市场调查报告书
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2023-2030 年全球 CRISPR 与 Cas 基因市场Global CRISPR and Cas Genes Market 2023-2030 |
根据美国国立卫生研究院 (NIH) 的数据,2022 年 12 月,CRISPR/Cas9 是主要工具 (85%),其次是 TALEN (3.0%)。水稻(13.0%)、番茄(7.0%)和小麦/大麦(3%)是研究最多的植物,而猪(7.0%)、鸡(2.0%)和牛(2.0%)是主要动物物种被调查的。
全球 CRISPR 和 Cas 基因市场按产品类型、服务类型和垂直行业细分。根据产品类型,市场分为基于载体的 Cas 和无 DNA Cas。根据服务类型,市场细分为细胞系工程、gRNA 设计、微生物基因编辑和 DNA 合成。根据应用,市场细分为基因组工程、疾病模型、功能基因体学等。此外,根据最终用户,市场又细分为生物技术公司以及製药、学术和政府研究机构以及 CRO。在这些服务类型中,由于可用于编辑微生物内基因的 CRISPR-Cas9 的开发不断增加,微生物基因编辑细分市场预计将占据相当大的市场份额。这种编辑过程具有广泛的应用,包括基础生物学研究、生物技术产品的开发和疾病的治疗。 ICRISPR-Cas系统也被用于治疗其他血液疾病,例如镰状细胞疾病(SCD)和B型血友病(HB)。它不仅限于治疗遗传性疾病,而且还被发现对治疗转移性癌症有效。
其中,基因组工程细分领域预计将在全球CRISPR和Cas基因市场中占据相当大的份额。分段成长归因于CRISPR和Cas技术在纠正致病突变、寻找癌症免疫治疗必需基因以及解决器官异种移植关键问题等领域的影响力日益增强。 CRISPR 和 Cas 基因产品的推出标誌着针对快速发展的基因组编辑和基因功能修改领域的专用解决方案。例如,2021 年 6 月,QIAGEN 推出了专用 CRISPR 产品,用于快速、简化地分析基因编辑实验。该公司推出了 QIAprep& CRISPR Kit 和 CRISPR Q-Primer Solutions,使研究人员能够以无与伦比的速度和效率分析编辑后的遗传物质,以确定他们的干预措施如何改变了相关 DNA 序列的功能。
全球 CRISPR 和 Cas 基因市场根据地理位置进一步细分,包括北美(美国和加拿大)、欧洲(英国、义大利、西班牙、德国、法国和欧洲其他地区)、亚太地区(印度、中国) 、日本、韩国和亚洲其他地区)以及世界其他地区(中东和非洲以及拉丁美洲)。其中,北美地区预计将在全球市场中占据显着份额,因为增强型单一产品的可用性,例如简单的基因敲除、选择性基因组切割、减少脱靶切割、基因组工程和更高的特异性。主要市场参与者包括Addgene Inc.、Danaher Corp.、GenScript Biotech、Takara Bio Inc.、赛默飞世尔科技公司等。
在所有地区中,亚太地区预计在预测期内将以可观的CAGR成长。区域成长归因于政府增加研发投资以开发新疗法,有助于市场扩张日本和中国预计将支持该地区的成长。例如,2021 年 3 月,日本生物技术公司 Setsuro Tech 从都柏林 ERS Genomics 获得了 CRISPR-Cas9 技术的专利。该公司正在利用这些先进技术创建动物和细胞模型。预计此类措施将增强该地区 CRISPR 技术的采用,进一步促进创造收入。
服务于 CRISPR 和 Cas Genes 市场的主要公司包括: Danaher Corp.、GenScript Biotech、Merck KGaA、Thermo Fisher Scientific, Inc.、Bio-Rad Laboratories, Inc.、GE Healthcare、Qiagen NV 等。市场参与者透过各种策略(包括併购、合作、合作、融资和新产品发布),为市场成长做出了巨大贡献,以保持市场竞争力。例如,2020 年6 月,Regeneron Pharmaceuticals, Inc. 和Intellia Therapeutics, Inc. 合作,为Regeneron 提供开发其他基于CRISPR/Cas9 的体内治疗靶点的产品的权利,并让两家公司共同开发用于治疗的潜在产品血友病A和B。
Title: Global CRISPR and Cas Genes Market Size, Share & Trends Analysis Report by Product Type (Vector-based Cas and DNA-free Cas), by Service Type (Cell Line Engineering, gRNA design, Microbial Gene Editing and DNA Synthesis), by Application (Genome Engineering, Disease Models, Functional Genomics and Other) and by End Users (Biotechnology Companies & Pharmaceutical, Academic and Government Research Institute and CROs),Forecast Period (2023-2030).
Global CRISPR and Cas genes market is anticipated to grow at a CAGR of 13.5% during the Forecast Period (2023-2030). CRISPR-Cas systems are the most widely used genome editing technology in molecular biology laboratories around the globe. The growing adoption of CRISPR-based screens with the improving genomic target is the key factor supporting the growth of the market globally. According to the National Institute of Health (NIH), in April 2020, CRISPR-based screens demonstrated improved versatility, efficacy, and lower off-target effects compared with approaches such as RNAi. Genome-wide CRISPR screen has emerged as a powerful tool for performing large-scale loss-of-function screens, with low noise, high knockout efficiency, and minimal off-target effects. Hence, the market players are also focusing on introducing CRISPR genome-wide knockout library solutions that further bolster the market growth. For instance, in October 2023, Cellecta, Inc. launched genome-wide CRISPR Chicken and Pig Knockout Libraries. Cellecta, Inc. released new pooled, single-module, CRISPR genome-wide knockout libraries for chicken (Gallus gallus) and pig (Sus scrofa). The new libraries allow the study of gene disruptions in a single experiment to enable improved breeding and more.
According to the National Institute of Health (NIH), in December 2022, CRISPR/Cas9 was the predominant tool (85%), followed by TALEN (3.0%). Rice (13.0%), tomato (7.0%), and wheat/barley (3%) were the most studied plants, whereas pig (7.0%), chicken (2.0%), and cow (2.0%) were the main animal species that were investigated.
The global CRISPR and Cas genes market is segmented on the product type, service type, and industry verticals. Based on the product type, the market is sub-segmented into vector-based Cas and DNA-free Cas. Based on the service type, the market is sub-segmented into cell line engineering, gRNA design, microbial gene editing, and DNA synthesis. Based on the application, the market is sub-segmented into genome engineering, disease models, functional genomics, and others. Further, based on end users, the market is sub-segmented into biotechnology companies and pharmaceutical, academic, and government research institutes and CROs. Among the service types, the microbial gene editing sub-segment is anticipated to hold a considerable share of the market owing to the rise in the development of CRISPR-Cas9 which can be used to edit genes within microorganisms. This editing process has a wide variety of applications including basic biological research, development of biotechnological products, and treatment of diseases. ICRISPR-Cas systems have also been used for the treatment of other hematologic diseases, such as sickle cell disease (SCD) and hemophilia B (HB). It is not only limited to the treatment of genetic disorders but also it has been found effective for the treatment of metastatic cancer.
Among the applications, the genome engineering sub-segment is expected to hold a considerable share of the global CRISPR and Cas genes market. The segmental growth is attributed to the growing influence of CRISPR and Cas technology in the field of correcting pathogenic mutations, searching for essential genes for cancer immunotherapy, and solving key problems in organ xenotransplantation. CRISPR and Cas genes product launch marks dedicated solutions specific to the fast-growing field of editing genomes and modifying gene function. For instance, in June 2021, QIAGEN launched dedicated CRISPR Products for rapid and simplified analysis of gene-editing experiments. The company launched QIAprep& CRISPR Kit and CRISPR Q-Primer Solutions that allow researchers to analyze edited genetic material with unparalleled speed and efficiency to determine how their interventions have changed the function of the DNA sequence in question.
The global CRISPR and Cas genes market is further segmented based on geography including North America (the US, and Canada), Europe (UK, Italy, Spain, Germany, France, and the Rest of Europe), Asia-Pacific (India, China, Japan, South Korea, and Rest of Asia), and the Rest of the World (the Middle East & Africa, and Latin America. Among these, North America is anticipated to hold a prominent share of the market across the globe, owing to the availability of enhanced individual products such as simple gene knockouts, selective genome cleavage, reduced off-target cutting, genome engineering, and higher specificity. The key market players include Addgene Inc., Danaher Corp., GenScript Biotech, Takara Bio Inc., Thermo Fisher Scientific, Inc., and others.
Among all regions, the Asia-Pacific region is anticipated to grow at a considerable CAGR over the forecast period. Regional growth is attributed to increasing government investment in R&D to develop novel treatments is aiding in market expansion Japan and China are anticipated to support the region's growth. For instance, in March 2021, Japanese biotech company Setsuro Tech received a patent for CRISPR-Cas9 technology from Dublin-based ERS Genomics. The company is creating animal and cell models using these advanced technologies. Such initiatives are predicted to enhance CRISPR technology adoption in the region, further contributing towards revenue generation.
The major companies serving the CRISPR and Cas Genes market include: Danaher Corp., GenScript Biotech, Merck KGaA, Thermo Fisher Scientific, Inc., Bio-Rad Laboratories, Inc., GE Healthcare, Qiagen NV, and others. The market players are considerably contributing to the market growth by the adoption of various strategies including mergers and acquisitions, partnerships, collaborations, funding, and new product launches, to stay competitive in the market. For instance, in June 2020, Regeneron Pharmaceuticals, Inc. and Intellia Therapeutics, Inc. collaborated to provide Regeneron with rights to develop products for additional in vivo CRISPR/Cas9-based therapeutic targets and for the companies to jointly develop potential products for the treatment of hemophilia A and B.