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市场调查报告书
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DNA损害反应市场:产业趋势和全球预测 - 各适应疾病，各治疗领域，目标分子，各分子类型，各给药途径，主要各地区

DNA Damage Response Market: Industry Trends and Global Forecasts - Distribution by Target Disease Indication, Therapeutic Area, Target Molecule, Type of Molecule, Route of Administration, and Key Geographical Regions
出版日期: | 出版商: Roots Analysis | 英文 265 Pages | 商品交期: 最快1-2个工作天内

价格

全球DNA损伤反应市场：概览

今年全球DNA损伤反应市场规模达1,300万美元。预计在预测期内，该市场将保持良好的复合年增长率。

市场区隔与机会分析依下列参数细分：

适应疾病

  • 急性骨髓性白血病
  • 新冠肺炎 (COVID-19)
  • 糖尿病黄斑水肿
  • 间皮瘤
  • 骨髓增生异常症候群
  • 非鳞状非小细胞肺癌
  • 摄护腺癌
  • 子宫浆液性癌

治疗领域

  • 骨髓恶性肿瘤
  • 固体癌
  • 其他

目标分子

  • APE1/Ref-1
  • 酪蛋白激梅2
  • CHK-1
  • C-Tak
  • DHODH
  • MAPKAPK2
  • p53
  • WEE 1

分子类型

  • 生技药品
  • 低分子

给药途径

  • 口服药
  • 静脉注射药

主要地区

  • 北美(美国，加拿大)
  • 欧洲(丹麦，法国，德国，义大利，西班牙，英国)
  • 亚太地区(澳洲，新加坡，韩国)

全球DNA损伤反应市场：成长与趋势

DNA损伤反应 (DDR) 由一个协调的路径网络组成，这些路径不仅促进DNA损伤修復，还能活化细胞週期检查点。这会导致细胞週期在关键阶段停滞，以维持整个基因组的完整性。值得注意的是，如果损伤无法修復，这个复杂的系统确保细胞要么在分裂前修復遗传物质，要么促进程序性细胞死亡，以防止突变的传播。此外，DDR 对常规疗法的高特异性和敏感性以及低脱靶毒性使 DDR 成为包括肿瘤和非肿瘤疾病在内的多种临床疾病的有希望的治疗标靶。因此，世界各地的研究人员正在开发 DDR 抑制剂，以对抗 DDR 介导的对 DNA 损伤抗癌疗法的抗药性，并透过靶向替代途径来利用癌症中的 DDR 功能障碍。

DNA Damage Response Market-IMG1

值得注意的是，目前已有四种针对 DNA 损伤修復过程的聚 ADP-核糖聚合酶 (PARP) 抑制剂获准用于治疗晚期癌症。此外，全球药物开发商正在研究 DNA 损伤反应路径中的其他分子标靶，包括 ATM、ATR、CHK1 和 WEE1。

全球 DNA 损伤反应市场：关键洞察

本报告深入探讨了全球 DNA 损伤反应市场的现状，并揭示了该行业的潜在成长机会。报告的主要发现包括：

  • 目前，近45家公司正在开发针对DNA损伤反应(DDR)的疗法，以治疗各种临床适应症。
  • 大多数候选药物处于早期开发阶段，主要针对各种癌症疾病特有的生物分子表位。
  • 针对DDR的疗法的临床前研发管线强劲且不断成长。这些候选药物中的大多数（超过75%）是小分子。
  • 超过70%的针对ATR的候选药物正在临床试验中，其中约55%的此类干预措施设计为口服给药。
  • 约65%的用于治疗实体瘤的DDR标靶药物已在临床前试验中得到概念验证。
  • 自2010年以来，已有超过220项临床试验註册，用于评估DDR标靶疗法的疗效，儘管亚太地区此类试验的平均完成时间相对较短。
DNA Damage Response Market-IMG2
  • 从顶尖期刊发表的大量科学论文可以看出，该领域的创新蓬勃发展。目前的重点似乎是寻找新的靶点，尤其是针对不同类型的癌症。
  • 过去一年，该领域的论文数量显着增加，约30%的论文发表于2021年后。
  • 根据已发表的论文/文章，目前的研究重点是ATR、ADP、ATR和HSP等标靶分子。
  • 针对癌症（包括白血病、肺癌和卵巢癌）的DDR标靶疗法的研究明显增加。
  • 从早期研发到药物上市，有多个参数会影响定价和采用率。研发人员必须综合考虑所有这些因素，才能在竞争中保持领先地位。
  • 为了获得竞争优势并赢得庞大的消费者群体，创新者必须了解直接和间接影响其产品采用率和定价的因素。
  • 鑑于前景光明的疗法研发管线和令人鼓舞的临床研究结果，预计到2035年，DDR标靶疗法市场将实现显着的年化成长。
  • 预期的市场机会可能在各种目标疾病适应症、给药途径和主要地区呈现高度多样化。
DNA Damage Response Market-IMG3

DNA损害反应市场参与企业案例

  • Aprea Therapeutics
  • AstraZeneca
  • Chordia Therapeutics
  • Mission Therapeutics
  • Repare Therapeutics
  • Senhwa Biosciences

全球DNA损害反应市场

  • 市场规模和机会分析：本研究报告对全球DNA损伤反应市场进行了深入分析，重点关注关键细分市场，例如[A]适应症、[B]治疗领域、[C]目标分子、[D]分子类型、 [E] 给药途径和 [F] 重点区域。
  • 市场格局：对DNA损伤反应标靶疗法进行全面评估，考虑各种参数，例如A]开发阶段、[B]适应症、[C]治疗领域、[D]标靶分子、[E]分子类型、[F]治疗类型、[G]剂型、[H]给药途径、[I]特定药物名称（如有）。此外，也根据[A]成立年份、[B]公司规模（员工人数）和[C]总部所在地，对从事DNA损伤反应标靶疗法开发的公司进行全面评估。
  • 关键洞察：使用四个图表对当代市场趋势进行深入分析，包括A]比较DNA损伤反应市场主要公司的气泡分析、[B]基于目标治疗领域和公司规模的DNA损伤反应靶向疗法开发公司的分析、[C]重点介绍DNA损伤反应市场开发公司区域分布的详细分析，以及[D]显示DNA损伤反应靶向疗法分布的综合分析。
  • 公司简介：A] 详细介绍从事 DNA 损伤反应标靶疗法开发的公司，重点关注 [A] 公司概况、[B] 每种候选药物的详细资讯以及 [C] 近期趋势和未来展望。
  • 临床试验分析：基于各种相关参数，对 250 多个已完成、正在进行和计划中的各种 DNA 损伤反应标靶疗法临床试验进行详细分析，这些参数包括 A] 临床试验註册年份、[B] 入组患者人数、[C] 入组患者性别、[D] 临床试验阶段、[E] 招募状态和研究设计、[F] 主要数量（G]）组织类型、[H] 热门治疗领域、[i] 临床试验的区域分布。
  • 文章分析：基于 A] 出版年份、[B] 出版类型、[C] 主要研究中心、[D] 最受欢迎的作者、[E] 资助金额、[F] 靶点分子、[G] 最受欢迎的期刊，对 150 多篇与 DNA 损伤反应靶向研究相关的同行评审科学文章进行了深入分析。

本报告概述了全球 DNA 损伤反应市场，并提供了详细的市场分析和市场概况，包括适应症、治疗领域、靶点分子、分子类型、按给药途径划分的趋势、按地区划分的趋势以及参与市场的公司概况。

目录

第1章 序文

第2章 摘要整理

第3章 简介

  • 章概要
  • DNA损伤概要
  • DNA损伤物质
  • DNA损害反应系统
  • DNA修復途径的种类
  • 结论

第4章 市场形势

  • 章概要
  • DNA损害反应标靶治疗药:临床实验平台
  • DNA损害反应标靶治疗药:前临床开发平台
  • DNA损害反应标靶治疗药:开发商清单

第5章 重要的洞察

  • 章概要
  • 组合的强度，开发阶段，不同企业规模分析(4D泡泡图)
  • 与治疗领域企业规模分别分析(树地图表示)
  • 总公司所在地分析(世界地图表示)
  • 开发阶段，治疗领域，分子类型，治疗方法的种类，各给药途径分析(电网表示)

第6章 企业简介

  • 章概要
  • Aprea Therapeutics
  • AstraZeneca
  • Chordia Therapeutics
  • Mission Therapeutics
  • Repare Therapeutics
  • Senhwa Biosciences

第7章 临床试验的分析

  • 章概要
  • 范围与调查手法
  • DNA损害反应标靶治疗药:临床试验分析

第8章 出版物的分析

  • 章概要
  • 范围与调查手法
  • DNA损害反应标靶治疗药:最近的出版物一览

第9章 影响药品定价与应用的关键参数分析

  • 章概要
  • 主要的推动市场要素
  • 始祖分析组成架构

第10章 市场预测

  • 章概要
  • 范围与限制
  • 预测调查手法主要的前提条件
  • 到2035年前的全球DNA损害反应标靶治疗药市场
    • DNA损害反应标靶治疗药市场:各适应疾病
    • DNA损害反应标靶治疗药市场:各治疗领域
    • DNA损害反应标靶治疗药市场:目标分子
    • DNA损害反应标靶治疗药市场:各分子类型
    • DNA损害反应标靶治疗药市场:各给药途径
    • DNA损害反应标靶治疗药市场:各地区
    • 各类医药品预测销售额
    • 结论

第11章 结论

第12章 附录I:表格形式资料

第13章 附录II:企业及组织一览

Product Code: RA100280

GLOBAL DNA DAMAGE RESPONSE MARKET: OVERVIEW

As per Roots Analysis, the global DNA damage response market valued at USD 13 million in the current year is anticipated to grow at a lucrative CAGR during the forecast period.

The market sizing and opportunity analysis has been segmented across the following parameters:

Target Disease Indication

  • Acute Myeloid Leukemias
  • COVID-19
  • Diabetic Macular Edemas
  • Mesotheliomas
  • Myelodysplastic Syndromes
  • Non-Squamous Non-Small Cell Lung Cancers
  • Prostate Cancers
  • Uterine Serous Carcinomas

Therapeutic Area

  • Hematological Malignancies
  • Solid Tumors
  • Other Disorders

Target Molecule

  • APE1/Ref-1
  • Casein Kinase 2
  • CHK-1
  • C-Tak
  • DHODH
  • MAPKAPK2
  • p53
  • WEE 1

Type of Molecule

  • Biologics
  • Small Molecule

Route of Administration

  • Oral Drugs
  • Intravenous Drugs

Key Geographical Regions

  • North America (US and Canada)
  • Europe (Denmark, France, Germany, Italy, Spain and UK)
  • Asia-Pacific (Australia, Singapore and South Korea)

GLOBAL DNA DAMAGE RESPONSE MARKET: GROWTH AND TRENDS

The DNA damage response (DDR) consists of a coordinated network of pathways that not only facilitate the repair of DNA lesions but also activate cell cycle checkpoints. This leads to cell cycle arrest at critical stages in order to maintain the overall genomic integrity. Notably, if the damage is irreparable, this intricate system ensures that cells either repair their genetic material before undergoing division or facilitate programmed cell death to prevent the propagation of mutations. Further, its high specificity and sensitivity to conventional therapies, and low off-target toxicity have made DDR a promising therapeutic target for a broad range of clinical conditions, including both oncological and non-oncological diseases. Consequently, researchers worldwide are developing DDR inhibitors to counter DDR-mediated resistance to DNA-damaging anticancer therapies and to exploit DDR dysfunction in cancer by targeting alternative pathways.

DNA Damage Response Market - IMG1

It is worth mentioning that four poly-ADP ribose polymerase (PARP) inhibitor drugs, which target the DNA damage repair process, are currently approved for advanced-stage cancer treatment. Additionally, drug developers worldwide are investigating other molecular targets within the DNA damage response pathway, including ATM, ATR, CHK1, and WEE1.

GLOBAL DNA DAMAGE RESPONSE MARKET: KEY INSIGHTS

The report delves into the current state of global DNA damage response market and identifies potential growth opportunities within industry. Some key findings from the report include:

  • Presently, close to 45 companies are engaged in the development of DNA damage response (DDR) targeting therapeutics in order to treat a range of clinical conditions.
  • Majority of pipeline drug candidates are in the early phases of development; these are predominantly designed to target epitopes on biological molecules that are a characteristic of various oncological disorders.
  • The preclinical pipeline of DDR targeting therapeutics is substantial and growing; majority of these drug candidates (over 75%) are small molecules.
  • Over 70% of drug candidates targeting ATR are in clinical trials and around 55% of such interventions are designed for oral administration.
  • About 65% of DDR targeting drugs intended to treat solid tumors have already demonstrated preclinical proof of concept.
  • Since 2010, over 220 clinical trials have been registered to evaluate the efficacy of DDR targeting therapies; average completion time for such studies was relatively less in Asia-Pacific.
DNA Damage Response Market - IMG2
  • Innovation in this field is evident across the plethora of scientific articles published in prestigious journals; the current focus appears to be on identification of novel targets, specifically against different types of cancers.
  • The number of publications in this domain has increased significantly in the past one year; around 30% of the articles have been published since 2021.
  • Published articles / papers indicate that the focus of current research activity is on target molecules, such as ATR, ADP, ATR and HSP.
  • There has been an evident increase in research focused on DDR targeting therapies against cancers, such as leukemia, lung and ovarian cancers.
  • Several parameters, ranging from initial stages of development to launch of the drug, influence the pricing and adoption rates; developers must consider the combination of all these factors to survive the competition.
  • In pursuit of a competitive edge and the successful establishment of a large consumer base, it is imperative for innovators to understand both direct and indirect influences on the adoption and pricing of their respective products.
  • Considering the promising development pipeline of therapies and encouraging clinical research outcomes, the DDR targeting therapeutics market is anticipated to grow at a significant annualized till 2035.
  • The projected market opportunity is likely to be well-distributed across different target disease indications, routes of administration and key geographical regions.
DNA Damage Response Market - IMG3

Example Players in the DNA Damage Response Market

  • Aprea Therapeutics
  • AstraZeneca
  • Chordia Therapeutics
  • Mission Therapeutics
  • Repare Therapeutics
  • Senhwa Biosciences

GLOBAL DNA DAMAGE RESPONSE MARKET

  • Market Sizing and Opportunity Analysis: The report features an in-depth analysis of the global DNA damage response market, focusing on key market segments, including [A] target disease indication, [B] therapeutic area, [C] target molecule, [D] type of molecule, [E] route of administration and [F] key geographical regions.
  • Market Landscape: A comprehensive evaluation of DNA damage response targeting therapeutics, considering various parameters, such as [A] phase of development, [B] target disease indication(s), [C] therapeutic area, [D] target molecule, [E] type of molecule, [F] type of therapy, [G] dosage form, [H] route of administration and [I] special drug designation awarded (if any). Additionally, a comprehensive evaluation of the companies engaged in development of DNA damage response targeting therapeutics, based on [A] year of establishment, [B] company size (in terms of employee count) and [C] location of respective headquarters.
  • Key Insights: An insightful analysis of contemporary market trends that have been depicted using four schematic representations, including [A] a bubble analysis comparing the leading players engaged in DNA damage response market, [B] an analysis of DNA damage response targeting therapeutics developers, based on their target therapeutic area and company size, [C] a detailed analysis highlighting the regional distribution of developers engaged in DNA damage response market, and [D] a comprehensive analysis illustrating the distribution of DNA damage response targeting therapeutics.
  • Company Profiles: In-depth profiles of companies engaged in the development of DNA damage response targeting therapeutics, focusing on [A] company overview, [B] details related to its respective drug candidates and [C] recent developments and an informed future outlook.
  • Clinical Trial Analysis: An in-depth analysis of more than 250 completed, ongoing and planned clinical studies of various DNA damage response targeting therapeutics, based on various relevant parameters, such as [A] trial registration year, [B] number of patients enrolled, [C] gender of patients enrolled, [D] trial phase, [E] recruitment status and study design, leading [F] sponsors / collaborators and leading players (in terms of number of trials conducted), [G] type of organization, [H] popular therapeutic areas and [I] regional distribution of trials.
  • Publication Analysis: An insightful analysis of more than 150 peer-reviewed scientific articles related to DNA damage response targeting therapeutics, based on [A] year of publication, [B] type of publication, [C] key research hubs, [D] most popular authors, [E] provision of grant awarded, [F] target molecule, and [G] most popular journals.

KEY QUESTIONS ANSWERED IN THIS REPORT

  • How many companies are currently engaged in this market?
  • Which are the leading companies in this market?
  • What factors are likely to influence the evolution of this market?
  • What is the current and future market size?
  • What is the CAGR of this market?
  • How is the current and future market opportunity likely to be distributed across key market segments?

REASONS TO BUY THIS REPORT

  • The report provides a comprehensive market analysis, offering detailed revenue projections of the overall market and its specific sub-segments. This information is valuable to both established market leaders and emerging entrants.
  • Stakeholders can leverage the report to gain a deeper understanding of the competitive dynamics within the market. By analyzing the competitive landscape, businesses can make informed decisions to optimize their market positioning and develop effective go-to-market strategies.
  • The report offers stakeholders a comprehensive overview of the market, including key drivers, barriers, opportunities, and challenges. This information empowers stakeholders to stay abreast of market trends and make data-driven decisions to capitalize on growth prospects.

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TABLE OF CONTENTS

1. PREFACE

  • 1.1. Scope of the Report
  • 1.2. Research Methodology
    • 1.2.1. Research Assumptions
    • 1.2.2. Project Methodology
    • 1.2.3. Forecast Methodology
    • 1.2.4. Robust Quality Control
    • 1.2.5. Key Considerations
      • 1.2.5.1. Demographics
      • 1.2.5.2. Economic Factors
      • 1.2.5.3. Government Regulations
      • 1.2.5.4. Supply Chain
      • 1.2.5.5. COVID Impact / Related Factors
      • 1.2.5.6. Market Access
      • 1.2.5.7. Healthcare Policies
      • 1.2.5.8. Industry Consolidation
  • 1.3 Key Questions Answered
  • 1.4. Chapter Outlines

2. EXECUTIVE SUMMARY

3. INTRODUCTION

  • 3.1. Chapter Overview
  • 3.2. Overview of DNA Damage
  • 3.3. DNA Damaging Agents
  • 3.4. DNA Damage Response Systems
    • 3.4.1. Key Components of DNA Repair Pathways
  • 3.5. Types of DNA Repair Pathways
    • 3.5.1. Direct Pathways
    • 3.5.2. Excision Repair Pathway
      • 3.5.2.1. Base Excision Repair Pathway
      • 3.5.2.2. Nucleotide Excision Repair Pathway
      • 3.5.2.3. Mismatch Repair Pathway
    • 3.5.3. Indirect Pathways
      • 3.5.3.1. Homologous Recombination (HR) Repair Pathway
      • 3.5.3.2. Non-homologous End Joining (NHEJ) Repair Pathway
  • 3.6. Concluding Remarks

4. MARKET LANDSCAPE

  • 4.1. Chapter Overview
  • 4.2. DNA Damage Response Targeting Therapeutics: Clinical Pipeline
    • 4.2.1. Analysis by Phase of Development
    • 4.2.2. Analysis by Target Disease Indication(s)
    • 4.2.3. Analysis by Therapeutic Area
    • 4.2.4. Analysis by Target Molecule
    • 4.2.5. Analysis by Type of Molecule
    • 4.2.6. Analysis by Type of Therapy
    • 4.2.7. Analysis by Dosage Form
    • 4.2.8. Analysis by Route of Administration
    • 4.2.9. Analysis by Special Drug Designation Awarded
  • 4.3. DNA Damage Response Targeting Therapeutics: Preclinical Pipeline
    • 4.3.1. Analysis by Phase of Development
    • 4.3.2. Analysis by Target Disease Indication(s)
    • 4.3.3. Analysis by Therapeutic Area
    • 4.3.4. Analysis by Type of Molecule
    • 4.3.5. Analysis by Type of Therapy
  • 4.4 DNA Damage Response Targeting Therapeutics: List of Developers
    • 4.4.1. Analysis by Year of Establishment
    • 4.4.2. Analysis by Company Size
    • 4.4.3. Analysis by Location of Headquarters
    • 4.4.4. Leading Developers: Analysis by Number of Proprietary Product Candidates

5. KEY INSIGHTS

  • 5.1. Chapter Overview
  • 5.2. Analysis by Portfolio Strength, Phase of Development and Company Size (4D Bubble Chart)
  • 5.3. Analysis by Therapeutic Area and Company Size (Treemap Representation)
  • 5.4. Analysis by Location of Headquarters (World Map Representation)
  • 5.5. Analysis by Phase of Development, Therapeutic Area, Type of Molecule, Type of Therapy and Route of Administration (Grid Representation)

6. COMPANY PROFILES

  • 6.1. Chapter Overview
  • 6.2. Aprea Therapeutics
    • 6.2.1. Company Overview
    • 6.2.2. DNA Damage Response Targeting Therapeutics Portfolio
    • 6.2.3. Recent Developments and Future Outlook
  • 6.3. AstraZeneca
    • 6.3.1. Company Overview
    • 6.3.2. DNA Damage Response Targeting Therapeutics Portfolio
    • 6.3.3. Recent Developments and Future Outlook
  • 6.4. Chordia Therapeutics
    • 6.4.1. Company Overview
    • 6.4.2. DNA Damage Response Targeting Therapeutics Portfolio
    • 6.4.3. Recent Developments and Future Outlook
  • 6.5. Mission Therapeutics
    • 6.5.1. Company Overview
    • 6.5.2. DNA Damage Response Targeting Therapeutics Portfolio
    • 6.5.3. Recent Developments and Future Outlook
  • 6.6. Repare Therapeutics
    • 6.6.1. Company Overview
    • 6.6.2. DNA Damage Response Targeting Therapeutics Portfolio
    • 6.6.3. Recent Developments and Future Outlook
  • 6.7. Senhwa Biosciences
    • 6.7.1. Company Overview
    • 6.7.2. DNA Damage Response Targeting Therapeutics Portfolio
    • 6.7.3. Recent Developments and Future Outlook

7. CLINICAL TRIALS ANALYSIS

  • 7.1. Chapter Overview
  • 7.2. Scope and Methodology
  • 7.3. DNA Damage Response Targeting Therapeutics: Clinical Trial Analysis
    • 7.3.1. Analysis by Trial Registration Year
    • 7.3.2. Analysis by Number of Patients Enrolled
    • 7.3.3. Analysis by Gender of Patients Enrolled
    • 7.3.4. Analysis by Trial Phase
    • 7.3.5. Analysis by Recruitment Status
    • 7.3.6. Analysis by Study Design
    • 7.3.7. Analysis by Type of Sponsor / Collaborator
    • 7.3.8. Analysis by Therapeutic Area
    • 7.3.9. Reginal Analysis
    • 7.3.10. Case Study
    • 7.3.11. Most Active Industry Players: Analysis by Number of Clinical Trails
    • 7.3.12. Concluding Remarks

8. PUBLICATION ANALYSIS

  • 8.1. Chapter Overview
  • 8.2. Scope and Methodology
  • 8.3. DNA Damage Response Targeting Therapeutics: List of Recent Publications
    • 8.3.1. Analysis by Year of Publication
    • 8.3.2. Analysis by Type of Publication
    • 8.3.3. Emerging Focus Areas
    • 8.3.4. Analysis by Key Research Journals
      • 8.3.4.1. Most Prominent Journals: Analysis by Number of Publications
      • 8.3.4.2. Analysis by Journal Impact Factor
      • 8.3.4.3. Most Prominent Journals: Analysis by Journal Impact Factor
    • 8.3.5. Analysis by Key Research Hubs
    • 8.3.6. Analysis by Target Molecule
      • 8.3.6.1. Most Popular Target Molecule: Analysis by Number of Publications
      • 8.3.6.2. Analysis by Year and Target Molecule
    • 8.3.7. Analysis by Grants Awarded
      • 8.3.7.1. Locations of Grant Awarding Organizations: Analysis by Number of Publications
    • 8.3.8. Publication Benchmarking Analysis

9. ANALYSIS OF KEY PARAMETERS IMPACTING DRUG PRICING AND ADOPTION

  • 9.1. Chapter Overview
  • 9.2. Key Market Drivers
  • 9.3. Roots Analysis Framework
    • 9.3.1. Benchmarking Parameters
    • 9.3.2. Methodology
    • 9.3.3. Impact on Price and Adoption
    • 9.3.4. Impact on Pricing and Adoption of Individual Drugs / Drug Candidates
      • 9.3.4.1. Adavosertib
      • 9.3.4.2. APX3330
      • 9.3.4.3. ASLAN003
      • 9.3.4.4. CBP-501
      • 9.3.4.5. Eprenetapopt
      • 9.3.4.6. Irofulven
      • 9.3.4.7. LB-100
      • 9.3.4.8. Silmitasertib
      • 9.3.4.9. TRC-102
    • 9.3.5. Concluding Remarks

10. MARKET FORECAST

  • 10.1. Chapter Overview
  • 10.2. Scope and Limitations
  • 10.3. Forecast Methodology and Key Assumptions
  • 10.4. Global DNA Damage Response Targeting Therapeutics Market, Till 2035
    • 10.4.1. DNA Damage Response Targeting Therapeutics Market: Distribution by Target Disease Indication
      • 10.4.1.1. DNA Damage Response Targeting Therapeutics Market for Acute Myeloid Leukemias, Till 2035
      • 10.4.1.2. DNA Damage Response Targeting Therapeutics Market for COVID-19, Till 2035
      • 10.4.1.3. DNA Damage Response Targeting Therapeutics Market for Diabetic Macular Edemas, Till 2035
      • 10.4.1.4. DNA Damage Response Targeting Therapeutics Market for Mesotheliomas, Till 2035
      • 10.4.1.5. DNA Damage Response Targeting Therapeutics Market for Myelodysplastic Syndromes, Till 2035
      • 10.4.1.6. DNA Damage Response Targeting Therapeutics Market for Non-Squamous Non-Small Cell Lung Cancers, Till 2035
      • 10.4.1.7. DNA Damage Response Targeting Therapeutics Market for Prostate Cancers, Till 2035
      • 10.4.1.8. DNA Damage Response Targeting Therapeutics Market for Uterine Serous Carcinomas, Till 2035
    • 10.4.2. DNA Damage Response Targeting Therapeutics Market: Distribution by Therapeutic Area
      • 10.4.2.1. DNA Damage Response Targeting Therapeutics Market for Hematological Malignancies, Till 2035
      • 10.4.2.2. DNA Damage Response Targeting Therapeutics Market for Solid Tumors, Till 2035
      • 10.4.2.3. DNA Damage Response Targeting Therapeutics Market for Other Disorders, Till 2035
    • 10.4.3. DNA Damage Response Targeting Therapeutics Market: Distribution by Target Molecule
      • 10.4.3.1. DNA Damage Response Targeting Therapeutics Market for APE1/Ref-1, Till 2035
      • 10.4.3.2. DNA Damage Response Targeting Therapeutics Market for Casein Kinase 2, Till 2035
      • 10.4.3.3. DNA Damage Response Targeting Therapeutics Market for CHK-1, Till 2035
      • 10.4.3.4. DNA Damage Response Targeting Therapeutics Market for C-Tak, Till 2035
      • 10.4.3.5. DNA Damage Response Targeting Therapeutics Market for DHODH, Till 2035
      • 10.4.3.6. DNA Damage Response Targeting Therapeutics Market for MAPKAPK2, Till 2035
      • 10.4.3.7. DNA Damage Response Targeting Therapeutics Market for p53, Till 2035
      • 10.4.3.8. DNA Damage Response Targeting Therapeutics Market for Protein Phosphatase 2A, Till 2035
      • 10.4.3.9. DNA Damage Response Targeting Therapeutics Market for WEE1, Till 2035
    • 10.4.4. DNA Damage Response Targeting Therapeutics Market: Distribution by Type of Molecule
      • 10.4.4.1. DNA Damage Response Targeting Therapeutics Market for Biologics, Till 2035
      • 10.4.4.2. DNA Damage Response Targeting Therapeutics Market for Small Molecules, Till 2035
    • 10.4.5. DNA Damage Response Targeting Therapeutics Market: Distribution by Route of Administration
      • 10.4.5.1. DNA Damage Response Targeting Therapeutics Market for Oral Drugs, Till 2035
      • 10.4.5.2. DNA Damage Response Targeting Therapeutics Market for Intravenous Drugs, Till 2035
    • 10.4.6. DNA Damage Response Targeting Therapeutics Market: Distribution by Geography
      • 10.4.6.1. DNA Damage Response Targeting Therapeutics Market in the US, Till 2035
      • 10.4.6.2. DNA Damage Response Targeting Therapeutics Market in Canada, Till 2035
      • 10.4.6.3. DNA Damage Response Targeting Therapeutics Market in Denmark, Till 2035
      • 10.4.6.4. DNA Damage Response Targeting Therapeutics Market in France, Till 2035
      • 10.4.6.5. DNA Damage Response Targeting Therapeutics Market in Germany, Till 2035
      • 10.4.6.6. DNA Damage Response Targeting Therapeutics Market in Italy, Till 2035
      • 10.4.6.7. DNA Damage Response Targeting Therapeutics Market in Spain, Till 2035
      • 10.4.6.8. DNA Damage Response Targeting Therapeutics Market in the UK, Till 2035
      • 10.4.6.9. DNA Damage Response Targeting Therapeutics Market in Australia, Till 2035
      • 10.4.6.10. DNA Damage Response Targeting Therapeutics Market in Singapore, Till 2035
      • 10.4.6.11. DNA Damage Response Targeting Therapeutics Market in South Korea, Till 2035
    • 10.4.7. Drug-wise Sales Forecast
      • 10.4.7.1 Adavosertib (AZD1775, MK-1775), AstraZeneca
        • 10.4.7.1.1. Target Patient Population
        • 10.4.7.1.2. Sales Forecast
        • 10.4.7.1.3. Net Present Value
        • 10.4.7.1.4. Value Creation Analysis
      • 10.4.7.2. APX3330, Apexian Pharmaceuticals
        • 10.4.7.2.1. Target Patient Population
        • 10.4.7.2.2. Sales Forecast
        • 10.4.7.2.3. Net Present Value
        • 10.4.7.2.4. Value Creation Analysis
      • 10.4.7.3. ASLAN003 (LAS 186323), Aslan Pharmaceuticals
        • 10.4.7.3.1. Target Patient Population
        • 10.4.7.3.2. Sales Forecast
        • 10.4.7.3.3. Net Present Value
        • 10.4.7.3.4. Value Creation Analysis
      • 10.4.7.4. CBP-501, CanBas
        • 10.4.7.4.1. Target Patient Population
        • 10.4.7.4.2. Sales Forecast
        • 10.4.7.4.3. Net Present Value
        • 10.4.7.4.4. Value Creation Analysis
      • 10.4.7.5. Eprenetapopt, Aprea Therapeutics
        • 10.4.7.5.1. Target Patient Population
        • 10.4.7.5.2. Sales Forecast
        • 10.4.7.5.3. Net Present Value
        • 10.4.7.5.4. Value Creation Analysis
      • 10.4.7.6. Irofulven, Allarity Therapeutics
        • 10.4.7.6.1. Target Patient Population
        • 10.4.7.6.2. Sales Forecast
        • 10.4.7.6.3. Net Present Value
        • 10.4.7.6.4. Value Creation Analysis
      • 10.4.7.7. LB-100 (Lixte Biotechnology)
        • 10.4.7.7.1. Target Patient Population
        • 10.4.7.7.2. Sales Forecast
        • 10.4.7.7.3. Net Present Value
        • 10.4.7.7.4. Value Creation Analysis
      • 10.4.7.8. Silmitasertib, Senhwa Biosciences
        • 10.4.7.8.1. Target Patient Population
        • 10.4.7.8.2. Sales Forecast
        • 10.4.7.8.3. Net Present Value
        • 10.4.7.8.4. Value Creation Analysis
    • 10.4.9 Concluding Remarks

11. CONCLUDING REMARKS

12. APPENDIX I: TABULATED DATA

13. APPENDIX II: LIST OF COMPANIES AND ORGANIZATION

List of Tables

  • Table 3.1 Key Components of DNA Repair System
  • Table 3.2 Comparison of HRR and NHEJ DNA Damage Repair Pathways
  • Table 3.3 DNA Damage Repair Related Inherited Mutations
  • Table 4.1 DNA Damage Response Targeting Therapeutics (Clinical Pipeline): Information on Phase of Development, Target Disease Indication(s), and Therapeutic Area
  • Table 4.2 DNA Damage Response Targeting Therapeutics (Clinical Pipeline): Information on Target Molecule, Type of Molecule, and Type of Therapy
  • Table 4.3 DNA Damage Response Targeting Therapeutics (Clinical Pipeline): Information on Dosage Form, Route of Administration, and Special Drug Designation Awarded
  • Table 4.4 DNA Damage Response Targeting Therapeutics (Preclinical Pipeline): Information on Phase of Development, Target Disease Indication(s), and Therapeutic Area
  • Table 4.5 DNA Damage Response Targeting Therapeutics (Preclinical Pipeline): Information on Target Molecule, Type of Molecule, Type of Therapy and Dosage Form
  • Table 4.6 DNA Damage Response Targeting Therapeutics: List of Drug Developers
  • Table 6.1 DNA Damage Response Targeting Therapeutics: List of Companies Profiled
  • Table 6.2 Aprea Therapeutics: Company Overview
  • Table 6.3 Aprea Therapeutics: DNA Damage Response Targeting Therapeutics Portfolio
  • Table 6.4 Aprea Therapeutics: Recent Developments and Future Outlook
  • Table 6.5 AstraZeneca: Company Overview
  • Table 6.6 AstraZeneca: DNA Damage Response Targeting Therapeutics Portfolio
  • Table 6.7 AstraZeneca: Recent Developments and Future Outlook
  • Table 6.8 Chordia Therapeutics: Company Overview
  • Table 6.9 Chordia Therapeutics: DNA Damage Response Targeting Therapeutics Portfolio
  • Table 6.10 Chordia Therapeutics: Recent Developments and Future Outlook
  • Table 6.11 Mission Therapeutics: Company Overview
  • Table 6.12 Mission Therapeutics: DNA Damage Response Targeting Therapeutics Portfolio
  • Table 6.13 Mission Therapeutics: Recent Developments and Future Outlook
  • Table 6.14 Repare Therapeutics: Company Overview
  • Table 6.15 Repare Therapeutics: DNA Damage Response Targeting Therapeutics Portfolio
  • Table 6.16 Repare Therapeutics: Recent Developments and Future Outlook
  • Table 6.17 Senhwa Biosciences: Company Overview
  • Table 6.18 Senhwa Biosciences: DNA Damage Response Targeting Therapeutics Portfolio
  • Table 6.19 Senhwa Biosciences: Recent Developments and Future Outlook
  • Table 8.1 List of Recent Publications, Since 2020
  • Table 8.2 Publication Analysis: List of Most Valued Publications
  • Table 10.1 DNA Damage Response Targeting Therapeutics: Promising Drug Candidates
  • Table 10.2 DNA Damage Response Targeting Therapeutics Forecast Assumptions: Price Estimations in Key Geographies
  • Table 10.3 Adavosertib (AZD1775, MK-1775), AstraZeneca: Target Patient Population
  • Table 10.4 Adavosertib (AZD1775, MK-1775), AstraZeneca: Net Present Value (USDMillion)
  • Table 10.5 Adavosertib (AZD1775, MK-1775), AstraZeneca: Value Creation Analysis (USDMillion)
  • Table 10.6 ASLAN003 (LAS 186323, Aslan Pharmaceuticals: Target Patient Population
  • Table 10.7 ASLAN003 (LAS 186323, Aslan Pharmaceuticals: Net Present Value (USDMillion)
  • Table 10.8 ASLAN003 (LAS 186323, Aslan Pharmaceuticals: Value Creation Analysis (USD Million)
  • Table 10.9 CBP-501, CanBas: Target Patient Population
  • Table 10.10 CBP-501, CanBas: Net Present Value (USD Million)
  • Table 10.11 CBP-501, CanBas: Value Creation Analysis (USD Million)
  • Table 10.12 Eprenetapopt (APR-246), Aprea Therapeutics: Target Patient Population
  • Table 10.13 Eprenetapopt (APR-246), Aprea Therapeutics: Net Present Value (USD Million)
  • Table 10.14 Eprenetapopt, (APR-246) Aprea Therapeutics: Value Creation Analysis (USD Million)
  • Table 10.15 Irofulven, Allarity Therapeutics: Target Patient Population
  • Table 10.16 Irofulven, Allarity Therapeutics: Net Present Value (USD Million)
  • Table 10.17 Irofulven, Allarity Therapeutics: Value Creation Analysis (USD Million)
  • Table 10.18 LB-100, Lixte Biotechnology: Target Patient Population
  • Table 10.19 LB-100, Lixte Biotechnology: Net Present Value (USD Million)
  • Table 10.20 LB-100, Lixte Biotechnology: Value Creation Analysis (USD Million)
  • Table 10.21 Sapacitabine, Cyclacel Pharmaceuticals: Target Patient Population
  • Table 10.22 Sapacitabine, Cyclacel Pharmaceuticals: Net Present Value (USD Million)
  • Table 10.23 Sapacitabine, Cyclacel Pharmaceuticals: Value Creation Analysis (USD Million)
  • Table 10.24 Silmitasertib, Senhwa Biosciences: Target Patient Population
  • Table 10.25 Silmitasertib, Senhwa Biosciences: Net Present Value (USD Million)
  • Table 10.26 Silmitasertib, Senhwa Biosciences: Value Creation Analysis (USD Million)
  • Table 10.27 TRC-102, TRACON Pharmaceuticals: Target Patient Population
  • Table 10.28 TRC-102, TRACON Pharmaceuticals: Net Present Value (USD Million)
  • Table 10.29 TRC-102, TRACON Pharmaceuticals: Value Creation Analysis (USD Million)
  • Table 12.1 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Phase of Development
  • Table 12.2 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Target Disease Indication(s)
  • Table 12.3 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Phase of Development and Target Disease Indication(s)
  • Table 12.4 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Therapeutic Area
  • Table 12.5 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Phase of Development and Therapeutic Area
  • Table 12.6 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Target Molecule
  • Table 12.7 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Phase of Development and Target Molecule
  • Table 12.8 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Type of Molecule
  • Table 12.9 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Target Molecule and Type of Molecule
  • Table 12.10 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Type of Therapy
  • Table 12.11 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Dosage Form
  • Table 12.12 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Route of Administration
  • Table 12.13 DNA Damage Response Targeting Therapeutics (Preclinical-stage Drug Candidates): Distribution by Phase of Development
  • Table 12.14 DNA Damage Response Targeting Therapeutics (Preclinical-stage Drug Candidates): Distribution by Target Disease Indication(s)
  • Table 12.15 DNA Damage Response Targeting Therapeutics: (Preclinical-stage Drug Candidates) Distribution by Phase of Development and Target Disease Indication(s)
  • Table 12.16 DNA Damage Response Targeting Therapeutics (Preclinical-stage Drug Candidates): Distribution by Therapeutic Area
  • Table 12.17 DNA Damage Response Targeting Therapeutics (Preclinical-stage Drug Candidates): Distribution by Phase of Development and Therapeutic Area
  • Table 12.18 DNA Damage Response Targeting Therapeutics (Preclinical-stage Drug Candidates): Distribution by Type of Therapy
  • Table 12.19 DNA Damage Response Targeting Therapeutics (Preclinical-stage Drug Candidates): Distribution by Dosage Form
  • Table 12.20 DNA Damage Response Targeting Therapeutics Developers: Distribution by Year of Establishment
  • Table 12.21 DNA Damage Response Targeting Therapeutics Developers: Distribution by Company Size
  • Table 12.22 DNA Damage Response Targeting Therapeutics Developers: Distribution by Location of Headquarters
  • Table 12.23 Leading Developers: Distribution by Number of DNA Damage Response Targeting Therapeutics
  • Table 12.24 4D Bubble Analysis: Distribution by Portfolio Strength, Target Molecule, Phase of Development and Company Size
  • Table 12.25 Treemap Representation: Distribution by Therapeutic Area and Company Size
  • Table 12.26 World Map Representation: Distribution by Location of Headquarters
  • Table 12.27 Grid Representation: Distribution by Phase of Development, Therapeutic Area, Type of Molecule, Type of Therapy and Route of Administration
  • Table 12.28 Clinical Trial Analysis: Cumulative Distribution of Trials by Registration Year, Since 2011
  • Table 12.29 Clinical Trial Analysis: Distribution of Number of Patients Enrolled by Registration Year, Since 2011
  • Table 12.30 Clinical Trial Analysis: Distribution of Patients Enrolled by Gender
  • Table 12.31 Clinical Trial Analysis: Distribution by Trial Phase
  • Table 12.32 Clinical Trial Analysis: Distribution by Year wise Distribution by Trial Phase
  • Table 12.33 Clinical Trial Analysis: Distribution of Patients Enrolled by Trial Phase
  • Table 12.34 Clinical Trial Analysis: Year wise Distribution of Patients Enrolled by Trial Phase
  • Table 12.35 Clinical Trial Analysis: Year wise Distribution by Trial Phase and Average Completion Time
  • Table 12.36 Clinical Trial Analysis: Distribution by Recruitment Status
  • Table 12.37 Clinical Trial Analysis: Cumulative Year-wise Trend by Recruitment Status
  • Table 12.38 Clinical Trial Analysis: Distribution by Study Design
  • Table 12.39 Clinical Trial Analysis: Distribution by Type of Sponsor / Collaborator
  • Table 12.40 Clinical Trial Analysis: Distribution by Therapeutic Area
  • Table 12.41 Clinical Trial Analysis: Year wise Distribution by Most Popular Therapeutic Areas
  • Table 12.42 Clinical Trial Analysis: Cumulative Year wise Trend of Patients Enrolled by Most Popular Therapeutic Areas
  • Table 12.43 Clinical Trial Analysis: Distribution by Therapeutic Area and Average Completion Time
  • Table 12.44 Clinical Trial Analysis: Regional Distribution of Patients Enrolled by Gender
  • Table 12.45 Clinical Trial Analysis: Regional Distribution by Trial Phase and Average Completion Time
  • Table 12.46 Clinical Trial Analysis: Regional Distribution by Therapeutic Area and Average Completion Time
  • Table 12.47 Clinical Trial Analysis: Regional Distribution by Patients Enrolled
  • Table 12.48 Clinical Trial Analysis: Regional Distribution by Average Completion Time
  • Table 12.49 Clinical Trial Analysis: Year wise Distribution by Trial Phase and Average Completion Time
  • Table 12.50 Leading Industry Players: Distribution by Number of Clinical Trials
  • Table 12.51 Clinical Trial Analysis: Concluding Remarks
  • Table 12.52 Publications Analysis: Distribution by Year of Publication
  • Table 12.53 Publications Analysis: Distribution by Type of Publication
  • Table 12.54 Key Journals: Distribution by Number of Publications
  • Table 12.55 Publications Analysis: Distribution by Journal Impact Factor
  • Table 12.56 Key Journals: Distribution by Journal Impact Factor
  • Table 12.57 Key Research Hubs: Distribution by Number of Publications
  • Table 12.58 Publications Analysis: Distribution by Target Molecule
  • Table 12.59 Publications Analysis: Distribution by Year wise Distribution by Most Popular Target Molecules
  • Table 12.60 Locations of Grant Awarding Organizations: Distribution by Number of Publications
  • Table 12.61 Global DNA Damage Response Targeting Therapeutics Market, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.62 DNA Damage Response Targeting Therapeutics Market: Distribution by Target Disease Indication
  • Table 12.63 DNA Damage Response Targeting Therapeutics Market for Acute Myeloid Leukemias, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.64 DNA Damage Response Targeting Therapeutics Market for COVID-19, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.65 DNA Damage Response Targeting Therapeutics Market for Diabetic Macular Edemas, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.66 DNA Damage Response Targeting Therapeutics Market for Mesotheliomas, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.67 DNA Damage Response Targeting Therapeutics Market for Myelodysplastic Syndromes, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.68 DNA Damage Response Targeting Therapeutics Market for Non-Squamous Non-Small Cell Lung Cancers, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.69 DNA Damage Response Targeting Therapeutics Market for Prostate Cancers, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.70 DNA Damage Response Targeting Therapeutics Market for Uterine Serous Carcinomas, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.71 Global DNA Damage Response Targeting Therapeutics Market: Distribution by Therapeutic Area
  • Table 12.72 DNA Damage Response Targeting Therapeutics Market for Hematological Malignancies, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.73 DNA Damage Response Targeting Therapeutics Market for Solid Tumors, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.74 DNA Damage Response Targeting Therapeutics Market for Other Disorders, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.75 Global DNA Damage Response Targeting Therapeutics Market: Distribution by Target Molecule
  • Table 12.76 Damage Response Targeting Therapeutics Market for APE1/Ref-1, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.77 Damage Response Targeting Therapeutics Market for Casein Kinase 2, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.78 Damage Response Targeting Therapeutics Market for CHK-1, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.79 Damage Response Targeting Therapeutics Market for C-Tak, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.80 Damage Response Targeting Therapeutics Market for DHODH, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.81 Damage Response Targeting Therapeutics Market for MAPKAPK2, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.82 Damage Response Targeting Therapeutics Market for p53, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.83 Damage Response Targeting Therapeutics Market for Protein Phosphatase 2A Market, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.84 Damage Response Targeting Therapeutics Market for WEE 1, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.85 Global DNA Damage Response Targeting Therapeutics Market: Distribution by Type of Molecule
  • Table 12.86 DNA Damage Response Targeting Therapeutics Market for Biologics, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.87 DNA Damage Response Targeting Therapeutics Market for Small Molecules, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.88 Global DNA Damage Response Targeting Therapeutics Market: Distribution by Route of Administration
  • Table 12.89 DNA Damage Response Targeting Therapeutics Market for Oral Drugs, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.90 DNA Damage Response Targeting Therapeutics Market for Intravenous Drugs, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.91 Global DNA Damage Response Targeting Therapeutics Market: Distribution by Geography
  • Table 12.92 DNA Damage Response Targeting Therapeutics Market in the US, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.93 DNA Damage Response Targeting Therapeutics Market in the Canada, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.94 DNA Damage Response Targeting Therapeutics Market in the Denmark, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.95 DNA Damage Response Targeting Therapeutics Market in France, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.96 DNA Damage Response Targeting Therapeutics Market in Germany, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.97 DNA Damage Response Targeting Therapeutics Market in Italy, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.98 DNA Damage Response Targeting Therapeutics Market in Spain, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.99 DNA Damage Response Targeting Therapeutics Market in the UK, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.100 DNA Damage Response Targeting Therapeutics Market in Australia, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.101 DNA Damage Response Targeting Therapeutics Market in Singapore, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.102 DNA Damage Response Targeting Therapeutics Market in South Korea, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.103 Adavosertib (AZD1775, MK-1775), AstraZeneca: Sales Forecast, till 2030, Conservative, Base and Optimistic Scenarios (USD Million)
  • Table 12.104 APX3330, Apexian Pharmaceuticals: Sales Forecast, till 2030, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.105 ASLAN003 (LAS 186323), Aslan Pharmaceuticals: Sales Forecast, till 2030, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.106 CBP-501, CanBas: Sales Forecast, till 2030, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.107 Eprenetapopt, Aprea Therapeutics: Sales Forecast, till 2030, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.108 Irofulven, Allarity Therapeutics: Sales Forecast, till 2030, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.109 LB-100, Lixte Biotechnology: Sales Forecast, till 2030, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.110 Silmitasertib, Senhwa Biosciences: Sales Forecast, till 2030, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Table 12.111 Global DNA Damage Response Targeting Therapeutics Market, Conservative, Base and Optimistic Scenarios, Till 2035: Conservative, Base and Optimistic Scenarios (USD Million)

List of Figures

  • Figure 3.1 Type of DNA Damage
  • Figure 3.2 Types of Causative Agents for DNA Damage
  • Figure 3.3 DNA Damage Causative Agents and Associated Repair System
  • Figure 3.4 DNA Damage Response System
  • Figure 3.5 Direct DNA Damage Repair Systems
  • Figure 3.6 Key Steps Involved in Base Excision Repair Pathway
  • Figure 3.7 Key Steps Involved in Nucleotide Excision Repair Pathway
  • Figure 3.8 Key Steps Involved in Mismatch Repair Pathway
  • Figure 3.9 Key Steps Involved in Homologous Recombination Repair Pathway
  • Figure 3.10 Key Steps Involved in Non-Homologous Repair Pathway
  • Figure 4.1 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Phase of Development
  • Figure 4.2 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Target Disease Indication(s)
  • Figure 4.3 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Phase of Development and Target Disease Indication(s)
  • Figure 4.4 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Therapeutic Area
  • Figure 4.5 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution Phase of Development and Therapeutic Area
  • Figure 4.6 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Target Molecule
  • Figure 4.7 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Phase of Development and Target Molecule
  • Figure 4.8 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Type of Molecule
  • Figure 4.9 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Target Molecule and Type of Molecule
  • Figure 4.10 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Type of Therapy
  • Figure 4.11 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Dosage Form
  • Figure 4.12 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Route of Administration
  • Figure 4.13 DNA Damage Response Targeting Therapeutics (Clinical-stage Drug Candidates): Distribution by Special Drug Designation Awarded
  • Figure 4.14 DNA Damage Response Targeting Therapeutics (Preclinical-stage Drug Candidates): Distribution by Phase of Development
  • Figure 4.15 DNA Damage Response Targeting Therapeutics (Preclinical-stage Drug Candidates): Distribution by Target Disease Indication(s)
  • Figure 4.16 DNA Damage Response Targeting Therapeutics (Preclinical-stage Drug Candidates): Distribution by Phase of Development and Target Disease Indication(s)
  • Figure 4.17 DNA Damage Response Targeting Therapeutics (Preclinical-stage Drug Candidates): Distribution by Therapeutic Area
  • Figure 4.18 DNA Damage Response Targeting Therapeutics (Preclinical-stage Drug Candidates): Distribution by Phase of Development and Therapeutic Area
  • Figure 4.19 DNA Damage Response Targeting Therapeutics (Preclinical-stage Drug Candidates): Distribution by Type of Therapy
  • Figure 4.20 DNA Damage Response Targeting Therapeutics (Preclinical-stage Drug Candidates): Distribution by Dosage Form
  • Figure 4.21 DNA Damage Response Targeting Therapeutics Developers: Distribution by Year of Establishment
  • Figure 4.22 DNA Damage Response Targeting Therapeutics Developers: Distribution by Company Size
  • Figure 4.23 DNA Damage Response Targeting Therapeutics Developers: Distribution by Location of Headquarters
  • Figure 4.24 Leading Developers: Distribution by Number of DNA Damage Response Targeting Therapeutics
  • Figure 5.1 4D Bubble Representation: Distribution by Portfolio Strength, Target Molecule, Phase of Development and Company Size
  • Figure 5.2 Treemap Representation: Distribution by Therapeutic Area and Company Size
  • Figure 5.3 World Map Representation: Distribution by Location of Headquarters
  • Figure 5.4 Grid Representation: Distribution by Phase of Development, Therapeutic Area, Type of Molecule, Type of Therapy and Route of Administration
  • Figure 7.1 Clinical Trial Analysis: Scope and Methodology
  • Figure 7.2 Clinical Trial Analysis: Cumulative Distribution of Trials by Registration Year, Since 2011
  • Figure 7.3 Clinical Trial Analysis: Distribution of Number of Patients Enrolled by Registration Year, Since 2011
  • Figure 7.4 Clinical Trial Analysis: Distribution of Patients Enrolled by Gender
  • Figure 7.5 Clinical Trial Analysis: Distribution by Trial Phase
  • Figure 7.6 Clinical Trial Analysis: Year wise Distribution by Trial Phase
  • Figure 7.7 Clinical Trial Analysis: Distribution of Patients Enrolled by Trial Phase
  • Figure 7.8 Clinical Trial Analysis: Year wise Distribution of Patients Enrolled by Trial Phase
  • Figure 7.9 Clinical Trial Analysis: Year wise Distribution by Trial Phase and Average Completion Time
  • Figure 7.10 Clinical Trial Analysis: Distribution by Recruitment Status
  • Figure 7.11 Clinical Trial Analysis: Cumulative Year wise Distribution by Recruitment Status
  • Figure 7.12 Clinical Trial Analysis: Distribution by Study Design
  • Figure 7.13 Clinical Trial Analysis: Distribution by Type of Sponsor / Collaborator
  • Figure 7.14 Clinical Trial Analysis: Distribution by Therapeutic Area
  • Figure 7.15 Clinical Trial Analysis: Year wise Distribution by Most Popular Therapeutic Areas
  • Figure 7.16 Clinical Trial Analysis: Cumulative Year wise Trend of Patients Enrolled by Most Popular Therapeutic Areas
  • Figure 7.17 Clinical Trial Analysis: Distribution by Therapeutic Area and Average Completion Time
  • Figure 7.18 Clinical Trial Analysis: Regional Distribution
  • Figure 7.19 Clinical Trial Analysis: Regional Distribution by Trial Phase and Average Completion Time
  • Figure 7.20 Clinical Trial Analysis: Regional Distribution by Therapeutic Area and Average Completion Time
  • Figure 7.21 Clinical Trial Analysis: Regional Distribution by Patients Enrolled
  • Figure 7.22 Clinical Trial Analysis: Regional Distribution by Average Completion Time
  • Figure 7.23 Clinical Trial Analysis: Year wise Distribution by Trial Phase and Average Completion Time
  • Figure 7.24 Leading Industry Players: Distribution by Number of Clinical Trials
  • Figure 7.25 Clinical Trial Analysis: Concluding Remarks
  • Figure 8.1 Publications Analysis: Methodology
  • Figure 8.2 Publications Analysis: Distribution by Year of Publication
  • Figure 8.3 Publications Analysis: Distribution by Type of Publication
  • Figure 8.4 Publications Analysis: Emerging Focus Areas
  • Figure 8.5 Key Journals: Distribution by Number of Publications
  • Figure 8.6 Publications Analysis: Distribution by Journal Impact Factor
  • Figure 8.7 Key Journals: Distribution by Journal Impact Factor
  • Figure 8.8 Key Research Hubs: Distribution by Number of Publications
  • Figure 8.9 Publications Analysis: Distribution by Target Molecule
  • Figure 8.10 Publications Analysis: Year wise Distribution by Most Popular Target Molecules
  • Figure 8.11 Locations of Grant Awarding Organizations: Distribution by Number of Publications
  • Figure 8.12 Publications Analysis: Multivariate Benchmark Analysis
  • Figure 9.1 Key Parameters Impacting Drug Pricing and Adoption
  • Figure 9.2 Adavosertib (AZD1775) (MK-1775)
  • Figure 9.3 APX3330
  • Figure 9.4 ASLAN003
  • Figure 9.5 CBP-501
  • Figure 9.5 Eprenetapopt
  • Figure 9.6 Irofulven
  • Figure 9.7 LB-100
  • Figure 9.8 Silmitasertib
  • Figure 9.9 TRC-102
  • Figure 10.1 Global DNA Damage Response Targeting Therapeutics Market, Conservative, Base and Optimistic Scenarios, Till 2035 (USD Million)
  • Figure 10.2 DNA Damage Response Targeting Therapeutics Market: Distribution by Target Disease Indication
  • Figure 10.3 DNA Damage Response Targeting Therapeutics Market for Acute Myeloid Leukemias, Till 2035 (USD Million)
  • Figure 10.4 DNA Damage Response Targeting Therapeutics Market for COVID-19, Till 2035 (USD Million)
  • Figure 10.5 DNA Damage Response Targeting Therapeutics Market for Diabetic Macular Edemas, Till 2035 (USD Million)
  • Figure 10.6 DNA Damage Response Targeting Therapeutics Market for Mesotheliomas, Till 2035 (USD Million)
  • Figure 10.7 DNA Damage Response Targeting Therapeutics Market for Myelodysplastic Syndromes, Till 2035 (USD Million)
  • Figure 10.8 DNA Damage Response Targeting Therapeutics Market for Non-Squamous Non-Small Cell Lung Cancers, Till 2035 (USD Million)
  • Figure 10.9 DNA Damage Response Targeting Therapeutics Market for Prostate Cancer, Till 2035 (USD Million)
  • Figure 10.10 DNA Damage Response Targeting Therapeutics Market for Uterine Serous Carcinomas, Till 2035 (USD Million)
  • Figure 10.11 Global DNA Damage Response Targeting Therapeutics Market: Distribution by Therapeutic Area
  • Figure 10.12 DNA Damage Response Targeting Therapeutics Market for Hematological Malignancies, Till 2035 (USD Million)
  • Figure 10.13 DNA Damage Response Targeting Therapeutics Market for Solid Tumors, Till 2035 (USD Million)
  • Figure 10.14 DNA Damage Response Targeting Therapeutics Market for Other Disorders, Till 2035 (USD Million)
  • Figure 10.15 Global DNA Damage Response Targeting Therapeutics Market: Distribution by Target Molecule
  • Figure 10.16 DNA Damage Response Targeting Therapeutics Market for APE1/Ref-1, Till 2035 (USD Million)
  • Figure 10.17 DNA Damage Response Targeting Therapeutics Market for Casein Kinase 2, Till 2035 (USD Million)
  • Figure 10.18 DNA Damage Response Targeting Therapeutics Market for CHK-1, Till 2035 (USD Million)
  • Figure 10.19 DNA Damage Response Targeting Therapeutics Market for C-Tak, Till 2035 (USD Million)
  • Figure 10.20 DNA Damage Response Targeting Therapeutics Market for DHODH, Till 2035 (USD Million)
  • Figure 10.21 DNA Damage Response Targeting Therapeutics Market for MAPKAPK2, Till 2035 (USD Million)
  • Figure 10.22 DNA Damage Response Targeting Therapeutics Market for p53, Till 2035 (USD Million)
  • Figure 10.23 DNA Damage Response Targeting Therapeutics Market for Protein Phosphatase 2A, Till 2035 (USD Million)
  • Figure 10.24 DNA Damage Response Targeting Therapeutics Market for WEE 1, Till 2035 (USD Million)
  • Figure 10.25 Global DNA Damage Response Targeting Therapeutics Market: Distribution by Type of Molecule
  • Figure 10.26 DNA Damage Response Targeting Therapeutics Market for Biologics, Till 2035 (USD Million)
  • Figure 10.27 DNA Damage Response Targeting Therapeutics Market for Small Molecules, Till 2035 (USD Million)
  • Figure 10.28 Global DNA Damage Response Targeting Therapeutics Market: Distribution by Route of Administration
  • Figure 10.29 DNA Damage Response Targeting Therapeutics Market for Oral Drugs, Till 2035 (USD Million)
  • Figure 10.30 DNA Damage Response Targeting Therapeutics Market for Intravenous Drugs, Till 2035 (USD Million)
  • Figure 10.31 Global DNA Damage Response Targeting Therapeutics Market: Distribution by Geography
  • Figure 10.32 DNA Damage Response Targeting Therapeutics Market in the US, Till 2035 (USD Million)
  • Figure 10.33 DNA Damage Response Targeting Therapeutics Market in Canada, Till 2035 (USD Million)
  • Figure 10.34 DNA Damage Response Targeting Therapeutics Market in Denmark, Till 2035 (USD Million)
  • Figure 10.35 DNA Damage Response Targeting Therapeutics Market in France, Till 2035 (USD Million)
  • Figure 10.36 DNA Damage Response Targeting Therapeutics Market in Germany, Till 2035 (USD Million)
  • Figure 10.37 DNA Damage Response Targeting Therapeutics Market in Italy, Till 2035 (USD Million)
  • Figure 10.38 DNA Damage Response Targeting Therapeutics Market in Spain, Till 2035 (USD Million)
  • Figure 10.39 DNA Damage Response Targeting Therapeutics Market in the UK, Till 2035 (USD Million)
  • Figure 10.40 DNA Damage Response Targeting Therapeutics Market in Australia, Till 2035 (USD Million)
  • Figure 10.41 DNA Damage Response Targeting Therapeutics Market in Singapore, Till 2035 (USD Million)
  • Figure 10.42 DNA Damage Response Targeting Therapeutics Market in South Korea, Till 2035 (USD Million)
  • Figure 10.43 Adavosertib (AZD1775, MK-1775), AstraZeneca: Sales Forecast, till 2030 (USD Million)
  • Figure 10.44 APX3330, Apexian Pharmaceuticals: Sales Forecast, till 2030 (USD Million)
  • Figure 10.45 ASLAN003 (LAS 186323), Aslan Pharmaceuticals: Sales Forecast, till 2030 (USD Million)
  • Figure 10.46 CBP-501, CanBas: Sales Forecast, till 2030 (USD Million)
  • Figure 10.47 Eprenetapopt (APR-246), Aprea Therapeutics: Sales Forecast, till 2030 (USD Million)
  • Figure 10.48 Irofulven, Allarity Therapeutics: Sales Forecast, till 2030 (USD Million)
  • Figure 10.49 LB-100, Lixte Biotechnology: Sales Forecast, till 2030 (USD Million)
  • Figure 10.50 Silmitasertib, Senhwa Biosciences: Sales Forecast, till 2030 (USD Million)
  • Figure 10.51 Global DNA Damage Response Targeting Therapeutics Market, Till 2035: Conservative, Base and Optimistic Scenarios, 2021, 2025 and 2030 (USD Million)
  • Figure 11.1 Concluding Remarks: Market Landscape
  • Figure 11.2 Concluding Remarks: Clinical Trial Analysis
  • Figure 11.3 Concluding Remarks: Publications
  • Figure 11.4 Concluding Remarks: Key Parameters Impacting Drug Pricing and Adoption
  • Figure 11.5 Concluding Remarks: Market Forecast