市场调查报告书
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1494844
2030 年冷冻电子显微镜市场预测:按产品类型、方法、奈米製剂、电压、技术、应用和地区进行的全球分析Cryo-Electron Microscopy Market Forecasts to 2030 - Global Analysis By Product Type, Method, Nano Formulations, Voltage, Technology, Application and By Geography |
根据 Stratistics MRC 的数据,2024 年全球冷冻电镜市场规模为 14.2 亿美元,预计到 2030 年将达到 30.5 亿美元,预测期内复合年增长率为 13.60%。
冷冻电子显微镜使我们能够以前所未有的细节观察生物分子结构,彻底改变了结构生物学领域。该技术使用低温下的电子显微镜快速冷冻样品并在自然状态下进行成像。冷冻电子显微镜无需化学固定或染色即可获得原始生物大分子的高解析度影像。此外,冷冻电子显微镜捕捉动态分子结构的能力使得生物化学、药理学和病毒学领域的重大进展成为可能。
世界卫生组织(WHO)表示,获得基本药物是一项基本人权,确保这些药物的公平分配和可负担性对于实现全球健康目标至关重要。
对药物开发和发现的需求不断增加
冷冻电子显微镜已成为製药业中先导化合物化合物优化、药物标靶结构阐明和合理药物设计的强大工具。以近原子分辨率观察动态蛋白质-药物相互作用和大分子复合物的能力为潜在治疗药物的作用机制提供了重要的见解。此外,随着药物发现管道转向更多关註生物製药、膜蛋白和困难的药物靶标,冷冻电镜服务和专业知识的需求量很大,从而推动了市场扩张。
资料分析和样品製备的复杂性
冷冻电镜样品的网格、玻璃化和成像条件的准备需要特定的知识和工具。对于没有经验的使用者来说,进入该领域的主要障碍是需要精通资料分析和冷冻电子显微镜技术,以及与样品製备相关的费力且复杂的工作流程。此外,冷冻电子显微镜实验会产生大量原始资料,需要复杂的影像处理演算法和可靠的计算基础设施来进行资料分析和结构细化。
硬体和软体技术进步
公司有很多机会发挥创意并提供尖端的冷冻电子显微镜硬体和软体。这包括开发和製造具有改进的自动化、灵敏度和分辨率的下一代电子显微镜。此外,对使用者友善的影像处理、资料撷取和结构分析软体平台的需求也日益增长。这使软体开发人员有机会开发高效且易于使用的工具,以改善使用者体验并简化冷冻电子显微镜工作流程。
市场饱和与竞争压力
提供冷冻电子显微镜解决方案的製造商、服务供应商和研究机构的数量不断增加,使得冷冻电子显微镜市场变得拥挤。价格战、利润空间缩小以及冷冻电子显微镜产品和服务的商品化可能是激烈竞争的后果。此外,中小企业与规模更大、实力更雄厚的公司竞争将变得更加困难,并且由于市场饱和,该行业可能会经历收益成长放缓、盈利下降和行业整合。
冷冻电子显微镜 (cryo-EM) 市场受到了 COVID-19 大流行的各种影响。疫情最初扰乱了供应链、製造业务和研究活动,导致设备安装、服务合约和合作计划延迟;增加了对法律的需求。由于迫切需要了解 SARS-CoV-2 的分子机制并促进疫苗、治疗和诊断的开发,冷冻电子显微镜已广泛应用于 COVID-19 研究。此外,向远端工作和虚拟协作的转变加速了基于云端基础的冷冻电镜资料分析平台和远端存取解决方案的采用。
脂质奈米颗粒製剂(LNFS)产业预计将在预测期内成为最大的产业
脂质奈米颗粒製剂 (LNF) 在冷冻电子显微镜 (Cryo-EM) 领域占据最大的市场占有率,因为它们广泛用于传递遗传物质,例如用于疫苗和治疗的 mRNA。这些脂质奈米颗粒可以使用冷冻电子显微镜 (Cryo-EM) 进行高解析度成像,提供有关其尺寸、成分和结构完整性的资讯。此外,先进的药物开发需要使用脂质体形成因子(LNF),因为它们具有生物相容性以及封装和保护脆弱有效负载的能力。
穿透式电子显微镜(TEM)产业预计在预测期内复合年增长率最高
在冷冻电子显微镜 (Cryo-EM) 市场中,穿透式电子显微镜(TEM) 领域预计将出现最高的复合年增长率。对生物大分子的高解析度成像和结构分析的需求正在不断增加,而这种增长是由材料科学、结构生物学和药物发现的进步的需求所推动的。此外,寻求了解复杂生物过程和分子结构的研究人员发现 TEM 能够产生原子级详细的原子态影像,尤其是与低温电子显微镜结合使用时,这一点非常宝贵。
冷冻电子显微镜(cryo-Electronic Microscopy)市场以主要行业参与者的集中、坚实的研究基础设施以及对最尖端科技的大规模投资为主导,北美占据压倒性的份额。该地区高度重视科学技术,公共和私营部门大力资助,推动冷冻电子显微镜在材料科学、製药和结构生物学等多个领域的应用。此外,顶尖学术机构和生物製药公司的集中促进了协作和创造力,巩固了北美作为冷冻电子显微镜产品市场领导的地位。
由于工业化的快速发展、研发支出的增加以及各行业越来越多地采用最尖端科技,冷冻电子显微镜 (Cryo-EM) 市场正以亚太地区最高的复合年增长率成长。该地区生物技术和製药行业的成长以及政府支持科学研究和创新的倡议不断增加,推动了对冷冻电子显微镜解决方案的需求。此外,大量高技能研究人员和科学家的存在以及与国际组织和学术机构的合作进一步推动了亚太地区冷冻电子显微镜市场的成长。
According to Stratistics MRC, the Global Cryo-Electron Microscopy Market is accounted for $1.42 billion in 2024 and is expected to reach $3.05 billion by 2030 growing at a CAGR of 13.60% during the forecast period. Due to its ability to enable researchers to see bio molecular structures in unprecedented detail, cryo-electron microscopy, or cryo-EM, has completely changed the field of structural biology. Using an electron microscope at extremely low temperatures, samples are imaged using this technique, which involves rapidly freezing them to preserve their natural state. High-resolution images of biological macromolecules in their natural habitat can be obtained using cryo-EM without the need for chemical fixation or staining. Moreover, significant advancements in the domains of biochemistry, pharmacology, and virology have resulted from its capacity to capture dynamic molecular structures.
According to the World Health Organization (WHO), access to essential medicines is a fundamental human right, and ensuring equitable distribution and affordability of these medicines is critical for achieving global health goals.
Growing need for drug development and discovery
Cryo-EM has become a potent tool in the pharmaceutical industry for lead optimization, structural elucidation of drug targets, and rational drug design. The capacity to observe dynamic protein-drug interactions and macromolecular complexes at near-atomic resolution provides significant insight into the potential therapeutics' mechanisms of action. Additionally, Cryo-EM services and expertise are in high demand as drug discovery pipelines shift to focus more on biologics, membrane proteins, and difficult drug targets, which is driving market expansion.
Complexity of data analysis and sample preparation
The preparation of grids, vitrification, and imaging conditions for cryo-EM samples necessitates specific knowledge and tools. A major barrier to entry for inexperienced users is the laborious and complicated workflows involved in sample preparation, in addition to the requirement for proficiency in data analysis and cryo-EM techniques. Furthermore, cryo-EM experiments produce massive amounts of raw data, which calls for sophisticated image processing algorithms and a reliable computing infrastructure for data analysis and structural refinement.
Technological progress in hardware and software
There are many chances for businesses to be creative and provide cutting-edge cryo-EM hardware and software. This involves developing and producing next-generation electron microscopes with enhanced automation, sensitivity, and resolution. Moreover, there is a growing need for user-friendly software platforms for image processing, data acquisition, and structural analysis. This presents opportunities for software developers to create tools that are efficient and easy to use, which can improve the user experience and streamline the cryo-EM workflow.
Market saturation and competitive pressures
There are a growing number of manufacturers, service providers, and research institutions offering cryo-EM solutions, which is congesting the cryo-EM market. Price wars, shrinking profit margins, and the commoditization of cryo-EM goods and services are possible outcomes of fierce competition. Additionally, the industry may experience slower revenue growth, lower profitability, and more industry consolidation as a result of market saturation, as smaller firms find it more difficult to compete with more established, larger firms.
The cryo-electron microscopy (cryo-EM) market has been impacted by the COVID-19 pandemic in a number of ways. The pandemic increased demand for cryo-EM in researching the virus's structure, host interactions, and drug development, even though it initially disrupted supply chains, manufacturing operations, and research activities, causing delays in instrument installations, service contracts, and cooperative projects. Cryo-EM has become widely used in COVID-19 research due to the pressing need to comprehend the molecular mechanisms of SARS-CoV-2 and expedite the development of vaccines, therapeutics, and diagnostics. Moreover, the adoption of cloud-based cryo-EM data analysis platforms and remote access solutions has been accelerated by the shift towards remote work and virtual collaboration.
The Lipid Nanoparticle Formulations (LNFS) segment is expected to be the largest during the forecast period
Due to their extensive application in the delivery of genetic materials like mRNA for vaccines and therapeutics, Lipid Nanoparticle Formulations (LNFs) command the largest market share in cryo-electron microscopy (Cryo-EM). These lipid nanoparticles can be imaged at high resolution using cryo-electron microscopy (Cryo-EM), providing information about their size, composition, and structural honesty. Additionally, advanced pharmaceutical development requires the use of liposome-forming factors (LNFs) due to their biocompatibility and capacity to encapsulate and safeguard delicate payloads.
The Transmission Electron Microscopy (TEM) segment is expected to have the highest CAGR during the forecast period
The transmission electron microscopy (TEM) segment is expected to have the highest CAGR in the cryo-electron microscopy (Cryo-EM) market. The need for high-resolution imaging and structural analysis of biological macromolecules is growing, and this growth is being driven by the need to advance materials science, structural biology, and drug discovery. Furthermore, researchers attempting to comprehend intricate biological processes and molecular structures find that TEM is invaluable due to its capacity to produce detailed images at the atomic level in their native state, especially when used in conjunction with cryo-TEM.
The market for cryo-electron microscopy, or cryo-EM, is dominated by North America due in large part to the region's concentration of major industry players, solid infrastructure for research, and large investments in cutting-edge technology. The region's emphasis on science and technology, along with strong funding initiatives from both public and private entities, drives advancements in the use of cryo-EM in a variety of fields, such as materials science, pharmaceuticals, and structural biology. Moreover, the concentration of top academic institutions and biopharmaceutical firms encourages cooperation and creativity, which strengthens North America's position as the market leader for cryo-EM products.
The cryo-electron microscopy (Cryo-EM) market is growing at the highest CAGR in the Asia-Pacific region due to rapid industrialization, rising R&D spending, and a growing uptake of cutting-edge technologies in a variety of industries. The demand for cryo-EM solutions is driven by the region's growing biotechnology and pharmaceutical industries as well as growing government initiatives to support scientific research and innovation. Additionally, cryo-EM market growth in the Asia-Pacific region is further accelerated by the presence of a large pool of highly skilled researchers and scientists, as well as partnerships with international organizations and academia.
Key players in the market
Some of the key players in Cryo-Electron Microscopy market include Charles River Laboratories, Hitachi High-Technologies Corporation, Intertek Group Plc, Caliber Imaging & Diagnostics, Lasertec Corporation, HORIBA, Ltd, Olympus Corporation, Gatan, Inc., JEOL Ltd, Oxford Instruments, Nikon Instruments Inc, Keyence Corporation, Helmut Hund Gmbh, Danaher, Creative Biostructure, ZEISS International and Thermo Fisher Scientific.
In May 2024, Intertek announced an agreement to acquire Base Metallurgical Laboratories and Base Met Labs US on Monday, which provides metallurgical testing services within the minerals sector in North America, for an undisclosed sum. The AIM-traded firm said the acquisition came ahead of expected heightened demand for diverse energy sources and minerals to sustain a growing global population.
In May 2024, Hitachi High-Tech and Roche have extended their partnership, committing to at least 10 years of additional collaboration. Bringing together the companies' expertise and track record in diagnostics innovation, engineering and manufacturing, the renewed contract further strengthens the two companies' long lasting partnership.
In February 2024, Charles River Laboratories International, Inc. announced a strategic agreement with Wheeler Bio, Inc., an antibody contract development and manufacturing organization (CDMO) focused on preclinical and early clinical supply of recombinant proteins, providing clients access to Wheeler's Portable CMC platform.
Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.