市场调查报告书
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2030 年 3D 细胞培养市场预测:按产品、应用、最终用户和地区进行的全球分析3D Cell Culture Market Forecasts to 2030 - Global Analysis By Product, Application, End User and By Geography |
根据 Stratistics MRC 的数据,2024 年全球 3D 细胞培养市场规模为 27.8 亿美元,预计预测期内复合年增长率为 20.2%,到 2030 年将达到 83.8 亿美元。
生物研究中使用一种称为 3D 细胞培养的复杂尖端方法,在3D和接近生物组织自然条件的环境中培养细胞。与传统的 2D 细胞培养(细胞在平坦、坚硬的表面上培养)相比,3D 细胞培养系统允许细胞从各个方向与周围环境相互作用,从而提供更生理相关的环境。此技术改善了细胞-细胞和细胞-基质相互作用,从而产生更准确的细胞反应和行为。
根据美国癌症研究协会 (AACR) 的说法,3D 细胞培养模型可以更真实地反映癌细胞在人体内的相互作用,从而显着提高临床前测试的准确性。
慢性病增加
全球癌症、心血管疾病和神经退化性疾病等慢性疾病的增加加剧了对尖端研究模型的需求。 3D 细胞培养提供了生理学上更准确的模型来研究这些疾病的原因并产生新的治疗方法。例如,3D 肿瘤球体可以概括癌症研究中肿瘤微环境的复杂性,包括营养物质、氧气和治疗药物梯度。此外,它可以为研究抗药性、转移和肿瘤生长提供与人体非常相似的环境。
设备和材料成本过高
最初推出和维护 3D 细胞培养系统是令人望而却步的。生物印表机、微流体装置和客製化支架等先进技术需要大量资本投资。此外,与传统的 2D 培养相比,3D 细胞培养的试剂、生长因子和专用培养基的成本通常更高。对于预算有限的小型研究机构和公司来说,如此高成本可能令人望而却步,并阻碍普及。
药物开发和癌症研究的发展
3D 细胞培养技术有潜力为癌症研究和药物开发带来显着益处。与传统的 2D 培养相比,球体和类器官等3D肿瘤模型更忠实地再现了肿瘤微环境。这些模型可以更详细地研究肿瘤生长、转移和抗药性。此外,使用3D细胞培养进行高通量药物筛检可以提高新型抗癌药物的鑑定并充分利用现有的治疗方法。
监管和道德问题
围绕 3D 细胞培养技术的法规环境仍在变化,获得新模型和应用的核准可能是一个困难且耗时的过程。由于需要监管机构提供大量检验资料以确保模型的安全性和有效性,这些模型的采用可能会减慢。围绕着人类来源的细胞,特别是干细胞的使用也出现了伦理问题。此外,道德核准和监管合规的需要使得研究过程变得更加复杂和昂贵。
3D 细胞培养市场受到了 COVID-19 大流行的显着影响,无论是正面还是负面。一方面,对疫苗和有效治疗方法的迫切需求加速了研发工作,导致采用复杂的 3D 细胞培养模型来研究病毒和测试潜在的治疗方法。这些模型为分析抗病毒药物和了解 SARS-CoV-2 感染机制提供了更精确和生理相关的框架。然而,疫情导致了资金分配的变化、研究计划的延迟和供应链的中断,使得开展新的和正在进行的研究倡议变得困难。
癌症研究领域预计在预测期内规模最大
癌症研究领域的驱动因素是癌症盛行率不断上升,以及迫切需要更精确和生理学准确的模型来研究肿瘤生物学和评估可能的治疗方法,该领域在 3D 细胞培养行业中占据最大的市场占有率。球体和类器官是 3D 细胞培养系统的两个例子,它们越来越多地被使用,因为传统的 2D 细胞培养通常无法重现复杂的肿瘤微环境。此外,由于这些 3D 模型更接近体内条件,因此可以更准确地进行癌细胞行为、肿瘤进展和转移的研究。
生物技术和製药公司领域预计在预测期内复合年增长率最高
在3D细胞培养市场中,复合年增长率最高的领域是生技和製药公司。该行业的强劲成长得益于其对尖端药物开发和发现的关注,其中 3D 细胞培养技术至关重要。为了重建组织和器官的复杂微环境,生物技术和製药公司使用 3D 细胞培养模型。这可以更准确地评估药物毒性、药物动力学和功效。此外,对再生疗法和个人化医疗的需求正在推动业界采用 3D 细胞培养技术。
北美在 3D 细胞培养市场中占有最大份额。这一优势得益于多种因素,包括知名生物技术和製药公司的存在、先进的医疗保健系统、大量的研发支出以及促进最尖端科技采用的强大法规环境。此外,支持生物医学研究的政府计划以及学术界和工业界之间的合作也正在加强该领域的市场。
在3D细胞培养市场中,亚太地区的复合年增长率最高。生技和製药产业不断扩张,医疗保健基础设施投资不断增加,研发活动不断增加,并且越来越关注个人化医疗和再生疗法。这些是推动这一成长的一些因素。此外,鼓励性的政府计划、产学界合作以及蓬勃发展的生物製药市场正在帮助加速 3D 细胞培养技术在亚太地区的采用。
According to Stratistics MRC, the Global 3D Cell Culture Market is accounted for $2.78 billion in 2024 and is expected to reach $8.38 billion by 2030 growing at a CAGR of 20.2% during the forecast period. A sophisticated and cutting-edge method called 3D cell culture is used in biological research to grow cells in an environment that closely resembles three dimensions and the natural conditions of living organisms' tissues. 3D cell culture systems offer a more physiologically relevant context, allowing cells to interact with their surroundings in all directions, in contrast to traditional 2D cell cultures, where cells are grown on flat, rigid surfaces. More accurate cellular responses and behaviours result from the improved cell-cell and cell-matrix interactions brought about by this technique.
According to the American Association for Cancer Research (AACR), 3D cell culture models significantly enhance the accuracy of preclinical testing by providing a more realistic representation of how cancer cells interact within the human body.
Growing rates of chronic illnesses
The need for cutting-edge research models is being driven by the global rise in chronic diseases like cancer, cardiovascular disease, and neurodegenerative disorders. More physiologically accurate models for researching the causes of these illnesses and creating novel treatment approaches are offered by 3D cell cultures. For instance, 3D tumor spheroids can replicate the intricacy of tumor microenvironments, including nutrient, oxygen, and therapeutic agent gradients, in cancer research. Additionally, this provides an environment that is very similar to the human body for researchers to study drug resistance, metastasis, and tumor growth.
Exorbitant equipment and material costs
It can be unaffordable to set up and maintain 3D cell culture systems on an initial basis. Significant capital investment is needed for advanced technologies like bioprinters, microfluidic devices, and customized scaffolds. Furthermore, compared to conventional 2D cultures, the cost of reagents, growth factors, and specialized culture media for 3D cell cultures is frequently higher. Widespread adoption may be hampered by this high cost, which may be prohibitive for smaller research organizations and businesses with tighter budgets.
Development in drug development and cancer research
3D cell culture technologies have enormous potential benefits for cancer research and drug development. Compared to conventional 2D cultures, 3D tumor models, such as spheroids and organoids, more closely resemble the tumor microenvironment. More precise research on tumor growth, metastasis, and drug resistance is made possible by these models. Moreover, high-throughput drug screening using 3D cell cultures can improve the identification of novel anticancer medications and maximize currently available treatments.
Regulatory and ethical issues
The regulatory environment surrounding 3D cell culture technologies is still changing, and getting new models and applications approved can be a difficult and drawn-out procedure. The adoption of these models may be slowed down by the need for substantial validation data from regulatory bodies to guarantee the security and effectiveness of the models. Challenges also arise from ethical issues surrounding the use of human-derived cells, particularly stem cells. Additionally, the process of conducting research can become more complex and expensive when ethical approvals and regulatory compliance are required.
The market for 3D cell culture has been significantly impacted by the COVID-19 pandemic, both positively and negatively. On the one hand, research and development efforts were accelerated by the pressing need for vaccines and effective treatments, which led to the adoption of sophisticated 3D cell culture models for studying the virus and testing possible therapies. These models offered more precise and physiologically relevant frameworks for analyzing antiviral medications and comprehending the mechanisms of SARS-CoV-2 infection. However, the pandemic caused funding reallocations, delayed research projects, and upset supply chains, making it difficult to pursue both new and ongoing research initiatives.
The Cancer Research segment is expected to be the largest during the forecast period
Due to the rising incidence of cancer and the urgent need for more precise and physiologically accurate models to investigate tumor biology and assess possible therapies, the cancer research segment holds the largest market share in the 3D cell culture industry. Spheroids and organoids are two examples of 3D cell culture systems that are increasingly being used because traditional 2D cell cultures frequently fall short of replicating the intricate tumor microenvironment. Moreover, studies of cancer cell behavior, tumor progression, and metastasis can be conducted more precisely to these 3D models since they more closely resemble in vivo conditions.
The Biotechnology and Pharmaceutical Companies segment is expected to have the highest CAGR during the forecast period
In the 3D cell culture market, the segment with the highest CAGR is biotechnology and pharmaceutical companies. This industry's strong growth can be attributed to its intense concentration on cutting-edge drug development and discovery, where 3D cell culture technologies are essential. To replicate the complex microenvironments of tissues and organs, biotech and pharmaceutical companies use 3D cell culture models. This allows for a more precise evaluation of drug toxicity, pharmacokinetics, and efficacy. Furthermore, the need for regenerative therapies and personalized medicine is driving the industry's adoption of 3D cell culture techniques.
In the market for 3D cell culture, North America has the largest share. Numerous elements contribute to this dominance, such as the existence of well-known biotech and pharmaceutical firms, a sophisticated healthcare system, large expenditures for R&D, and a strong regulatory environment that promotes the uptake of cutting-edge technologies. Additionally, government programs that support biomedical research and partnerships between academia and business strengthen the market in this area.
In the 3D cell culture market, the Asia-Pacific region exhibits the highest CAGR. The biotechnology and pharmaceutical industries are expanding, healthcare infrastructure investments are rising, research and development activities are increasing, and the focus on personalized medicine and regenerative therapies is becoming more and more important. These are some of the factors driving this growth. Furthermore, encouraging government programs, industry-academia partnerships, and a quickly growing biopharmaceutical market all play a part in the Asia Pacific region's accelerated adoption of 3D cell culture technologies.
Key players in the market
Some of the key players in 3D Cell Culture market include Lena Biosciences, Hurel Corporation, Becton, Dickinson And Company, Lonza AG, Advanced Biomatrix, Inc., InSphero AG, Corning Incorporated, Merck KGaA, Thermo Fisher Scientific, Inc., Reprocell Inc., Avantor, Inc., Synthecon Incorporated, Nortis Inc., Tecan Trading AG, Promocell GmbH, VWR International LLC and Sartorius AG.
In May 2024, Merck KGaA, Darmstadt, Germany has signed a definitive agreement to acquire life science company Mirus Bio for $600 million (around €550 million). Based in Madison, Wisconsin, Mirus Bio is a specialist in the development and commercialization of transfection reagents. Transfection reagents, such as Mirus Bio's TransIT-VirusGEN, are used to help introduce genetic material into cells.
In January 2024, BD (Becton, Dickinson and Company), a leading global medical technology company, announced a collaboration agreement with Hamilton, a leading global manufacturer of laboratory automation technology, to develop automated applications together with robotics-compatible reagent kits to enable greater standardization and reduced human error when conducting large-scale single-cell multiomics experiments.
In June 2023, Corning Incorporated and SGD Pharma announced a joint venture that includes the opening of a new glass tubing facility to expand pharmaceutical manufacturing in India and allows SGD Pharma to adopt Corning's Velocity Vial technology platform.
Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.