市场调查报告书
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1250772
到 2028 年的亨廷顿病治疗市场预测——按疗法(疾病修饰疗法、对症治疗)、药剂、最终用户和地区进行的全球分析Huntington's Disease Treatment Market Forecasts to 2028 - Global Analysis By Treatment (Disease-modifying therapies and Symptomatic treatment), Drug, End User and By Geography |
根据 Stratistics MRC 的数据,2022 年亨廷顿病治疗的全球市场规模将达到 85 亿美元,预计到 2028 年将达到 187 亿美元,预测期内增长 14.1%。预计将以 CAGR 增长。
亨廷顿舞蹈症是一种罕见的遗传性疾病,会导致大脑神经细胞进行性破坏,主要影响运动、情绪和认知能力。 在这种疾病中,大脑中的神经细胞发生故障并形成称为神经原纤维缠结的蛋白质团块,影响运动、思维、推理和情绪。 它会导致不受控制的运动和肌肉痉挛(霍乱)、语言模式改变、抑郁、焦虑和性格改变。
根据美国亨廷顿病协会 (HDSA) 的数据,2021 年将有大约 41,000 名有症状的美国人,超过 200,000 人有遗传该病的风险。
亨廷顿病的发病率增加
全球范围内亨廷顿舞蹈病患病率的上升是推动市场增长的主要因素之一。 该程序经常用于停止不受控制的抽搐和跛行并改善生活质量。 此外,越来越多地采用临床试验、强大的药物类型管道以及改进的医疗程序和疗法预计将推动市场增长。
缺乏批准的药物和严格的监管政策
目前,只有两种药物被批准用于治疗与这种疾病相关的角膜炎,而且这些药物只能控制和抑制症状,不能治癒疾病。 世界各地的公司要想批准药品,就必须扫清严格的监管障碍。 此类监管限制可能会影响市场进入者的口味,导致预测期内市场增长放缓。
激活研发
由于缺乏有效的治疗方法和药物,亨廷顿病的治疗方法是一个广阔的研究和开发领域。 预计这将在预测期内显着促进市场增长。 此外,据推测,政府为促进新药开发所做的努力也有望成为支持市场增长的因素之一。
药物获取困难
由于严格的政策法规,许可药品的数量有限。 预计世界许多地区对这种疾病缺乏了解将限制市场扩张。 寻找治疗这种疾病的药物一直是一项重大挑战,许多药物未能证明疗效或与显着毒性有关。 预计这将阻碍市场增长。
预计 COVID-19 的爆发将对亨廷顿氏病治疗的市场规模产生不利影响。 世界各地的大量诊所和医院正在重组以容纳更多 COVID-19 患者。 患者人数的激增有时会减慢非必要任务的执行速度。 由于医疗保健所需物资的生产和交付受阻,它已经停止。 无法获得医疗保健、医疗机构人员不足以及与 COVID-19 相关的住院率上升也是影响市场的其他变量。
在预测期内,疾病缓解疗法领域预计将成为最大的领域
由于疾病缓解疗法的研究和开发不断增加,疾病缓解疗法领域预计将实现有利增长。 静脉内或口服给予的疾病缓解疗法可以减轻当前症状或减缓进展。 疾病改善疗法可以改善与这种疾病相关的问题,例如精神障碍和抑郁症,但尚未显示可以改变患者死亡率。
抗抑郁药细分市场有望在预测期内实现最高复合年增长率
预计抗抑郁药在预测期内将以最快的复合年增长率增长,因为它们旨在恢復精神稳定性。 抗抑郁药是改善临床抑郁症、听力损失、社交焦虑、焦虑和其他症状的处方药。 抗抑郁药治疗主要集中在缓解严重抑郁症的症状上。 这些是该领域增长的驱动力。
市场份额最高的地区
由于这种疾病的患病率相对较低,预计亚太地区在预测期内将占据最大的市场份额。 然而,在预测期内,这些地区改进的报销政策以及患者对可用治疗的认识提高,预计将有助于增长前景。
由于产品渗透率不断提高,预计北美在预测期内的复合年增长率最高。 公众对该疾病的认识很高,许多公共和私人组织的研究资金和支持正在促进对该疾病的研究。 随着各国政府加紧努力改善其人口的健康,预计该地区的市场将会增长。
亨廷顿氏病治疗市场的主要参与者包括Novartis AG、Teva Pharmaceutical Industries Ltd.、Dr. Reddy's Laboratories Ltd.、Sun Pharmaceutical Industries, Inc.、Lupin、Hetero、Hikma Pharmaceuticals PLC、Bausch Health Companies Inc.、 Alterity Therapeutics、H. Lundbeck A/S、Neurocrine Biosciences, Inc.、Annexon Biosciences、PTC Therapeutics、Prilenia Therapeutics、Amneal Pharmaceuticals LLC.、SOM BIOTECH、Vertex Pharmaceuticals Incorporated。
2021 年 12 月,Novartis AG 获得了 FDA 对 Branaplam 治疗亨廷顿舞蹈病的快速通道指定。 Branaplam 是一种 mRNA 剪接调节剂,其靶向 HTT 蛋白,该蛋白负责引起导致亨廷顿舞蹈病的神经元变性。
2021 年 10 月,Teva Pharmaceutical Industries Limited 获得了在巴西治疗与亨廷顿舞蹈症相关的角膜炎和迟发性运动障碍的上市许可。
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According to Stratistics MRC, the Global Huntington's Disease Treatment Market is accounted for $8.5 billion in 2022 and is expected to reach $18.7 billion by 2028 growing at a CAGR of 14.1% during the forecast period. Huntington's disease is a rare inherited disease that causes progressive breakdown of nerve cells in the brain, mainly affecting physical movements, emotions and cognitive abilities. It is a condition in which the nerve cells of the brain malfunction and create clumps of a protein called neurofibrillary tangles that affect movement, thinking, reasoning, moods, and more. It can cause uncontrolled movements or muscle twitches (chorea), changes in speech patterns, depression, anxiety, and personality changes.
According to the Huntington's disease Society of America (HDSA), there were approximately 41,000 symptomatic Americans in 2021, with over 200,000 individuals at risk of inheriting the disease.
The rising incidence of Huntington's disease
The rising incidence of Huntington's disease across the globe is one of the primary factors driving the market growth. The procedure is frequently used to stop uncontrollable jerking and writhing motion, which enhances quality of life. In addition, clinical trials, strong drug type pipeline and growing adoption of improved medical treatments and therapies are expected to fuel the market growth.
Lack of approved drugs and stringent regulatory policies
Currently, there are only two drugs approved for the treatment of chorea associated with this condition and these drugs can only manage or control the symptoms but cannot cure the disease. Companies across the globe need to clear strict regulatory hurdles for the approval of drugs. Such regulatory limits may impact market participants' preferences, resulting in slower market growth during the projection period.
Growing research and development activities
There is a vast area of research and development for Huntington's disease treatment approaches because there is no effective treatment or medication. This is expected to significantly boost market growth during the forecast period. Moreover, the promising government initiatives that promote the development of new drugs are estimated to be another factor supporting the market growth.
Limited availability of drugs
The number of licensed pharmaceuticals is limited due to tight policies and restrictions. It is anticipated that the market's expansion will be constrained by the lack of knowledge about this illness in many regions of the world. Many medications have failed to show efficacy or have been linked to significant toxicity, which has presented significant challenges for the discovery of drugs to treat the disease. This is expected to hamper the market growth.
The COVID-19 outbreak is projected to have a detrimental effect on the size of the market for treating Huntington's disease. To accommodate more patients with COVID-19, a sizable number of clinics and hospitals around the world underwent restructuring. Because of the sharp increase in patients, non-essential operations could be delayed. Production and delivery of supplies for healthcare were halted as a result of the lockdown. Lack of access to healthcare, a staffing deficit in the medical field, and an increase in COVID-19-related hospitalisation are some additional variables that have an impact on the market.
The disease-modifying therapies segment is expected to be the largest during the forecast period
The disease-modifying therapies segment is estimated to have a lucrative growth, due to an increase in disease-modifying therapy R&D. They can be administered intravenously or orally to lessen current symptoms or slow their progression. Disease-modifying therapies can help with problems like psychological illnesses and depression linked to this condition, but they have not been found to change patient mortality rates.
The antidepressants segment is expected to have the highest CAGR during the forecast period
The antidepressants segment is anticipated to witness the fastest CAGR growth during the forecast period, due to they are intended to restore the mental stability. Antidepressants are prescription medications that can help with symptoms of clinical depression, dysthymia, social anxiety, anxiety, and other conditions. Treatment with antidepressants focuses primarily on reducing the symptoms of severe depression. These are driving the segment growth.
Region with Largest share:
Asia Pacific is projected to hold the largest market share during the forecast period owing to the comparatively lower prevalence rate of this condition amongst the population. However, increasing awareness among the patient population toward available treatment along with improving reimbursement policies in these regions during the forecast period will contribute to their growth prospects.
North America is projected to have the highest CAGR over the forecast period, owing to the increasing product penetration. A high level of public awareness about the condition, as well as growing support from numerous public and private organisations through research funding, to expedite the study of this disease. As governments take more initiatives to improve the health status of the populations, the market in the region is expected to grow.
Some of the key players profiled in the Huntington's Disease Treatment Market include Novartis AG, Teva Pharmaceutical Industries Ltd., Dr. Reddy's Laboratories Ltd., Sun Pharmaceutical Industries, Inc., Lupin, Hetero, Hikma Pharmaceuticals PLC, Bausch Health Companies Inc., Alterity Therapeutics, H. Lundbeck A/S, Neurocrine Biosciences, Inc., Annexon Biosciences, PTC Therapeutics, Prilenia Therapeutics, Amneal Pharmaceuticals LLC., SOM BIOTECH and Vertex Pharmaceuticals Incorporated.
In December 2021, Novartis AG received Fast Track designation for Branaplam from the FDA for Huntington's disease treatment. Branaplam is an mRNA splicing modulator that targets the HTT protein responsible for causing the degeneration of nerve cells leading to Huntington's disease.
In October 2021, Teva Pharmaceutical Industries Ltd. Received marketing approval for the treatment of chorea associated with Huntington's disease treatment and for the treatment of tardive dyskinesia in Brazil.
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