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全球 3D 水凝胶培养市场 - 2024-2031

Global 3D Hydrogel Culture Market - 2024-2031

出版日期: 2024年11月08日 | 出版商:

DataM Intelligence | 英文 182 Pages | 商品交期: 最快1-2个工作天内

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简介目录

概述

2023年，全球3D水凝胶培养市场规模达15.8亿美元，预估至2031年将达43.6亿美元，2024-2031年预测期间复合年增长率为13.5%。

3D 水凝胶细胞培养是一种在模拟自然细胞外环境的三维 (3D) 水凝胶基质中培养细胞的先进方法。水凝胶是交联的亲水性聚合物网络，能够吸收大量的水，同时保持其结构完整性。

在这项技术中，细胞嵌入水凝胶基质中，使它们能够在所有三个维度上与周围环境相互作用，类似于它们在活组织中的行为。此设定提供了比传统二维 (2D) 细胞培养物更生理相关的模型，因为它更准确地反映了体内发生的细胞与其细胞外基质 (ECM) 之间的复杂相互作用。

用于 3D 细胞培养的水凝胶可以源自天然材料，例如胶原蛋白、纤维蛋白和藻酸盐，也可以是合成材料，例如聚乙二醇 (PEG) 和聚丙烯酰胺。这些水凝胶可以透过改变其成分、硬度和孔隙率来定制以复製特定的组织特征。这种适应性对于研究和医学的各种应用至关重要，包括癌症研究、干细胞研究、组织工程和药物发现。

市场动态：

司机

技术进步

全球3D水凝胶培养市场的需求是由多种因素所驱动的。主要因素之一是技术进步。水凝胶配方及其应用的创新，特别是 JellaGel Hydrogel 等产品的出现，在 3D 水凝胶培养市场的扩张中发挥关键作用。 JellaGel 由水母胶原蛋白製成，为研究人员提供了一种新颖的非哺乳动物替代品，可满足细胞培养中对可靠且一致材料不断增长的需求。

此外，该行业的主要参与者更加关注研发活动和产品发布，这将推动 3D 水凝胶培养市场的成长。例如，2024 年 6 月，印度科学研究所 (IISc) 生物工程系 (BE) 的研究人员开发了一种创新的 3D 水凝胶培养系统，可以紧密复製哺乳动物的肺部环境。

此外，2023 年6 月，新型生物相容性水凝胶树脂的推出代表了生物列印领域的关键时刻，标誌着一个新时代的开始，该时代的特点是创建复杂、高分辨率生物结构的能力增强。这种创新树脂有利于 2 光子聚合 (2PP)，这是一种尖端的 3D 列印技术，可以精确製造从微米到介观尺度的结构。

限制

高生产成本、原材料供应有限以及严格的监管要求等因素预计将阻碍市场发展。

3D hydrogel cell culture is an advanced method for cultivating cells within a three-dimensional (3D) hydrogel matrix that simulates the natural extracellular environment. Hydrogels are networks of cross-linked, hydrophilic polymers capable of absorbing significant amounts of water while retaining their structural integrity.

In this technique, cells are embedded within the hydrogel matrix, enabling them to interact with their surroundings in all three dimensions, akin to their behavior in living tissues. This setup offers a more physiologically relevant model than traditional two-dimensional (2D) cell cultures, as it more accurately reflects the intricate interactions between cells and their extracellular matrix (ECM) that occur in vivo.

The hydrogels used for 3D cell culture can be sourced from natural materials such as collagen, fibrin, and alginate, or they can be synthetic, like polyethylene glycol (PEG) and polyacrylamide. These hydrogels can be customized to replicate specific tissue characteristics by modifying their composition, stiffness, and porosity. This adaptability is crucial for various applications in research and medicine, including cancer studies, stem cell research, tissue engineering, and drug discovery.

Market Dynamics: Drivers

Technological advancements

The demand for the global 3D hydrogel culture market is driven by multiple factors. One of the primary factors is the technological advancements. Innovations in hydrogel formulations and their applications, particularly with the emergence of products like JellaGel Hydrogel, are playing a pivotal role in the expansion of the 3D hydrogel culture market. JellaGel, made from jellyfish collagen, provides researchers with a novel non-mammalian alternative that meets the growing demand for reliable and consistent materials in cell culture.

Moreover, key players in the industry more focus on R&D activities and product launches that would drive this 3D hydrogel culture market growth. For instance, in June 2024, researchers from the Department of Bioengineering (BE) at the Indian Institute of Science (IISc) developed an innovative 3D hydrogel culture system that closely replicates the mammalian lung environment.

Also, in June 2023, the launch of a new biocompatible hydrogel resin represents a pivotal moment in the field of bioprinting, marking the beginning of a new era characterized by enhanced capabilities in creating complex, high-resolution bio-structures. This innovative resin facilitates 2-photon polymerization (2PP), a cutting-edge 3D printing technology that allows for the precise fabrication of structures ranging from the micro- to mesoscale.

Restraints

Factors such as high production costs, limited availability of raw materials, and stringent regulatory requirements, are expected to hamper the market.

Segment Analysis

The global 3D hydrogel culture market is segmented based on product, application, end-user, and region.

The scaffold based segment accounted for approximately 52.1% of the global 3D hydrogel culture market share

The scaffold based segment is expected to hold the largest market share over the forecast period. Scaffold-based 3D hydrogel cell cultures utilize scaffolds to provide essential physical support for cells, enabling them to aggregate, proliferate, and migrate effectively. Traditionally, cells have been cultured on extracellular matrix (ECM) proteins in two-dimensional (2D) environments; however, this approach often fails to accurately replicate the complexities of the in vivo environment.

scaffold-based 3D hydrogel cultures allow cells to be embedded within a supportive matrix, which means that the characteristics of the scaffold material can significantly influence cellular behavior. Therefore, it is crucial to select the most appropriate scaffold for your specific application to ensure it aligns well with the requirements of drug screening and development processes.

Moreover, key player's strategies such as partnerships & collaborations, and research activities would drive this segment growth in the 3D hydrogel culture market. For instance, in April 2022, Cell Guidance Systems Ltd, a company specializing in the control, manipulation, and monitoring of cells both in vitro and in vivo, partnered with Manchester BIOGEL, a biotechnology firm focused on designing and manufacturing 3D synthetic peptide hydrogels, to introduce PODS-PeptiGels. This new kit integrates the advantages of two innovative cell culture technologies: synthetic peptide hydrogels (PeptiGels) and a selection of sustained-release growth factors (PODS). The collaboration aims to provide researchers with a reproducible and highly adaptable environment for 3D cell culture, enhancing experimental flexibility and reliability.

Similarly, in a research publication in Frontiers in May 2022, scaffold-based 3D hydrogel cultures, 3D bioprinting, and ECM-based bioinks present promising opportunities for replicating native tissue architectures, but several significant challenges persist. To fully realize the potential of this technology and enable its application in clinical environments, it is crucial to tackle these issues through dedicated research and interdisciplinary collaboration. This approach will help transform healthcare and enhance the quality of life for patients.

Geographical Analysis

North America accounted for approximately 44.6% of the global 3D hydrogel culture market share

North America region is expected to hold the largest market share over the forecast period owing to the growing prevalence of chronic diseases, including diabetes, cardiovascular conditions, and obesity, which has led to an increased demand for effective treatment solutions. Hydrogel-based products are being increasingly adopted for their therapeutic advantages in addressing these issues, especially in areas like wound care and drug delivery systems.

Moreover, in this region, a major number of key player's presence, well-advanced healthcare infrastructure, strong investment in research and development, favorable regulatory environment, and technological advancements help to propel this 3D hydrogel culture market growth. For instance, in December 2021, Inventia Life Science, an Australian specialist in 3D bioprinting, successfully closed a Series B funding round, raising $25 million (USD).

This funding was led by Blackbird Ventures and supported by long-time investor Skip Capital, bringing the company's total funding to $32 million. With this new capital, Inventia Life Science plans to accelerate the rollout of its flagship product, the RASTRUM 3D bioprinter. A key focus of this expansion will be in the U.S. market, where Inventia sees significant potential. The company estimates that the biomedical research and drug discovery sector in the U.S. is worth over $40 billion, indicating a substantial opportunity for their technology.

Market Segmentation

By Product

Scaffold Based
- Hydrogels
- Polymeric Scaffolds
- Micropatterned Surface Microplates
- Nanofiber Based Scaffolds
Scaffold Free
- Hanging Drop Microplates
- Spheroid Microplates with ULA coating
- Magnetic Levitation
Bioreactors
Microfluidic
Bioprinting

By Application

Cancer Research
Stem Cell Research & Tissue Engineering
Drug Discovery & Toxicology Testing
Others

By End-User

Pharmaceutical & Biotechnology Companies
Academic & Research Institutes
Hospitals
Others

By Region

North America
- U.S.
- Canada
- Mexico
Europe
- Germany
- U.K.
- France
- Spain
- Italy
- Rest of Europe
South America
- Brazil
- Argentina
- The rest of South America
Asia-Pacific
- China
- India
- Japan
- South Korea
- Rest of Asia-Pacific
Middle East and Africa

Competitive Landscape

The major global 3D hydrogel culture market players include Corning Incorporated, Thermo Fisher Scientific, Inc., Lonza., Merck KGaA, Advanced BioMatrix, 3D Biotek LLC., PromoCell GmbH, Avantor, Inc., MIMETAS, and CN Bio Innovations Ltd, among others.

Key Developments

In May 2023, AMSBIO announced the launch of MatriMix, an innovative 3D culture substrate designed to advance cell biology and tissue engineering research. This innovative hydrogel is notable for its fully defined components, which include medical-grade collagens, laminin-511 E8 fragments, and hyaluronic acid.
In July 2022, Dolomite Bio launched new hydrogel-focused reagent kits designed to facilitate the high-throughput encapsulation of cells within hydrogel scaffolds. The two kits, named nadAROSE and nadi3D, specifically cater to researchers working on projects involving both agarose encapsulation and collagen-based hydrogels in the realm of 3D cell culture.

Why Purchase the Report?

To visualize the global 3D hydrogel culture market segmentation based on product, application, end-user, and region and understand key commercial assets and players.
Identify commercial opportunities by analyzing trends and co-development.
Excel data sheet with numerous data points of the 3D hydrogel culture market with all segments.
PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
Product mapping is available in excel consisting of key products of all the major players.

The global 3D hydrogel culture market report would provide approximately 62 tables, 56 figures, and 182 pages.

Target Audience 2023

Manufacturers/ Buyers
Industry Investors/Investment Bankers
Research Professionals
Emerging Companies

1. Methodology and Scope

1.1. Research Methodology
1.2. Research Objective and Scope of the Report

2. Definition and Overview

3. Executive Summary

3.1. Snippet by Product
3.2. Snippet by Application
3.3. Snippet by End-User
3.4. Snippet by Region

4. Dynamics

4.1. Impacting Factors
- 4.1.1. Drivers
  - 4.1.1.1. Technological Advancements
- 4.1.2. Restraints
  - 4.1.2.1. High Production Cost
- 4.1.3. Opportunity
- 4.1.4. Impact Analysis

5. Industry Analysis

5.1. Porter's Five Force Analysis
5.2. Supply Chain Analysis
5.3. Pricing Analysis
5.4. Regulatory Analysis

6. By Product

6.1. Introduction
- 6.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
- 6.1.2. Market Attractiveness Index, By Product
6.2. Scaffold Based *
- 6.2.1. Introduction
- 6.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
- 6.2.3. Hydrogels
- 6.2.4. Polymeric Scaffolds
- 6.2.5. Micropatterned Surface Microplates
- 6.2.6. Nanofiber Based Scaffolds
6.3. Scaffold Free
- 6.3.1. Hanging Drop Microplates
- 6.3.2. Spheroid Microplates with ULA coating
- 6.3.3. Magnetic Levitation
6.4. Bioreactors
6.5. Microfluidic
6.6. Bioprinting

7. By Application

7.1. Introduction
- 7.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 7.1.2. Market Attractiveness Index, By Application
7.2. Cancer Research*
- 7.2.1. Introduction
- 7.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
7.3. Stem Cell Research & Tissue Engineering
7.4. Drug Discovery & Toxicology Testing
7.5. Others

8. By End-User

8.1. Introduction
- 8.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
- 8.1.2. Market Attractiveness Index, By End-User
8.2. Pharmaceutical & Biotechnology Companies *
- 8.2.1. Introduction
- 8.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
8.3. Academic & Research Institutes
8.4. Hospitals
8.5. Others

9. By Region

9.1. Introduction
- 9.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Region
- 9.1.2. Market Attractiveness Index, By Region
9.2. North America
- 9.2.1. Introduction
- 9.2.2. Key Region-Specific Dynamics
- 9.2.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
- 9.2.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 9.2.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
- 9.2.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
  - 9.2.6.1. U.S.
  - 9.2.6.2. Canada
  - 9.2.6.3. Mexico
9.3. Europe
- 9.3.1. Introduction
- 9.3.2. Key Region-Specific Dynamics
- 9.3.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
- 9.3.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 9.3.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
- 9.3.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
  - 9.3.6.1. Germany
  - 9.3.6.2. U.K.
  - 9.3.6.3. France
  - 9.3.6.4. Spain
  - 9.3.6.5. Italy
  - 9.3.6.6. Rest of Europe
9.4. South America
- 9.4.1. Introduction
- 9.4.2. Key Region-Specific Dynamics
- 9.4.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
- 9.4.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 9.4.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
- 9.4.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
  - 9.4.6.1. Brazil
  - 9.4.6.2. Argentina
  - 9.4.6.3. Rest of South America
9.5. Asia-Pacific
- 9.5.1. Introduction
- 9.5.2. Key Region-Specific Dynamics
- 9.5.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
- 9.5.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 9.5.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
- 9.5.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
  - 9.5.6.1. China
  - 9.5.6.2. India
  - 9.5.6.3. Japan
  - 9.5.6.4. South Korea
  - 9.5.6.5. Rest of Asia-Pacific
9.6. Middle East and Africa
- 9.6.1. Introduction
- 9.6.2. Key Region-Specific Dynamics
- 9.6.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
- 9.6.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 9.6.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User

10. Competitive Landscape

10.1. Competitive Scenario
10.2. Market Positioning/Share Analysis
10.3. Mergers and Acquisitions Analysis

11. Company Profiles

11.1. Corning Incorporated *
- 11.1.1. Company Overview
- 11.1.2. Product Portfolio and Description
- 11.1.3. Financial Overview
- 11.1.4. Key Developments
11.2. Thermo Fisher Scientific, Inc.
11.3. Lonza.
11.4. Merck KGaA
11.5. Advanced BioMatrix
11.6. 3D Biotek LLC.
11.7. PromoCell GmbH
11.8. Avantor, Inc.
11.9. MIMETAS
11.10. CN Bio Innovations Ltd

LIST NOT EXHAUSTIVE