特发性肺纤维化（IPF）：市场展望、流行病学、竞争格局、市场预测报告（2025-2035年）

市场概览

• 德国市场预计将从约 2.1 亿美元成长到约 4.15 亿美元（年复合成长率约 7%）。
• 虽然抗纤维化疗法和诊断技术的进步推动了成长，但对根治性治疗的需求仍然没有得到满足。

特发性肺纤维化（IPF）概述

特发性肺纤维化（IPF）是一种病因不明的慢性进行性间质性肺部疾病，其特征是肺实质不可逆性纤维化，高解析度CT或组织病理学检查显示典型的间质性肺炎（UIP）模式。此病主要影响60岁以上的成年人，是特发性间质性肺炎中最严重的类型之一。

临床上，特发性肺纤维化（IPF）表现为进行进行性劳力性呼吸困难及持续性干咳，听诊时可闻及特征性的「尼龙搭扣样」吸气性啰音。此病以持续性上皮损伤、创伤治疗异常和纤维化过度沉积为特征，导致肺功能下降和气体交换受损。

特发性肺纤维化（IPF）的病程呈持续进展性，常伴随急性加重，预后不良，存活期缩短。虽然抗纤维化疗法（例如Pirfenidone、尼达尼布）可以延缓疾病进展，但无法逆转纤维化，肺移植仍是合格的患者唯一的根治性治疗方法。

主要亮点

• 特发性肺纤维化是进行性、高度致命的纤维性肺病，治疗选择有限。
• 英国确诊病例数预计将从约 38,700 例增加到约 49,100 例（年复合成长率约 2.4%）。

格式化和更新讯息

• 详细报告（PDF）
• 市场预测模型（基于微软Excel）
• 流行病学数据（MS Excel，互动式工具）
• 高阶主管洞察（PPT简报）
• 其他功能：定期更新、自订和顾问支援。
• 根据 Thelansis 的政策，我们确保所有最新更新在发布前都反映在报告内容和市场模型中。

主要问题

• 我们如何优化 G8 市场（美国、欧盟 5 国、日本、中国）的药物开发与生命週期管理策略？
• 从发病率、盛行率、人群组成以及接受药物治疗的患者人数来看，患者数量分别是多少？
• 未来十年市场收入和病患份额的预测是多少？
• 哪些因素对市场趋势影响最大？
• 受访专家对目前和新兴疗法有何看法？
• 哪款在研发线产品最有前景？其上市潜力及未来市场定位如何？
• 主要未被满足的需求是什么？ KOL 对目标受众有何期望？
• 为确保药物核准并顺利进入市场，必须满足哪些关键的监管和支付方要求？

目标国家

• G8
  • 我们
  • EU5
    • 法国
    • 德国
    • 义大利
    • 西班牙
    • 英国
  • 日本
  • 中国

大公司

• PureTech
• AbbVie
• Mediar Therapeutics
• Tvardi Therapeutics, Incorporated
• Contineum Therapeutics
• Calluna Pharma AS
• Haisco Pharmaceutical Group Co., Ltd.
• Boehringer Ingelheim
• Syndax Pharmaceuticals
• Cumberland Pharmaceuticals
• Guangdong Hengrui Pharmaceutical Co., Ltd
• Bristol-Myers Squibb
• Arrowhead Pharmaceuticals
• Rein Therapeutics
• Regend Therapeutics
• Trevi Therapeutics
• Vicore Pharma AB
• Actelion
• Daewoong Pharmaceutical Co. LTD.
• Overseas Pharmaceuticals, Ltd.
• Pliant Therapeutics, Inc.
• Chiesi Farmaceutici SpA
• Bridge Biotherapeutics, Inc.
• GlaxoSmithKline
• HuniLife Biotechnology, Inc.
• Endeavor Biomedicines, Inc.
• siRNAgen Therapeutics Inc.
• Genosco Inc.
• SPARK Biopharma
• Dragonboat Biopharmaceutical Company Limited
• Mannkind Corporation
• Beijing Tide Pharmaceutical Co., Ltd
• Shanghai Synvida Biotechnology Co.,Ltd.
• Guangdong Raynovent Biotech Co., Ltd
• Avalyn Pharma Inc.
• InSilico Medicine Hong Kong Limited
• MediciNova
• GRI Bio Operations, Inc.
• Nerre Therapeutics Ltd.
• Sunshine Lake Pharma Co., Ltd.
• United Therapeutics
• Melius Pharma AB
• Pulmongene Ltd.
• Agomab Spain SL

目录

第一章：主要调查结果及分析师说明

• 主要趋势：市场概况、SWOT分析、商业性利益与风险等。

第二章：疾病背景

• 疾病定义、分类、病因和病理生理学、药物标靶等。

第三章：流行病学

• 重点
• 发病率/盛行率
• 已确诊并接受药物治疗的患者人数
• 合併症
• 其他相关患者群

第四章 市场规模及预测

• 重点
• 市场驱动因素与限制因素
• 按药物类别分類的趋势
• 各国具体趋势

第五章 竞争情势

• 目前疗法
  • 重点
  • 诊断和治疗过程/演算法
  • 主要疗法概述及KOL洞察
• 新兴疗法
  • 重点
  • 值得关注的后期新疗法—概述、市场上市预期和KOL洞察
  • 值得关注的早期研发管线

第六章：未满足的需求与目标产品分析

• 主要未满足的需求以及透过新兴疗法实现的未来可能性
• TPP分析与KOL展望

第七章 监理与报销环境

第八章附录

Idiopathic Pulmonary Fibrosis (IPF) Market Outlook

Thelansis's "Idiopathic Pulmonary Fibrosis (IPF) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report - 2025 To 2035" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Idiopathic Pulmonary Fibrosis treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

Idiopathic Pulmonary Fibrosis (IPF) Overview

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease of unknown etiology, characterized by irreversible fibrosis of lung parenchyma and a usual interstitial pneumonia (UIP) pattern on high-resolution CT or histopathology. It primarily affects adults over the age of 60 and is one of the most severe forms of idiopathic interstitial pneumonias.

Clinically, IPF presents with progressive exertional dyspnea and persistent dry cough, along with characteristic "Velcro-like" inspiratory crackles on auscultation. The disease is marked by ongoing epithelial injury, aberrant wound healing, and excessive fibrotic deposition, leading to declining lung function and impaired gas exchange.

IPF follows a relentlessly progressive course, often punctuated by acute exacerbations, and is associated with poor prognosis and reduced survival. While antifibrotic therapies (e.g., pirfenidone and nintedanib) can slow disease progression, they do not reverse fibrosis, and lung transplantation remains the only definitive treatment in eligible patients.

Key Highlights

• IPF is a progressive, high-mortality fibrotic lung disease with limited therapeutic options
• UK diagnosed prevalence expected to increase from ~38.7K to ~49.1K (~2.4% CAGR)

Market Overview

• Germany market projected to grow from ~$210M to ~$415M (~7% CAGR)
• Growth driven by antifibrotic therapies and improved diagnosis, with ongoing unmet need for curative treatments

Insights driven by robust research, including:

• In-depth interviews with leading KOLs and payers
• Physician surveys
• RWE analysis for claims and EHR datasets
• Secondary research (e.g., peer-reviewed journal articles, third-party research databases)

Deliverables format and updates*:

• Detailed Report (PDF)
• Market Forecast Model (MS Excel-based automated dashboard)
• Epidemiology (MS Excel; interactive tool)
• Executive Insights (PowerPoint presentation)
• Others: regular updates, customizations, consultant support
• As per Thelansis's policy, we ensure that we include all the recent updates before releasing the report content and market model.

Salient features of Market Forecast model:

• 10-year market forecast (2025-2035)
• Bottom-up patient-based market forecasts validated through the top-down sales methodology
• Covers clinically and commercially-relevant patient populations/ line of therapies
• Annualized drug-level sales and patient share projections
• Utilizes our proprietary Epilansis and Analog tool (e.g., drug uptake and erosion) datasets and conjoint analysis approach
• Detailed methodology/sources & assumptions
• Graphical and tabular outputs
• Users can customize the model based on requirements

Key business questions answered:

• How can drug development and lifecycle management strategies be optimized across G8 markets (US, EU5, Japan, and China)?
• How large is the patient population in terms of incidence, prevalence, segments, and those receiving drug treatments?
• What is the 10-year market outlook for sales and patient share?
• Which events will have the greatest impact on the market's trajectory?
• What insights do interviewed experts provide on current and emerging treatments?
• Which pipeline products show the most promise, and what is their potential for launch and future positioning?
• What are the key unmet needs and KOL expectations for target profiles?
• What key regulatory and payer requirements must be met to secure drug approval and favorable market access?

Countries Covered

• G8
  • United States
  • EU5
    • France
    • Germany
    • Italy
    • Spain
    • U.K.
  • Japan
  • China

Apart from the G8 Market, adding any additional country data to the dashboard/report will cost USD 1,750 per country

Companies Mentioned

• PureTech
• AbbVie
• Mediar Therapeutics
• Tvardi Therapeutics, Incorporated
• Contineum Therapeutics
• Calluna Pharma AS
• Haisco Pharmaceutical Group Co., Ltd.
• Boehringer Ingelheim
• Syndax Pharmaceuticals
• Cumberland Pharmaceuticals
• Guangdong Hengrui Pharmaceutical Co., Ltd
• Bristol-Myers Squibb
• Arrowhead Pharmaceuticals
• Rein Therapeutics
• Regend Therapeutics
• Trevi Therapeutics
• Vicore Pharma AB
• Actelion
• Daewoong Pharmaceutical Co. LTD.
• Overseas Pharmaceuticals, Ltd.
• Pliant Therapeutics, Inc.
• Chiesi Farmaceutici S.p.A.
• Bridge Biotherapeutics, Inc.
• GlaxoSmithKline
• HuniLife Biotechnology, Inc.
• Endeavor Biomedicines, Inc.
• siRNAgen Therapeutics Inc.
• Genosco Inc.
• SPARK Biopharma
• Dragonboat Biopharmaceutical Company Limited
• Mannkind Corporation
• Beijing Tide Pharmaceutical Co., Ltd
• Shanghai Synvida Biotechnology Co.,Ltd.
• Guangdong Raynovent Biotech Co., Ltd
• Avalyn Pharma Inc.
• InSilico Medicine Hong Kong Limited
• MediciNova
• GRI Bio Operations, Inc.
• Nerre Therapeutics Ltd.
• Sunshine Lake Pharma Co., Ltd.
• United Therapeutics
• Melius Pharma AB
• Pulmongene Ltd.
• Agomab Spain S.L.

Table of Contents

1. Key Findings and Analyst Commentary

• Key trends: market snapshots, SWOT analysis, commercial benefits and risks, etc.

2. Disease Context

• Disease definition, classification, etiology and pathophysiology, drug targets, etc.

3. Epidemiology

• Key takeaways
• Incidence / Prevalence
• Diagnosed and Drug-Treated populations
• Comorbidities
• Other relevant patient segments

4. Market Size and Forecast

• Key takeaways
• Market drivers and constraints
• Drug-class specific trends
• Country-specific trends

5. Competitive Landscape

• Current therapies
  • Key takeaways
  • Dx and Tx journey/algorithm
  • Key current therapies - profiles and KOL insights
• Emerging therapies
  • Key takeaways
  • Notable late-phase emerging therapies - profiles, launch expectations, KOL insights
  • Notable early-phase pipeline

6. Unmet Need and TPP Analysis

• Top unmet needs and future attainment by emerging therapies
• TPP analysis and KOL expectations

7. Regulatory and Reimbursement Environments (by country and payer insights)

8. Appendix (e.g., bibliography, methodology)