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市场调查报告书
商品编码
1371920
噬菌体疗法的全球市场,到 2030 年的市场预测:按产品、类型、目标细菌、适应症、给药途径、给药配销通路、用途、最终用户、地区进行全球分析Bacteriophage Therapy Market Forecasts to 2030 - Global Analysis By Product, Type, Targeted Bacteria, Disease Indication, Route of Administration, Distribution Channel, Application, End User and By Geography |
根据 Stratistics MRC 的数据,2023 年全球噬菌体治疗市场规模为 4,659 万美元,预计 2030 年将达到 8,090 万美元,年复合成长率为 8.2%。
噬菌体是仅攻击和杀死细菌的病毒。噬菌体是最常见的生物体,可以对抗和消灭具有多重抗药性的细菌。当所有其他抗生素都失效时,噬菌体可以消除引起感染疾病的细菌,使医护人员得以挽救生命。此外,噬菌体正在被研究作为抗生素的替代疗法。这种治疗方法使用病毒将遗传物质注入细菌中,使它们能够利用宿主的机器进行繁殖。
根据美国疾病管制与预防中心 (CDC) 的数据,欧洲每年约有 33,000 人受到抗生素抗药性细菌感染疾病的影响。预计全球抗生素抗药性将增加,对噬菌体产生巨大需求。
在人类医学和农业中过度使用抗生素会产生严重后果,包括抗生素抗药性增加。这种令人震惊的趋势导致了抗生素抗药性超级细菌的出现,并迫切需要噬菌体疗法等替代疗法。此外,噬菌体是天然存在的病毒,能够靶向并消灭细菌,使其成为对抗这些抗药性病原体的有前途的武器。研究人员正在研究如何使用噬菌体混合物和专门设计的噬菌体有效地瞄准和消除这些顽固的细菌菌株。
要让法规相信噬菌体疗法的安全性和有效性是很困难的。这是因为能够提供足够临床证据的大规模随机对照试验并不多。然而,新治疗方法的法规环境非常严格,需要大量的临床资料,这使得获得产品核准既耗时又昂贵。在克服这些挑战的同时,开发人员还必须解决临床试验中使用的噬菌体製剂的一致性和品质问题。
快速增加的研发成本推动了噬菌体疗法的创新。噬菌体工程、噬菌体文库的创建以及噬菌体疗法与免疫疗法和抗生素等其他治疗方法的结合都是活跃的研究主题。此外,这种动态环境不仅使治疗工具箱多样化,而且促进了对噬菌体生物学及其临床应用的深入理解。
缺乏大规模、一流的临床资料是噬菌体治疗市场的最大威胁之一。由于噬菌体疗法的临床试验相对较少,法规可能会推迟核准并增加开发成本。此外,法规机构核准新治疗方法需要强有力的临床证据。对于开发商来说,适应新治疗方法的法规环境可能既困难又耗时。
噬菌体治疗市场受到了 COVID-19大流行的各种影响。虽然噬菌体和其他替代疗法由于人们对感染疾病和抗生素抗药性的日益关注而受到更多关注,但这场大流行也将更多的资源、注意力和研究工作集中在了 COVID-19 上。供应链问题推迟了噬菌体疗法的临床试验和研究,并导致生产中断。儘管如此,这场大流行病还是引起了人们对多种治疗选择的需求的关注,特别是医疗机构中持续存在的细菌威胁,以及在大流行后时代加速采用噬菌体疗法治疗抗生素抗药性感染疾病的潜力。是。
尿道感染(UTI)领域占据噬菌体治疗市场的最大份额。每年,数百万人患有尿道结石,这是最常见的细菌感染疾病之一。此外,由于导致尿道结石的抗生素抗药性菌株数量不断增加,噬菌体疗法已成为有前途的选择。噬菌体疗法可有效针对特定的泌尿道致病细菌,尿道结石。尿道结石的复发性和抗生素在预防復发方面的限制进一步增加了基于噬菌体的治疗方法在该市场的市场潜力。
在噬菌体治疗市场,抗菌药物的发现正以最高的年复合成长率成长。世界各地对抗生素抗药性的担忧日益增加,导致寻找新抗菌药物的资金和研究不断增加。噬菌体靶向并消灭抗生素抗药性细菌的能力引起了药物研发配合措施的极大兴趣。此外,不断探索噬菌体发现和创造新抗菌药物的潜力是该市场快速成长的关键驱动力,是解决严重的抗药性感染疾病问题的迫切需求的解决方案。
预计北美地区将拥有噬菌体疗法最高的市场占有率。造成这一优势的因素有很多,包括强大的医疗基础设施、抗生素抗药性细菌引起的感染疾病发生率高、研发方面的大量投资以及支持性的法规环境。北美由于该地区生物技术和製药行业的蓬勃发展以及噬菌体疗法在临床实践中的使用不断增加而引领市场。此外,透过学术机构、製药公司和政府机构之间的合作,噬菌体疗法在北美迅速扩张,目前占据最大的市场占有率。
在全球噬菌体治疗市场中,亚太地区的年复合成长率最高。这种快速扩张是多种要素共同作用的结果,包括抗生素抗药性感染疾病的流行、医疗保健行业的扩张以及公众对噬菌体疗法潜在优势的认识不断提高。亚太地区正在大力投资研发,重点是建立高效的生产技术和扩大临床应用。此外,当地学术机构、外国製药公司和当地生物技术公司之间的合作正在促进创新并扩大市场。
According to Stratistics MRC, the Global Bacteriophage Therapy Market is accounted for $46.59 million in 2023 and is expected to reach $80.90 million by 2030 growing at a CAGR of 8.2% during the forecast period. Bacteriophages are viruses that only attack and kill bacteria. They are among the most prevalent biological organisms capable of battling and eliminating bacteria with multiple drug resistances. Phages can eliminate the bacteria causing an infection when all other antibiotics have failed to treat it, enabling medical professionals to save a life. Additionally, bacteriophages are being investigated as an alternative to antibiotics. In this therapy, viruses are used to inject bacteria with their genetic material so that the bacteria can use the machinery of their hosts to grow.
According to the Centers for Disease Control and Prevention (CDC), antibiotic-resistant bacterial infections affect approximately 33 000 people in Europe each year. Antibiotic resistance is predicted to increase globally, creating considerable demand for bacteriophages.
The overuse and abuse of antibiotics in both human medicine and agriculture have serious consequences, including the rise in antibiotic resistance. Antibiotic-resistant superbugs have emerged as a result of this worrying trend, necessitating the urgent need for alternative therapies like bacteriophage therapy. Moreover, bacteriophages are naturally occurring viruses that target and destroy bacteria, making them a promising weapon against these pathogens that are drug-resistant. Researchers are investigating how to effectively target and get rid of these tough bacterial strains using phage cocktails and specially created phages.
It is difficult to persuade regulatory agencies of the safety and effectiveness of bacteriophage therapy because there aren't many large-scale, randomized controlled trials that can provide sufficient clinical evidence. However, it may take longer to get a product approved for the market and cost more money because of the strict regulatory environment for new therapies and the requirement for extensive clinical data. While overcoming these challenges, developers must also address issues with the consistency and quality of phage preparations used in clinical trials.
Innovation in bacteriophage therapy is accelerating as a result of the surge in R&D spending. Phage engineering, the creation of phage libraries, and the combination of phage therapy with other therapeutic modalities like immunotherapies or antibiotics are all topics of active research. Moreover, this dynamic environment encourages a deeper comprehension of phage biology and its clinical applications, in addition to diversifying the therapeutic toolbox.
Lack of large-scale, top-notch clinical data is one of the biggest threats to the bacteriophage therapy market. Because there have been relatively few clinical trials for bacteriophage therapy, regulatory agencies may delay approvals and raise development costs. Furthermore, regulatory agencies need strong clinical evidence to approve new therapies. It can be challenging and time-consuming for developers to navigate the regulatory environment for novel therapies.
The bacteriophage therapy market has been affected in different ways by the COVID-19 pandemic. Although bacteriophages and other alternative therapies have received more attention due to the increased focus on infectious diseases and antibiotic resistance, the pandemic has also focused more resources, attention, and research efforts on COVID-19. Due to supply chain issues, bacteriophage therapy clinical trials and research were delayed, and some production interruptions happened. Despite this, the pandemic brought attention to the need for a wider range of treatment options, which may hasten the adoption of bacteriophage therapy in the post-pandemic era, particularly for persistent bacterial threats in healthcare settings and antibiotic-resistant infections.
In the market for bacteriophage therapy, the urinary tract infections (UTIs) segment commands the largest share. Each year, millions of people experience UTIs, which are among the most prevalent bacterial infections. Moreover, bacteriophage therapy has become a promising alternative due to the rise in antibiotic-resistant strains that cause UTIs. It is a compelling option for both simple and complex UTIs due to its effectiveness in targeting particular uropathogenic bacteria. Further boosting the market potential for bacteriophage-based treatments in this market are the recurrent nature of UTIs and the limitations of antibiotics in preventing relapses.
In the market for bacteriophage therapy, antimicrobial drug discovery is growing at the highest CAGR. There has been an increase in funding and research into finding new antimicrobial agents as a result of the growing concern about antibiotic resistance around the world. The ability of bacteriophages to target and destroy bacteria that are resistant to antibiotics has attracted a lot of interest in drug discovery efforts. Furthermore, the ongoing investigation of bacteriophages potential for locating and creating novel antimicrobial remedies-solutions that are urgently required to address the mounting problem of drug-resistant infections-is the primary driver of this market's rapid growth.
The largest market share for bacteriophage therapy is anticipated to be in the North American region. A number of elements, such as a strong healthcare infrastructure, a high incidence of infections caused by bacteria resistant to antibiotics, significant investments in research and development, and a supportive regulatory environment, can be credited for this dominance. The region's thriving biotechnology and pharmaceutical sectors, along with the growing use of bacteriophage therapy in clinical settings, place North America as a market leader. Additionally, bacteriophage therapy has expanded more quickly in North America thanks to partnerships between academic institutions, pharmaceutical companies, and governmental organizations, where it now accounts for the largest market share.
In the global market for bacteriophage therapy, Asia-Pacific is growing at the highest CAGR. This rapid expansion is a result of a number of factors, including the heavy prevalence of infections that are resistant to antibiotics, the expanding healthcare industry, and growing public awareness of the potential advantages of bacteriophage therapy. With a focus on creating efficient production techniques and extending clinical applications, the Asia-Pacific region is seeing significant investments in research and development. Furthermore, collaborations between local academic institutions, pharmaceutical firms from abroad, and regional biotechnology companies are promoting innovation and expanding the market.
Some of the key players in Bacteriophage Therapy market include: InnoPhage Ltd, Eliava Biopreparations Ltd., Adaptive Phage Therapeutics, Inc, Nextbiotics, Armata Pharmaceuticals Inc., Enbiotix Inc., Eligo Bioscience SA, BiomX Ltd., Phagomed Biopharma GmbH, Intodeworld Inc., Phi Therapeutics, ContraFect Corporation, Locus Biosciences Inc., Intralytix Inc., PhagePro Inc., Pherecydes Pharma and TechnoPhage SA.
In May 2023, Adaptive Phage Therapeutics (APT), a clinical-stage biotechnology company pioneering the development of phage-based therapies to combat bacterial infections, is pleased to announce a collaboration and license agreement with the Israeli Phage Therapy Center (IPTC) of the Hebrew University of Jerusalem and Hadassah Medical Center. Researchers at the IPTC have discovered several phages that have exceptionally broad coverage against antibiotic resistant bacteria.
In January 2023, Armata Pharmaceuticals, Inc., a biotechnology company focused on pathogen-specific bacteriophage therapeutics for antibiotic-resistant and difficult-to-treat bacterial infections, today announced that it has closed a secured convertible credit agreement with Innoviva Strategic Opportunities LLC, a wholly-owned subsidiary of Innoviva, Inc, Armata's largest shareholder.
In July 2022, Micro biome firm BiomX is to continue collaborating with pharma giants Boehringer Ingelheim in a partnership that looks to identify biomarkers for inflammatory bowel disease (IBD). BiomX Ltd. The agreement, the second one between the two firms, uses BiomX's XMarker micro biome-based biomarker discovery platform to aid in identifying IBD-linked pathogenic bacterium. Additional agreement terms see BiomX receive research payments with Boehringer able to negotiate an exclusive right to biomarkers discovered under the collaboration.
Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.