市场调查报告书
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2030 年胃滞留给药系统市场预测:按类型、剂型、配销通路和地区分類的全球分析Gastro-retentive Drug Delivery Systems Market Forecasts to 2030 - Global Analysis By Type, Dosage Form, Distribution Channel and By Geography |
根据 Stratistics MRC 的数据,2023 年全球胃滞留给药系统市场规模为 149 亿美元,预测期内年复合成长率为 12.1%,到 2030 年将达到 331 亿美元。
「胃滞留药物递送」指用于将药物化合物递送至胃肠道内目标部位的方法、製剂、製造技术、储存系统和技术,并决定药物递送系统的功效和安全性。应用製造、给药途径、位点特异性标靶、代谢和毒性来提高药物生产。透过胃滞留给药方法加强黏膜保护可用于预防和控制病理。
根据亚利桑那大学发表的论文,新兴国家的幽门螺旋桿菌病菌感染高于已开发国家。在开发中国家% 。
主要製药公司配合措施改善胃滞留药物传输系统,以及由于生物利用度提高而增加的药物需求和减少的给药,推动了市场成长。此外,胃滞留药物输送系统在治疗各种类型的胃病(包括消化性溃疡和胃溃疡)方面的功效已得到证实,而导致胃炎和胃癌的幽门螺旋桿菌病菌感染的患病正在增加。使胃滞留药物得以使用,并对市场扩张产生了重大影响。
由于这些新的给药技术具有创新性,因此很难被患者接受。此外,传统的口服剂型可能是优选的,特别是对于吞嚥困难或喜欢较小剂型的患者。此外,确保一致的依从性也很困难,因为它依赖于患者遵循特定的给药指示。因此,有些患者发现胃滞留药物输送系统(GRDDS)的尺寸和特性较不方便,市场可能会大幅下降。
胃滞留给药技术的使用已被证明是控制各种药物给药同时提高生物利用度的有效技术。此外,近年来,超越胃排空时间不规则和胃停留时间短等物理挑战的技术创新导致了受控口服给药系统的改进。此外,once-GRDDS可以透过延长在上胃肠道的停留时间来提高治疗效果和口服生物利用度。因此,这些进步是推动市场规模扩大的驱动力。
在创造能够始终黏附在胃肠黏膜或漂浮在胃中同时以受控速率释放药物的药物製剂中,需要克服一些挑战。此外,实现黏度、浮力和控制释放之间的平衡需要精确的配方方法和彻底的研究。此外,需要确保药物在胃肠道环境中的稳定性进一步增加了难度。因此,这些困难往往会导致更长的开发时间和更高的价格,从而影响市场成长。
胃滞留给药系统 (GRDDS) 市场受到了 COVID-19 爆发的负面影响。当医疗保健系统专注于对抗病毒时,基于 GRDDS 的药物开发的临床试验和研究被推迟。此外,进入医疗保健设施受到限制,影响了临床试验的患者招募和创新药物输送方法的引入。此外,经济限制和供应链中断阻碍了 GRDDS 产品的生产和分销。因此,由于疫情导致医疗保健系统的财政负担日益增加,《新药交付法案》的预算受到影响,逐渐阻碍了市场的成长。
预计浮动给药系统领域将占最大份额。这些药物製剂会长时间悬浮在胃中。此外,这些方法允许药物在胃液中漂浮的同时逐渐释放,改善药物吸收并延长治疗效果。漂浮药物输送系统(FDDS)可以减少副作用、减少给药频率并增加药物吸收。此外,它对吸收窗较小的药物特别有效,用于治疗多种胃肠道疾病。因此,FDDS作为一种最先进的改善药物传递的方法,可以提高患者的依从性并确保胃肠滞留药物的治疗效果,从而扩大市场规模。
由于在药物配方中使用小球形颗粒来改善药物在胃肠道的吸收,因此预计微球细分市场在预测期内将出现最高的年复合成长率。此外,这些微球可以含有控制释放的药物,并且通常由生物相容性材料製成。这些提供了消费后的好处,例如更长的给药、更少的给药和更少的副作用。使用微球的GRDDS已用于治疗各种胃肠道疾病,提高了患者的依从性和治疗效果。因此,本节提出了独特的药理学策略,以增强消化器官系统药物吸收和治疗效果,从而显着推动市场。
由于其优异的药物吸收和患者依从性,亚太地区在预测期内占据了最大的市场占有率。此外,亚太地区还在医学研究和基础设施开发上投入资金,这正在推动创新和市场成长。法规变化和慢性病的增加进一步加速了 GRDDS 的采用。因此,GRDDS 行业的药房、研究人员和医疗保健专业人员在该地区有很多机会。
欧洲在 GRDDS 技术的进步中发挥着重要作用,预计在预测期内将表现出最高的年复合成长率,因为它同时注重创新和优质医疗保健。此外,该地区高龄化和胃肠道疾病的高患病需要更好的给药方法。此外,欧洲医疗保健系统正在鼓励 GRDDS 的开发和部署,以改善治疗结果、患者依从性和生活品质。因此,严格的法规标准确保了产品安全和充满活力的市场。
According to Stratistics MRC, the Global Gastro-retentive Drug Delivery Systems Market is accounted for $14.9 billion in 2023 and is expected to reach $33.1 billion by 2030 growing at a CAGR of 12.1% during the forecast period. The term "gastro-retentive drug delivery" refers to methods, formulations, production techniques, storage systems, and technologies used to deliver pharmaceutical compounds to the target location in the gastro-intestinal tract, to enhance the effectiveness and safety of a drug delivery system, principles relating to drug manufacturing, route of administration, site-specific targeting, metabolism, and toxicity are applied. The enhancement of mucosal protection by the gastro-retentive drug delivery method can be used to prevent and control the condition.
According to the article published by the University of Arizona, H.pylori infection is higher in developing countries than the developed countries. The incidence of new infections in developing countries is 3 to 10% of the population compared to 0.5% in developed economies.
The market's growth has been accelerated by large pharmaceutical companies' efforts to improve gastro-retentive drug delivery systems, together with dose reductions due to improved bioavailability and an increase in the demand for drugs. Additionally, the market is greatly influenced by the well-established effectiveness of gastro-retentive drug delivery systems in treating various kinds of stomach disorders, including peptic ulcer and gastric ulcer, as well as an increase in the prevalence of H.pylori infection, which can lead to gastritis and gastric cancer which enabled the use of gastro-retentive drugs resulting in market expansion.
The innovative nature of these new medicine delivery techniques may make them difficult for patients to accept. Additionally, patients may prefer traditional oral dosage forms especially for individuals who have difficulty swallowing or who prefer smaller-sized dosage forms. Moreover, ensuring consistent compliance is also challenging, as it relies on patients following specific administration instructions. Thus, some patients may find the size or characteristics of Gastro-retentive Drug Delivery Systems (GRDDS) less convenient by which the market gets significantly retrain.
The use of gastro-retentive drug delivery technology has proven to be an effective technique to control the dosage of a variety of pharmaceuticals while increasing bioavailability. Moreover, technology innovations that go beyond physical challenges like erratic stomach emptying timings and brief gastric residency times have led to improvements in controlled oral medicine administration systems in recent years. Additionally, once-GRDDS can improve therapeutic effectiveness and oral bioavailability by prolonging their duration in the upper GI tract. Hence, these advancements drive the market size.
There are challenging obstacles to overcome when creating pharmacological formulations that can consistently stick to the gastrointestinal mucosa or float in the stomach while releasing the drug at a controlled rate. Moreover, it takes exact formulation methods and in-depth research to achieve this balance of adhesion, buoyancy, and controlled release. Additionally, the difficulty is increased further by the need to ensure the drug's stability in the gastrointestinal environment. Therefore, these difficulties frequently lead to longer development times and higher prices, which have an effect on market growth.
The market for gastro-retentive drug delivery systems (GRDDS) has been negatively impacted by the COVID-19 epidemic. Clinical trials and research for the development of GRDDS-based drugs were delayed while healthcare systems concentrated on fighting the virus. Additionally, access to medical facilities became restricted, which had an impact on the recruitment of patients for clinical trials and the uptake of innovative drug delivery methods. Moreover, economical limitations and supply chain interruptions have hampered the manufacture and distribution of GRDDS goods. Therefore, budgets for novel drug delivery methods were impacted as a result of the pandemic's increasing financial load on healthcare systems which gradually hampered the market growth.
The floating drug delivery system segment is estimated to hold the largest share. These are drug formulations that remain buoyant in the stomach for an extended period. Additionally, these methods allow medications to release gradually while floating on the gastric fluid, improving drug absorption and extending therapeutic benefits. Floating drug delivery system (FDDS) can reduce side effects, decrease dosage frequency, and increase drug absorption. Furthermore, they are particularly helpful for medications with small absorption windows and are used in the treatment of a variety of gastrointestinal ailments. Therefore, a cutting-edge method for improving medication delivery, FDDS ensures higher patient compliance and therapeutic effectiveness in gastro-retentive medicines thereby increasing the market expansion.
The microspheres segment is anticipated to have highest CAGR during the forecast period due to the use of small, spherical particles in medicine formulations to improve absorption of the medicament in the gastrointestinal tract. Additionally, these microspheres can contain medications for controlled release and are typically made of biocompatible substances. They provide advantages after consumption, including longer drug administration, decreased dosage frequency, and reduced side effects. GRDDS with microspheres is used to treat a variety of gastrointestinal illnesses, enhancing patient compliance and therapeutic results. Hence, this section shows an original pharmacological strategy for enhancing gastrointestinal system drug absorption and therapeutic efficacy by significantly driving the market.
Asia Pacific commanded the largest market share during the extrapolated period owing to due to their better drug absorption and patient compliance. Additionally, the Asia-Pacific region is spending money on medical research and infrastructure, which encourages innovation and market growth. Adoption of GRDDS is further fuelled by regulatory changes and the rise in chronic diseases. Therefore, pharmacies, researchers, and healthcare practitioners in the GRDDS industry have a lot of opportunities in this region.
Europe is expected to witness highest CAGR over the projection period, owing to a major role in the advancement of GRDDS technology, placing a strong emphasis on both innovation and high-quality healthcare. Additionally, there is a need for better drug delivery methods due to the aging population in the area and the high prevalence of gastrointestinal illnesses. Moreover, in order to improve treatment outcomes, patient compliance, and quality of life, European healthcare systems encourage the development and deployment of GRDDS. Hence, stringent regulatory standards ensure product safety, making it a thriving market.
Some of the key players in the Gastro-retentive Drug Delivery Systems Market include: Ranbaxy, GlaxoSmithKline, Competition Deep Dive, Depomed, Pharmacia, Alcon, Inc., Lupin, Galanix, Sun Pharma and F. Hoffmann La Roche.
In October 2023, Sun Pharmaceutical Industries Ltd announced that the U.S. Food and Drug Administration (FDA) has accepted the New Drug Application (NDA) for deuruxolitinib, an investigational oral selective inhibitor of Janus kinases, for the treatment of adults with moderate to severe alopecia areata.
In March 2023, Sun Pharmaceutical Industries Limited announced the successful completion of its acquisition of Concert Pharmaceuticals, Inc., a late-stage clinical biopharmaceutical company that is developing deuruxolitinib, a novel, deuterated, oral JAK1/2 inhibitor, for the potential treatment of adult patients with moderate to severe alopecia area.