市场调查报告书
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1372012
到 2030 年 G 蛋白偶联受体 (GPCR) 市场预测:按产品类型、检测类型、应用和地区进行的全球分析G-Protein Coupled Receptors Market Forecasts to 2030 - Global Analysis By Product, By Assay Type, Application and By Geography |
根据Stratistics MRC预测,2023年全球G蛋白偶联受体(GPCR)市场规模将达到37亿美元,并在预测期内以7.1%的复合年增长率成长,到2030年将达到59.8亿美元。
称为 G 蛋白偶联受体 (GPCR) 的多种膜受体也称为 7(透过)跨膜受体。它们存在于细胞膜中,负责与外部化学物质相互作用并将讯号传递给细胞内分子。 GPCR 是细胞表面受体,可作为以胜胜肽、蛋白质、光能、脂质和糖等形式传递的讯息的收件匣。这些受体经常用于治疗多种疾病,包括发炎疾病、代谢紊乱、心臟疾病、癌症和单一疾病。
根据 2021 年《美国心臟协会杂誌》报道,预计到 2035 年,美国将有超过 1.3 亿成年人患有某种形式的心臟病。
慢性病的增加是 G 蛋白偶联受体 (GPCR) 市场的强大驱动因素。 GPCR 在许多生理过程的调节中发挥着至关重要的作用,使其成为有价值的药物研发标靶。随着糖尿病、心血管疾病和神经退化性疾病等慢性病的全球负担日益加重,针对 GPCR 的药物干预措施的需求不断增长。研究人员正在探索 GPCR 来寻找创新治疗方法,这正在刺激製药业的研究和开发。
G蛋白偶联受体(GPCR)细胞株的高价格是GPCR市场的主要抑制因素。取得这些细胞株的高昂成本让小型研究机构和生物技术新兴企业望而却步,限制了他们从事 GPCR 相关研究和药物开发的能力。这种定价障碍会抑制创新、减少竞争、阻碍理解和标靶化GPCR 的科学进展,并减缓新药的发现。
G 蛋白偶联受体 (GPCR) 在药物研发中的广泛采用代表着市场的重大机会。 GPCR 是涉及多种生理过程调节的多种药物标靶,对于药物研究至关重要。由于其多样性和参与许多疾病,包括癌症、神经系统疾病和代谢疾病,它越来越受到人们的关注。随着药物研发研究日益全球化,GPCR 代表了创新药物开发的一种有前途的工具。采用 GPCR 作为新疗法的标靶正在加强研究和开发配合措施,为新药铺平道路,并增加 GPCR 市场全球显着增长的潜力。
被称为 GPCR 的细胞表面受体家族包括许多不同类型的受体,并具有复杂的讯号传导系统。要了解 GPCR 如何与各种配体和下游讯号级联相互作用很困难,这使得新药的发现和现有药物的开发变得更加困难。这种复杂性使得预测候选药物的有效性变得困难,并增加了意外不良反应的风险。此外,它需要大量的研究、最尖端科技和协作研究,这是昂贵且耗时的。所有这些因素预计将抑制市场成长。
G蛋白偶联受体(GPCR)市场在不同方面受到了COVID-19大大流行的显着影响。由于实验室关闭以及资源重新分配给大流行相关研究,对药物研发至关重要的 GPCR 研究已经陷入停滞。另一方面,迫切需要引入计算科学方法和虚拟筛选方法来进行GPCR药物研发。由于 GPCR 在免疫反应中发挥的作用及其在治疗病毒感染疾病的潜力,市场对针对 GPCR 的治疗药物的需求不断增加。总体而言,疫情影响了 GPCR 市场,透过转向数位方法推动创新并抑制创新。
cAMP 功能分析领域预计将在预测期内占据最大的市场占有率。 cAMP 检测广泛用于研究 GPCR 活化和讯号途径,对于识别潜在候选药物至关重要。 cAMP 测定使研究人员能够评估 GPCR 对配体的反应,为药物功效和安全性提供有价值的见解。随着针对 GPCR 的药物需求的增加,cAMP 检测越来越受到关注,并增强了其在市场上的主导地位。
由于 GPCR 在癌症进展中发挥的关键作用,癌症研究领域在预测期内呈现最高的成长率。研究表明,GPCR 参与肿瘤生长、血管生成和转移,使其成为癌症治疗的有吸引力的标靶。此外,对个人化医疗的日益重视以及针对 GPCR 的抗癌药物的开发也支持了新兴市场的成长。随着对癌症中 GPCR 讯号传导的了解不断深入,创新治疗方法不断涌现,对 GPCR 相关研究工具的需求也随之增加。
在预测期内,北美预计将占据最大的市场占有率,其中以美国、加拿大和墨西哥等经济和技术先进国家为首。据美国癌症协会称,2022 年,仅美国就会新增 190 万癌症病例,并有 609,360 例癌症相关死亡。同样,2021 年加拿大癌症统计数据显示,大约五分之二的加拿大人在其一生中将被诊断出患有癌症,四分之一的人将死于该疾病。进一步推动北美市场成长的是慢性疾病的负担,特别是心血管疾病和癌症,这推动了对尖端疗法和治疗的需求。
由于 NB Health Laboratory、HD Biosciences Co.Ltd.、Sosei Heptares 等许多年轻公司的存在,预计亚太地区在预测期内将出现最高的成长。区域成长受到公司为扩大市场占有率而采取的一系列配合措施的影响。此外,文明病的日益普及以及中国、印度和其他经济体不断增长的人口对受体介导治疗的需求也将推动区域扩张。
According to Stratistics MRC, the Global G-Protein Coupled Receptors (GPCRs) Market is accounted for $3.70 billion in 2023 and is expected to reach $5.98 billion by 2030 growing at a CAGR of 7.1% during the forecast period. The diverse group of membrane receptors known as G-Protein Coupled Receptors (GPCRs), also referred to as seven-(pass)-trans membrane receptors. These can be found in the cell membrane and are in charge of interacting with external chemicals and relaying signals to intracellular molecules. GPCRs are cell surface receptors that function as an inbox for messages delivered as peptides, proteins, light energy, lipids, and sugars. These receptors are frequently employed in the management of a wide range of illnesses, including inflammatory disorders, metabolic disturbances, cardiac disorders, cancer, and monogenic disorders.
According to the American Heart Association's 2021 Journal, more than 130 million adults in the United States are expected to have some type of heart disease by 2035.
The increasing prevalence of chronic diseases serves as a robust driver in the G-Protein Coupled Receptors (GPCRs) market. GPCRs play a pivotal role in regulating numerous physiological processes, making them valuable drug targets. With a growing global burden of chronic conditions such as diabetes, cardiovascular diseases, and neurodegenerative disorders, the demand for pharmaceutical interventions that target GPCRs is on the rise. Researchers are exploring GPCRs for innovative therapeutic solutions, which has stimulated research and development in the pharmaceutical industry.
The high price of G-Protein Coupled Receptors (GPCRs) cell lines represents a significant restraint in the GPCR market. The substantial cost associated with acquiring these cell lines can be prohibitive for smaller research institutions and biotech startups, limiting their ability to engage in GPCR-related research and drug development. This pricing barrier can stifle innovation, reduce competition, and impede scientific progress in understanding and targeting GPCRs, potentially slowing down the discovery of new pharmaceuticals.
The widespread adoption of G-Protein Coupled Receptors (GPCRs) in drug discovery represents a significant opportunity for the market. GPCRs are a diverse class of drug targets involved in regulating various physiological processes, making them crucial for pharmaceutical research. Their versatility and involvement in numerous diseases, including cancer, neurological disorders, and metabolic conditions, have led to increased interest. As drug discovery efforts become increasingly globalized, GPCRs offer a promising avenue for innovative drug development. This adoption of GPCRs as targets for new therapeutics enhances research and development initiatives, paving the way for novel medications, and underscores the substantial growth potential in the GPCR market on a global scale.
The family of cell surface receptors known as GPCRs includes many different types of receptors and has complex signaling systems. It can be difficult to comprehend how they interact with different ligands and downstream signaling cascades, which makes it more difficult to find new drugs and develop existing ones. Because of this complexity, it is harder to predict a drug candidate's effectiveness, and there is a higher risk of unanticipated negative effects. Additionally, a lot of research, cutting-edge technology, and collaboration are needed, which are expensive and time-consuming. All of these elements are expected to restrain market growth.
The G-Protein Coupled Receptors (GPCR) market has been significantly impacted by the COVID-19 pandemic in a number of ways. Lab closures and resource redistribution towards pandemic-related studies resulted in a slowdown in the study of GPCRs, which are essential for drug discovery. On the other hand, it has hastened the adoption of computational and virtual screening techniques for GPCR drug development. Due to the role that GPCRs play in immune responses and the potential they provide for treating viral infections, the market saw an increase in demand for GPCR-targeted therapies. Overall, the pandemic affected the GPCR market by fostering innovation and stifling it with a move toward digital methods.
The cAMP functional assays segment is anticipated to register the largest market share in the anticipated timeframe. This is due to its critical role in drug discovery and understanding cellular signaling. cAMP assays are widely utilized for studying GPCR activation and signaling pathways, making them integral to identifying potential drug candidates. They enable researchers to assess GPCR responses to ligands, providing valuable insights into drug efficacy and safety. With the rising demand for GPCR-targeted drugs, cAMP assays have gained prominence, driving their dominance in the market.
The cancer research segment is experiencing the highest growth rate during the forecast period due to the pivotal role GPCRs play in cancer progression. Research has revealed GPCRs' involvement in tumor growth, angiogenesis, and metastasis, making them attractive targets for cancer therapy. Additionally, the market's growth is fueled by the increased emphasis on personalized medicine and the development of GPCR-targeted cancer drugs. Advances in understanding GPCR signaling in cancer have led to a surge in innovative therapies and a growing demand for GPCR-related research tools, positioning this segment for substantial expansion in the near future.
During the forecast period, North America is anticipated to witness largest market share, led by the economically and technologically developed nations of the United States, Canada, and Mexico. According to the American Cancer Society, there will be 1.9 million new cases of cancer and 609,360 cancer-related deaths in the United States alone in 2022. In a similar vein, the Canadian Cancer Statistics 2021 revealed that roughly 2 in 5 Canadians will receive a cancer diagnosis during their lifetime and that 1 in 4 will pass away from the disease. Further bolstering market growth in North America is the burden of chronic diseases, particularly in cardiovascular and cancer applications, which is raising demand for cutting-edge therapies and treatments.
Asia-Pacific is expected to experience the highest growth during the forecast period due to the presence of a number of young businesses like NB Health Laboratory, HD Biosciences Co., Ltd., and Sosei Heptares. Regional growth is influenced by the number of initiatives companies take to enhance their market presence. Furthermore, regional expansion is also fueled by the growing prevalence of lifestyle disorders among the expanding populations of China, India, and other economies, as well as the need to treat them with receptors.
Some of the key players in G-Protein Coupled Receptors (GPCRs) market include: Abcam PLC, Accure Pharma, Actelion, Addex Pharmaceuticals Ltd, Arena Pharmaceuticals, Inc., BD (Becton, Dickinson and Company), BioInvenu, Inc., Cisbio Bioassays, Corning Incorporated, Enzo Life Sciences, Inc., Eurofins DiscoverX, HD Biosciences Co., Ltd, Merck Group, Molecular Devices, LLC., PerkinElmer Inc., Promega Corporation, Qiagen, Thermo Fisher Scientific WuXi AppTec and Confo Therapeutics.
In March 2023, Confo Therapeutics, a leader in targeting G-Protein Coupled Receptors (GPCRs) (GPCRs), this week announced an agreement with Daiichi Sankyo for the discovery and development of small molecule agonists against an undisclosed CNS target. Confo will receive upfront and milestone payments totaling $183 million and tiered royalties on sales from any resulting products.
In December 2022, Sosei Group Corporation announced its partnership with Eli Lilly and Company, a global biopharmaceutical firm. The collaboration aims to facilitate drug discovery for novel G protein-coupled receptor (GPCR) targets linked to diabetes and metabolic diseases, including the development and commercialization of small molecules with therapeutic potential.
In April 2022, Ono Pharmaceutical Co., Ltd. signed a new collaboration agreement with Domain Therapeutics and Universite de Montreal to discover novel small molecules targeting G-Protein Coupled Receptors (GPCRs) (GPCRs) in a metabolic disease area.