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2023-2030年全球分子细胞遗传学市场Global Molecular Cytogenetics Market 2023-2030 |
荧光原位杂交(FISH)研究是癌症和白血病诊断和临床研究以及诊断的重要工具。FISH可用于评估染色体异常,其荧光标记的DNA探针针对特定的DNA序列。基于FISH的测试和比较基因组杂交(CGH),以及多色核型,已经在临床应用中得到利用。这些测试可以对基因组失衡进行全局扫描,并解决复杂的核型畸变问题。跨物种阵列CGH分析已被用于癌症基因的鉴定。
FISH的临床效果至关重要,主要是在血液病的诊断、预后和治疗决策方面,这有利于个性化医疗领域的发展。分子细胞遗传学能够正确区分致癌细胞和正常细胞,这反过来又导致了它在癌症诊断中的应用。此外,由于下一代测序(NGS)的出现和个性化药物研究的增加,该市场有很大的增长机会。然而,限制市场增长的某些因素包括仪器的高成本和不利于基因组工具的报销政策。
Global molecular cytogenetics market is estimated to grow at a CAGR of 8.5% during the forecast period. The major factors contributing to the growth of the market include a significant prevalence of Cancer and increasing demand for genetic testing tools. As per the World Health Organization (WHO), the global Cancer burden is estimated to have risen to 18.1 million new cases and 9.6 million mortality in 2018. 43.8 million persons were living with Cancer in 2018 and were diagnosed within the last 5 years. This rising prevalence of Cancer is attributed to the demand for molecular cytogenetic tools.
Fluorescence in-situ hybridization (FISH) study is a crucial tool for both diagnostics and clinical research, as well as diagnostics, in Cancer and Leukemia. FISH can be utilized to assess chromosomal abnormalities with fluorescent-labeled DNA probes that target specific DNA sequences. FISH-based tests and comparative genomic hybridization (CGH), and multicolor karyotyping, have been utilized in clinical applications. These tests allow the whole global scanning of genomic imbalances and the resolution of complex karyotypic aberrations. Cross-species array CGH analysis has been used in the identification of Cancer genes.
The clinical effect of FISH is crucial, primarily in the diagnosis, prognosis, and treatment decisions for hematological conditions, which facilitate the area of personalized medicine. Molecular cytogenetics enables to properly differentiate of Cancer-causing and normal cells, which in turn, is leading to its adoption in Cancer diagnostics. Further, the market has significant growth opportunities owing to the advent of next-generation sequencing (NGS) and increasing research on personalized medicines. However, certain factors restricting market growth include the high cost of instruments and unfavorable reimbursement policies for genomic tools.
The global molecular cytogenetics market is segmented based on its product, application, and technique. Based on product, the market is segmented into consumables, software & services, and instruments. Based on application, the market is categorized into cancer, genetic disorders, and personalized medicine. Further, based on technique, the market is segmented into fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH), and others. Among the product segments, the consumables segment is expected to hold a prominent market share due to the recurring demand for consumables in diagnostic procedures.
Fluorescence in situ hybridization (FISH) is one of the major techniques in molecular cytogenetics testing.
Molecular cytogenetic techniques mainly rely on FISH, which is based on the principle of complementary hybridization of labeled DNA or RNA probes with normal or abnormal nucleic acid sequences on metaphase chromosomes, interphase cells, or tissue sections. FISH takes us to a colorful chromosome world, which involves a fluorescently labeled DNA probe hybridized to a specific genomic segment of interest. FISH can detect small chromosomal rearrangements that cannot be detected by conventional cytogenetic techniques. The use of the FISH technique enhanced the interpretation of the numerical and complex chromosomal rearrangements, bridging the gap between conventional cytogenetics and molecular biology. Therefore, it is being significantly adopted technique in genome research and cancer diagnostics. In genome research, FISH enables researchers to map and visualize the genetic material in an individual's cells, including portions of genes or specific genes. This technique may be applied to understand a range of chromosomal abnormalities and other genetic mutations.
Regional Outlooks
The global molecular cytogenetics market is further segmented based on geography, including North America, Europe, Asia-Pacific, and the Rest of the World. The market can be analyzed for a particular region or country level as per the requirement. The Asia-Pacific region is projected to experience considerable growth in the molecular cytogenetics market due to rising healthcare expenditure and increasing awareness about personalized medicine in the region.
Global Molecular Cytogenetics Market Growth, by Region 2023-2030
Source: OMR Analysis
Among these, the North American region is anticipated to hold a significant market share owing to the significant prevalence of Cancer, increasing funding for genome research, and significant share in life science research in the region. In addition, the presence of major players, including Abbott Laboratories, Inc., Thermo Fisher Scientific Inc., and Illumina, Inc. are offering a potential opportunity for market growth in the region. These companies are focusing on introducing advanced molecular cytogenetics tools that will likely increase their market share.
Market Players Outlook
The major players in the global molecular cytogenetics market include Abbott Laboratories, Inc., Thermo Fisher Scientific Inc., Illumina, Inc., Bio-Rad Laboratories Inc., and F. Hoffman La-Roche AG. Product launches and mergers and acquisitions are considered some key strategies adopted by the market players to increase market share and gain a competitive advantage. For instance, in January 2020, Oxford Gene Technology (OGT) introduced an NGS panel for constitutional cytogenetics research. The CytoSure Constitutional NGS Panel enables reliable and accurate detection of copy number variations (CNVs), insertion/deletions (indels), single nucleotide variations (SNVs), and loss of heterozygosity (LOH), such as in mosaic samples. It combines the advantages of NGS and microarrays in one cost-effective assay. This new launch will likely support those laboratories that are focusing on transitioning from arrays to NGS.