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mRNA 疫苗市场 - 2018-2028 年全球行业规模、份额、趋势、机会和预测,按 mRNA 类型、应用、地区和竞争细分mRNA Vaccine Market- Global Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028 Segmented By mRNA Type, By Application, Region and Competition |
由于 mRNA 疫苗在生产、安全性、有效性和分销等方面相对于 DNA 疫苗具有多种优势,全球 mRNA 疫苗市场将在预测期内以惊人的速度增长。全球 mRNA 疫苗市场受到癌症、遗传异常和病毒感染髮病率上升的推动。 2020 年,癌症导致约 1000 万人死亡,即近六分之一的死亡,使其成为全球最主要的死因之一。 TAA(肿瘤相关抗原)、TSA(肿瘤特异性抗原)及其相关细胞因子都可以由mRNA疫苗编码和表达,构成了一类重要的癌症疫苗。这些疫苗更适合各种疾病和患者,因为 mRNA 癌症疫苗可以增强体液和细胞免疫。此外,COVID-19大流行的突然爆发和蔓延以及Moderna和辉瑞-BioNTech针对COVID-19疫苗的成功预计将为未来几年mRNA疫苗市场的增长创造新的前景。这反过来又促使许多生物技术和製药公司以及学术研究机构挺身而出,开始研发和开展不同类型mRNA疫苗的临床试验,从而为全球mRNA疫苗的增长创造了丰厚的机会。预测期内的市场。根据 ClinicalTrials.gov 的数据,大约 444 项与 mRNA 疫苗相关的临床研究正处于不同的开发阶段,正在全球不同地区进行。
与大多数疫苗的生产相比,mRNA 疫苗的生产比其他同类疫苗具有优势,因为它不需要使用细胞培养物。由于反应时间快,污染的风险比其他復杂的疫苗生产技术要小。此外,mRNA 疫苗由于其非整合性和细胞内短暂表达而更安全。 mRNA 疫苗利用脂质封装或裸露形式的序列优化 mRNA,在流感病毒、寨卡病毒、狂犬病病毒等动物模型中产生了针对传染病靶标的有效免疫力,特别是近年来。
与其他治疗方式相比,mRNA 具有众多优势,例如更高的生物功效、更强的免疫原性以及低毒性水平的多功能递送平台,是该领域正在进行的研究和开发工作的主要驱动力。开发基于 mRNA 的疫苗来预防糖尿病、艾滋病毒、癌症和心血管疾病等传染病或慢性疾病是广泛研究的主题。目前有 430 项临床试验使用 mRNA 疫苗来预防除 COVID-19 以外的疾病。根据 ClinicalTrials.gov 的分析,大多数临床试验是在美国进行的。
宾夕法尼亚大学佩雷尔曼医学院的研究人员研製出了一种基于 mRNA 的多价疫苗,可以预防所有 20 种已知的流感病毒亚型。他们采用了与早期尝试创建通用流感疫苗不同的方法,即包含每种亚型特有的抗原,而不仅仅是亚型共享的较小的一组抗原。辉瑞和 Moderna 生产的 SARS-CoV-2 疫苗使用了与该策略相同的 mRNA 技术。 Penn 是开髮用于 COVID-19 疫苗的 mRNA 技术的领导者。
全球 mRNA 疫苗市场可以按 mRNA 类型、应用和地区进行细分。根据mRNA类型,市场可分为核苷修饰mRNA、未修饰mRNA和自扩增mRNA。根据应用,市场分为 COVID-19 mRNA 疫苗、非 COVID-19 mRNA 疫苗等。从地区来看,mRNA疫苗可分为北美、欧洲、亚太地区、南美、中东和非洲。
Arcturus Therapeutics Holdings Inc.、BioNTech SE、CureVac NV、Daiichi Sankyo Company Limited.、Ethris GmbH、葛兰素史克plc、Gennova Biopharmaceuticals Ltd、Moderna, Inc.、Pantherna Therapeutics GmbH、Providence Therapeutics、Silence Therapeutics、Translate Bio、VERSAMEB AG、Verve Therapeutics Inc. 是全球 mRNA 疫苗市场的一些领先参与者。
根据给定的市场数据,TechSci Research 可根据公司的具体需求提供定制服务。该报告可以使用以下自定义选项:
Global mRNA vaccine market is poised to grow at an impressive rate during the forecast period on account of the various benefits of mRNA vaccine over DNA vaccine in terms of production, safety, efficacy, and distribution, among others. Global mRNA Vaccine Market is driven by the rising incidence of cancer, genetic abnormalities, and viral infections. Approximately 10 million deaths, or nearly one in six deaths, happened due to cancer in 2020, making it one of the top causes of death globally. TAA (tumor-associated antigens), TSA (tumor-specific antigens), and their related cytokines can all be encoded and expressed by mRNA vaccines, which constitute a significant class of cancer vaccines. These vaccines are more adaptable to various diseases and patients because mRNA cancer vaccines can boost both humoral and cellular immunity. Besides, the sudden outbreak and spread of the COVID-19 pandemic and the success of Moderna's and Pfizer- BioNTech's vaccines against COVID-19 are expected to create new prospects for growth of the mRNA vaccine market in the coming years. This has, in turn, resulted in many biotechnology & pharmaceutical companies and academic & research institutions coming forward and starting research and development and launching clinical trials for the development of different types of mRNA vaccines, thereby creating lucrative opportunities for the growth of global mRNA vaccine market during the forecast period. According to clinicaltrials.gov, around 444 clinical studies related to mRNA Vaccines are in different phases of development being conducted across different parts of the globe.
The important reason for encouraging extensive study and deployment of mRNA vaccines is their numerous distinctive benefits. One of the main causes for the development of mRNA vaccines is their convenience of production. Simple in form, its active component, RNA, is often produced in vitro utilizing linear DNA as a template. Through codon optimization, nucleoside modification, and an additional delivery method, the stability and translation efficiency of mRNA can be enhanced during this process to create a nucleic acid vaccine with high specificity and resilient stability. The vaccine's safety is another important aspect that encourages widespread use. There is no potential risk of infection or genetic damage because the mRNA does not integrate into the host genome.
mRNA vaccines create proteins that cause human bodies to generate an immune response. Since these vaccines don't involve live viruses, there is absolutely no risk of getting sick after receiving them. The body quickly breaks down mRNA, and cells don't readily take up foreign mRNA. Recent technological advancements have improved the stability of the mRNA molecule and wrapped the molecules in lipids to improve cell delivery effectiveness. These developments boost the production of spike protein in your cells, triggering a stronger immunological response.
Furthermore, owing to recent technological developments in enhanced translation, stability, and delivery methods, messenger RNAs have emerged as a promising therapeutic tool. In fact, mRNA vaccines have opened the door to new pharmacological fields and have become a significant therapeutic class. The development of vaccines is entering a new age because of these mRNA vaccines, which support next-generation vaccinations.
Industry expansion is anticipated to be supported during the projected time by increased investments in the development of cutting-edge and efficient mRNA vaccines. For instance, American mRNA therapeutic developer Arcturus Therapeutics established a Japanese company in Chiba Prefecture in April 2021 as part of a joint venture with Axcelead, Inc., and is currently building a production plant in Minamisoma City, Fukushima Prefecture. In the upcoming years, such investments are probably going to supplement market expansion.
mRNA vaccine production has advantages over the other counterparts, when compared to the production of most vaccines, since it does not require the use of cell cultures. The risk of contamination is smaller than what is seen with other sophisticated vaccine manufacturing techniques because of its quick reaction time. Additionally, mRNA vaccines are safer due to their non-integrative nature and transitory expression within cells. Using lipid-encapsulated or naked forms of sequence-optimized mRNA, mRNA vaccines have produced potent immunity against infectious disease targets in animal models of influenza virus, Zika virus, rabies virus, and others, particularly in recent years.
The numerous benefits mRNA offers over other therapeutic modalities, such as higher biological efficacy, enhanced potent immunogenicity, and versatile delivery platforms at low toxicity levels, are the main drivers of the ongoing research and development efforts being made in this field. The development of mRNA-based vaccines to prevent infectious or chronic diseases like diabetes, HIV, cancer, and cardiovascular diseases is the subject of extensive research. There are currently 430 clinical trials using mRNA vaccines to prevent diseases other than COVID-19. The majority of these clinical trials, according to an analysis by Clinicaltrials.gov, are conducted in the United States.
A multivalent, mRNA-based vaccine that protects against all 20 known influenza virus subtypes has been created by researchers at the Perelman School of Medicine at the University of Pennsylvania. They take a different approach from earlier attempts to create a universal flu vaccine by including antigens unique to each subtype rather than just a smaller set of antigens shared by subtypes. The SARS-CoV-2 vaccines made by Pfizer and Moderna used the same mRNA technology as this strategy. Penn was a leader in the development of the mRNA technology used in those COVID-19 vaccines.
Global mRNA Vaccine Market can be segmented by mRNA type, by application, and by region. Based on mRNA type, the market can be divided into nucleoside-modified mRNA, unmodified mRNA, and self-amplifying mRNA. Based on application the market is divided into COVID-19 mRNA Vaccines, Non COVID-19 mRNA Vaccines, and others. Regionally, the mRNA Vaccine can be categorized into North America, Europe, Asia Pacific, South America, and Middle East & Africa.
Arcturus Therapeutics Holdings Inc., BioNTech SE, CureVac N.V., Daiichi Sankyo Company Limited., Ethris GmbH, GlaxoSmithKline plc, Gennova Biopharmaceuticals Ltd, Moderna, Inc., Pantherna Therapeutics GmbH, Providence Therapeutics, Silence Therapeutics, Translate Bio, VERSAMEB AG, Verve Therapeutics Inc., are some of the leading players operating in the Global mRNA Vaccine Market.
In this report, Global mRNA Vaccine Market has been segmented into the following categories, in addition to the industry trends, which have also been detailed below:
Company Profiles: Detailed analysis of the major companies present in Global mRNA Vaccine Market.
With the given market data, TechSci Research offers customizations according to a company's specific needs. The following customization options are available for the report: