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到 2030 年原代细胞培养市场预测:按产品、细胞类型、分离方法、应用、最终用户和地区进行的全球分析Primary Cell Culture Market Forecasts to 2030 - Global Analysis By Product (Primary Cells, Reagents and Supplements and Other Products), Cell Type (Human Cells and Animal Cells), Separation Method, Application, End User and By Geography |
根据 Stratistics MRC 的数据,2024 年全球原代细胞培养市场规模为 56.2 亿美元,预计预测期内复合年增长率为 15.3%,到 2030 年将达到 131.9 亿美元。
原代细胞培养是指直接从组织或生物体分离细胞并在受控条件下进行试管内培养的过程。此方法保留了细胞的大部分生理、生化和遗传特性,并提供了密切模拟体内条件的培养物。然而,原代培养细胞的寿命有限,通常具有有限的分裂次数。
根据世界卫生组织预测,全球癌症死亡人数将持续增加,到2030年将达到1,700万以上。
不断成长的製药和生物技术产业
製药和生物技术领域的成长正在推动原代细胞培养市场,刺激了对创新和可靠的细胞模型的需求。这些领域需要高品质的原代细胞来进行药物发现、开发和测试,因为与永生化细胞株相比,它们提供了更多的生理相关资料。个人化医疗和再生疗法的进步进一步增加了对特定原代细胞的需求。此外,对生技药品和生物相似药的日益关注需要使用原代细胞来评估药物功效和安全性。
有限的可用率
原代细胞培养市场的供应有限是指采购和取得原代细胞用于研究和生产的挑战。原代细胞非常稀有且昂贵,因为它们直接源自组织并且寿命有限。分离过程在技术上很困难,只能产生有限数量的活细胞。此外,捐助者的可变性、道德考虑和严格的监管要求进一步限制了其可用性。
3D 细胞培养的进展
3D 细胞培养技术的进步正在显着增强原代细胞培养市场。与传统的 2D 培养相比,这些技术透过更好地模仿体内环境,提供了更生理相关的模型。基于支架的系统、球体和类器官等创新可以实现更精确的细胞-细胞和细胞-基质相互作用。这将导致疾病建模、药物筛检和组织工程应用的改进。此外,3D 培养可支持原代细胞的生长,保留其分化状态和功能,使它们对个人化医疗和再生治疗有价值。
再现性和标准化问题
再现性和标准化是原代细胞培养市场的关键问题。直接源自组织的原代细胞表现出固有的生物变异性,导致实验结果不一致。标准化问题源自于缺乏统一的协议和品管,使得难以确保不同实验室和实验的一致性。这些挑战可能会妨碍研究结果的可靠性,影响基于细胞的检测的开发,并使监管核准复杂化。
COVID-19 大流行对原代细胞培养市场产生了重大影响,主要是透过供应链中断和实验室操作延误。对 SARS-CoV-2 相关研究的需求不断增长,推动了市场成长,原代细胞培养对于研究病毒行为、开发疫苗和测试抗病毒药物至关重要。各研究所将重点转向 COVID-19 研究,加速细胞培养技术的创新和资金筹措。然而,我们对流行病相关研究的关注导致了非 COVID-19 研究的延误,影响了我们的整体研究管道和计划时间表。
预计原电池产业在预测期内将是最大的
原代细胞培养市场中原代细胞细分市场的成长归因于多种因素。对于用于药物开发和测试的更生理相关的细胞模型的需求不断增长,而原代细胞可以提供这一点,因为它们是直接从组织中提取的。该领域受益于维持细胞完整性和功能的分离技术的进步,提高了效用。此外,与永生化细胞株相比,原代细胞使研究人员能够更精确地研究复杂的细胞间相互作用和疾病机制。
酵素降解领域预计在预测期内复合年增长率最高
原代细胞培养市场中的酵素降解是在细胞培养过程中使用酵素将细胞从组织中解离或降解不必要的细胞成分的过程。该领域的成长是由于对高效、良性细胞分离和维护方法的需求不断增长而推动的。胰蛋白酶、胶原蛋白酶和分散酶等酶对于以最小的损伤实现高细胞产量至关重要,从而支持研究、药物开发和再生医学中的各种应用。酵素技术的进步,包括重组酶的开发和改进的配方,使酵素消化方法更加可靠和具体。
由于多种因素,北美地区的原代细胞培养市场正在经历显着成长。首先,生物技术和製药领域的研发活动不断增加,推动了药物发现和药物开发对原代细胞培养技术的需求。慢性病的增加和个人化医疗的需求强调了原代细胞培养在研究疾病机制和开发标靶治疗中的重要性。此外,学术机构、研究机构和产业相关人员之间的合作透过促进知识交流为该地区的发展做出了贡献。
由于多种因素,亚太地区的原代细胞培养市场正在经历显着成长。需求受到中国、印度、日本和韩国等国家生物技术和製药业投资增加的推动。这些国家正在扩大其研究能力和基础设施,并培育适合细胞培养技术的环境。此外,慢性病盛行率的上升推动了对药物开发高级研究的需求,进一步推动了市场的发展。
According to Stratistics MRC, the Global Primary Cell Culture Market is accounted for $5.62 billion in 2024 and is expected to reach $13.19 billion by 2030 growing at a CAGR of 15.3% during the forecast period. Primary cell culture refers to the process of isolating cells directly from a tissue or organism and growing them in vitro under controlled conditions. This method provides a culture that closely mimics the in vivo state of the cells, retaining most of their physiological, biochemical, and genetic characteristics. However, primary cultures have a limited lifespan and usually undergo senescence after a finite number of divisions.
According to WHO projections, the number of cancer deaths worldwide will continue to climb and will reach over 17 million by 2030.
Growing pharmaceutical and biotech sectors
The growing pharmaceutical and biotech sectors are driving the primary cell culture market by fueling the demand for innovative and reliable cell-based models. These sectors require high-quality primary cells for drug discovery, development, and testing, as they provide more physiologically relevant data compared to immortalized cell lines. Advances in personalized medicine and regenerative therapies further amplify the need for specific primary cells. Additionally, the increasing focus on biologics and biosimilars necessitates the use of primary cells to evaluate drug efficacy and safety.
Limited availability
The limited availability restraint in the Primary Cell Culture Market refers to the challenges in sourcing and obtaining primary cells for research and production. Primary cells are derived directly from tissues and have a finite lifespan, making them scarce and expensive. Isolation processes can be technically demanding and may yield limited quantities of viable cells. Additionally, donor variability, ethical considerations, and stringent regulatory requirements further restrict their availability.
Advancements in 3D cell culture
Advancements in 3D cell culture technology are significantly enhancing the primary cell culture market. These technologies provide more physiologically relevant models by better mimicking the in vivo environment compared to traditional 2D cultures. Innovations such as scaffold-based systems, spheroids, and organoids allow for more accurate cell-cell and cell-matrix interactions. This leads to improved disease modeling, drug screening, and tissue engineering applications. Moreover, 3D cultures support the growth of primary cells that retain their differentiated state and functionality, making them valuable for personalized medicine and regenerative therapies.
Reproducibility and standardization issues
In the primary cell culture market, reproducibility and standardization are critical challenges. Primary cells, derived directly from tissues, exhibit inherent biological variability, leading to inconsistent experimental outcomes. Standardization issues arise due to the lack of uniform protocols and quality controls, making it difficult to ensure consistency across different labs and experiments. Such challenges can hinder the reliability of research findings, affect the development of cell-based assays, and complicate regulatory approvals.
The COVID-19 pandemic significantly impacted the primary cell culture market, primarily through disruptions in supply chains and operational delays in laboratories. Increased demand for research related to SARS-CoV-2 spurred growth in the market, as primary cell cultures became crucial for studying virus behavior, developing vaccines, and testing antiviral drugs. Laboratories pivoted to COVID-19 research, which accelerated innovation and funding in cell culture technologies. However, the focus on pandemic-related studies also caused delays in non-COVID-19 research, affecting the overall research pipeline and project timelines.
The primary cells segment is expected to be the largest during the forecast period
The growth of the primary cells segment in the primary cell culture market can be attributed to several factors. There is increasing demand for more physiologically relevant cellular models for drug development and testing, which primary cells provide due to their direct extraction from tissues. This segment benefits from advancements in isolation techniques that preserve cellular integrity and function, enhancing their utility in research and clinical applications. Additionally, primary cells offer researchers the ability to study complex cellular interactions and disease mechanisms more accurately compared to immortalized cell lines.
The enzymatic degradation segment is expected to have the highest CAGR during the forecast period
Enzymatic degradation in the primary cell culture market is the process of using enzymes to dissociate cells from tissues or to degrade unwanted cellular components during cell culture. This segment's growth is driven by the increasing demand for efficient and gentle methods of cell isolation and maintenance. Enzymes such as trypsin, collagenase, and dispase are crucial in achieving high cell yields with minimal damage, thereby supporting various applications in research, drug development, and regenerative medicine. Advancements in enzyme technology, including the development of recombinant enzymes and improved formulations, further enhance the reliability and specificity of enzymatic degradation methods.
The North American region has experienced significant growth in the primary cell culture market due to several factors. First, there is increasing research and development activity in the biotechnology and pharmaceutical sectors, driving demand for primary cell culture techniques for drug discovery and development. The rising prevalence of chronic diseases and the need for personalized medicine have emphasized the importance of primary cell cultures in studying disease mechanisms and developing targeted therapies. Moreover, collaborations between academic institutions, research organizations, and industry players have contributed to the region's growth by facilitating knowledge exchange.
The Asia-Pacific region has witnessed significant growth in the primary cell culture market due to several factors. Increasing investments in the biotechnology and pharmaceutical industries across countries like China, India, Japan, and South Korea have driven demand. These nations are expanding their research capabilities and infrastructure, fostering a conducive environment for cell culture technologies. Additionally, the rising prevalence of chronic diseases has fuelled the need for advanced research in drug development, further boosting the market.
Key players in the market
Some of the key players in Primary Cell Culture market include American Type Culture Collection, Axol Bioscience Ltd., BioIVT, CGT Global, Corning Incorporated, Creative Bioarray, Cyagen , Danaher, Epithelix Sarl, FUJIFILM Wako Pure Chemical Corporation, HemaCare Corporation, Lonza Bioscience, Mattek, Merck KGaA, Neuromics, PPA Research Group, Inc., ReachBio LLC, STEMCELL Technologies, Thermo Fisher Scientific Inc. and XenoTech, LLC.
In February 2024, BioIVT announced it has increased its capacity to deliver readily-available fresh, standard and mobilized, human leukopaks. Building on decades of human derived cell collection expertise, this additional capability enables BioIVT to further scale its world-class network of diverse, highly characterized donors and makes the company a leading provider of fresh leukopaks in the UK and mainland Europe.
In June 2024, Danaher Corporation has launched a strategic collaboration with Cincinnati Children's Hospital Medical Center, with the goal of improving patient safety by addressing a leading cause of failure in clinical trials. As part of the Danaher Beacons program, the multi-year collaboration aims to improve liver organoid technology as a drug toxicity screening solution for safeguarding patients.
Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.