市场调查报告书
商品编码
1143412
数位 PCR 全球市场-2022-2029Global Digital PCR Market - 2022-2029 |
※ 本网页内容可能与最新版本有所差异。详细情况请与我们联繫。
数位 PCR 是一种终点 PCR 技术,用于准确量化和研究与相关大序列相比的小序列。 PCR是指聚合□炼式反应。多次扩增 DNA 和 RNA 片段。您可以发现个体的基因变化和传染病。
由于多种因素,预计全球数位 PCR 市场将扩大。其中一些是技术进步的提高、新产品的推出、传染病事件的增加以及生物製药公司研发活动的激增。
各主要参与者的研发活动激增是推动市场的主要因素。 PCR 诊断多种疾病,包括感染和基因改变。疾病的早□□期诊断是可能的,即使是微量抗体或癌细胞的存在也可以通过多次扩增 DNA 或 RNA 来检测。数位 PCR (dPCR) 能够准确和高灵敏度地测量核酸。常规PCR使用琼脂糖凝胶电泳检测扩增产物,使其成为半定量终点检测。数位 PCR (dPCR) 主要分为三种亚型:束流式、液滴式和基于芯片的数位 PCR。
全球 PCR 市场的主要可能性之一是 d-PCR 分子诊断的研发支出增加。为了促进有效诊断,几家生物技术和生命科学公司正在合作开发 d-PCR 在几种疾病适应症中的诊断测试和治疗用途,以提供良好的治疗。
各大公司的新产品推出和PCR技术的技术突破正在推动市场的扩大。例如,一些市场进入者创造了自己的 d-PCR 产品,可以识别各种疾病或检测各种基因异常。例如,2021 年 3 月,赛默飞宣布美国食品药品监督管理局完成其实时 PCR 产品 QuantStudio 5 的上市,并将其推向市场。它可以帮助实验室和开发人员满足检测需求。
主要的主要参与者正在开发具有新鲜创新和进步的最新产品和模型。大多数获批产品正在推动市场增长。例如,赛默飞世尔在 2020 年创建了几个 PCR 试剂盒和测试用于诊断和研究,以对抗 COVID-19 爆发。在获得美国 FDA 对 SARS CoV 2 多重实时 PCR 测试的紧急使用授权 (EUA) 后,他们发布了 AcroMetrix 冠状病毒 2019 (COVID-19) RNA Control。
PCR 的昂贵设备和技术限制预计会阻碍市场扩张。经典的 d-PCR 方法需要优化和验证分析程序、在 PCR 扩增的指数生长期测量所有信号、由于存在反应修饰剂而难以检测靶标以及需要 DNA 序列模板。具有各种技术限制,例如由于效率低下而无法识别生物分子。此外,还有一些程序限制不能用于基因组研究,例如使用致癌化学物质、d-PCR 试剂与 dsDNA 的化学结合以及无法评估 DNA 质量。
COVID-19 影响分析
COVID-19 疫情严重影响了医疗保健行业。 PCR 市场经历了繁荣,其中诊断行业受到的影响最为严重。实时 PCR 和数位 PCR 的需求量很大,因为它们用于药物发现研究和诊断。行业团体越来越重视创建液滴数位 PCR 试剂盒来测试 COVID-19。监管机构完全支持这些测试,以限制 COVID-19 大流行的影响。
预计 COVID-19 流行病将对全球 PCR 市场的增长产生积极影响,因为数位 PCR 技术被用于诊断 COVID-19 感染。随着各种传染病变得越来越普遍,市场正在增长。
该技术部分进一步细分为数位微滴 PCR、光束数位 PCR 和基于芯片的数位 PCR。由于产品推出的增加和各种新技术的进步,预计数位微滴 PCR 将占据最大的市场份额。随着数位 PCR 的发展,核酸分析可以以极高的灵敏度、精密度和准确度进行。它还可用于监测低丰度目标、等位基因变异 (SNP)、具有復杂背景的目标以及实时 PCR 无法检测到的目标水平的细微变化。该技术现已获准用于体外研究。
微滴式数位 PCR 使用水乳液微滴技术将 DNA 样本分成 20,000 个微滴。然后每个液滴都经过模板的 PCR 复製,阳性液滴的定量使我们能够推断出确切的目标。液滴数位 PCR 提供绝对定量、精确度和灵敏度,从而实现更有用和更准确的分析。例如,2020 年,Bio-Rad 宣布其液滴数位 PCR SARS-CoV-2 检测试剂盒获得美国食品和药物管理局的 COVID 检测紧急使用授权。
由于慢性病的广泛存在、数位 PCR 设备进步的主要参与者的存在以及区域渗透基础的迅速增加,北美将在 2021 年获得数位 PCR 市场的广泛份额。并且由于其起落架,预计在未来几年内将掩盖全球市场。开发数位 PCR 产品的技术进步将刺激市场。有利的报销政策和更好的医疗设施将推动市场增长。
该地区的主要参与者包括 Thermo Fisher Scientific、Bio-Rad Laboratories Inc.、Becton, Dickinson and Company 和 F. Hoffmann-La Roche, Ltd.,它们提供各种创新产品。所有这些公司都推出了各种创新的新产品。它还经历了各种收购和合併,以推动该地区的市场增长,北美是最大的股东。
全球数位 PCR 市场与多个国际和区域市场竞争激烈。产品多样化、收入安全和机会使市场更具竞争力。 Thermo Fisher Scientific、Bio-Rad Laboratories, Inc. 和 F. Hoffmann-La-Roche, Inc. 是全球数位 PCR 市场的三大主要参与者。其他知名企业包括安捷伦科技、雅培实验室、Becton Dickinson and Company、丹纳赫公司、Eppendorf、默克、Promega Corporation、Takara Bio、Enzo Life Sciences、Meridian Bioscience、Bioneer、QIAGEN N.V、ELITech Group、Genetron Holdings Limited。
公司正在寻求联合研究、战略合作伙伴关係、收购和合併,以扩大对数位 PCR 的需求并将其扩展到全球。公司还利用新产品发布、产品开发、市场扩张和技术进步等战略来维持其在市场中的地位。例如:
概述 Samo Fisher Scientific 是一家致力于科学的医疗保健经销商公司。我们製造和销售试剂、科学仪器和设备、耗材、软件和服务。成立于 1956 年,总部位于美国马萨诸塞州沃尔瑟姆。
QuantStudio*6 和 7 Pro 实时 PCR 系统-一种高度灵活的 PCR 系统,可补充各种应用和有利条件。可以免提使用并最大限度减少污染的智能係统。您甚至可以使用手机来安排和监控您的跑步。 QuantStudio 6 和 7 Pro 系统包括一个 96 孔模块,该模块采用称为 VeriFlex 的技术构建,用于特定的温度控制。所有这些块都分配到隔离区域,因此它们在一次运行中单独循环,这是优化的理想选择。
重大进展。 22022 年 2 月,Therma Fisher 启动了一项快速 Renvo PCR 测试以对抗 COVID-19。这是我们病原体监测产品组合中的一种新型解决方案机载产品。该测试是对气溶胶传感采样器收集的空气样本进行的。
The end-point PCR technique, digital PCR, is utilized for accurate quantification and studying small sequences compared to related large sequences. PCR stands for a polymerase chain reaction. It amplifies the DNA or RNA segments multiple times. Finds genetic changes or infections in any individual.
The global digital PCR market will expand due to several factors. Some of them are rising technological advancements, novel product launches, growing infectious disease incidents, and a surge in R&D activities by biopharma companies.
The surge in research and development activities by various major key players is a major factor in driving the market. PCR diagnoses various illnesses, such as infectious diseases and genetic changes. It can diagnose the disease in its earliest stage, and even if only minute amounts of antibodies or cancer cells are present, it can detect it by amplifying the DNA or RNA multiple times. Nucleic acid measurement is accurate and sensitive, thanks to digital PCR (dPCR). Traditional PCR uses agarose gel electrophoresis to detect the amplified product, making it a semi-quantitative end-point examination. The three main subtypes of digital PCR (dPCR) are beaming, droplet, and chip-based digital PCR.
One of the significant possibilities in the worldwide PCR market is the growth of R&D spending for d-PCR molecular diagnostics. To facilitate effective diagnosis, several biotechnologies and life sciences, businesses are collaborating on developing diagnostic tests and the therapeutic use of d-PCR in several illness indications to provide effective treatment.
Introducing new products by major companies and technological breakthroughs in PCR technologies fuel the market's expansion. For instance, some market participants have created unique d-PCR products that can recognize various diseases or detect various genetic abnormalities. For instance, in Mar 2021, Thermo Fisher announced United States Food and Drug Administration had completed the listing for QuantStudio 5, a real-time PCR and launched it in the market. It helps labs and developers fulfill the demands of testing.
Major key players develop the latest products or models with novel technological innovations and advancements. Most of the products receiving approval are driving the market's growth. For instance, in 2020, Thermo Fisher created several PCR kits and tests for diagnostic and research to fight the COVID-19 outbreak. They released AcroMetrix Coronavirus 2019 (COVID-19) RNA Control after receiving the US FDA's emergency use authorization (EUA) for the SARS CoV 2 multiplex real-time PCR test.
Costly equipment and PCR's technological limitations are predicted to impede market expansion. A classic d-PCR method is accompanied by a variety of technical limitations, including the need for assay procedure optimization and validation, the measurement of signals all through the exponential growth phase of the PCR amplification, difficulties in target detection caused by the existence of reaction modulators, and the inability to identify biomolecules due to the poor efficiency of the DNA sequence template. Additionally, the usage of carcinogenic chemicals, chemical binding of d-PCR reagent to dsDNA and inability to evaluate DNA quality are some of the procedural restrictions that prevent using these reagents in genomic research.
COVID-19 Impact Analysis
The COVID-19 outbreak severely impacted the healthcare industry. The PCR market has experienced a boom, and the diagnosis sector was most severely affected. Real-time and digital PCR are in high demand since they are used for drug research and diagnostic purposes. It is becoming increasingly important for industry entities to test COVID-19 by creating droplet digital PCR kits. The regulatory agencies have given these tests their full support to limit the COVID-19 pandemic's effects.
Since digital PCR techniques are utilized to diagnose COVID-19 infection, the COVID-19 epidemic is projected to affect the global PCR market's growth positively. The market is expanding because various infectious diseases are becoming more common.
The technology segment is further sub-segmented into digital droplet PCR, beaming digital PCR and chip-based digital PCR. Digital droplet PCR is expected to hold the largest market share due to the increasing number of product launches and various novel technological advances. Nucleic acid analysis can be done with extreme sensitivity, accuracy and exactness because of the development of digital PCR. It is also helpful for monitoring low-abundance targets, allelic variations (SNPs), targets with complicated backgrounds, and tiny changes in target levels that real-time PCR cannot pick up on. The use of this technology in in-vitro testing has now been authorized.
The droplet digital PCR divides the sample of DNA into 20,000 droplets using water-emulsion droplet technology. Every particular droplet then experiences PCR replication of the template and quantifying the positive droplets provides accurate target estimation. Absolute quantification, high precision and high sensitivity can be seen in droplet digital PCR so that it will be more helpful and accurate for analysis. For instance, in 2020, Bio-Rad announced that the droplet digital PCR SARS-CoV-2 test kit got emergency use permission from the United States Food and Drug Administration for COVID testing.
In 2021 North America reserve an extensive share in the digital PCR market, and it is estimated that it is also going to overshadow the global market in the coming years owing to the upsurge in widespread presence of chronic diseases, the existence of key players for the progress of digital PCR devices, and prevalent foundation and substructure in the region. The growing technological advancement for developing digital PCR products shall stimulate the market. Favorable reimbursement policies and better healthcare facilities shall fuel market growth.
Most of the key players in this region are Thermo Fisher Scientific, Bio-Rad Laboratories Inc., Becton, Dickinson and Company and F. Hoffmann-La Roche, Ltd. All of them are launching various innovative and novel products. Various acquisitions and merges are also taking place, fueling the market's growth in this region and making North America the largest shareholder.
The global digital PCR market is highly competitive with several international and local markets. Product diversification, revenue generation, and opportunities intensify the market competition. Thermo Fisher Scientific, Bio-Rad Laboratories Inc., and F. Hoffmann-La Roche, Ltd. are the three key players operating in the global digital PCR market. Other well-known players are Agilent Technologies, Abbott Laboratories, Becton Dickinson and Company, Danaher Corporation, Eppendorf, Merck, Promega Corporation, Takara Bio, Enzo Life Sciences, Meridian Bioscience, Bioneer, QIAGEN N.V, ELITech Group, Genetron Holdings Limited.
The companies are entering into collaborations, strategic partnerships, acquisitions and mergers to increase the demand for digital PCR and their global expansion. Companies are also using new product launches, product development, market expansion and technical advancement strategies to hold their market position. For instance,
Overview: Thermo Fisher Scientific is a healthcare distributor company that serves science. They manufacture and market reagents, scientific instruments & equipment, consumables and software services. It was established in 1956 and is based in Waltham, Massachusetts, United States.
QuantStudio*6 and 7 Pro Real-Time PCR Systems - These are PCR systems that are very flexible as they reinforce various kinds of applications and favorable conditions. The smartness of these systems is created to minimize contamination by making them run hands-free. Mobile phones can be used to schedule and even monitor the run. The QuantStudio 6 and 7 Pro systems contain 96-well blocks that comprise a technology known as VeriFlex that is used for specific temperature control. All these blocks are prorated into secluded zones, due to which there are separate cycling surrounding inside the one and same run that is ideal for optimization.
Key Developments: In Feb 2022, Therma Fisher launched its rapid Renvo PCR test to fight COVID-19. It is a novel solution in-air product that is included in its portfolio of pathogen surveillance. This test is done on the air samples collected by the aerosol sense sampler.
The digital PCR market report would provide access to an approx. 45+ market data table, 40+ figures and 180 pages.