平来减轻神经性疼痛。刺激 B2 肾上腺素受体可减少神经性 TNFa 的产生并减轻神经性疼痛。去甲替林通常以溶液或胶囊形式口服。胶囊剂有多种规格,如 75mg、50mg、25mg 和 10mg,溶液剂的成分为 10mg/5mL (473mL)。因此,越来越多的神经性疼痛患者增加了对盐酸去甲替林的需求,促进了疼痛治疗药物的生产,并为市场提供了利润丰厚的成长机会。
该报告考察了全球盐酸去甲替林市场,并提供了市场概述,包括依纯度、形式、应用、地区和参与市场的公司概况划分的趋势。
Global nortriptyline hydrochloride market is projected to witness a CAGR of 2.3% during the forecast period 2024-2031, growing from USD 239.7 million in 2023 to USD 287.52 million in 2031F. The market growth is aided by increasing incidences of nerve pain and the rising prevalence of mood disorders such as depression.
Nortriptyline inhibits the reuptake of norepinephrine and serotonin by the presynaptic neuronal membrane, resulting in an increased concentration of these neurotransmitters in the synapse. Nortriptyline also inhibits the activity of acetylcholine, histamine, and 5-hydroxytryptamine. The increasing prevalence of depression in various regions around the globe is one of the major market trends that is fostering market growth. For instance, according to the estimates of the World Health Organization (WHO), approximately 5% of the adult global population suffers from depression. It is 50% more common in women as compared to men. This increase in the number of individuals suffering from depression will provide lucrative growth opportunities to the market as nortriptyline hydrochloride, an active metabolite of amitriptyline acts as a tricyclic antidepressant and is used for treating major depression.
The rise in incidences of individuals suffering from neuropathic pain is another major factor bolstering the global nortriptyline hydrochloride market size. Nortriptyline reduces neuropathic pain by increasing noradrenaline levels that act within the dorsal root ganglia on B2-adrenoceptors expressed by the non-neuronal satellite cells. Stimulating B2-adrenoceptors results in the reduced neuropathy-induced production of TNFa, thereby relieving neuropathic pain. Nortriptyline is usually administered orally as a solution or a capsule. The capsule is available in varying strengths including 75 mg, 50 mg, 25 mg, and 10 mg and the solution is available in the composition of 10mg/ 5mL (473 mL). Hence, due to the increasing cases of individuals suffering from neuropathic pain, the requirement for nortriptyline hydrochloride is rising to support the production of medication for pain management, thereby providing lucrative growth opportunities to the market.
Growing Prevalence of Depression Supports Global Nortriptyline Hydrochloride Market Growth
The nortriptyline hydrochloride treats depression by increasing the quantity of norepinephrine and serotonin in the brain, the substances that are responsible for regulating mood. Thus, supporting the market's growth by propelling the demand for nortriptyline hydrochloride. The dosage of the medication is based on the condition of the patient and their response to the treatment. The dose of the medication is directed at a lower range which is then increased gradually to reduce the risk of side effects associated with the medication.
The susceptibility of the contemporary population to depression is growing due to several factors including intense individual competitiveness, rising social failure, low social support, and increased inequality. For instance, according to the estimates of the World Health Organization (WHO), approximately 3.8% of the population suffers from depression. This includes 5% of the adult population of which 5.7% are older than 60 years. Nearly 280 million individuals across the globe are living with depression. Hence, this increase will augment the requirement for nortriptyline hydrochloride as the product belongs to a group of medications that are known as tricyclic antidepressants.
Increasing Incidences of Diabetic Neuropathy Boosts Global Nortriptyline Hydrochloride Market Demand
The presence of high blood glucose levels and fats, including triglycerides in blood due to diabetes can result in nerve damage causing diabetic neuropathy. High blood sugar levels can also cause damage to the blood vessels that provide the nerves with nutrients and oxygen. For instance, according to the estimates of the National Institute of Diabetes and Digestive and Kidney Diseases, approximately 30% of the individuals suffering from diabetes have automatic neuropathy. This, in turn, is bolstering the requirement for nortriptyline hydrochloride to support the production of medication for managing diabetic neuropathy. Henceforth, augmenting the market demand in various regions across the globe.
Meanwhile, the rising consumption of food products with high amounts of sugar and carbonated beverages coupled with changing lifestyle patterns are increasing the number of individuals suffering from diabetes. This, in turn, is propelling the incidences of diabetic neuropathy, bolstering the product demand to ensure the production of appropriate medication to support the management of the condition. For instance, according to the projections of the International Diabetes Federation, by 2045, approximately 783 million people, 1 in 8 adults, will be living with diabetes. As the incidences of diabetes increase, the cases of diabetic neuropathy will also increase, thus augmenting the global nortriptyline hydrochloride market growth.
North America Accounts for Significant Market Share
The presence of a well-established healthcare sector and increasing investments by various pharmaceutical, healthcare, and biotechnology companies towards research and development activities is bolstering the demand for nortriptyline hydrochloride in various countries in North America. The increasing prevalence of depression in the region is further supporting the market expansion. For instance, according to the estimates of Mental Health America, more than 8% of American adults, approximately 21 million individuals are affected by depression. This increased prevalence coupled with the easy accessibility to various medications that help in treating depression are supporting the market growth as nortriptyline hydrochloride works as a tricyclic antidepressant. Therefore, the increasing incidences of individuals suffering from chronic pain is another major factor supporting the market expansion in the region, as the product finds applications in various medications that are used for treating chronic pain.
Rising Demand for More than 99% Nortriptyline Hydrochloride Boosts Market Growth
The increasing requirement for nortriptyline hydrochloride with more than 99% purity can be attributed to their rising demand by academic and research institutions and medicine manufacturing facilities in various regions across the globe. The pharmaceutical sector is significantly growing in various regions, for instance, according to the estimates of The Association of the British Pharmaceutical Industry, the pharmaceutical industry spends approximately USD 160 billion every year on research and development activities as the development of novel medications involves significant rates of failure. Due to such growing efforts and investments in medicine manufacturing, the requirement for nortriptyline hydrochloride will increase, thus propelling the growth of the market. The preference for nortriptyline hydrochloride with more than 99% purity can also be attributed to the high efficacy offered by the product as opposed to their counterparts, thus augmenting their demand, and supporting the expansion of the market.
Capsules Account for Significant Global Nortriptyline Hydrochloride Market Share
The expansion of the segment can be attributed to the higher bioavailability offered by the capsules as opposed to their counterparts, making them more effective than tablets. The nortriptyline hydrochloride capsules contain various inactive ingredients including sodium lauryl sulfate, colloidal silicon dioxide, pregelatinized starch, and magnesium stearate. For instance, the 75 mg, 50 mg, 25 mg, and 10 mg capsule shells contain titanium dioxide, gelatin, sodium lauryl sulfate, propylparaben, and methylparaben. They can also contain edetate calcium disodium, benzyl alcohol, silicon dioxide or sodium propionate, and butylparaben. The 75 mg, 25 mg, and 10 mg capsule shells also contain FD&C Blue No. 1 and D&C Yellow No. 10. The nortriptyline hydrochloride is usually prescribed for the smallest quantity of capsules with good patient management, to reduce the risk of overdose. Thus, the increased accessibility to nortriptyline hydrochloride capsules coupled with the rising awareness about mental health and depression are supporting the growth of the segment, thus boosting the market expansion.
Future Market Scenario (2024-2031F)
According to the global nortriptyline hydrochloride market analysis, the demand for nortriptyline hydrochloride will increase over the forecast period due to increasing research and development activities and utilization of the product for drug repurposing. Various studies are being conducted to evaluate the potential candidacy of nortriptyline hydrochloride for repurposing of drugs. For instance, according to an article published by researchers from the Department of Oncology, the Affiliated Hospital of Qingdao University, Qingdao, China, nortriptyline hydrochloride exhibits significant antitumor activities in both in-vitro and in-vivo. The product can inhibit gastric cancer by inducing oxidative stress and apoptosis. Conduction of such studies will bolster the requirement for nortriptyline hydrochloride over the forecast period by academic and research institutions augmenting the market demand.
Key Players Landscape and Outlook
The companies are undergoing continuous research and development. Furthermore, they are collaborating with other companies and organizations to support their R&D activities. Such initiatives will provide lucrative growth opportunities for the market as at times such efforts bring economies of scope that would not have been possible through organic growth. Thus, supporting the expansion of the global nortriptyline hydrochloride market.
In October 2023, Viatris Inc., one of the leading healthcare and pharmaceutical corporations, announced that they would be selling their Active Pharmaceutical Ingredients (API) business to Iquest Enterprises. The transaction includes a research and development lab and three manufacturing sites in Hyderabad, third-party API sales, and three manufacturing sites in Vizag.
All segments will be provided for all regions and countries covered
Companies mentioned above DO NOT hold any order as per market share and can be changed as per information available during research work