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市场调查报告书
商品编码
1797895
全球卡路里限制模拟物市场:预测至 2032 年—按产品类型、剂型、分销管道、应用、最终用户和地区进行分析Caloric Restriction Mimetics Market Forecasts to 2032 - Global Analysis By Product Type, Formulation Type, Distribution Channel, Application, End User and By Geography |
根据 Stratistics MRC 的数据,全球卡路里限制模拟物市场预计在 2025 年达到 13.4 亿美元,到 2032 年将达到 28.7 亿美元,预测期内的复合年增长率为 11.5%。
热量限制模拟物 (CRM) 是一种能够模拟热量限制的正面效应的物质,例如提高新陈代谢、增强抗压性和延长寿命,而无需显着减少热量摄取。它们的作用标靶是受热量限制影响的类似分子通路,例如AMP活化蛋白激酶 (AMPK)、Sirtuin活化以及雷帕霉素靶点 (mTOR) 的抑制。此外,在临床前研究中,亚精胺、二甲双胍和白藜芦醇等 CRM 已显示出延长寿命和降低老龄化性疾病风险的良好效果。模拟热量限制引起的细胞和代谢变化的 CRM 干预措施正在被研究,以期促进健康老化并预防慢性疾病。
美国国立卫生研究院 (NIH) 发表的一项人体研究发现,适度(约 30%)的热量限制会引起骨骼肌的转录转变,从与生长相关的途径转向维持和修復过程,类似于在长寿囓齿动物中看到的效果,这表明热量限制的益处在不同物种之间具有很强的保留性。
健康长寿意识
预防性医疗保健服务、穿戴式健康追踪器以及日益普及的讯息,鼓励消费者采取更积极主动的方式来维护健康。这种「长寿思维」已从专门的健康和健身活动演变为普遍性的锻炼,激发了人们对长期生活品质干预措施的兴趣。 CRM 非常适合这一趋势,因为它提供了一种与生活方式相容、非侵入性的方式,无需剧烈的饮食改变即可获得卡路里限制的好处。此外,这种意识在都市区和健身群体中尤其强烈,在那些愿意儘早投资预防性健康措施的年轻消费者中也特别明显。
对健康人的影响有限
CRM 的主要缺点之一是其对健康个体的影响尚不清楚。儘管许多物质,例如亚精胺、二甲双胍和白藜芦醇,在动物研究和代谢紊乱患者中显示出显着的健康益处,但关于这些影响对健康个体的影响程度,证据尚不明确。一些研究表明,与老化、发炎和代谢健康相关的生物标记仅发生了轻微变化,这让人怀疑其在没有潜在疾病的情况下作为预防措施的潜力。这使得公司很难在不做出不切实际的宣传的情况下向广大受众推广 CRM,并且可能会在获得更可靠、更清晰的健康人群长期研究数据之前,抑制消费者的热情。
世界各地对长寿科学的兴趣日益浓厚
长寿研究领域正在迅速扩展,其研究重点从单纯治疗与老龄化相关的疾病转向积极延长寿命。随着CRM的分子通路研究深入,CRM已成为热门话题,学术界、研究机构和生技公司也越来越关注减缓生物老化过程的介入措施。此外,消费者对新型干预措施的接受度以及商业性和学术投资也受益于这种认知的提升。随着人们关注的重点从“活得更长”转向“活得更长寿、更健康”,CRM已占据有利地位,能够充分利用市场对科学支持的长寿产品的购买意愿。
与其他抗衰老策略的竞争
CRM并非长寿市场上唯一的竞争对手。替代疗法,例如高级胜肽、抗衰老化合物、生酮饮食、NAD+增强剂、干细胞疗法和禁食疗法,正日益普及。许多此类治疗方法效果更显着、更立竿见影,因此对消费者更具吸引力。例如,运动和禁食方案免费且得到良好支持,有可能超越CRM。此外,CRM必须不断突显其独特的价值提案、安全性和有效性,从而在众多竞争解决方案中脱颖而出。
新冠疫情对卡路里限制模拟物 (CRM) 市场产生了许多影响。封锁和生产延误最初扰乱了供应链、原材料采购和临床研究时间表。然而,这场危机也提高了人们对 CRM 能够发挥作用的三个关键领域的认识:免疫力、慢性病管理和预防保健。随着消费者越来越注重健康,并寻求干预措施来增强代谢韧性、降低对老龄化相关感染疾病的易感性,人们对 CRM 和其他促进长寿的补充剂的兴趣也日益浓厚。此外,儘管实体零售受到限制,但疫情推动的电商蓬勃发展使 CRM 品牌能够触及更多消费者,部分抵消了早期的市场挫折。
预计片剂和胶囊市场在预测期内将占据最大份额
预计片剂和胶囊细分市场将在预测期内占据最大市场占有率,这得益于其易用性、精准剂量和广泛的消费者接受度。这种剂型能够稳定地递送生物活性物质,例如亚精胺、二甲双胍类似物和白藜芦醇,而这些物质可能会受到光照和湿度等环境条件的影响。药片和胶囊尤其受到临床患者和预防性用药者的青睐,因为它们便于携带、保质期长,并且易于融入日常营养补充方案。此外,成熟的生产技术、可扩展的生产能力和明确的监管途径进一步增强了它们相对于粉末、液体製剂或功能性混合物的优势,所有这些都有利于快速商业化和全球广泛分销。
预计预测期内候选药物(治疗)部分将以最高的复合年增长率成长。
在精准医疗和长寿科学快速发展的推动下,候选药物(治疗性药物)领域预计将在预测期内呈现最高成长率。此领域专注于开发经临床验证的新型药物,透过针对mTOR抑制、AMPK刺激和sirtuin活化等途径,模拟热量限制带来的细胞和代谢益处。製药和生物技术公司正在大力投资临床前和临床试验,以确立CRM作为治疗方法与老龄化相关的疾病、代谢紊乱和慢性发炎的有效方法。强劲的专利机会、不断增长的老年人口以及不断上涨的医疗成本推动了需求。此外,随着监管核准的推进,治疗性CRM有望使健康老龄化成为一项共同的医疗目标。
预计北美将在预测期内占据最大的市场占有率,这得益于其强劲的生物技术和製药行业、先进的医疗基础设施以及消费者对长寿和预防保健的高度认识。大量的研发支出、强大的临床试验生态系统以及鼓励创新 CRM 的创建和行销的有利法律规范都是该地区的优势。人口快速老化和文明病的增加进一步刺激了需求。此外,北美广泛使用膳食补充剂、机能性食品和抗衰老疗法,加上电子商务的普及,使其成为 CRM 创新和市场收益的主要中心。
预计亚太地区在预测期内将呈现最高的复合年增长率,这得益于中国、日本、韩国和印度等国家日益增强的健康意识、快速的都市化以及不断增长的可支配收入。文明病的发病率上升以及人们对健康老龄化的认识不断增强,推动了对先进治疗和预防补充剂的需求。此外,该地区还受益于不断扩大的製药和营养保健品生产能力、政府鼓励的生物技术研究项目以及蓬勃发展的电子商务行业,这些行业提供了更便捷的 CRM 获取途径。亚太地区人口老化问题严重,再加上重视长寿的文化,正在推动市场大幅扩张。
According to Stratistics MRC, the Global Caloric Restriction Mimetics Market is accounted for $1.34 billion in 2025 and is expected to reach $2.87 billion by 2032 growing at a CAGR of 11.5% during the forecast period. Caloric Restriction Mimetics (CRMs) are substances that, without requiring a substantial calorie reduction, replicate the positive effects of caloric restriction, such as increased metabolism, increased resilience to stress, and prolonged lifespan. Similar molecular pathways impacted by calorie restriction, such as AMP-activated protein kinase (AMPK), sirtuin activation, and inhibition of the mechanistic target of rapamycin (mTOR), are the targets of their action. Moreover, in preclinical studies, CRMs such as spermidine, metformin, and resveratrol have demonstrated encouraging outcomes for extending life expectancy and lowering the risk of age-related illnesses. Potential interventions for healthy aging and the prevention of chronic diseases are being investigated by CRMs, which mimic the cellular and metabolic alterations brought on by calorie restriction.
According to a human study published via the NIH, moderate (~30%) caloric restriction induced a transcriptional shift in skeletal muscle from growth-related pathways to maintenance and repair processes. Crucially, this involved down-regulation of the IGF-1/insulin/FOXO signaling axis-mirroring effects seen in long-lived rodents and suggesting strong conservation of CR benefits across species.
Awareness of health and longevity
Preventive health services, wearable health trackers, and increased information availability have made consumers more proactive in preserving their health. This "longevity mindset" has evolved from a specialized wellness movement to a popular one, with increasing interest in long-term quality of life-improving interventions. CRMs are a suitable fit for this trend because they provide a lifestyle-compatible, non-invasive way to benefit from calorie restriction without requiring drastic dietary changes. Additionally, this awareness is particularly high among younger consumers who are prepared to make early investments in preventive health measures, as well as in urban areas and fitness communities.
Limited effectiveness in healthy people
The unknown effect of CRMs on otherwise healthy people is one of their primary drawbacks. Even though a number of substances, including spermidine, metformin, and resveratrol, have shown significant health benefits in animal studies or in patients with metabolic disorders, there has been mixed evidence regarding how well these benefits translate to healthy humans. Some trials have shown only slight changes in biomarkers associated with aging, inflammation, or metabolic health, which raises questions about their potential as a preventive measure in the absence of underlying disease. This makes it challenging for businesses to advertise CRMs to a wide audience without making unrealistic claims, and it might also stifle customer excitement until more solid, lucid data from long-term research in healthy populations becomes available.
Growing interest in longevity science worldwide
The field of longevity research is expanding quickly as it moves from merely treating age-related illnesses to actively prolonging life expectancy. CRMs are a key topic of interest because of their thoroughly researched molecular pathways, and conferences, research institutes, and biotech companies are focusing more and more on interventions that slow the biological aging process. Furthermore, consumer receptivity to new interventions and commercial and academic investment are both benefiting from this growing awareness. As the emphasis shifts from "living longer" to "living healthier for longer," CRMs can capitalize on a market that is open to purchasing longevity products with scientific support.
Competition from other anti-aging strategies
There are other competitors in the longevity market besides CRMs. Alternatives such as advanced peptides, senolytic compounds, ketogenic diets, NAD+ boosters, stem cell therapies, and intermittent fasting are becoming more and more well-liked. Customers find many of these interventions more appealing because of their more obvious or instantaneous results. For instance, exercise routines and fasting protocols are free and well-supported, and they may eventually eclipse CRMs. Moreover, CRMs must constantly set themselves apart from the competition due to the abundance of competing solutions by showcasing their unique value propositions, safety, and efficacy.
The COVID-19 pandemic had a mixed effect on the market for Caloric Restriction Mimetics (CRM). Lockdowns and manufacturing slowdowns initially caused supply chains, raw material sourcing, and clinical research timelines to be disrupted. But the crisis also raised awareness of immunity, chronic disease management, and preventive health-three important areas where CRMs can be helpful. Interest in CRMs and other longevity-promoting supplements increased as consumers grew more health-conscious and looked for interventions to enhance metabolic resilience and lessen age-related susceptibility to infections. Additionally, despite physical retail limitations, the pandemic's spike in e-commerce allowed CRM brands to reach a larger audience, partially offsetting early market setbacks.
The pills and capsules segment is expected to be the largest during the forecast period
The pills and capsules segment is expected to account for the largest market share during the forecast period, propelled by their ease of use, accurate dosage, and broad consumer recognition. This format enables the stable delivery of bioactive substances that can be affected by environmental conditions like light and moisture, such as spermidine, metformin analogs, and resveratrol. Particularly well-liked by patients in clinical settings as well as those using them for preventive health, pills and capsules are portable, have a long shelf life, and blend in easily with daily supplement regimens. Moreover, their dominance over powders, liquids, or functional blends is further reinforced by proven manufacturing techniques, scalable production capacities, and well-defined regulatory pathways, all of which facilitate quick commercialization and extensive worldwide distribution.
The drug candidates (therapeutics) segment is expected to have the highest CAGR during the forecast period
Over the forecast period, the drug candidates (therapeutics) segment is predicted to witness the highest growth rate, propelled by rapid developments in precision medicine and longevity science. This section concentrates on creating new, clinically proven substances that mimic the cellular and metabolic advantages of calorie restriction by focusing on pathways such as mTOR inhibition, AMPK stimulation, and sirtuin activation. In order to establish CRMs as viable therapies for age-related illnesses, metabolic disorders, and chronic inflammation, pharmaceutical and biotech companies are making significant investments in preclinical and clinical trials. Demand is being driven by strong patent opportunities, growing geriatric populations, and rising healthcare costs. Additionally, therapeutic CRMs have the potential to make healthy aging a common medical objective as regulatory approvals move forward.
During the forecast period, the North America region is expected to hold the largest market share, driven by its robust biotechnology and pharmaceutical industries, sophisticated healthcare infrastructure, and high levels of consumer awareness regarding longevity and preventive health. Significant R&D expenditures, a strong clinical trial ecosystem, and advantageous regulatory frameworks that encourage the creation and marketing of innovative CRMs are all advantages for the region. Demand has been further accelerated by the rapidly aging population and the rising prevalence of lifestyle-related disorders. Furthermore, North America is positioned as the primary center for CRM innovation and market revenue due to the extensive use of dietary supplements, functional foods, and anti-aging therapies-as well as the robust penetration of e-commerce.
Over the forecast period, the Asia-Pacific region is anticipated to exhibit the highest CAGR, driven in nations like China, Japan, South Korea, and India by growing health consciousness, fast urbanization, and rising disposable incomes. The demand for both advanced therapeutics and preventive supplements is being driven by rising rates of lifestyle-related diseases and growing awareness of healthy aging. Additionally, the region gains from growing pharmaceutical and nutraceutical manufacturing capacities, encouraging government programs for biotechnology research, and a flourishing e-commerce industry that facilitates the accessibility of CRMs. Asia-Pacific is positioned for remarkable market expansion due to its sizable and aging population and cultural emphasis on longevity.
Key players in the market
Some of the key players in Caloric Restriction Mimetics Market include Cayman Chemical Company, E. Merck KG, Archer Daniels Midland Company (ADM), Hangzhou DayangChem Co. Ltd, DSM Nutritional Products, Chengdu Yazhong, Evolva Holding, Lonza Group, Biodor Holding AG, Laurus Labs Inc, Sabinsa Corporation, Calico Life Sciences, Tokyo Chemical Industry (TCI), Sirtris Pharmaceuticals and InterHealth Inc.
In February 2025, Archer Daniels Midland (ADM), a global food processing and nutrition company, has officially opened a new facility at Lagos Free Trade Zone (LFZ), Nigeria. The expansion marks a major milestone in ADM's strategy to strengthen its presence in Africa and enhance its ability to serve customers and partners in the region.
In October 2024, Lonza has expanded its drug product (DP) services offering by adding a new facility for quality control and bioanalytics at its DPS site in Basel (CH) to support its global DP capacity increase. The expansion includes 6000m2 of state-of-the-art labs and office space to support early and late-stage clinical and commercial DP QC.
In October 2024, Sabinsa Corporation and Postbiotics, Inc. announced a multinational distribution agreement (including the USA, Canada, European Union, and other significant markets (including India and Japan) for the dietary supplement and functional food ingredient PoZibio(R) for age-related digestive health conditions including Leaky Gut Syndrome (LGS).
Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.