市场调查报告书
商品编码
1617062
到 2030 年抗神经丝 L 抗体的全球市场预测:按产品类型、应用、最终用户和地区进行分析Anti Neurofilament L Antibody Market Forecasts to 2030 - Global Analysis By Product Type (Monoclonal Antibodies, Polyclonal Antibodies and Other Product Types), Application, End User and By Geography |
根据 Stratistics MRC 的数据,2024 年全球抗神经丝 L 抗体市场规模为 3.188 亿美元,预计到 2030 年将达到 6.1258 亿美元,预测期内复合年增长率为 11.5%。
抗神经丝 L (NfL) 抗体是专门设计用于与神经丝轻链 (NfL) 结合的特殊蛋白质,神经丝轻炼是神经细胞中普遍存在的结构蛋白。 NfL是识别神经元损伤的重要生物标记物,可用于研究和诊断日益增多的阿兹海默症、多发性硬化症和肌萎缩侧索硬化症(ALS)等神经退化性疾病。这些抗体支持神经系统疾病的早期检测和监测,对于开发诊断分析、研究神经元完整性和推进治疗技术至关重要。
据帕金森氏症基金会称,截至 2022 年,美国约有 100 万人患有帕金森氏症 (PD)。
神经退化性疾病盛行率上升
对抗神经丝 L (NfL) 抗体的需求主要是由神经退化性疾病(如多发性硬化症、帕金森氏症和阿兹海默症)日益流行所驱动。 NfL 是识别神经元细胞损伤的重要生物标记物,可用于早期诊断和病情监测。随着全球人口老化和这些疾病盛行率的增加,越来越需要先进的诊断技术。此外,学术界和医疗保健专业人员对 NfL 生物标记重要性的广泛了解加速了其在临床和研究环境中的使用,支持了市场扩张。
缺乏标准化的检测法
缺乏标准化检测方法是抗神经丝 L (NfL) 抗体市场的主要挑战,这对市场成长产生负面影响。检测通讯协定的变异性会损害临床诊断和研究的可靠性和再现性。这削弱了研究人员、医生和监管机构的信心,并阻碍了更广泛的采用。此外,缺乏通用标准使得很难比较不同研究的资料,从而减缓了新治疗方法的开发和神经退化性疾病的研究。为了解决这个问题,相关人员必须共同努力製定规范,以确保准确性、统一性和更广泛的可用性。
生物标记研究进展
生物标记研究正在推动抗神经丝 L (NfL) 抗体市场的显着成长。自从 NfL 被确定为神经退化性疾病的重要生物标记以来,超灵敏免疫测量(例如 Simoa)等新技术已将检测能力提高到以前无法达到的水平。这些进展使得早期诊断多发性硬化症、阿兹海默症和 ALS 等疾病、追踪病程、评估治疗效果等变得更加容易。随着研究进展证明 NfL 在临床试验中的效用,製药公司现在正在投资生物标记研究。
假阳性和假阴性的可能性
儘管 NfL 是神经退化性疾病的一种有前途的生物标记物,但它也存在假阳性和假阴性结果的风险,这可能会显着影响临床决策。样品处理、储存条件和干扰物质的存在等因素可能会影响 NfL 测量的准确性。此外,个体 NfL 水平各不相同,因此很难建立明确的诊断阈值。优化检测通讯协定、使用高品质试剂并实施严格的品管措施对于最大限度地减少错误结果的风险至关重要。
COVID-19 的影响
抗神经丝 L (NfL) 抗体的销售受到 COVID-19 疫情的严重影响。由于 COVID-19 与神经发炎和神经退化等神经系统症状有关,因此人们越来越关注 NfL 作为确定神经损伤程度和追踪疾病进程的生物标记。因此,出于诊断和研究目的,对 NfL 抗体的需求不断增加。基于 NfL 的诊断测试的采用也可能受到以下事实的影响:大流行加速了远距医疗解决方案的开发。
单株抗体领域预计将成为预测期内最大的市场
单株抗体片段估计是最大的,因为它们的高特异性、敏感性和重现性使其成为检测和定量各种生物样本中 NfL 水平的理想选择。单株抗体可设计用于靶向 NfL 蛋白上的特定表位,从而实现精确且准确的测量。此外,单株抗体技术的进步促进了高灵敏度和特异性检测的发展,进一步推动了市场成长。
学术机构领域预计在预测期内复合年增长率最高
学术机构领域预计在预测期内复合年增长率最高。这些机构对神经退化性疾病进行广泛的研究,利用 NfL 作为有价值的生物标记来了解疾病机制并确定潜在的治疗标靶。用于研究目的的高品质 NfL 抗体的需求正在推动市场成长。此外,与製药和生物技术公司的学术合作正在加速基于 NfL 的创新诊断工具和治疗性介入的开发。
由于人口迅速老化、神经系统疾病发病率上升以及医疗设施扩张,预计亚太地区将在预测期内占据最大的市场占有率。该地区庞大的人口和不断增长的医疗保健支出显着增加了对 NfL 检测等先进诊断设备的需求。政府支持医疗保健和医学研究的计划的增加也推动了市场扩张。随着该地区进一步开发市场,对 NfL 抗体的需求预计将会增加,使其成为国际公司的重要市场。
由于其发达的医疗基础设施、不断增加的老年人口以及对医疗保健研究和开发的重视,预计北美在预测期内的复合年增长率最高。该地区 ALS 和老年痴呆症神经退化性疾病的发生率不断增加,增加了对 NfL 等精确、敏感生物标记的需求。此外,北美着名製药和生物技术公司的存在也促进了基于 NfL 的诊断测试和治疗性介入的开发和行销。
According to Stratistics MRC, the Global Anti Neurofilament L Antibody Market is accounted for $318.80 million in 2024 and is expected to reach $612.58 million by 2030 growing at a CAGR of 11.5% during the forecast period. Anti-neurofilament L (NfL) antibodies are specialized proteins made to attach to the neurofilament light chain (NfL), a structural protein that is widely present in neurons. Research and diagnosis of neurodegenerative illnesses like Alzheimer's, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) are increasingly using NfL, a critical biomarker for identifying neuronal damage. These antibodies support early detection and monitoring of neurological diseases and are essential for the development of diagnostic assays, research into neuronal integrity, and advancement of therapeutic techniques.
According to Parkinson's Foundation, as of 2022, nearly one million people in the United States are living with Parkinson's disease (PD).
Rising prevalence of neurodegenerative diseases
The need for anti-neurofilament L (NfL) antibodies is mostly driven by the increasing incidence of neurodegenerative illnesses such as multiple sclerosis, Parkinson's, and Alzheimer's. NfL is an essential biomarker for identifying neuronal injury, which helps with early diagnosis and status monitoring. Advanced diagnosis technologies are becoming more and more necessary as populations age and the prevalence of these ailments rises worldwide. Furthermore, increased knowledge of the significance of NfL biomarkers among academics and healthcare professionals has accelerated their use in clinical and research settings, supporting the market's expansion.
Lack of standardized assay methods
The lack of standardized assay methods in the Anti-Neurofilament L (NfL) Antibody Market poses significant challenges, negatively impacting its growth. Assay protocol variability produces variable results, which compromises clinical diagnostics and research study reliability and reproducibility. This hinders wider adoption by undermining trust among academics, physicians, and regulatory agencies. Furthermore, the lack of common standards makes it more difficult to compare data from different studies, which slows down the development of new treatments and research on neurodegenerative diseases. In order to resolve this issue, stakeholders must work together to create norms that guarantee accuracy, uniformity, and wider accessibility.
Advancements in biomarker research
Research on biomarkers is propelling the market for anti-neurofilament L (NfL) antibodies to rise significantly. Novel technologies such as ultrasensitive immunoassays (e.g., Simoa) have improved detection capabilities at previously unachievable levels since NfL was identified as a crucial biomarker for neurodegenerative disorders. These developments facilitate early diagnosis, tracking the course of the disease, and assessing the effectiveness of treatment, especially for diseases like multiple sclerosis, Alzheimer's, and ALS. Pharmaceutical corporations are now investing in biomarker studies as a result of research advances that have demonstrated the usefulness of NfL in clinical trials.
Potential for false positive and negative results
While NfL is a promising biomarker for neurodegenerative diseases, there is a risk of false positive and negative results, which can significantly impact clinical decision-making. Factors such as sample handling, storage conditions, and the presence of interfering substances can influence the accuracy of NfL measurements. Additionally, variations in individual NfL levels can make it challenging to establish definitive diagnostic thresholds. To minimize the risk of false results, it is essential to optimize assay protocols, use high-quality reagents, and implement rigorous quality control measures.
Covid-19 Impact
Anti-Neurofilament L (NfL) antibody sales have been greatly influenced by the COVID-19 epidemic. Since COVID-19 has been linked to neurological symptoms like neuroinflammation and neurodegeneration, there has been more interest in NfL as a possible biomarker for determining the extent of neurological damage and tracking the course of the illness. As a result, there is now more demand for NfL antibodies for both diagnostic and research applications. The adoption of NfL-based diagnostic tests may also be influenced by the pandemic's acceleration of the development of remote healthcare solutions.
The monoclonal antibodies segment is expected to be the largest during the forecast period
The monoclonal antibodies segment is estimated to be the largest, due to their high specificity, sensitivity, and reproducibility make them ideal for detecting and quantifying NfL levels in various biological samples. Monoclonal antibodies can be engineered to target specific epitopes on the NfL protein, enabling precise and accurate measurements. Additionally, advances in monoclonal antibody technology have led to the development of highly sensitive and specific assays, further driving the growth of the market.
The academic institutions segment is expected to have the highest CAGR during the forecast period
The academic institutions segment is anticipated to witness the highest CAGR during the forecast period. These institutions conduct extensive research on neurodegenerative diseases, utilizing NfL as a valuable biomarker to understand disease mechanisms and identify potential therapeutic targets. The demand for high-quality NfL antibodies for research purposes fuels the market's growth. Additionally, academic collaborations with pharmaceutical companies and biotechnology firms accelerate the development of innovative NfL-based diagnostic tools and therapeutic interventions.
Asia Pacific is expected to have the largest market share during the forecast period due to rapidly aging population, rising neurological disease rates, and expanding medical facilities. The need for sophisticated diagnostic instruments like NfL tests has increased significantly because to the region's high population and growing healthcare expenditures. The market's expansion is also being driven by an increase in government programs to support healthcare and medical research. The demand for NfL antibodies is anticipated to increase as the region develops further, making it a crucial market for international companies.
North America is projected to witness the highest CAGR over the forecast period, because of a developed healthcare infrastructure, a growing senior population, and a strong emphasis on healthcare research and development. The increasing incidence of neurodegenerative illnesses like ALS and Alzheimer's in the area has raised the need for precise and sensitive biomarkers like NfL. Furthermore, the development and marketing of NfL-based diagnostic tests and therapeutic interventions have been expedited by the presence of prominent pharmaceutical and biotechnology firms in North America.
Key players in the market
Some of the key players profiled in the Anti Neurofilament L Antibody Market include Merck KGaA, Abcam plc, Thermo Fisher Scientific Inc., Santa Cruz Biotechnology, Inc., Proteintech Group, Inc., R&D Systems, Inc., Boster Biological Technology, Rockland Immunochemicals Inc., Bio-Rad Laboratories, Inc., Cell Signaling Technology, Inc., GeneTex, Inc., Novus Biologicals, LLC, ProSci Inc., Atlas Antibodies AB, LifeSpan BioSciences, Inc., Creative Biolabs, BioLegend, Inc., Abnova Corporation, PeproTech, Inc., and US Biological Life Sciences.
In October 2023, Quanterix Corporation launched a new high-sensitivity assay for measuring neurofilament light chain (NfL) levels, aimed at enhancing the early detection and monitoring of neurodegenerative diseases.
In September 2023, BioLegend introduced a new anti-neurofilament L antibody aimed at research applications, providing enhanced specificity and sensitivity for studying neurodegeneration.
In April 2023, Merck KGaA released an updated version of their anti-neurofilament L antibody, which includes improved formulations for better performance in clinical diagnostics.