CAR-T 细胞疗法全球市场 - 市场规模、预测、试验、趋势（2025 年）

全球监理核准

自2017年以来，13种CAR-T细胞疗法已在多个医疗市场商业化。继美国FDA批准这七种治疗方法后，其他主要医疗市场也纷纷获得批准。这些治疗包括：

1. Kymriah（tisagenlecleucel） 2. Yescarta（axicabtagene ciloleucel） 3.Tecartus（brexucabtagene autoleucel） 4.Breyanzi（lisocabtagene maraleucel）

5.Abecma（idecabtagene vicleucel） 6.卡维克蒂（ciltacabtagene autoleucel） 7.Aucatzyl（obecabtagene autoleucel）

在美国以外，四种CAR-T疗法已获得中国NMPA批准：Relma-cel，Fucaso，元瑞达和Zever-cel。此外，另外两种疗法NexCAR19和Qartemi已获得印度CDSCO的批准。

市场扩张与产业成长

这些监管部门的批准标誌着 CAR-T 市场确立其作为领先生物技术领导者地位的一个重要里程碑。併购活动特别活跃，显示投资者信心强劲。 Celgene 以 90 亿美元收购 Juno Therapeutics 凸显了该行业的潜力，随后百时美施贵宝（BMS）以 740 亿美元收购 Celgene。另一项重要举措是吉利德以119亿美元收购Kite Pharma，进一步巩固了其在该领域的地位。此外，安斯泰来製药也以 6.65 亿美元收购了 Xyphos Biosciences，扩大了其投资组合。这些交易表明，各大製药公司正增加对CAR-T技术的投资，为未来的癌症治疗铺路。

随着CAR-T疗法的不断发展，该行业面临重大课题，包括提高基因传递效率和降低毒性风险。研究人员正在积极探索使用 CRISPR 和电穿孔技术来增强 T 细胞改造，而其他公司正在开发 "开/关" 开关来控制 CAR-T 活性。

实体瘤的治疗仍然是最大的障碍之一，因为临床试验表明，与血癌相比，实体瘤的反应率较低。因此，人们的重点是识别实体肿瘤特异性抗原并提高对这些癌症的疗效。

目前，近75%正在进行的临床试验和所有上市的CAR-T疗法均依赖自体（患者来源）细胞。然而，下一个突破可能在于异体 CAR-T 疗法，这是一个现成的解决方案，可以简化製造过程、降低成本并扩大患者使用机会。

全球 CAR-T 细胞治疗市场

CAR-T细胞治疗市场已从早期的实验性治疗方法发展成为一个覆盖全球的价值数十亿美元的产业。早期在血癌治疗方面取得的成功为更广泛的应用铺平了道路，从新创公司到大型生物科技公司等一系列公司都在努力拓展该领域。随着科技的不断创新，CAR-T疗法未来将具有巨大潜力，彻底改变全球癌症治疗。

精选公司与组织

目录

第 1 章报告概述

• 报告声明
• 执行摘要
• 简介

第2章 CAR-T细胞疗法：技术发展

• CAR-T细胞疗法概述
• CAR-T 发展的演变
• 存在于造血系统恶性细胞上的抗原
• 将受体基因插入T细胞的工具
• 将 T 细胞转化为 CAR-T 细胞
• 全球现有的 13 种 CAR-T 疗法概况：
  • Kymriah（tisagenlecleucel）
  • Yescarta（axicabtagene ciloleucel） Tecartus（brexucabtagene autoleucel）
  • Breyanzi（lysocabtagene maraleucel） Abecma（idecabtagene vicleucel） Relma-cel（relmacabtagene autoleucel）
  • Carvykti（ciltacabtagene autoleucel）
  • Fucaso（equecabtagene autoleucel）
  • NexCAR19（actalycabtagene autoleucel）
  • 元瑞达（inaticabtagene autoleucel） Zevor-cel（zevorcabtagene autoleucel） Qartemi（varnimcabtagene autoleucel） Aucatzyl（obecabtagene autoleucel）
• 全球 CAR-T 疗法的成本
• 与 CAR-T 疗法相关的毒性

第 3 章 未来 CAR-T 疗法的策略

• 可切换 CAR（sCAR/通用 CAR）
• 亲和力调节型汽车
• 装甲车
• 从液体肿瘤转变为实体肿瘤
• 专注于减少住院时间
• 专注于发现新抗原
• 大众的 CAR-T 疗法
• 新的体内 CAR-T 方法
• 与 mRNA 疫苗结合
• 与溶瘤病毒结合

第4章 CAR-T发展的关键里程碑（1989-2024）

• CAR-T细胞疗法实现的15个重要里程碑
• 未来的 CAR-T 明星
• CAR-T 仅适合少数癌症患者
• CAR-T细胞疗法的益处
• CAR-T细胞疗法的缺点
• CAR-T疗法的成功率

第5章 CAR-T标靶抗原

• CAR-T标靶血癌抗原
• CAR-T 标靶实体肿瘤中的抗原
• 临床试验中 CAR-T 细胞最常针对的抗原

第 6 章 CAR-T 细胞的可扩展製造

• 製造过程
• CAR-T製造平台的演变
• 同种异体 CAR-T 製造
• 目前使用的 CAR-T 製造平台
• CAR-T製造平台比较
• CAR-T製造成本

第 7 章：CAR-T 专利格局

• CAR-T细胞疗法专利的地理分布
• CAR-T细胞疗法专利申请人
• CAR-T 专利发明者
• CAR-T 细胞疗法专利持有者
• CAR-T疗法专利的法律地位
• 如何延长专利的有效期限

第 8 章：CAR-T 临床试验现况

• CAR-T 临床试验：依开发阶段划分
• CAR-T临床试验的类型
• 按资助类型划分的 CAR-T 临床试验
• 临床试验中正在研究的血液（液体）癌症类型
• 使用一种 CAR-T 同时进行标靶治疗
• 临床试验中使用的CAR-T代类型
• CAR-T试验：透过使用SvFv
• 以所用载体类型划分的 CAR-T 试验
• 临床试验中的自体和同种异体 CAR-T
• 临床试验主要集中于实体肿瘤

第 9 章 CAR-T 科学论文发表于 PUBMED.GOV

• 自体和同种异体 CAR-T 细胞疗法的 PubMed 文章
• 针对液体和实体肿瘤的 CAR-T 细胞疗法（2013-2024）
• PubMed.gov 上有关五代 CAR-T 细胞疗法的文章

第 10 章 CAR-T 融资前景

• CAR-T 领域的创投融资情形（2014 年至 2024 年）
• 投资于 CAR-T 公司的 IPO 资本（2014 年至 2024 年）
• CAR-T许可协议
• CAR-T合作研究协议
• CAR-T 併购 (M&A) 交易（2015 年至 2024 年）
• CAR-T 资金概况

第 11 章 CAR-T 细胞治疗的费用和报销

• 新的付款模式
• 已获批准的 CAR-T 细胞疗法的标价
• 美国 CAR-T 细胞疗法的报销
• 欧洲 CAR-T 疗法的成本
• 亚太地区的CAR-T细胞疗法

第 12 章 CAR-T 标靶的血癌

• 急性淋巴性白血病 (ALL)
• 瀰漫性大 B 细胞淋巴瘤 (DLBCL)
• 套细胞淋巴瘤 (MCL)
• 多发性骨髓瘤 (MM)
• 血癌治疗费用大

第 13 章 市场分析

• CAR-T细胞疗法的全球渗透率（2017-2024）
• 全球 CAR-T 细胞治疗产品市场（2024-2032 年）
• 全球 CAR-T 疗法市场（按地区划分） (2024-2032)
• 全球 CAR-T 疗法市场按适应症划分（2024-2032 年）
• 全球采用 CAR-T 细胞疗法的障碍

第 14 章：CAR-T 公司：概述

• 2seventy bio
• Abintus Bio, Inc.
• AffyImmune Therapeutics, Inc.
• Aleta BioTherapeutics
• Allogene Therapeutics
• Anixa Biosciences, Inc.
• Arbele, Ltd.
• Arcellx
• Atara Biotherapeutics
• Aurora BioPharma
• Autolus Therapeutics plc
• AvenCell Europe GmbH
• Beam Therapeutics, Inc
• Bellicum Pharmaceuticals
• BioNTech
• Biosceptre
• Bluebird bio
• Bristol Myers Squibb/Celgene Corporation
• Cabaletta Bio
• Carina Biotech
• CARsgen Therapeutics
• Cartesian Therapeutics
• CARTherics Pty Ltd.
• CASI Pharmaceuticals
• Cellectis
• Celularity, Inc.
• Celyad Oncology
• CRISPR Therapeutics
• Curocell, Inc.
• DiaCarta
• Elicera Therapeutics AB
• EXUMA Biotech
• Fate Therapeutics
• Galapagos NV
• Gilead Sciences, Inc.
• Gracell Biotechnologies
• IASO Biotherapeutics
• ImmPACT Bio
• Immuneel Therapeutics, Pvt., Ltd.
• ImmunoACT
• Interius BioTherapeutics
• Juventas Cell Therapy
• JW Therapeutics
• Kite Pharma（Gilead）
• Kyverna Therapeutics
• Legend Biotech
• Leucid Bio
• Luminary Therapeutics, Inc.
• Lyell Immunopharma, Inc.
• March Biosciences
• MaxCyte, Inc.
• Minerva Biotechnologies Corporation
• Mustang Bio
• Noile-Immune Biotech
• Novartis AG
• Oncternal Therapeutics
• Oxford Biomedica plc
• PeproMene Bio, Inc.
• Poseida Therapeutics, Inc.
• Precigen, Inc.
• Prescient Therapeutics
• ProMab Biotechnologies, Inc.
• SOTIO Biotech BV
• Syngene International, Ltd
• Synthekine
• TC BioPharm
• T-CURX
• Umoja Biopharma
• ViTToria Biotherapeutics
• Vor Biopharma
• Wugen
• WuXi Advanced Therapies
• Xenetic Biosciences
• Xyphos Biosciences, Inc

图形索引

表格索引

AR-T cell therapy is a groundbreaking advancement in cancer treatment, offering remarkable promise for patients. This form of immunotherapy harnesses the power of the body's own immune cells, modifying them in a laboratory to enhance their ability to recognize and destroy cancer cells. Once infused back into the patient, these engineered cells multiply and persist in the body as "living drugs," continually working to fight the disease.

T-cells, a crucial component of the immune system, form the foundation of CAR-T therapy. These immune workhorses play a key role in directing immune responses and eliminating infected or abnormal cells. In CAR-T cell therapy, a patient's blood is drawn, and T-cells are separated out. Scientists then use a disarmed virus to genetically engineer these cells to express chimeric antigen receptors (CARs) on their surface. These CARs enable the T-cells to specifically target antigens found on cancer cells, leading to their destruction upon infusion back into the patient.

Global Regulatory Approvals

Since 2017, 13 CAR-T cell therapies have reached commercialization across multiple healthcare markets. Seven therapies have been approved by the U.S. FDA, after which approvals for them were issued in other major healthcare markets as well. These therapies include:

1. Kymriah (tisagenlecleucel) 2. Yescarta (axicabtagene ciloleucel) 3. Tecartus (brexucabtagene autoleucel) 4. Breyanzi (lisocabtagene maraleucel)

5. Abecma (idecabtagene vicleucel) 6. Carvykti (ciltacabtagene autoleucel) 7. Aucatzyl (obecabtagene autoleucel)

Beyond the U.S., four CAR-T therapies-Relma-cel, Fucaso, Yuanruida, and Zever-cel-have been approved by China's National Medical Products Administration (NMPA). Additionally, two therapies, NexCAR19 and Qartemi, have received approval from India's Central Drugs Standard Control Organisation (CDSCO).

Market Expansion and Industry Growth

These regulatory approvals mark a major milestone, solidifying the CAR-T market as a dominant force in biotech. Mergers and acquisitions have been particularly aggressive, demonstrating strong investor confidence. Celgene's acquisition of Juno Therapeutics for $9 billion underscored the industry's potential, followed by Bristol-Myers Squibb (BMS) acquiring Celgene for $74 billion. Another significant move was Gilead's acquisition of Kite Pharma for $11.9 billion, further strengthening its position in the space. Additionally, Astellas Pharma expanded its portfolio by purchasing Xyphos Biosciences for $665 million. These transactions highlight the increasing commitment from major pharmaceutical companies to invest in CAR-T technologies and shape the future of cancer treatment.

As CAR-T therapy continues to evolve, the industry faces key challenges, including improving gene-transfer efficiency and mitigating toxicity risks. Researchers are actively exploring CRISPR and electroporation technologies to enhance T-cell modification, while others develop "on-off" switches to regulate CAR-T activity.

One of the biggest hurdles remains the treatment of solid tumors, as clinical trials have shown lower response rates compared to blood cancers. Thus, a major focus is on identifying solid tumor-specific antigens to improve efficacy in these cancers.

Currently, nearly 75% of ongoing clinical trials and all marketed CAR-T therapies rely on autologous (patient-derived) cells. However, the next breakthrough lies in allogeneic CAR-T therapies-off-the-shelf solutions that could streamline manufacturing, reduce costs, and expand patient accessibility.

Global CAR-T Cell Therapy Market

The CAR-T cell therapy market has grown from early experimental treatments to a multi-billion-dollar industry with global reach. Early successes in blood cancers have paved the way for broader applications, with companies ranging from startups to biotech giants working to expand the field. As innovation continues, the future of CAR-T therapy holds immense potential to revolutionize cancer treatment worldwide.

This report aims to provide readers with the following insights:

• An overview of CAR-T therapy, covering the structure and function of T cells, how they normally act on infected cells, and how they are "armed" with engineered receptors to target and destroy cancer cells.
• A breakdown of chimeric antigen receptors (CARs), cancer cell antigens, CAR-T cell manufacturing, and the available CAR-T products, including autologous and allogeneic CAR-Ts.
• A brief history of CAR-T therapy, highlighting its evolution from 1989 to the present, its transformative potential, and the accelerating activities within the CAR-T sector.
• An examination of the manufacturing process and the costs associated with developing autologous and allogeneic CAR-T cell therapies.
• An overview of cancer biomarkers or antigens targeted by CAR-T cells.
• A detailed analysis of the global CAR-T patent landscape, including leading sponsors, inventors, and regions
• An in-depth look at the rates, types, and trends for clinical trials involving CAR-T cells.
• A review of the rates and types of CAR-T cell therapy scientific publications.
• An overview of NIH grants awarded to support CAR-T cell therapy research.
• A review of industry dealmaking and strategic partnerships within the CAR-T sector in 2024.
• Descriptions of CAR-T therapies, including Kymriah, Yescarta, Tecartus, Breyanzi, Abecma, Relma-cel, Carvykti, NexCAR19, Yuanruida, Qartemi, Aucatzyl, Fucaso, and Zever-cel.
• A review of reimbursement policies for CAR-T therapies in the U.S. and outcome-based reimbursement policies in Europe.
• A global market analysis for CAR-T cell therapies by Geography, Product, and Indication.
• Profiles of leading CAR-T cell therapy market competitors, including their novel products, emerging candidates, and proprietary technology platforms.

Key Questions Answered in This Report:

• What are T cells, and how do they target and destroy infected cells and pathogens?
• How are T cells armed with chimeric antigen receptors (CARs) to become CAR-T cells?
• What do first-, second-, third-, fourth-, and fifth-generation CAR-T therapies refer to?
• How are CAR genes inserted into T cells?
• What are the features of the FDA-approved CAR-T therapies currently available?
• What future developments are expected within the CAR-T sector?
• Which new CAR-T products are anticipated to enter the market soon?
• How many automated manufacturing systems are available for CAR-T production?
• Which antigens are most commonly targeted in liquid and solid cancers?
• What is the number of CAR-T-related patent publications and granted patents from 2012 to present?
• Which countries hold the most CAR-T patents?
• Which companies have filed the most CAR-T patents?
• Who are the top CAR-T patent inventors?
• How many CAR-T-related clinical trials have been registered from 2003 to the present?
• Which biomarker antigens dominate the CAR-T clinical trial landscape?
• How many CAR-T deals were signed in 2023-2024 and who entered into them?
• What is the current market size for FDA-approved CAR-T therapies?
• What promising CAR-T candidates are expected to reach commercialization soon?
• How are CAR-T therapies reimbursed in the U.S. and Europe?
• What is the market size for CAR-T therapies by geography, product, and indication?
• Which major companies are developing CAR-T cell therapies?

This global strategic report will position you to:

• 1. Capitalize on rapidly emerging trends
• 2. Optimize decision-making
• 3. Reduce company risk
• 4. Approach partners/investors for collaboration or funding
• 5. Implement an informed and advantageous business strategy in 2025

With the competitive nature of this global market, you don't have the time to do the research. Claim this report to become immediately informed, without missing critical opportunities.

Companies and Organizations Mentioned:

TABLE OF CONTENTS

1. REPORT OVERVIEW

• 1.1. Statement of the Report
• 1.2. Executive Summary
• 1.3. Introduction

2. CAR-T CELL THERAPY: TECHNOLOGY DEVELOPMENT

• 2.1. An Overview of CAR-T cell Therapy
• 2.2. Evolution of CAR-T Development
  • 2.2.1. CAR-T cell Therapy Technology Progression
    • 2.2.1.1. First Generation CARs
    • 2.2.1.2. Second Generation CARs
    • 2.2.1.3. Third Generation CARs
    • 2.2.1.4. Fourth Generation CARs
    • 2.2.1.5. Fifth Generation CARs
• 2.3. Antigens Present on Hematological Malignant Cells
• 2.4. Tools for Inserting Receptor Genes into T cells
• 2.5. Transforming T cells into CAR-T cells
• 2.6. The 13 CAR-T Therapies Available Globally: A Brief Overview
  • 2.6.1. Kymriah (tisagenlecleucel)
    • 2.6.1.1. Manufacturing
    • 2.6.1.2. Indication
    • 2.6.1.3. Dosage Composition
    • 2.6.1.4. Approval History of Kymriah
    • 2.6.1.5. Sales Revenue
  • 2.6.2. Yescarta (axicabtagene ciloleucel)
    • 2.6.2.1. Manufacturing of Yescarta
    • 2.6.2.2. Indication
    • 2.6.2.3. Dosage Composition
    • 2.6.2.4. Approval History of Yescarta
    • 2.6.2.5. Sales Revenue
  • 2.6.3. Tecartus (brexucabtagene autoleucel)
    • 2.6.3.1. Manufacturing of Tecartus
    • 2.6.3.2. Indication
    • 2.6.3.3. Dosage Composition
    • 2.6.3.4. Approval History of Tecartus
    • 2.6.3.5. Sales Revenue
  • 2.6.4. Breyanzi (lysocabtagene maraleucel)
    • 2.6.4.1. Manufacturing of Breyanzi
    • 2.6.4.2. Indication
    • 2.6.4.3. Dosage Composition
    • 2.6.4.4. Approval History of Breyanzi
    • 2.6.4.5. Sales Revenue
  • 2.6.5. Abecma (idecabtagene vicleucel)
    • 2.6.5.1. Manufacturing of Abecma
    • 2.6.5.2. Indications
    • 2.6.5.3. Dosage Composition
    • 2.6.5.4. Approval History of Abecma
    • 2.6.5.5. Sales Revenue
  • 2.6.6. Relma-cel (relmacabtagene autoleucel)
  • 2.6.7. Carvykti (ciltacabtagene autoleucel)
    • 2.6.7.1. Manufacturing of Carvykti
    • 2.6.7.2. Indications
    • 2.6.7.3. Dosage
    • 2.6.7.4. Approval History of Carvykti
    • 2.6.7.5. Sales Revenue
  • 2.6.8. Fucaso (equecabtagene autoleucel)
    • 2.6.8.1. Dosage & Overall Response Rate
  • 2.6.9. NexCAR19 (actalycabtagene autoleucel)
  • 2.6.10. Yuanruida (inaticabtagene autoleucel)
  • 2.6.11. Zevor-cel (zevorcabtagene autoleucel)
  • 2.6.12. Qartemi (varnimcabtagene autoleucel)
    • 2.6.12.1. Indication & Dosage
    • 2.6.12.2. Product Description & Mechanism of Action
    • 2.6.12.3. Manufacture
  • 2.6.13. Aucatzyl (obecabtagene autoleucel)
    • 2.6.13.1. Manufacturing
    • 2.6.13.2. Indication & Dosage
    • 2.6.13.3. Approval
    • 2.6.13.4. Wholesale Price
• 2.7. Cost of CAR-T Therapy around the World
• 2.8. Toxicities Associated with CAR-T Treatment

3. STRATEGIES FOR FUTURE CAR-T THERAPIES

• 3.1. Switchable CARs (sCARs/Universal CARs)
  • 3.1.1. Switchable CAR-Ts in the Clinic
  • 3.1.2. Suicide Genes
  • 3.1.3. Transient Transfection
• 3.2. Affinity-Tuned CARs
• 3.3. Armored CARs
• 3.4. Shift from Liquid Cancers to Solid Cancers
• 3.5. Focus on Shortening Hospital Stay
• 3.6. Focus on Discovering New Antigens
• 3.7. CAR-T for the Masses
• 3.8. New In Vivo CAR-T Approaches
• 3.9. Combination with mRNA Vaccine
• 3.10. Combination with Oncolytic Virus

4. MAJOR EVENTS DURING THE DEVELOPMENT OF CAR-T, 1989-2024

• 4.1. Major 15 Milestones Crossed by CAR-T cell Therapy
  • 4.1.1. First CAR Developed by Zelig Eshhar (1993)
  • 4.1.2. Development of First Generation CAR-T (1993)
  • 4.1.3. First Effective CAR-T Cells Developed (2002)
  • 4.1.4. Second Generation CARs Developed (2003)
  • 4.1.5. Recipe for CD19 CARs Published (2009)
  • 4.1.6. Coley Award Given for CAR-T Cell Therapy (2012)
  • 4.1.7. Results for CAR-T Leukemia Published (2013)
  • 4.1.8. Cancer Immunotherapy Voted "Breakthrough of the Year" (2013)
  • 4.1.9. FDA Designates CARs a "Breakthrough" Therapy (2014)
  • 4.1.10. Mesothelin-Directed CARs Developed (2014)
  • 4.1.11. Armored CARs Developed (2015)
  • 4.1.12. CRISPR CARs Built (2017)
  • 4.1.13. First CAR-T Crosses Regulatory Finish Line (August 30, 2017)
  • 4.1.14. Second CAR-T Approval (October 18, 2017)
  • 4.1.15. Third CAR-T Approval (July 24, 2020)
  • 4.1.16. Fourth CAR-T Approval (February 5, 2021)
  • 4.1.17. Fifth CAR-T Approval (March 26, 2021)
  • 4.1.18. Sixth CAR-T Approval (September 6, 2021)
  • 4.1.19. Seventh CAR-T Approved (February 28, 2022)
  • 4.1.20. Eighth CAR-T Approval (July 2, 2023)
  • 4.1.21. Ninth CAR-T Approval (October 16, 2023)
  • 4.1.22. Tenth CAR-T Approval (November 8, 2023)
  • 4.1.23. Eleventh CAR-T Approval (March 1, 2024)
  • 4.1.24. Twelfth CAR-T Approval (May 7, 2024)
  • 4.1.25. Thirteenth CAR-T Approval (November 8, 2024)
• 4.2. The Upcoming CAR-T Stars
  • 4.2.1. ALLO-501 & ALLO-501A
  • 4.2.2. CTX-110, CTX-112, CTX-130 & CTX-131
  • 4.2.3. UCART19
  • 4.2.4. AUT01/22
  • 4.2.5. JCARH125
  • 4.2.6. PBCAR-20A
  • 4.2.7. PRGN-3006
  • 4.2.8. UCART22
  • 4.2.9. UCARTCS1
• 4.3. The Very Small Cancer Population Addressed by CAR-T
• 4.4. Advantages of CAR-T cell Therapy
• 4.5. Disadvantages of CAR-T cell Therapy
• 4.6. Success Rate of CAR-T Therapy

5. CAR-T TARGETED ANTIGENS

• 5.1. CAR-T Target Antigens in Hematological Cancers
• 5.2. CAR-T Target Antigens in Solid Cancers
• 5.3. Most Common Antigens Targeted by CAR-T Cells in Clinical Trials
  • 5.3.1. Cluster Differentiation 19 (CD19)
  • 5.3.2. Mesothelin
  • 5.3.3. Beta Cell Maturation Agent (BCMA)
  • 5.3.4. GD2
  • 5.3.5. Glypican-3 (GPC3)
  • 5.3.6. Cluster Differentiation-22 (CD22)

6. SCALABLE MANUFACTURING OF CAR-T CELLS

• 6.1. Manufacturing Process
  • 6.1.1. Local & Centralized CAR-T Supply Chain Pathways
• 6.2. The Evolution of CAR-T Manufacturing Platforms
  • 6.2.1. Open vs. Closed Systems
  • 6.2.2. Manual Processing vs. Automation
• 6.3. Allogeneic CAR-T Manufacturing
• 6.4. Currently Used CAR-T Manufacturing Platforms
  • 6.4.1. CliniMACS Prodigy
  • 6.4.2. Cocoon
  • 6.4.3. Xuri Cell Expansion System W25
  • 6.4.4. G-Rex
• 6.5. Comparison of CAR-T Manufacturing Platforms
• 6.6. CAR-T Manufacturing Cost
  • 6.6.1. Breakdown of CAR-T Manufacturing Cost

7. CAR-T PATENT LANDSCAPE

• 7.1. Geographical Distribution of CAR-T Cell Therapy Patents
• 7.2. CAR-T Cell Therapy Patent Applicants
• 7.3. CAR-T Patent Inventors
• 7.4. CAR-T Cell Therapy Patent Owners
• 7.5. Legal Status of CAR-T Therapy Patents
• 7.6. Ways to Extend Patent Life

8. CAR-T CLINICAL TRIAL LANDSCAPE

• 8.1. CAR-T Clinical Trials by Phase of Development
• 8.2. Types of CAR-T Clinical Trials
• 8.3. CAR-T Clinical Trials by Funding Type
• 8.4. Types of Hematologic Cancers (Liquid Cancers) Addressed by Clinical Trials
• 8.5. Simultaneous Targets by One CAR-T
• 8.6. CAR-T Generation Types used in Clinical Trials
• 8.7. CAR-T Trials by SvFv Used
• 8.8. CAR-T Trials by Type of Vectors Used
• 8.9. Autologous & Allogeneic CAR-Ts in Clinical Trials
• 8.10. Landscape of Clinical Trials Focusing on Solid Cancers
  • 8.10.1. Geographical Distribution of CAR-T Clinical Trials for Solid Tumors
  • 8.10.2. Vectors used to Transduce CAR Gene into T Cells

9. PUBLISHED CAR-T SCIENTIFIC PAPERS IN PUBMED.GOV

• 9.1. PubMed Papers in Autologous and Allogeneic CAR-T Cell Therapies
• 9.2. CAR-T Cell Therapy for Liquid vs. Solid Cancers, 2013-2024
• 9.3. PubMed.gov Papers on Five Generations of CAR-T Cell Therapy

10. CAR-T FUNDING LANDSCAPE

• 10.1. Venture Capital Funding in CAR-T Sector, 2014-2024
  • 10.1.1. VC Funding for CAR-T Companies by Year, 2014-2024
• 10.2. IPO Funding Invested in CAR-T Companies, 2014-2024
• 10.3. CAR-T Licensing Deals
• 10.4. CAR-T Collaboration Deals
• 10.5. CAR-T Merger & Acquisition (M&A) Deals, 2015-2024
• 10.6. Summary of CAR-T Funding

11. COST OF CAR-T CELL THERAPY & REIMBURSEMENT

• 11.1. New Payment Models
• 11.2. List Prices of Approved CAR-T Cell Therapies
  • 11.2.1. Component Costs Associated with CAR-T Cell Therapy
  • 11.2.2. Adverse Events (AEs) Costs
• 11.3. Reimbursement in the U.S. for CAR-T Cell Therapy
  • 11.3.1. Medicare Payment Changes in 2025 for CAR-T Cases
    • 11.3.1.1. High-Cost Outlier Payments
    • 11.3.1.2. Adjustment for Clinical Trial Cases
    • 11.3.1.3. Inpatient & Outpatient Medicare Spend for CAR-T
• 11.4. Cost of CAR-T Therapies in Europe
  • 11.4.1. Financing CAR-T Therapies in the E.U.
  • 11.4.2. Estimated Cost of CAR-T Therapies in the E.U.
  • 11.4.3. Utilization of CAR-T Cell Therapy in Europe
  • 11.4.4. Utilization of CAR-T in Europe by Indication
• 11.5. CAR-T Cell Therapy in Asia Pacific (APAC)
  • 11.5.1. CAR-T Funding in Australia
  • 11.5.2. CAR-T Funding in Singapore
  • 11.5.3. CAR-T in South East Asia (SEA) [Except in Singapore]
    • 11.5.3.1. Cost & Reimbursement for CAR-T in Japan
    • 11.5.3.2. Cost & Reimbursement for CAR-T in South Korea
    • 11.5.3.3. CAR-T Reimbursement in China
    • 11.5.3.4. CAR-T Reimbursement in Malaysia
    • 11.5.3.5. Cost & Reimbursement for CAR-T in India

12. BLOOD CANCERS ADDRESSED BY CAR-T

• 12.1. Acute Lymphoblastic Leukemia (ALL)
  • 12.1.1. Available Therapies for ALL
• 12.2. Diffuse Large B-cell Lymphoma (DLBCL)
  • 12.2.1. Available Therapies for DLBCL
• 12.3. Mantle Cell Lymphoma (MCL)
  • 12.3.1. Available Therapies for MCL
• 12.4. Multiple Myeloma (MM)
  • 12.4.1. Available Therapies for Multiple Myeloma
  • 12.5.1. Available Therapies for Follicular Lymphoma
• 12.6. The Staggering Cost of Blood Cancer Therapies

13. MARKET ANALYSIS

• 13.1. Global Rates of CAR-T Cell Therapies, 2017-2024
  • 13.1.1. Current Global Market for CAR-T by Product, 2017-2024
• 13.2. Global Market for CAR-T Cell Therapy Products, 2024-2032
• 13.3. Global Market for CAR-T Therapy by Geography, 2024-2032
• 13.4. Global Market for CAR-T Therapies by Indication, 2024-2032
• 13.5. Obstacles to Global Implementation of CAR-T Cell Therapies
  • 13.5.1. Patient-Related Factors
  • 13.3.2. Disease Biology Factor
  • 13.3.3. Adverse Events
  • 13.3.4. Cost
  • 13.3.5. Manufacturing Chain and Supply
  • 13.3.6. Hospitals and Pathways of Care

14. CAR-T COMPNIES: AN OVERVIEW

• 14.1 2seventy bio
  • 14.1.1. Abecma (idecabtagene vicleucel)
• 14.2. Abintus Bio, Inc.
• 14.3. AffyImmune Therapeutics, Inc.
  • 14.3.1. Affinity-Tuned CARs
    • 14.3.1.1. ICAM-1: AffyImmune's Target Antigen
    • 14.3.1.2. Targeted Indication
• 14.4. Aleta BioTherapeutics
  • 14.4.1. Aleta's CAR-T Engager Pipeline
• 14.5. Allogene Therapeutics
  • 14.5.1. AlloCAR-T
    • 14.5.1.1. Manufacturing of AlloCAR-T
• 14.6. Anixa Biosciences, Inc.
• 14.7. Arbele, Ltd.
  • 14.7.1. Advanced Cell Therapy
• 14.8. Arcellx
  • 14.8.1. D-Domain Technology
  • 14.8.2. ddCAR Platform
  • 14.8.3. ARC-SparX Platform
• 14.9. Atara Biotherapeutics
  • 14.9.1. Technology
  • 14.9.2. Allogeneic CAR-T Programs
• 14.10. Aurora BioPharma
  • 14.10.1. HER2 Platform
• 14.11. Autolus Therapeutics plc
  • 14.11.1. Technology
  • 14.11.2. CAR-T Cell Production
  • 14.11.3. Manufacturing
  • 14.11.4. Therapies in Development
    • 14.11.4.1. obe-cel
• 14.12. AvenCell Europe GmbH
  • 14.12.1. Universal Switchable CAR
  • 14.12.2. Allogeneic Platform
  • 14.12.3. Clinical & Preclinical Pipeline Overview
• 14.13. Beam Therapeutics, Inc
  • 14.13.1. BEAM-201
• 14.14. Bellicum Pharmaceuticals
  • 14.14.1. GoCAR Technology
  • 14.14.2. CaspaCIDe Safety Switch
• 14.15. BioNTech
  • 14.15.1. BioNTech's Engineered Cell Therapies
  • 14.15.2. BN211
  • 14.15.3. BN212
• 14.16. Biosceptre
  • 14.16.1. Biosceptre's Unique Target nf2X
  • 14.16.2. BRiDGECAR Program
• 14.17. Bluebird bio
  • 14.17.1. Blebird bio's CAR-T Collaborations
  • 14.17.2. Collaboration with BMS
  • 14.17.3. Collaboration with TC BioPharm
  • 14.17.4. Collaboration with Inhibrx
  • 14.17.5. Collaboration with PsiOxus
• 14.18. Bristol Myers Squibb/Celgene Corporation
  • 14.18.1. Products
    • 14.18.1.1. Abecma (idecabtagene vicleucel)
    • 14.18.1.2. Breyanzi (lisocabtagene maraleucel)
• 14.19. Cabaletta Bio
  • 14.19.1. CABA Platform
  • 14.19.2. Cabaletta's Pipeline
• 14.20. Carina Biotech
• 14.21. CARsgen Therapeutics
  • 14.21.1. CycloCAR-T
  • 14.21.2. THANK-uCAR
  • 14.21.3. LADAR
• 14.22. Cartesian Therapeutics
  • 14.22.1. mRNA CAR-T Cell Program (RNA Armory)
  • 14.22.2. Pipeline
• 14.23. CARTherics Pty Ltd.
  • 14.23.1. Autologous CAR-T Cells
• 14.24. CASI Pharmaceuticals
  • 14.24.1. Yuanruida (inaticabtagene autoleucel; CNCT19)
• 14.25. Cellectis
  • 14.25.1. TAL nucleases, or TALEN
  • 14.25.2. Gene Editing
  • 14.25.3. PulseAgile Technology
  • 14.25.4. Main Product Candidates
• 14.26. Celularity, Inc.
  • 14.26.1. P CAR-T
• 14.27. Celyad Oncology
  • 14.27.1. NKG2D-Based CAR-T Cells
  • 14.27.2. Multispecific CAR
  • 14.27.3. Short Hairpin RNA-based Platform
  • 14.27.4. CAR-T Therapy Development Services
  • 14.27.5. Biomarker Identification and Selection
  • 14.27.6. scFv Generation
  • 14.27.7. CAR-T Gene Packaging and Delivery
  • 14.27.8. Virus Testing Service
  • 14.27.9. CAR Cell in vitro Assay Service
  • 14.27.10. CAR-T Preclinical in vivo Assay
  • 14.27.11. IND Development for CAR-T Cell Therapy
  • 14.27.12. GMP Production for CAR-T Products
  • 14.27.13. CAR-T Clinical Trial Services
• 14.28. CRISPR Therapeutics
  • 14.28.1. CRISPR Therapeutics' Immuno-Oncology Programs
  • 14.28.2. CRISPR/Cas9-enabled Allogeneic CAR-T Design
• 14.29. Curocell, Inc.
  • 14.29.1. OVIS Technology
• 14.30. DiaCarta
  • 14.30.1. Personalized CAR-T Immunotherapy Platform
• 14.31. Elicera Therapeutics AB
  • 14.31.1. iTANK CAR-T Technology
  • 14.31.2. Elicera's Product Pipeline
• 14.32. EXUMA Biotech
  • 14.32.1. TMR CAR-T Technology
  • 14.32.2. CCT3 CAR-T
  • 14.32.3. rPOC SC CAR-TaNKs
  • 14.32.4. GCAR "in vivo Cell Therapy"
• 14.33. Fate Therapeutics
  • 14.33.1. FT819
  • 14.33.2. FT825
• 14.34. Galapagos NV
• 14.35. Gilead Sciences, Inc.
  • 14.35.1. CAR-T Products
    • 14.35.1.1. Tecartus (brexucabtagene autoleucel)
    • 14.34.1.2. Yescarta (axicabtagene ciloleucel)
• 14.36. Gracell Biotechnologies
  • 14.36.1. FasTCAR
  • 14.36.2. TruUCAR
  • 14.36.3. SMART CAR-T
  • 14.36.4. Gracell's Product Pipeline
• 14.37. IASO Biotherapeutics
  • 14.37.1. Technology Platforms
  • 14.37.2. Fully Human Antibody Discovery Platform
  • 14.37.3. High-Throughput Screening Platform for CAR-T Candidates
  • 14.37.4. Universal CAR-T Technology Platform
  • 14.37.5. CAR-T Manufacturing Technology Platform
  • 14.37.6. IASO's Diverse Product Pipeline
• 14.38. ImmPACT Bio
  • 14.38.1. CD19/20 Bispecific CAR
  • 14.38.2. TGF-Beta
• 14.39. Immuneel Therapeutics, Pvt., Ltd.
  • 14.39.1. Immuneel's R&D Roadmap
• 14.40. ImmunoACT
  • 14.40.1. NexCAR19 (Actalycabtagene autoleucel)
• 14.41. Interius BioTherapeutics
  • 14.41.1. Core Technology
• 14.42. Juventas Cell Therapy
  • 14.42.1. Yuanruida (inaticabtagene autoleucel)
• 14.43. JW Therapeutics
  • 14.43.1. Carteyva (relmacabtagene autoleucel; relma-cel)
• 14.44. Kite Pharma (Gilead)
  • 14.44.1. Kite's Marketed CAR-T Products
    • 14.44.1.1. Yescarta (axicabtagene ciloleucel)
    • 14.44.1.2. Tecartus (brexucabtagene autoleucel)
  • 14.44.2. Kite's Pipeline Cancer Therapies
• 14.45. Kyverna Therapeutics
  • 14.45.1. Kyverna's CAR-T Therapy for Autoimmune Diseases
• 14.46. Legend Biotech
  • 14.46.1. Technology Platforms
    • 14.46.1.1. CAR-T
    • 14.46.1.2. CAR-Gamma Delta T
    • 14.46.1.3. CAR-NK
    • 14.46.1.4. Non-Gene-Editing Universal CAR-T
  • 14.46.2. Product Pipeline
• 14.47. Leucid Bio
  • 14.47.1. Leucid's Lateral CAR-Platform
  • 14.47.2. LEU011 - NKG2D CAR-T Cell Therapy
  • 14.47.3. T2, Gamma Delta T-Cells for Off-The-Shelf Therapy
  • 14.47.4. T4 Immunotherapy
  • 14.47.5. Novel Manufacturing Platform
• 14.48. Luminary Therapeutics, Inc.
  • 14.48.1. Allogeneic Gamma 2.0+ Platform
  • 14.48.2. Non-Viral Gene Modification Process
  • 14.48.3. Split Co-Stim Dual CAR
  • 14.48.4. Ligand-Based CAR to Target Three Antigens
  • 14.48.5. Product Pipeline
• 14.49. Lyell Immunopharma, Inc.
  • 14.49.1. Technology
    • 14.49.1.1. Gen-R Technology
    • 14.49.1.2. Epi-R Technology
  • 14.49.2. Lyell's Product Pipeline
• 14.50. March Biosciences
  • 14.50.1. MB-105
  • 14.50.2. March Biosciences' Pipeline
• 14.51. MaxCyte, Inc.
  • 14.51.1. Technology: Flow Electroporation
  • 14.51.2. MaxCyte's Electroporation Systems
    • 14.51.2.1. ATx
    • 14.51.2.2. GTx
    • 14.51.2.3. STx
    • 14.51.2.4. VLx
• 14.52. Minerva Biotechnologies Corporation
  • 14.52.1. CAR-T (huMNC2-CAR44)
• 14.53. Mustang Bio
  • 14.53.1. Mustang's CAR-T Focus
• 14.54. Noile-Immune Biotech
  • 14.54.1. PRIME CAR-T
• 14.55. Novartis AG
  • 14.55.1. The Pioneer in CAR-T
  • 14.55.2. Kymriah (tisagenlecleucel)
  • 14.55.3. T-Charge Platform
    • 14.55.3.1. Phase I YTB323 Clinical Study
    • 14.55.3.2. Phase I PHE 885 Clinical Study
• 14.56. Oncternal Therapeutics
  • 14.56.1. ONCT-808
• 14.57. Oxford Biomedica plc
  • 14.57.1. LentiVector Platform
  • 14.57.2. inAAVate Platform
  • 14.57.3. CDMO Services
• 14.58. PeproMene Bio, Inc.
  • 14.58.1. BAFFR CAR-T Cells
• 14.59. Poseida Therapeutics, Inc.
  • 14.59.1. Poseida's Genetic Engineering Platforms
  • 14.59.2. PiggyBac Platform for Insertion
  • 14.59.3. Cas-CLOVER Platform for Editing
  • 14.59.4. Poseida's CAR-T Product Candidates
• 14.60. Precigen, Inc.
  • 14.60.1. UltraCAR-T
  • 14.60.2. Sleeping Beauty System
  • 14.60.3. UltraPorator System
  • 14.60.4. Product Pipeline
• 14.61. Prescient Therapeutics
  • 14.61.1. OmniCAR
  • 14.61.2. CellPryme
• 14.62. ProMab Biotechnologies, Inc.
  • 14.62.1. ProMab's CAR-T Cells
  • 14.62.2. ProMab's Services
  • 14.62.3. ProMab's Preclinical and Clinical Study Services
• 14.63. SOTIO Biotech BV
  • 14.63.1. BOXR Technology
  • 14.63.2. BOXR1030
• 14.64. Syngene International, Ltd
  • 14.64.1. CAR-T Services
• 14.65. Synthekine
  • 14.65.1. STK-009 + SYNCAR-001
• 14.66. TC BioPharm
  • 14.66.1. Gamma Delta T Cells
  • 14.66.2. Cell Banks
  • 14.66.3. Co-Stim CAR-T
  • 14.66.4. Product Pipeline
    • 14.66.4.1. OmnImmune
  • 14.66.5. CAR-T Programs
• 14.67. T-CURX
  • 14.67.1. Technologies
• 14.68. Umoja Biopharma
  • 14.68.1. Umoja's Technology Platforms
    • 14.68.1.1. VivoVec in vivo Gene Delivery
    • 14.68.1.2. RACR-Induced Cytotoxic Lymphocytes (iCIL)
    • 14.68.1.3. RACR/CAR: in vivo Cell Programming
    • 14.68.1.4. TumorTag: Universal CAR Tumor Targeting
• 14.69. ViTToria Biotherapeutics
  • 14.69.1. Senza5
  • 14.69.2. VIPER-101
• 14.70. Vor Biopharma
  • 14.70.1. Vor Biopharma's Approach
• 14.71. Wugen
• 14.72. WuXi Advanced Therapies
  • 14.72.1. WuXi's Closed Process CAR-T manufacturing
• 14.73. Xenetic Biosciences
  • 14.73.1. DNase-based Oncology Platform
• 14.74. Xyphos Biosciences, Inc
  • 14.74.1. ACCEL & UDC Technology
  • 14.74.2. convertibleCAR
  • 14.74.3. Universal Donor Cells

INDEX OF FIGURES

• FIGURE 2.1: The Basic Structure of a T cell
• FIGURE 2.2: Binding of a T cell on to an Infected Cell
• FIGURE 2.3: Components of a CAT-T cell
• FIGURE 2.4: The Three Domains of a CAR
• FIGURE 2.5: First Generation CARs
• FIGURE 2.6: Second Generation CARs
• FIGURE 2.7: Third Generation CARs
• FIGURE 2.8: Fourth Generation CARs
• FIGURE 2.9: Fifth Generation CARs
• FIGURE 2.10: Antigens Present on Normal and Cancer Cells
• FIGURE 2.11: Preparation and Administration of CAR-T cells
• FIGURE 2.12: Kymriah in Infusion Bag
• FIGURE 2.13: Yescarta in Infusion Bag
• FIGURE 2.14: Tecartus in Infusion Bag
• FIGURE 2.15: Breyanzi in Package
• FIGURE 2.16: Abecma in the Infusion Bag
• FIGURE 2.17: Relma-cel in Infusion Bag
• FIGURE 3.1: Switchable CAR
• FIGURE 3.2: Action of Suicide Genes
• FIGURE 3.3: Graphical Abstract for Transient Transfection
• FIGURE 3.4: A Model of Armored CAR
• FIGURE 4.1: The Five Generations of CARs
• FIGURE 6.1: CAR-T Target Antigens Evaluated in Clinical Trials
• FIGURE 6.1: CAR-T Manufacturing Process Schematics
• FIGURE 6.2: Local and Centralized Supply Chain Pathways
• FIGURE 6.2: Scaling up off Allogeneic CAR-T Cells
• FIGURE 7.1: Number of CAR-T Cell Therapy Patents Filed, 2000-2024
• FIGURE 8.1: Types of Hematological Cancers Addressed by CAR-T Trials
• FIGURE 8.2: Studies for Simultaneous Targets for One CAR-T
• FIGURE 8.3: CAR-T Generation Types used in Clinical Trials
• FIGURE 8.4: CAR-T Trials by Type of SeFv Used
• FIGURE 8.5: CAR-T Trials by Type of Vectors Used
• FIGURE 8.6: Autologous & Allogeneic CAR-Ts in Clinical Trials
• FIGURE 8.7: Geographical Distribution of CAR-T Clinical Trials for Solid Tumors
• FIGURE 8.8: Vectors used to Transduce CAR Genes into T Cells for Solid Tumor Studies
• FIGURE 9.1: Number of Published CAR-T Papers on PubMed.gov, 2000-2024
• FIGURE 9.2: PubMed.gov Papers on Autologous & Allogeneic CAR-T, 2013-2024
• FIGURE 9.3: Number of PubMed.gov Papers on Liquid vs. Solid Cancers, 2013-2024
• FIGURE 9.4: Percent Shares of the Five Generations of CARs
• FIGURE 10.1: VC Funding for CAR-T Companies, 2014-2024
• FIGURE 10.2: IPO Funds Raised by CAR-T Companies, 2014-2024
• FIGURE 11.1: Total Medicare Spend for CAR-T in OP & IP Setting
• FIGURE 11.1: Utilization of CAR-T Cell Therapy in Europe
• FIGURE 11.2: CAR-T Cell Therapy Uptake in Europe by Indication
• FIGURE 11.3: Cost Breakdown of CAR-T Cell Therapy in Singapore
• FIGURE 13.1: Estimated CAR-T Uptake in Numbers, 2017-2024
• FIGURE 13.2: Revenue Generation by CAR-T Cell Therapies by Product, 2017-2024
• FIGURE 13.3: Global Market for CAR-T Cell Therapy Products, 2024-2032
• FIGURE 13.4: Global Market for CAR-T Cell Therapy by Geography, 2024-2032
• FIGURE 13.5: Global market Share for CAR-T Therapies by Indication, 2024
• FIGURE 14.1: Atara's Approach to Allogeneic Cell Therapy
• FIGURE 14.2: Illustration of CycloCAR-T
• FIGURE 14.3: Illustration of THANK-uCAR-T
• FIGURE 14.5: Schematic of Allogeneic P CAR-T with TCR KO
• FIGURE 14.6: NKG2D-based CAR
• FIGURE 14.7: Celyad's Multispecific CAR
• FIGURE 14.8: CRISPR/Cas9-enabled Allogeneic CAR-T Design
• FIGURE 14.9: FT819
• FIGURE 14.10: FT825
• FIGURE 14.11: FasTCAR vs. Conventional CAR-T Manufacturing Time
• FIGURE 14.12: Action of TruUCAR
• FIGURE 14.13: SMART CAR-T
• FIGURE 14.14: CD19/CD20 CAR-T Technology
• FIGURE 14.15: TGF-Beta Bispecific CAR Technology
• FIGURE 14.16: Lateral CAR
• FIGURE 14.17: T4 T-Cell
• FIGURE 14.18: Split Co-Stim Dual CAR
• FIGURE 14.19: Ligand-Based CAR to Target Three Antigens
• FIGURE 14.20: Natural Killing of CAR-T Cells
• FIGURE 14.21: ATx
• FIGURE 14.22: GTx
• FIGURE 14.23: STx
• FIGURE 14.24: VLx
• FIGURE 14.25: Features of PRIME CAR-T Cell Therapy
• FIGURE 14.26: BAFFR CAR-T Cells
• FIGURE 14.27: Poseida's PiggyBac Platform for Insertion
• FIGURE 14.28: Poseida's Cas-CLOVER Platform for Editing
• FIGURE 14.29: UltraCAR-T Cell
• FIGURE 14.30: Precigen's Ultraporator System
• FIGURE 14.31: Prescient's OmniCAR
• FIGURE 14.32: VIPER-101, the Lead Program of ViTToria
• FIGURE 14.33: WuXi's Closed Process CAR-T Platform
• FIGURE 14.34: Convertible CAR Parts
• FIGURE 14.35: Xyphos' Universal Donor Cells

INDEX OF TABLES

• TABLE 2.1: Potential Antigens Present on Hematological Malignant Cells
• TABLE 2.2: Key Differences between the Available Vectors
• TABLE 2.3: The 13 CAR-T Therapies Available Globally
• TABLE 2.3: (CONTINUED)
• TABLE 2.3: (CONTINUED)
• TABLE 2.3: (CONTINUED)
• TABLE 2.4: Acquisition Cost of CAR-T Therapy Products around the World
• TABLE 3.1: Strategies for Future CAR-T Therapies
• TABLE 3.2: A Sample of Clinical Studies on Solid Cancers
• TABLE 3.3: New Target Antigens and New Target Cancers
• TABLE 4.1: History of CAR-T Therapy Development
• TABLE 4.2: Upcoming CAR-T Stars
• TABLE 4.3: The Small Cancer Population Addressed by CAR-T Therapy
• TABLE 5.1: CAR-T Target Antigens in Hematological Cancers
• TABLE 5.2: Select CAR-T Target Antigens in Clinical Trials
• TABLE 5.3: Targeted Antigens by Approved CAR-Ts
• TABLE 6.2: Key Process Metrics with Increasing Levels of Automation
• TABLE 6.3: Breakdown of CAR-T Manufacturing Cost
• TABLE 7.1: Geographical Distribution of CAR-T Cell Therapy Patents
• TABLE 7.2: CAR-T Cell Therapy Patent Applicants
• TABLE 7.2: (CONTINUED)
• TABLE 7.2: (CONTINUED)
• TABLE 7.3: Top 100 CAR-T Patent Inventors
• TABLE 7.3: (CONTINUED)
• TABLE 7.3: (CONTINUED)
• TABLE 7.4: Top 100 CAR-T Cell Therapy Patent Owners
• TABLE 7.4: (CONTINUED)
• TABLE 7.4: (CONTINUED)
• TABLE 7.5: Legal Status of CAR-T Therapy Patents
• TABLE 8.1: CAR-T Clinical Trials by Phase of Development, January 15, 2025
• TABLE 8.2: Types of CAR-T Clinical Trials
• TABLE 8.3: CAR-T Clinical Trials by Funding Type
• TABLE 8.4: CAR-T for Solid Cancers: An Overview of Data
• TABLE 10.1: Venture Capital Funding in CAR-T Sector, 2014-2024
• TABLE 10.1: (CONTINUED)
• TABLE 10.1: (CONTINUED)
• TABLE 10.2: IPOs by CAR-T Cell Therapy Companies, 2014-2024
• TABLE 10.2: (CONTINUED)
• TABLE 10.3: CAR-T Licencing Deals, 2015-2024
• TABLE 10.3: (CONTINUED)
• TABLE 10.3: (CONTINUED)
• TABLE 10.3: (CONTINUED)
• TABLE 10.4: CAR-T Collaboration Deals, 2013-2024
• TABLE 10.4: (CONTINUED)
• TABLE 10.4: (CONTINUED)
• TABLE 10.4: (CONTINUED)
• TABLE 10.5: CAR-T Merger & Acquisition (M&A) Deals, 2015-2024
• TABLE 10.5: (CONTINUED)
• TABLE 10.6: Summary of CAR-T Funding, 2014-2024
• TABLE 11.1: List Prices of CAR-T Cells
• TABLE 11.2: Pre-, Peri- & Post Infusion Unit Costs
• TABLE 11.3: Adverse Events Rates & Unit Costs of Management
• TABLE 11.4: Reimbursement for CAR-T Cases, 2024 vs. 2025
• TABLE 11.5: EU-Approved CAR-T Cell Therapies
• TABLE 11.7: Approximate Cost of CAR-T Cell Therapies in Select E.U. Countries
• TABLE 11.8: CAR-T Funding Sources in Singapore
• TABLE 12.1: Available Therapies for ALL
• TABLE 12.2: Available Therapies for DLBCL
• TABLE 12: Available Therapies for MCL
• TABLE 12.4: Approved Therapies for Multiple Myeloma
• TABLE 12.5 Available Therapies for Follicular Lymphoma (FL)
• TABLE 12.6: The Staggering Cost of Blood Cancer Therapies
• TABLE 13.2: Revenue Generation by CAR-T Cell Therapies by Product, 2017-2024
• TABLE 13.3: Global Market for CAR-T Cell Therapy Products, 2024-2032
• TABLE 13.4: Global Market for CAR-T Therapy by Geography, 2024-2032
• TABLE 13.5: Global Market for CAR-T Therapies by Indication, 2024-2032
• TABLE 14.1: AffyImmune's Affinity-Tuned Pipeline Products
• TABLE 14.2: Aleta's CAR-T Engager Pipeline
• TABLE 14.3: Allogene's AlloCAR-T Pipeline
• TABLE 14.4: Anixa's CAR-T Pipeline
• TABLE 14.5: Arbele's Advanced Cell Therapy Product Candidates
• TABLE 14.6: ArcellX's Current Product Pipeline
• TABLE 14.7: Atara's Product Pipeline
• TABLE 14.8: Autolus' Therapies in Development
• TABLE 14.9: Clinical & Preclinical Pipeline Overview
• TABLE 14.10: Bellicum's Pipeline
• TABLE 14.11: BRiDGECAR Program
• TABLE 14.12: Cabaletta's Autoimmune Therapy Candidates in Development
• TABLE 14.13: Carina's Clinical Programs
• TABLE 14.14: CARsgen's Product Pipeline
• TABLE 14.15: Cartesian's Product Pipeline
• TABLE 14.16: Cellectis' Allogeneic CAR-T Cell Product Pipeline
• TABLE 14.17: CRISPR Therapeutics' CAR-T Programs
• TABLE 14.18: Elicera's Product Pipeline
• TABLE 14.19: EXUMA's Pipeline Assets
• TABLE 14.20: Galapagos' Oncology CAR-T Pipeline
• TABLE 14.21: Gracell's Rich Product Pipeline
• TABLE 14.22: IASO's Diverse Product Pipeline
• TABLE 14.23: ImmPACT Bio's Product Pipeline
• TABLE 14.24: Immuneels Product Pipeline
• TABLE 14.25: JW Therapeutics' Product Pipeline
• TABLE 14.26: Kite's Pipeline Cancer Therapies
• TABLE 14.27: Product Pipeline to address Autoimmune Diseases
• TABLE 14.28: Legend Biotech's Product Pipeline
• TABLE 14.29: Leucid's Product Pipeline
• TABLE 14.30: Luminary's Product Pipeline
• TABLE 14.31: Lyell's Product Pipeline
• TABLE 14.32: March Biosciences' Product Pipeline
• TABLE 14.33: A Comparison Guide for MaxCyte's Electroporation Systems
• TABLE 14.34: Minerva's CAR-T Pipeline Products for Solid Tumors
• TABLE 14.35: Mustang's CAR-T Product Candidates
• TABLE 14.36: Noile-Immune's PRIME-Based Product Pipeline
• TABLE 14.37: Oxford Biomedica's CDMO Services
• TABLE 14.38: PeproMene's Product Pipeline
• TABLE 14.39: Poseida's CAR-T Product Pipeline
• TABLE 14.40: Precigen's UltraCAR-T Pipeline
• TABLE 14.41: Prescient's CAR-T Pruct Pipeline
• TABLE 14.42: ProMabs CAR-T Cells
• TABLE 14.43: ProMab's Discovery Services Plans & Prices
• TABLE 14.44: Synthekine's Pipeline with SYNCAR-001 + STK-009
• TABLE 14.45: T-CURX' Product Candidates in Clinical Trials
• TABLE 14.46: Umoja's Product Pipeline
• TABLE 14.47: Vor Biopharma's Current Product Pipeline
• TABLE 14.48: Wugen's Product Pipeline
• TABLE 14.49: Xenetic's CAR-T Product Pipeline