![]() |
市场调查报告书
商品编码
1342642
外周血单核细胞市场 - 2018-2028 年全球行业规模、份额、趋势、机会和预测,按产品、按应用、技术、来源、地区、竞争、预测和机会细分Peripheral Blood Mononuclear Cells Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028 Segmented By Product, By Application, By Techniques, By Source, By Region, Competition, Forecast and Opportunities |
2022年,全球外周血单核细胞市场价值为2.3568亿美元,由于细胞疗法数量的增长、研究和开发的高需求,预计2023-2028年期间复合年增长率为10.39%对化合物的毒理学测试和反应机理负责新产品的稳定开发。例如,2023 年 6 月,国家医学图书馆发表的一项研究评估了体外感染克氏锥虫哥伦比亚株 (Col) 并用苯并硝唑治疗的外周血单核细胞 (PBMC) 的免疫反应。
客户对外周血单核细胞的认识不断增强,以及对抗体开发的日益偏好,是该行业的两个重要增长动力。 PBMC对于开展生物学和病理学相关研究以及与致命疾病、免疫学、疫苗开发等相关的临床研究至关重要。例如,根据clinicaltirals.gov.in的数据,已针对外周血进行了972项研究单核细胞。 PBMC 提供有关前瞻性新型药物分子对人类尤其是免疫系统影响的信息。影响 PBMC 的药物毒性可能会导致几种严重的、有时甚至是致命的毒副作用,包括免疫系统抑制和中毒。毒理学研究旨在评估化学物质、药物和环境因素对生物体的潜在有害影响。 PBMC 用于免疫毒性研究,以评估这些物质对免疫系统的影响。通过将 PBMC 暴露于不同的化合物并分析免疫反应,研究人员可以确定免疫毒性作用,包括免疫细胞群、细胞因子产生和免疫功能的改变。因此,免疫毒性研究对 PBMC 的需求不断增加,促进了全球外周血单核细胞市场的增长。
相对于传统的再生药物,患者现在有了更好的细胞疗法替代方案,但其副作用阻碍了它们在客户中的使用。在这一产品类别中,北美和欧洲等发达地区在促进人类福祉的细胞疗法方面拥有强大的影响力。人们越来越认识到在细胞和基因治疗中使用外周血单核细胞。因此,外周血单个核细胞的提取和使用被证明是市场扩张的关键驱动力。然而,急性心肌梗塞、慢性心力衰竭、脊髓损伤、中风和伤口癒合等致命疾病都已在临床前研究中使用凋亡外周血单核细胞的分泌组成功治疗,这推动了全球市场的增长。例如,根据美国疾病控制与预防中心的数据,美国每年约有 37,300 例新发 HPV+ 肿瘤病例,占女性所有恶性肿瘤的 3%,占男性所有癌症的 2%。随着HPV在该国的流行率不断上升,公司不断致力于开发疗法和药物以进入美国市场。 PBMC 是细胞治疗免疫细胞的宝贵来源。它们含有各种类型的免疫细胞,包括 T 细胞、B 细胞和自然杀伤 (NK) 细胞,在免疫反应和疾病靶向中发挥着至关重要的作用。 PBMC 提供了多种免疫细胞,可以在不同的细胞治疗方法中分离、操作和利用它们。
此外,过继细胞移植 (ACT) 是一种细胞疗法,涉及将免疫细胞(通常是 T 细胞)转移到患者体内,以靶向和消除癌症等疾病。 PBMC 通常用作分离和扩增特定 T 细胞亚群的起始材料,例如肿瘤浸润淋巴细胞 (TIL)、肿瘤相关抗原特异性 T 细胞或基因工程 T 细胞。 PBMC 为 ACT 疗法提供了便捷的 T 细胞来源。
随着用于治疗致命疾病的新型细胞/基因疗法/药物和新产品的开发,研发 (R&D) 实践和活动的快速进步正在推动市场的增长。 PBMC 是从常规采集的血液样本中获取生理相关(免疫)蛋白质的合理方法,而且它们这样做时,不会遇到天然人血浆中因高丰度蛋白质的存在而带来的众所周知的分析挑战,从而推动市场的增长。此外,为了促进医疗保健领域的发展,各国政府正在为正在进行的外周血单核细胞研究提供资金。
此外,人们对 PBMC 在疾病研究中的潜力的认识不断增强,导致研发活动增加,并促进了市场增长。 PBMC 在药物发现和开发中发挥着至关重要的作用。它们用于早期研究,以评估潜在候选药物的功效和安全性。 PBMC 提供了一个与人类相关的模型,用于研究免疫反应和评估新化合物对免疫细胞的影响。人们越来越认识到 PBMC 在药物发现中的价值,导致对这些细胞的需求和利用增加,从而推动 PBMC 市场的增长。人们对基于细胞的疗法的治疗潜力的认识正在迅速增强。 PBMC 在细胞疗法的开发和製造中至关重要,例如过继细胞移植、CAR-T 细胞疗法和免疫疗法。这些先进疗法的治疗效果,加上人们对 PBMC 在其发育中的作用的认识不断提高,导致了重大的研发工作和全球外周血单核细胞市场的增长。学术机构、研究组织和生物製药行业之间的合作显着增加。这种合作促进了知识交流、联合研究项目和资助计划,重点关注 PBMC 在各个研究领域的应用。人们对 PBMC 潜力的认识不断增强以及研发方面的协作努力对全球外周血单核细胞市场的增长产生了积极影响。
根据给定的市场数据,TechSci Research 可根据公司的具体需求提供定制服务。该报告可以使用以下自定义选项:
Global peripheral blood mononuclear cells market was valued at USD 235.68 million in 2022 and is anticipated to grow at a CAGR of 10.39% during the period 2023-2028 owing to the rising rate in the number of cell therapies, high demand of research, and development for toxicology testing and reaction mechanism of the compound responsible for new and stable development of products. For instance, in June 2023, a study published in the National Library of Medicine assessed the immune response of peripheral blood mononuclear cells (PBMC) that were infected in vitro with the Colombian strain (Col) of Trypanosoma cruzi and treated with Benzonidazole.
Peripheral blood mononuclear cells (PBMCs) are a type of blood cell that plays a crucial role in the immune system. PBMCs are a heterogeneous population of cells that are isolated from the peripheral blood, which is the blood circulating throughout the body. They are composed of lymphocytes, monocytes, and other immune cells. Lymphocytes are a type of white blood cell that includes T cells, B cells, and natural killer (NK) cells. T cells are responsible for cell-mediated immune responses, B cells produce antibodies for humoral immune responses, and NK cells are involved in the innate immune system and killing infected or cancerous cells. Monocytes are another type of white blood cell that circulates in the bloodstream and can differentiate into macrophages or dendritic cells when they migrate into tissues. Macrophages are responsible for engulfing and destroying foreign substances, dead cells, and cellular debris, while dendritic cells play a critical role in initiating and regulating immune responses by presenting antigens to T cells. The isolation and characterization of PBMCs have revolutionized the understanding of the immune system and have contributed to advancements in various fields, including cancer research, infectious diseases, autoimmune disorders, and transplantation medicine.
PBMCs are widely used in various research applications, including immunology, cell therapy, vaccine development, and drug discovery. They provide valuable insights into immune responses, allow researchers to study various immune cell populations, and serve as a source of cells for cell-based therapies. PBMCs can be isolated from peripheral blood using techniques such as density gradient centrifugation or specialized cell separation methods.
Additionally, the rise in number of cell therapies, expansion in research & development schemes, increasing focus of key players on R&D in peripheral blood mononuclear cells, increasing focus on regenerative medicine, as well as an increase in demand for cell operations among the population, increasing investigation of various aspects of immunology, infectious diseases, autoimmune disorders, transplantation, and vaccine development are projected to provide market players with lucrative prospects in the future.
The growing awareness of customers for peripheral blood mononuclear cells, as well as a growing preference for antibody development, are two important growth drivers for the industry. PBMC is crucial to carry out biology and pathology-related studies as well as in clinical research related to fatal diseases, immunology, vaccine development, etc. For instance, according to clinicaltirals.gov.in, 972 studies have been carried out for peripheral blood mononuclear cells. PBMCs provide information on the effects of prospective novel medication molecules on people, particularly on their immune systems. Drug toxicity that affects PBMCs can result in several serious, sometimes fatal toxic side effects, including immune system suppression and poisoning. Toxicology research aims to evaluate the potentially harmful effects of chemical substances, drugs, and environmental factors on living organisms. PBMCs are used in immunotoxicity studies to assess the impact of these substances on the immune system. By exposing PBMCs to different compounds and analyzing immune responses, researchers can determine the immunotoxic effects, including alterations in immune cell populations, cytokine production, and immune function. The demand for PBMCs in immunotoxicity research is thus increasing, contributing to the growth of the global peripheral blood mononuclear cells market.
Patients now have a better alternative to cell-based therapies with respect to traditional regenerative medicines, but their side effects have hindered their use among customers. In this product category, developed regions such as North America and Europe have a strong presence in cell therapies for human well-being. The population is gaining awareness regarding the use of peripheral blood mononuclear cells in cell and gene therapy. Hence, the extraction and usage of peripheral blood mononuclear cells prove to be the key driving force for market expansion. However, fatal diseases such as acute myocardial infarction, chronic heart failure, spinal cord injury, stroke, and wound healing have all been successfully treated in pre-clinical studies using the secretome of apoptotic peripheral blood mononuclear cells, which drives the market growth globally. For instance, according to the Centers for Disease Control and Prevention, around 37,300 new cases of HPV+ tumors occur each year in the U.S., accounting for 3% of all malignancies in women and 2% of all cancers in men. With the increasing prevalence of HPV in the country, companies are continuously focusing on the development of therapy and drugs to enter the US market. PBMCs serve as a valuable source of immune cells for cell therapy. They contain various types of immune cells, including T cells, B cells, and natural killer (NK) cells, which play crucial roles in immune responses and disease targeting. PBMCs provide a diverse population of immune cells that can be isolated, manipulated, and utilized in different cell therapy approaches.
Also, Adoptive Cell Transfer (ACT) is a type of cell therapy that involves the transfer of immune cells, typically T cells, into patients to target and eliminate diseases, such as cancers. PBMCs are often used as a starting material to isolate and expand specific subsets of T cells, such as tumor-infiltrating lymphocytes (TILs), tumor-associated antigen-specific T cells, or genetically engineered T cells. PBMCs provide a convenient source of T cells for ACT therapies.
Rapid advancements in research and development (R&D) practices and activities are propelling the growth of the market as novel cell/gene therapies/medications and new products are developed for the treatment of fatal diseases. PBMCs are a reasonable way to acquire physiologically relevant (immune) proteins from routinely collected blood samples, and they do so without the native human plasma's well-known analytical challenges brought on by the presence of highly abundant proteins for driving the growth of the market. Furthermore, the government of different countries, for their growth in the healthcare sector, are providing funds for the ongoing research of peripheral blood mononuclear cells.
Additionally, the growing awareness of the potential of PBMCs in disease research has led to increased R&D activities and contributed to market growth. PBMCs play a crucial role in drug discovery and development. They are utilized in early-stage research to assess the efficacy and safety of potential drug candidates. PBMCs provide a human-relevant model for studying immune responses and evaluating the effects of new compounds on immune cells. The growing awareness of the value of PBMCs in drug discovery has resulted in increased demand and utilization of these cells, driving the growth of the PBMCs market. The awareness of the therapeutic potential of cell-based therapies has been growing rapidly. PBMCs are essential in the development and manufacturing of cell-based therapies, such as adoptive cell transfer, CAR-T cell therapy, and immunotherapies. The therapeutic benefits of these advanced therapies, coupled with the increasing awareness of PBMCs' role in their development, have led to significant R&D efforts and the growth of global peripheral blood mononuclear cells market. There has been a notable increase in collaboration between academic institutions, research organizations, and the biopharmaceutical industry. This collaboration has fostered knowledge exchange, joint research projects, and funding initiatives focused on the application of PBMCs in various areas of research. The growing awareness of the potential of PBMCs and the collaborative efforts in R&D have positively impacted the growth of the global peripheral blood mononuclear cells market.
The global peripheral blood mononuclear cells market is segmented based on product, application, technique, source, region, and competitive landscape. Based on the product, the market can be split into cryopreserved or frozen PBMC, cultured or fresh PBMC, and peripheral blood mononuclear cell isolation & viability kits. Based on application, the market can be divided into immunology, hematology, infectious disease, and others. Based on techniques, the market is divided into density gradient centrifugation, leukapheresis, and others. In terms of sources, the market can be categorized into humans and animals.
Charles River Laboratories International, Inc., Lonza Group AG, Corning Inc, Bio-Rad Laboratories Inc, ABCAM, Biolegend Inc, ZEN-Bio Inc, DAPCEL, Inc., Creative Bioarray, iXCells Biotechnologies USA, LLC, Miltenyi Biotec B.V. & CO. KG, STEMCELL Technologies Inc., Precision Medicine Group, LLC, StemExpress, LLC, RayBiotech Life, Inc., REPROCELL Inc., Cytologics LLC, BioIVT LLC, Biopredic International, and Cell Applications, Inc. etc. are among the major players in the global peripheral blood mononuclear cells market.
In this report, Global Peripheral Blood Mononuclear Cells Market has been segmented into the following categories, in addition to the industry trends, which have also been detailed below:
Company Profiles: Detailed analysis of the major companies present in global peripheral blood mononuclear cells market.
With the given market data, TechSci Research offers customizations according to a company's specific needs. The following customization options are available for the report: