The global market for Bi-Specific Antibodies Therapy was estimated to be worth US$ 4165 million in 2024 and is forecast to a readjusted size of US$ 18056 million by 2031 with a CAGR of 23.4% during the forecast period 2025-2031.
A bispecific antibody (BsAb), or specific monoclonal antibody (BsMAb) is an artificial protein comprised of fragments from two different antibodies. By virtue of the inclusion of two different antigen binding regions, a bispecific antibody is capable of recognizing and binding to two different antigens, or two different epitope on an antigen.
The growth of the bispecific antibody therapy market is driven by a combination of rising clinical demand, technological advancements, investment momentum, and regulatory support. One of the primary drivers is the increasing global incidence of cancer-particularly hematological malignancies and treatment-resistant solid tumors-which has created a strong demand for more precise and effective immunotherapies. Bispecific antibodies, with their ability to simultaneously target two different antigens, offer enhanced specificity and immune activation, positioning them as a promising next-generation therapeutic approach in oncology.
Advancements in biotechnology and antibody engineering have significantly accelerated the development of bispecific platforms. Historically, challenges such as structural complexity, poor stability, and low manufacturing yield limited their progress. However, breakthroughs in protein design, expression systems, and drug delivery technologies have enabled the emergence of clinically viable formats such as BiTEs (bispecific T-cell engagers), CrossMabs, and DVD-Igs. These innovations have improved manufacturability, stability, and efficacy, paving the way for a broader clinical pipeline.
In parallel, growing investor interest and funding in the biopharmaceutical sector have fueled the expansion of bispecific antibody R\&D. Both established pharmaceutical companies and biotech startups are increasingly investing in this field, supported by active venture capital and strategic partnerships. Regulatory bodies like the FDA and EMA are also showing flexibility in reviewing novel biologics, facilitating faster development timelines and market access for bispecific therapies.
On the patient side, there is increasing acceptance of targeted, personalized treatments that offer superior outcomes compared to traditional therapies. Bispecific antibodies often demonstrate reduced off-target toxicity and enhanced immune-mediated tumor cell killing, further driving clinical adoption.
In summary, the bispecific antibody therapy market is being propelled by unmet clinical needs, technological maturation, strong financial backing, and a favorable regulatory environment-factors that together are shaping a rapidly growing and high-potential therapeutic space.
Global Bi-Specific Antibodies Therapy key players include Roche, Amgen, Sanofi, Pfizer, Johnson & Johnson, etc. Global top five manufacturers hold a share over 95%. North America is the largest market, with a share about 65%, followed by Europe and China, both have a share over 30 percent. In terms of product, IgG-Based Antibodies is the largest segment, with a share over 85%. And in terms of application, the largest application is Haemophilia, followed by Cancer, etc.
This report aims to provide a comprehensive presentation of the global market for Bi-Specific Antibodies Therapy, focusing on the total sales revenue, key companies market share and ranking, together with an analysis of Bi-Specific Antibodies Therapy by region & country, by Type, and by Application.
The Bi-Specific Antibodies Therapy market size, estimations, and forecasts are provided in terms of sales revenue ($ millions), considering 2024 as the base year, with history and forecast data for the period from 2020 to 2031. With both quantitative and qualitative analysis, to help readers develop business/growth strategies, assess the market competitive situation, analyze their position in the current marketplace, and make informed business decisions regarding Bi-Specific Antibodies Therapy.
Market Segmentation
By Company
- Roche
- Amgen
- Sanofi
- Pfizer
- Johnson & Johnson
- AstraZeneca
- AbbVie
- Lindis Biotech
- MacroGenics, Inc
- Genmab
- Alphamab Co. Ltd
- Akeso, Inc.
Segment by Type
- Fragment-Based Antibodies
- IgG-Based Antibodies
Segment by Application
- Cancer
- Haemophilia
- Other Non-Cancer Diseases
By Region
- North America
- Asia-Pacific
- China
- Japan
- South Korea
- Southeast Asia
- India
- Australia
- Rest of Asia-Pacific
- Europe
- Germany
- France
- U.K.
- Italy
- Netherlands
- Nordic Countries
- Rest of Europe
- Latin America
- Mexico
- Brazil
- Rest of Latin America
- Middle East & Africa
- Turkey
- Saudi Arabia
- UAE
- Rest of MEA
Chapter Outline
Chapter 1: Introduces the report scope of the report, global total market size. This chapter also provides the market dynamics, latest developments of the market, the driving factors and restrictive factors of the market, the challenges and risks faced by manufacturers in the industry, and the analysis of relevant policies in the industry.
Chapter 2: Detailed analysis of Bi-Specific Antibodies Therapy company competitive landscape, revenue market share, latest development plan, merger, and acquisition information, etc.
Chapter 3: Provides the analysis of various market segments by Type, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different market segments.
Chapter 4: Provides the analysis of various market segments by Application, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different downstream markets.
Chapter 5: Revenue of Bi-Specific Antibodies Therapy in regional level. It provides a quantitative analysis of the market size and development potential of each region and introduces the market development, future development prospects, market space, and market size of each country in the world.
Chapter 6: Revenue of Bi-Specific Antibodies Therapy in country level. It provides sigmate data by Type, and by Application for each country/region.
Chapter 7: Provides profiles of key players, introducing the basic situation of the main companies in the market in detail, including product revenue, gross margin, product introduction, recent development, etc.
Chapter 8: Analysis of industrial chain, including the upstream and downstream of the industry.
Chapter 9: Conclusion.
Table of Contents
1 Market Overview
- 1.1 Bi-Specific Antibodies Therapy Product Introduction
- 1.2 Global Bi-Specific Antibodies Therapy Market Size Forecast (2020-2031)
- 1.3 Bi-Specific Antibodies Therapy Market Trends & Drivers
- 1.3.1 Bi-Specific Antibodies Therapy Industry Trends
- 1.3.2 Bi-Specific Antibodies Therapy Market Drivers & Opportunity
- 1.3.3 Bi-Specific Antibodies Therapy Market Challenges
- 1.3.4 Bi-Specific Antibodies Therapy Market Restraints
- 1.4 Assumptions and Limitations
- 1.5 Study Objectives
- 1.6 Years Considered
2 Competitive Analysis by Company
- 2.1 Global Bi-Specific Antibodies Therapy Players Revenue Ranking (2024)
- 2.2 Global Bi-Specific Antibodies Therapy Revenue by Company (2020-2025)
- 2.3 Key Companies Bi-Specific Antibodies Therapy Manufacturing Base Distribution and Headquarters
- 2.4 Key Companies Bi-Specific Antibodies Therapy Product Offered
- 2.5 Key Companies Time to Begin Mass Production of Bi-Specific Antibodies Therapy
- 2.6 Bi-Specific Antibodies Therapy Market Competitive Analysis
- 2.6.1 Bi-Specific Antibodies Therapy Market Concentration Rate (2020-2025)
- 2.6.2 Global 5 and 10 Largest Companies by Bi-Specific Antibodies Therapy Revenue in 2024
- 2.6.3 Global Top Companies by Company Type (Tier 1, Tier 2, and Tier 3) & (based on the Revenue in Bi-Specific Antibodies Therapy as of 2024)
- 2.7 Mergers & Acquisitions, Expansion
3 Segmentation by Type
- 3.1 Introduction by Type
- 3.1.1 Fragment-Based Antibodies
- 3.1.2 IgG-Based Antibodies
- 3.2 Global Bi-Specific Antibodies Therapy Sales Value by Type
- 3.2.1 Global Bi-Specific Antibodies Therapy Sales Value by Type (2020 VS 2024 VS 2031)
- 3.2.2 Global Bi-Specific Antibodies Therapy Sales Value, by Type (2020-2031)
- 3.2.3 Global Bi-Specific Antibodies Therapy Sales Value, by Type (%) (2020-2031)
4 Segmentation by Application
- 4.1 Introduction by Application
- 4.1.1 Cancer
- 4.1.2 Haemophilia
- 4.1.3 Other Non-Cancer Diseases
- 4.2 Global Bi-Specific Antibodies Therapy Sales Value by Application
- 4.2.1 Global Bi-Specific Antibodies Therapy Sales Value by Application (2020 VS 2024 VS 2031)
- 4.2.2 Global Bi-Specific Antibodies Therapy Sales Value, by Application (2020-2031)
- 4.2.3 Global Bi-Specific Antibodies Therapy Sales Value, by Application (%) (2020-2031)
5 Segmentation by Region
- 5.1 Global Bi-Specific Antibodies Therapy Sales Value by Region
- 5.1.1 Global Bi-Specific Antibodies Therapy Sales Value by Region: 2020 VS 2024 VS 2031
- 5.1.2 Global Bi-Specific Antibodies Therapy Sales Value by Region (2020-2025)
- 5.1.3 Global Bi-Specific Antibodies Therapy Sales Value by Region (2026-2031)
- 5.1.4 Global Bi-Specific Antibodies Therapy Sales Value by Region (%), (2020-2031)
- 5.2 North America
- 5.2.1 North America Bi-Specific Antibodies Therapy Sales Value, 2020-2031
- 5.2.2 North America Bi-Specific Antibodies Therapy Sales Value by Country (%), 2024 VS 2031
- 5.3 Europe
- 5.3.1 Europe Bi-Specific Antibodies Therapy Sales Value, 2020-2031
- 5.3.2 Europe Bi-Specific Antibodies Therapy Sales Value by Country (%), 2024 VS 2031
- 5.4 Asia Pacific
- 5.4.1 Asia Pacific Bi-Specific Antibodies Therapy Sales Value, 2020-2031
- 5.4.2 Asia Pacific Bi-Specific Antibodies Therapy Sales Value by Region (%), 2024 VS 2031
- 5.5 South America
- 5.5.1 South America Bi-Specific Antibodies Therapy Sales Value, 2020-2031
- 5.5.2 South America Bi-Specific Antibodies Therapy Sales Value by Country (%), 2024 VS 2031
- 5.6 Middle East & Africa
- 5.6.1 Middle East & Africa Bi-Specific Antibodies Therapy Sales Value, 2020-2031
- 5.6.2 Middle East & Africa Bi-Specific Antibodies Therapy Sales Value by Country (%), 2024 VS 2031
6 Segmentation by Key Countries/Regions
- 6.1 Key Countries/Regions Bi-Specific Antibodies Therapy Sales Value Growth Trends, 2020 VS 2024 VS 2031
- 6.2 Key Countries/Regions Bi-Specific Antibodies Therapy Sales Value, 2020-2031
- 6.3 United States
- 6.3.1 United States Bi-Specific Antibodies Therapy Sales Value, 2020-2031
- 6.3.2 United States Bi-Specific Antibodies Therapy Sales Value by Type (%), 2024 VS 2031
- 6.3.3 United States Bi-Specific Antibodies Therapy Sales Value by Application, 2024 VS 2031
- 6.4 Europe
- 6.4.1 Europe Bi-Specific Antibodies Therapy Sales Value, 2020-2031
- 6.4.2 Europe Bi-Specific Antibodies Therapy Sales Value by Type (%), 2024 VS 2031
- 6.4.3 Europe Bi-Specific Antibodies Therapy Sales Value by Application, 2024 VS 2031
- 6.5 China
- 6.5.1 China Bi-Specific Antibodies Therapy Sales Value, 2020-2031
- 6.5.2 China Bi-Specific Antibodies Therapy Sales Value by Type (%), 2024 VS 2031
- 6.5.3 China Bi-Specific Antibodies Therapy Sales Value by Application, 2024 VS 2031
- 6.6 Japan
- 6.6.1 Japan Bi-Specific Antibodies Therapy Sales Value, 2020-2031
- 6.6.2 Japan Bi-Specific Antibodies Therapy Sales Value by Type (%), 2024 VS 2031
- 6.6.3 Japan Bi-Specific Antibodies Therapy Sales Value by Application, 2024 VS 2031
- 6.7 South Korea
- 6.7.1 South Korea Bi-Specific Antibodies Therapy Sales Value, 2020-2031
- 6.7.2 South Korea Bi-Specific Antibodies Therapy Sales Value by Type (%), 2024 VS 2031
- 6.7.3 South Korea Bi-Specific Antibodies Therapy Sales Value by Application, 2024 VS 2031
- 6.8 Southeast Asia
- 6.8.1 Southeast Asia Bi-Specific Antibodies Therapy Sales Value, 2020-2031
- 6.8.2 Southeast Asia Bi-Specific Antibodies Therapy Sales Value by Type (%), 2024 VS 2031
- 6.8.3 Southeast Asia Bi-Specific Antibodies Therapy Sales Value by Application, 2024 VS 2031
- 6.9 India
- 6.9.1 India Bi-Specific Antibodies Therapy Sales Value, 2020-2031
- 6.9.2 India Bi-Specific Antibodies Therapy Sales Value by Type (%), 2024 VS 2031
- 6.9.3 India Bi-Specific Antibodies Therapy Sales Value by Application, 2024 VS 2031
7 Company Profiles
- 7.1 Roche
- 7.1.1 Roche Profile
- 7.1.2 Roche Main Business
- 7.1.3 Roche Bi-Specific Antibodies Therapy Products, Services and Solutions
- 7.1.4 Roche Bi-Specific Antibodies Therapy Revenue (US$ Million) & (2020-2025)
- 7.1.5 Roche Recent Developments
- 7.2 Amgen
- 7.2.1 Amgen Profile
- 7.2.2 Amgen Main Business
- 7.2.3 Amgen Bi-Specific Antibodies Therapy Products, Services and Solutions
- 7.2.4 Amgen Bi-Specific Antibodies Therapy Revenue (US$ Million) & (2020-2025)
- 7.2.5 Amgen Recent Developments
- 7.3 Sanofi
- 7.3.1 Sanofi Profile
- 7.3.2 Sanofi Main Business
- 7.3.3 Sanofi Bi-Specific Antibodies Therapy Products, Services and Solutions
- 7.3.4 Sanofi Bi-Specific Antibodies Therapy Revenue (US$ Million) & (2020-2025)
- 7.3.5 Sanofi Recent Developments
- 7.4 Pfizer
- 7.4.1 Pfizer Profile
- 7.4.2 Pfizer Main Business
- 7.4.3 Pfizer Bi-Specific Antibodies Therapy Products, Services and Solutions
- 7.4.4 Pfizer Bi-Specific Antibodies Therapy Revenue (US$ Million) & (2020-2025)
- 7.4.5 Pfizer Recent Developments
- 7.5 Johnson & Johnson
- 7.5.1 Johnson & Johnson Profile
- 7.5.2 Johnson & Johnson Main Business
- 7.5.3 Johnson & Johnson Bi-Specific Antibodies Therapy Products, Services and Solutions
- 7.5.4 Johnson & Johnson Bi-Specific Antibodies Therapy Revenue (US$ Million) & (2020-2025)
- 7.5.5 Johnson & Johnson Recent Developments
- 7.6 AstraZeneca
- 7.6.1 AstraZeneca Profile
- 7.6.2 AstraZeneca Main Business
- 7.6.3 AstraZeneca Bi-Specific Antibodies Therapy Products, Services and Solutions
- 7.6.4 AstraZeneca Bi-Specific Antibodies Therapy Revenue (US$ Million) & (2020-2025)
- 7.6.5 AstraZeneca Recent Developments
- 7.7 AbbVie
- 7.7.1 AbbVie Profile
- 7.7.2 AbbVie Main Business
- 7.7.3 AbbVie Bi-Specific Antibodies Therapy Products, Services and Solutions
- 7.7.4 AbbVie Bi-Specific Antibodies Therapy Revenue (US$ Million) & (2020-2025)
- 7.7.5 AbbVie Recent Developments
- 7.8 Lindis Biotech
- 7.8.1 Lindis Biotech Profile
- 7.8.2 Lindis Biotech Main Business
- 7.8.3 Lindis Biotech Bi-Specific Antibodies Therapy Products, Services and Solutions
- 7.8.4 Lindis Biotech Bi-Specific Antibodies Therapy Revenue (US$ Million) & (2020-2025)
- 7.8.5 Lindis Biotech Recent Developments
- 7.9 MacroGenics, Inc
- 7.9.1 MacroGenics, Inc Profile
- 7.9.2 MacroGenics, Inc Main Business
- 7.9.3 MacroGenics, Inc Bi-Specific Antibodies Therapy Products, Services and Solutions
- 7.9.4 MacroGenics, Inc Bi-Specific Antibodies Therapy Revenue (US$ Million) & (2020-2025)
- 7.9.5 MacroGenics, Inc Recent Developments
- 7.10 Genmab
- 7.10.1 Genmab Profile
- 7.10.2 Genmab Main Business
- 7.10.3 Genmab Bi-Specific Antibodies Therapy Products, Services and Solutions
- 7.10.4 Genmab Bi-Specific Antibodies Therapy Revenue (US$ Million) & (2020-2025)
- 7.10.5 Genmab Recent Developments
- 7.11 Alphamab Co. Ltd
- 7.11.1 Alphamab Co. Ltd Profile
- 7.11.2 Alphamab Co. Ltd Main Business
- 7.11.3 Alphamab Co. Ltd Bi-Specific Antibodies Therapy Products, Services and Solutions
- 7.11.4 Alphamab Co. Ltd Bi-Specific Antibodies Therapy Revenue (US$ Million) & (2020-2025)
- 7.11.5 Alphamab Co. Ltd Recent Developments
- 7.12 Akeso, Inc.
- 7.12.1 Akeso, Inc. Profile
- 7.12.2 Akeso, Inc. Main Business
- 7.12.3 Akeso, Inc. Bi-Specific Antibodies Therapy Products, Services and Solutions
- 7.12.4 Akeso, Inc. Bi-Specific Antibodies Therapy Revenue (US$ Million) & (2020-2025)
- 7.12.5 Akeso, Inc. Recent Developments
8 Industry Chain Analysis
- 8.1 Bi-Specific Antibodies Therapy Industrial Chain
- 8.2 Bi-Specific Antibodies Therapy Upstream Analysis
- 8.2.1 Key Raw Materials
- 8.2.2 Raw Materials Key Suppliers
- 8.2.3 Manufacturing Cost Structure
- 8.3 Midstream Analysis
- 8.4 Downstream Analysis (Customers Analysis)
- 8.5 Sales Model and Sales Channels
- 8.5.1 Bi-Specific Antibodies Therapy Sales Model
- 8.5.2 Sales Channel
- 8.5.3 Bi-Specific Antibodies Therapy Distributors
9 Research Findings and Conclusion
10 Appendix
- 10.1 Research Methodology
- 10.1.1 Methodology/Research Approach
- 10.1.1.1 Research Programs/Design
- 10.1.1.2 Market Size Estimation
- 10.1.1.3 Market Breakdown and Data Triangulation
- 10.1.2 Data Source
- 10.1.2.1 Secondary Sources
- 10.1.2.2 Primary Sources
- 10.2 Author Details
- 10.3 Disclaimer