市场调查报告书
商品编码
1494453
到 2030 年北美微载体市场预测 - 区域分析 - 按产品、设备、应用和最终用户North America Microcarriers Market Forecast to 2030 - Regional Analysis - by Product, Equipment, Application, and End User |
北美微载体市场预计将从2022年的7.3667亿美元成长到2030年的19.3356亿美元。
细胞和基因治疗製造服务的自动化推动了北美微载体市场
在细胞和基因治疗製造中纳入自动化将降低污染风险、提高一致性并降低生产成本。 Lonza Cocoon 和 Miltenyi 的 CliniMACS Prodigy 系统是市场上现有的一些设备,这些设备旨在实现单一系统内 CAR-T 流程的大多数顺序单元操作的自动化。对细胞和基因疗法不断增长的需求已将全球范围内的生产从小批量製程转向大批量製程。细胞和基因疗法从学术和临床环境到大规模生产和商业化的进展进一步推动了商业製造对自动化的需求。 2020 年 7 月,Thermo Fisher Scientific Inc. 和 Lyell Nutrition 合作开发流程,为癌症患者设计有效的细胞疗法。根据这项合作关係,两家公司的目标是提高 T 细胞的能力,并支持开发符合现行良好生产规范 (cGMP) 的综合平台(系统和软体)以及试剂、耗材和仪器。此外,美国政府援助的组织正在细胞疗法的製造中采用自动化,以提高该国的国家生产能力。因此,自动化正在成为微载体市场的新趋势。
北美微载体市场概况
北美微载体市场分为美国、加拿大和墨西哥。美国在该地区市场占据主导地位。北美微载体市场的成长归因于生物技术和生物製药公司推出的产品数量不断增加、主要市场参与者的存在以及各个学术和研究机构的广泛研发。慢性病盛行率的上升是推动美国微载体市场成长的主要因素。根据美国疾病管制与预防中心 (CDC) 的数据,十分之六的美国人患有至少一种慢性疾病,例如心臟病、中风、癌症或糖尿病。这些疾病是美国死亡和残疾的重要原因,而且还导致巨大的医疗费用。细胞和基因疗法(CGT)领域取得了广泛的临床进展,因此这些疗法的应用范围在过去5年中不断扩大。在 2016 年至 2021 年的分析期间,随着 12 种新疗法的批准和超过 2,900 项临床试验的启动,CGT 创新得到了广泛的投资。基因编辑技术的进步,以及评估此技术治疗效果的临床试验,是有利于美国微载体市场的其他因素。例如,Poseida Therapeutics, Inc. 的P-CD19CD20-ALLO1 的研究性新药(IND) 申请获得美国食品和药物管理局(FDA) 批准,这是该公司首款同时靶向CD19 和CD19 的同种异体双CAR-T 细胞候选产品。 2023 年 4 月,新型同种异体 CAR T 细胞疗法在转移性透明细胞肾细胞癌患者中取得了成果。因此,增加临床试验的参与和投资可以加速新疗法的采用和可用性。德州大学MD 安德森癌症中心的研究人员领导了I 期试验,并在美国癌症研究协会(AACR) 2023 年年会上进行了报告。 , Inc. 宣布对支持 Poseida 重新定义癌细胞疗法的承诺。安斯泰来投资 5000 万美元获得 Poseida 一项临床阶段计画的许可,该计画专注于 P-MUC1C-ALLO1,这是一种用于多种实体瘤适应症的同种异体 CAR T 细胞疗法。因此,随着慢性病病例数量的增加以及不同细胞和基因疗法的批准,美国对微载体的需求正在增加。
北美微载体市场营收及 2030 年预测(百万美元)
北美微载体市场细分
北美微载体市场分为产品、设备、应用、最终用户和国家。
根据产品,北美微载体市场分为微载体珠和培养基和试剂。 2022 年,微载体珠细分市场在北美微载体市场中占有更大份额。
在设备方面,北美微载体市场分为生物反应器、培养皿等。 2022 年,生物反应器领域占据北美微载体市场的最大份额。
根据应用,北美微载体市场分为生物製药生产、细胞和基因治疗、组织工程和再生医学等。 2022年,生物製药生产领域在北美微载体市场中占据最大份额。
根据最终用户,北美微载体市场分为製药和生物技术公司、合约研究组织和合约製造组织以及学术和研究机构。 2022 年,製药和生物技术公司领域占据北美微载体市场的最大份额。
根据国家/地区,北美微载体市场分为美国、加拿大和墨西哥。 2022 年,美国主导北美微载体市场。
Teijin Ltd、Bio-Rad Laboratories Inc、Sartorius AG、Danaher Corp、Corning Inc、Eppendorf SE、Asahi Kasei Corp 和 Polysciences Inc 是北美微载体市场上的一些领先公司。
The North America microcarriers market is expected to grow from US$ 736.67 million in 2022 to US$ 1,933.56 million by 2030. It is estimated to record a CAGR of 12.8% from 2022 to 2030.
Automation of Cell and Gene Therapy Manufacturing Services Fuels North America Microcarriers Market
Incorporating automation in cell and gene therapy manufacturing would lead to a reduced risk of contamination, improved consistency, and decreased cost of production. Lonza Cocoon and the CliniMACS Prodigy system from Miltenyi are a few of the devices available in the market that have been designed to enable the automation of most sequential unit operations for a CAR-T process within a single system. The rising demand for cell and gene therapies has shifted production from a small-volume process to a large-volume process worldwide. The progress of cell and gene therapy from an academic and clinical setting to mass production and commercialization further propels the demand for automation in commercial manufacturing. In July 2020, Thermo Fisher Scientific Inc. and Lyell Immunopharma partnered to develop processes to design effective cell therapies for cancer patients. Under this partnership, the companies aim to improve the capability of T-cells and support the development of an integrated current good manufacturing practice (cGMP) compliant platform (system and software), along with reagents, consumables, and instruments. Further, the US government-aided organizations are adopting automation in the manufacturing of cell therapies to increase the national production capabilities of the country. Thus, automation is emerging as a new trend in the microcarriers market.
North America Microcarriers Market Overview
The North America microcarriers market is segmented into the US, Canada, and Mexico. The US dominates the market in this region. The growth of the microcarriers market in North America is attributed to the increasing number of product launches by biotechnology and biopharmaceutical companies, the presence of key market players, and extensive R&D by various academic and research institutes. The rising prevalence of chronic diseases is a leading factor propelling the growth of the microcarrier market in the US. According to the Centers for Disease Control and Prevention (CDC), 6 in 10 Americans live with at least 1 chronic disease, such as heart disease and stroke, cancer, or diabetes. These diseases are the significant causes of mortality and disability in the US, and they also lead to significant costs of healthcare. There have been extensive clinical developments in the field of cell and gene therapies (CGT), owing to which the application range of these therapies has expanded in the past 5 years. With the approval of 12 new therapies and the commencement of over 2,900 clinical trials during the analysis period of 2016-2021, there have been extensive investments in CGT innovations. Technological advancements in gene editing, followed by clinical trials to evaluate the therapeutic effectiveness of the technique, are the other factors that have benefitted the microcarriers market in the US. For example, Poseida Therapeutics, Inc. received the US Food and Drug Administration (FDA) approval for its Investigational New Drug (IND) application for P-CD19CD20-ALLO1-the company's first allogeneic dual CAR-T cell product candidate targeting both CD19 and CD20 antigens for the treatment of relapsed or refractory B-cell malignancies-being developed in partnership with Roche. In April 2023, Novel allogeneic CAR T-cell therapy delivered results in patients with metastatic clear cell renal cell carcinoma. Thus, increased participation and investments in clinical trials can accelerate the adoption and availability of new therapies. Researchers at the University of Texas MD Anderson Cancer Center led the Phase I trial and presented at the American Association for Cancer Research (AACR) Annual Meeting 2023. In August 2023, Astellas Pharma Inc. and Poseida Therapeutics, Inc. announced a strategic investment to support the advancement of Poseida's commitment to redefining cancer cell therapy. Astellas invested US$ 50 million to license one of Poseida's clinical-stage programs focusing on P-MUC1C-ALLO1, an allogeneic CAR T-cell therapy for multiple solid tumor indications. Thus, the demand for microcarriers is on the rise in the US with the increasing number of chronic disease cases and approval of different cell and gene therapies.
North America Microcarriers Market Revenue and Forecast to 2030 (US$ Million)
North America Microcarriers Market Segmentation
The North America microcarriers market is segmented into product, equipment, application, end user, and country.
Based on product, the North America microcarriers market is bifurcated into microcarriers beads and media & reagents. The microcarriers beads segment held a larger share of the North America microcarriers market in 2022.
In terms of equipment, the North America microcarriers market is segmented into bioreactors, culture vessels, and others. The bioreactors segment held the largest share of the North America microcarriers market in 2022.
Based on application, the North America microcarriers market is segmented into biopharmaceutical production, cell and gene therapy, tissue engineering and regenerative medicine, and other. The biopharmaceutical production segment held the largest share of the North America microcarriers market in 2022. Further, biopharmaceutical production segment is categorized into therapeutic protein production and vaccine production.
Based on end user, the North America microcarriers market is segmented into pharmaceutical & biotechnology companies, contract research organizations & contract manufacturing organizations, and academic & research institutes. The pharmaceutical & biotechnology companies segment held the largest share of the North America microcarriers market in 2022.
Based on country, the North America microcarriers market is segmented into the US, Canada, and Mexico. The US dominated the North America microcarriers market in 2022.
Teijin Ltd, Bio-Rad Laboratories Inc, Sartorius AG, Danaher Corp, Corning Inc, Eppendorf SE, Asahi Kasei Corp, and Polysciences Inc are some of the leading companies operating in the North America microcarriers market.