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市场调查报告书
商品编码
1401866
到 2030 年毒蕈碱乙酰胆碱受体的全球市场预测:按类型、产品、配销通路、应用、最终用户和地区进行分析Muscarinic Acetylcholine Receptor Market Forecasts to 2030 - Global Analysis By Type (M1, M4, M5 and Other Types), Product (Tropicamide, Nu-0467154, Anauex-273 and Other Products), Distribution Channel, Application, End User and By Geography |
根据 Stratistics MRC 的数据,2023 年全球毒蕈碱乙酰胆碱受体市场规模为 17.5 亿美元,预计在预测期内复合年增长率为 6.9%,到 2030 年将达到 27.9 亿美元。
毒蕈碱乙酰胆碱受体是一类可以抑制突触后神经元并参与多种週边和中枢活动的控制的受体。它负责调节副交感神经系统的生理后果。它具有抑制和兴奋作用,可以阻断或刺激反应,并作为胆碱能神经元储存在产生乙酰胆碱的神经元中。
据支持医学研究的美国非营利组织美国心臟协会称,到 2060 年,美国患有阿兹海默症和相关失智症的人数预计将增加到 930 万人。
神经系统疾病盛行率增加
由于人口高龄化和生活方式的改变,阿兹海默症、帕金森氏症和思觉失调症等神经系统疾病变得越来越普遍。毒蕈碱乙酰胆碱受体在这些疾病中发挥重要作用,并且是药物开发的有吸引力的标靶。此外,由于迫切需要解决医疗保健系统中神经系统疾病的负担以及对创新治疗方法的需求不断增长,市场正在扩大。这为该领域的製药公司和研究人员提供了巨大的潜力,也为患者带来了潜在的希望。
副作用和安全问题
针对毒蕈碱乙酰胆碱受体的药物可能会引起口干、视力模糊、便秘、头晕和认知障碍等副作用。这些副作用会影响患者的依从性和生活质量,尤其是老年人群,他们可能已经因老龄化相关问题而出现这些症状。平衡治疗效果和副作用可能很困难,并且限制了患者的医嘱遵从性。还有安全性问题,因为它可能会影响心血管和呼吸系统。结果,它阻碍了市场的扩张。
标靶治疗
标靶治疗可以提供更精确的治疗选择、最大限度地减少副作用并改善治疗结果。根据每个患者的受体特征定制干预措施可以使个人化医疗成为现实,并彻底改变阿兹海默症、思觉失调症和帕金森氏症等疾病的治疗方法。此外,药物传递系统和诊断工具的进步可以优化这些治疗的功效。这为製药公司和研究人员开发创新的、以患者为中心的解决方案并推动市场成长提供了一条充满希望的道路。
监管障碍
开发针对毒蕈碱受体的药物需要遵守严格的监管要求,包括广泛的临床试验和安全性评估。此类要求会延长开发时间、增加成本并带来监管脱轨的风险。延误和拒绝阻碍了市场进入并阻碍了製药公司。这些障碍可能会抑制创新,延迟神经和精神疾病新治疗方法的推出,并影响市场成长和竞争。
COVID-19 的爆发严重影响了肌肉乙酰胆碱受体市场。由于供应链中断、研发业务受到限制以及医疗资源的重新调整,临床试验和药物开发正在推迟。此外,由于对远距医疗的重视和亲自就诊的减少,患者获得毒蕈碱受体相关药物的机会受到影响。然而,这场大流行凸显了神经学研究和创新的重要性,随着医疗保健系统适应未来的挑战和机会,也可能增加对该市场的兴趣和投资。
托吡卡胺产业预计将在预测期内成为最大的产业
预计托吡卡胺领域将占最大占有率。托吡卡胺是一种药物,属于抗胆碱能药物或毒蕈碱拮抗类药物。在眼科领域主要用作环丁二烯促效剂和散瞳剂。透过抑制虹膜和睫状肌中的毒蕈碱乙酰胆碱受体,托吡卡胺麻痹眼睛的聚焦肌肉并导致瞳孔扩张。托吡卡胺在眼科领域的应用强调了它与更大市场的联繫,该市场包括针对这些受体的药物和治疗方法,以治疗各种疾病,包括精神疾病和神经系统疾病。
预计精神疾病产业在预测期内复合年增长率最高
预计精神疾病领域在预测期内将出现良好成长。毒蕈碱乙酰胆碱受体是一组存在于中枢神经系统中的受体,在调节多种脑部功能中发挥重要作用。这些受体的功能障碍与多种精神疾病有关,包括思觉失调症、躁郁症和重度忧郁症。该市场专注于能够为精神疾病患者提供更有效、更有针对性的治疗的创新治疗方法,使其成为医疗进步的一个有前途的途径。因此,该领域的需求预计将会增加。
由于医疗保健支出增加和老年人口增加,亚太地区在预测期内获得了最大的市场占有率。该市场包括与毒蕈碱乙酰胆碱受体(神经系统的重要组成部分)相关的药品、研究工具和诊断产品。该市场受到神经系统疾病的流行、药物开发的进步以及神经系统研究的增加等因素的影响。此外,该地区的主要製药公司、研究机构和生物技术公司正在致力于开发和商业化与这些受体相关的产品。学术界和工业界之间的合作很常见,精准医疗方法和标靶治疗是主要趋势,反映出该地区对个人化医疗解决方案的日益关注。
由于成熟的医疗基础设施、高研发投资和大量患者人口,预计北美在预测期内将出现有益增长。市场规模受到与这些受体相关的疾病的流行、药物开发的进展以及神经病学和相关领域的研究等因素的影响。此外,製药公司正在开发针对多种医疗状况的毒蕈碱乙酰胆碱受体的药物,包括阿兹海默症神经系统疾病。
According to Stratistics MRC, the Global Muscarinic Acetylcholine Receptor Market is accounted for $1.75 billion in 2023 and is expected to reach $2.79 billion by 2030 growing at a CAGR of 6.9% during the forecast period. Muscarinic acetylcholine receptors are a class of receptors that can inhibit postsynaptic neurons and are involved in the regulation of several peripheral and central activities. They are responsible for regulating the parasympathetic nervous system's physiological consequences. It has both inhibitory and excitatory effects that can block or stimulate the response and is stored in the acetylcholine-producing neurons as cholinergic neurons.
According to the American Heart Association, a US-based nonprofit organization that supports medical research, the number of persons affected by Alzheimer's disease and associated dementias in the United States is expected to rise to 9.3 million by 2060.
Increasing prevalence of neurological disorders
Neurological conditions, such as Alzheimer's disease, Parkinson's disease, and schizophrenia, are becoming more widespread due to ageing populations and changing lifestyles. Muscarinic acetylcholine receptors play a crucial role in these disorders, making them attractive targets for drug development. Moreover, the market is growing as a result of a dire need to address the burden of neurological illnesses on healthcare systems and the growing need for innovative therapies. This presents both significant possibilities for pharmaceutical companies and researchers in the field, as well as potential hope for patients.
Side effects and safety concerns
Medications targeting muscarinic acetylcholine receptors can lead to adverse effects such as dry mouth, blurred vision, constipation, dizziness, and cognitive impairment. These side effects can impact patient compliance and quality of life, particularly in elderly populations that may already experience some of these symptoms due to age-related issues. Balancing therapeutic benefits with side effects is challenging, potentially limiting patient adherence. Safety concerns also arise due to the potential impact on cardiovascular and respiratory systems. Thus, they are limiting market expansion.
Targeted therapies
Targeted therapies can offer more precise treatment options, minimising side effects and enhancing therapeutic outcomes. By tailoring interventions to the individual patient's receptor profile, personalised medicine becomes a reality, potentially revolutionising the treatment of conditions like Alzheimer's disease, schizophrenia, and Parkinson's disease. Furthermore, advancements in drug delivery systems and diagnostic tools can optimise the effectiveness of these therapies. This presents a promising avenue for pharmaceutical companies and researchers to develop innovative, patient-centric solutions and drive growth in the market.
Regulatory hurdles
Developing drugs targeting muscarinic receptors requires adherence to rigorous regulatory requirements, including extensive clinical trials and safety assessments. These demands lead to extended timelines, increased costs, and the risk of regulatory setbacks. Delays or rejections can hinder market entry and deter pharmaceutical companies. These obstacles may impede innovation, potentially delaying the availability of new treatments for neurological and psychiatric disorders and impacting the market's growth and competitiveness.
The COVID-19 pandemic has significantly impacted the muscle acetylcholine receptor market. Clinical trial and medication development have been delayed as a result of supply chain interruptions, limitations imposed on research and development operations, and the reorganisation of healthcare resources. Additionally, patient access to muscarinic receptor-related medicines was impacted by the emphasis on telehealth and the decline in in-person healthcare visits. However, the pandemic also underscored the importance of neurological research and innovation, potentially driving increased interest and investment in this market as healthcare systems adapt to future challenges and opportunities.
The Tropicamide segment is expected to be the largest during the forecast period
The Tropicamide segment is estimated to hold the largest share. Tropicamide is a pharmaceutical medication that belongs to a class of drugs known as anticholinergics or muscarinic antagonists. In ophthalmology, it is mainly employed as a cycloplegic and mydriatic agent. Tropicamide works by paralysing the focusing muscle of the eye and dilatation of the pupil by inhibiting muscarinic acetylcholine receptors in the iris and ciliary muscle. The application of tropicamide in ophthalmology highlights its connection to the larger market, which includes medications and treatments that target these receptors to treat a range of illnesses, including psychological and neurological diseases.
The Psychiatric Disorders segment is expected to have the highest CAGR during the forecast period
The Psychiatric Disorders segment is anticipated to have lucrative growth during the forecast period. Muscarinic acetylcholine receptors are a group of receptors in the central nervous system that play a crucial role in regulating various brain functions. Dysfunction in these receptors is implicated in several psychiatric conditions, including schizophrenia, bipolar disorder, and major depressive disorder. This segment of the market focuses on innovative therapies that can offer more effective and targeted treatments for individuals suffering from psychiatric conditions, representing a promising avenue for medical advancements. Hence, this will propel segment demand.
Asia Pacific commanded the largest market share during the extrapolated period due to rising healthcare expenditures and a growing geriatric population. It encompasses pharmaceuticals, research tools, and diagnostics associated with muscarinic acetylcholine receptors, vital components in the nervous system. This market is influenced by factors such as the prevalence of neurological disorders, advancing drug development, and increasing research in neurology. Moreover, major pharmaceutical companies, research institutions, and biotechnology firms in the region engage in the development and commercialization of products related to these receptors. Collaborations between academia and industry are common, and precision medicine approaches and targeted therapies are key trends, reflecting a growing focus on personalised healthcare solutions in the region.
North America is expected to witness profitable growth over the projection period, due to the presence of a well-established healthcare infrastructure, high research and development investments, and a large patient population. The market size is influenced by factors such as the prevalence of conditions related to these receptors, advancements in drug development, and research in neurology and related fields. Furthermore, pharmaceutical companies develop drugs targeting muscarinic acetylcholine receptors for various medical conditions, including neurological disorders like Alzheimer's disease.
Some of the key players in the Muscarinic Acetylcholine Receptor Market include AstraZeneca, Anavex Life Sciences Corp., Sosei Heptares, Karuna Therapeutics, Sumitomo Dainippon Pharma Co., Ltd., NeuroHealing Pharmaceuticals Inc., Heptares Therapeutics Ltd., Pfizer Inc., GlaxoSmithKline plc, Novartis AG, Johnson & Johnson, Boehringer Ingelheim International Gmbh, Eli Lilly and Company, Takeda Pharmaceutical Company Ltd, Merck & Co., Inc, AbbVie Inc., Elsevier B.V., Eurofins DiscoverX Corporation and Novus Biologicals.
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