市场调查报告书
商品编码
1540908
2024-2032 年按产品、应用(PCR 引子、PCR 测定和麵板、定序、DNA 微阵列、萤光原位杂交、反义寡核苷酸等)、最终用途和区域分類的寡核苷酸合成市场报告Oligonucleotide Synthesis Market Report by Product, Application (PCR Primers, PCR Assays and Panels, Sequencing, DNA Microarrays, Fluorescence In-Situ Hybridization, Antisense Oligonucleotides, and Others), End Use, and Region 2024-2032 |
IMARC Group年全球寡核苷酸合成市场规模达30亿美元。遗传性疾病在大众中的日益流行、新型治疗策略的开发以及使用小干扰 RNA (siRNA) 和反义寡核苷酸的疗法的广泛采用是推动市场的一些主要因素。
寡核苷酸合成是指依照预定序列建构短 DNA 或 RNA 分子(称为寡核苷酸)的过程。它们的长度范围可以从几个碱基到大约 200 个核苷酸。该过程是在受控实验室环境中以化学方式完成的,通常使用固相亚磷酰胺化学。在这种方法中,核苷酸被顺序添加到不断增长的链中,每次添加都涉及一系列化学反应。该技术使科学家能够产生用于各种应用的客製化寡核苷酸,包括基因合成、聚合酶炼式反应 (PCR)、基因编辑工具(如 CRISPR-Cas9)和分子诊断测试。寡核苷酸合成的进步极大地加速了基因组学和分子生物学的研究,为医学和生物学研究的许多突破奠定了基础。
大众遗传疾病盛行率的上升主要推动了全球市场。这就需要开发新的治疗策略,其中基于寡核苷酸的疗法发挥重要作用。例如,正在研究使用小干扰 RNA (siRNA) 和反义寡核苷酸的疗法,并将其用于治疗遗传性疾病,例如杜氏肌肉营养不良症和脊髓性肌肉萎缩症。因此,遗传疾病的日益普及推动了全球范围内的需求。同时,生物资讯学和资料科学的发展对寡核苷酸合成产业产生直接影响。分析大型基因组数据集的能力不断增强也对市场产生了积极影响。因此,计算能力的提高正在推动对新型寡核苷酸合成的需求增加。此外,寡核苷酸,特别是反义寡核苷酸,已被证明是表观遗传学研究和治疗的有效工具,有助于调节基因表达,从而创造了积极的市场前景。
医疗保健和製药业的需求不断增长
全球对个人化医疗和治疗的需求正在迅速增长,导致寡核苷酸合成市场空前扩张。这些合成的序列是开发针对各种遗传性疾病和疾病(包括癌症)的标靶疗法的不可或缺的组成部分。同时,反义寡核苷酸、适体、siRNA 和免疫刺激寡核苷酸等治疗性寡核苷酸的进步,透过特异性抑製或改变基因表达,正在彻底改变疾病治疗。此外,客製化寡核苷酸的合成是疫苗生产的基础,包括基于 mRNA 的 COVID-19 疫苗,该疫苗已被证明有效且现已广泛使用。随着製药公司和研究人员不断发现寡核苷酸在治疗和预防疾病方面的新应用,寡核苷酸合成的需求即将上升。
技术进步与创新
寡核苷酸合成技术的稳定发展和完善正在推动市场成长。此外,合成製程的创新,包括高通量和自动化合成系统,提高了寡核苷酸生产的效率、准确性和可扩展性。此外,生物资讯学和合成生物学的发展,包括DNA定序和基因编辑(例如CRISPR-Cas9),在很大程度上依赖准确合成寡核苷酸的能力。这些进步允许创建具有更大复杂性和多样性的客製化序列,并促进合成生物学中的快速原型测试,从而促进更有效的研究和开发。这些不断的技术进步和发展也在为市场做出贡献。
不断加强的合作和伙伴关係
製药公司、生技公司和研究机构之间的合作和伙伴关係已成为推动遗传疾病寡核苷酸疗法的开发和商业化的重要驱动力。这些合作汇集了不同的专业知识、资源和资金,创造了一个协同环境,加速将科学发现转化为实际有效的治疗方法。製药公司在药物开发、临床试验和监管流程方面拥有丰富的经验,为此合作贡献了重要的专业知识。他们拥有必要的基础设施、知识和资源来应对药物开发的复杂局面,并确保寡核苷酸疗法符合安全性和有效性的监管标准。他们的参与有助于利用现有网路、製造能力和分销管道简化商业化之路。
The global oligonucleotide synthesis market size reached US$ 3.0 Billion in 2023. Looking forward, IMARC Group expects the market to reach US$ 8.0 Billion by 2032, exhibiting a growth rate (CAGR) of 11.1% during 2024-2032. The growing prevalence of genetic diseases among the masses, the development of novel therapeutic strategies, and the widespread adoption of therapies using small interfering RNAs (siRNAs), and antisense oligonucleotides are some of the major factors propelling the market.
Oligonucleotide synthesis refers to the process of constructing short DNA or RNA molecules, called oligonucleotides, in a predetermined sequence. These can range from just a few bases to around 200 nucleotides in length. The process is accomplished chemically in a controlled laboratory environment, typically using solid phase phosphoramidite chemistry. In this method, nucleotides are sequentially added to a growing chain, each addition involving a series of chemical reactions. This technology enables scientists to generate custom-made oligonucleotides for various applications including gene synthesis, polymerase chain reaction (PCR), gene editing tools, such as CRISPR-Cas9, and molecular diagnostic tests. Advances in oligonucleotide synthesis have dramatically accelerated research in genomics and molecular biology, underpinning many breakthroughs in medical and biological research.
The rising prevalence of genetic diseases among the masses majorly drives the global market. This necessitates the development of novel therapeutic strategies, where oligonucleotide-based therapies play a significant role. For instance, therapies using small interfering RNAs (siRNAs) and antisense oligonucleotides are being investigated and utilized in the treatment of genetic disorders, such as Duchenne muscular dystrophy and spinal muscular atrophy. As such, the growing prevalence of genetic diseases drives the demand on the global level. Along with this, the growth of bioinformatics and data science has a direct impact on the oligonucleotide synthesis industry. The escalating capacity to analyze large genomic datasets is also positively influencing the market. Therefore, the rising computational capability is driving an increased demand for the synthesis of novel oligonucleotides. Furthermore, oligonucleotides particularly antisense oligonucleotides, have been shown to be effective tools in epigenetic research and therapy, helping to modulate gene expression, which is creating a positive market outlook.
Rising Demand in the Healthcare and Pharmaceutical Industries
The global demand for personalized medicine and therapeutics is rapidly increasing, leading to an unprecedented expansion in the oligonucleotide synthesis market. These synthesized sequences are integral components in developing targeted therapies for various genetic disorders and diseases, including cancer. Along with this, the advancement of therapeutic oligonucleotides, such as antisense oligonucleotides, aptamers, siRNAs, and immunostimulatory oligonucleotides, is revolutionizing disease treatment by specifically inhibiting or altering gene expression. Furthermore, the synthesis of custom oligonucleotides is fundamental to the production of vaccines, including mRNA-based COVID-19 vaccines, which have proven effective and are now widely used. As pharmaceutical companies and researchers continue to discover novel applications for oligonucleotides in the treatment and prevention of diseases, the demand for oligonucleotide synthesis is poised to rise.
Technological Advancements and Innovation
The steady development and refinement of oligonucleotide synthesis technologies are driving market growth. In addition, innovations in the synthesis process, including high-throughput and automated synthesis systems, have increased the efficiency, accuracy, and scalability of oligonucleotide production. Moreover, developments in bioinformatics and synthetic biology, including DNA sequencing and gene editing (e.g., CRISPR-Cas9), heavily rely on the ability to synthesize oligonucleotides accurately. These advancements allow for the creation of custom sequences with greater complexity and diversity and facilitate rapid prototype testing in synthetic biology, thereby fostering more efficient research and development. These continuous technological advancements and developments are also contributing to the market.
Growing Collaborations and Partnerships
Collaborations and partnerships between pharmaceutical companies, biotechnology firms, and research institutions have become essential drivers in advancing the development and commercialization of oligonucleotide therapies for genetic diseases. These collaborations bring together diverse expertise, resources, and funding, creating a synergistic environment that accelerates the translation of scientific discoveries into practical and effective treatments. Pharmaceutical companies, with their experience in drug development, clinical trials, and regulatory processes, contribute vital expertise to the collaboration. They have the infrastructure, knowledge, and resources necessary to navigate the complex landscape of drug development and ensure that oligonucleotide therapies meet regulatory standards for safety and efficacy. Their involvement helps streamline the path to commercialization by leveraging existing networks, manufacturing capabilities, and distribution channels.
IMARC Group provides an analysis of the key trends in each segment of the global oligonucleotide synthesis market report, along with forecasts at the global, regional and country levels from 2024-2032. Our report has categorized the market based on product, application and end use.
Synthesized Oligonucleotide Products
Reagents
Equipment
Services
Synthesized oligonucleotide products dominate the market
The report has provided a detailed breakup and analysis of the market based on the product. This includes synthesized oligonucleotide products, reagents, equipment, and services. According to the report, synthesized oligonucleotide products represented the largest segment.
The market for synthesized oligonucleotide products in the oligonucleotide synthesis industry is being driven by the ever-increasing demand from pharmaceutical and biotechnological companies for drug discovery and development, especially for personalized medicine and targeted therapeutics. Along with this, the rise in genomics and molecular research, fueled by significant advancements in technologies such as Next Generation Sequencing (NGS) and CRISPR gene-editing, is enhancing the requirement for synthesized oligonucleotides. Additionally, the growth in diagnostic applications of oligonucleotides, such as in PCR and microarray assays for genetic and infectious diseases, is propelling the market forward. The expanding field of epigenetics also represents a key driver, with oligonucleotides playing a crucial role in gene expression studies. Moreover, the increasing prevalence of genetic disorders and the resultant demand for novel therapeutic strategies involving oligonucleotides further accelerates the market growth for synthesized oligonucleotide products.
PCR Primers
PCR Assays and Panels
Sequencing
DNA Microarrays
Fluorescence In-Situ Hybridization (FISH)
Antisense Oligonucleotides
Others
PCR primers dominate the market
A detailed breakup and analysis of the market based on the application has also been provided in the report. This includes PCR primers, PCR assays and panels, sequencing, DNA microarrays, Fluorescence In-Situ Hybridization (FISH), antisense oligonucleotides, and others. According to the report, the PCR primers represented the largest segment.
The demand for PCR primers in the oligonucleotide synthesis industry is driven by the ongoing global health crisis necessitating extensive viral testing, in which PCR is a primary method. Furthermore, the increasing application of PCR in medical diagnostics, forensics, and research to detect genetic mutations and infectious diseases fuels the demand for primers. In the field of genomics and molecular biology, PCR is considered a crucial tool for DNA sequencing, cloning, and genetic manipulation, and this broad utilization further drives the need for PCR primer synthesis. Apart from this, technological advancements in PCR techniques, such as real-time PCR and digital PCR, are also playing a role in boosting demand. Moreoevr, the growing funding for research in healthcare and life sciences has resulted in expanded use of PCR, thus driving the demand for PCR primers in the overall industry.
Pharmaceutical and Biotechnology Companies
Hospital and Diagnostic Laboratories
Academic Research Institutes
Academic research institutes dominate the market
The report has provided a detailed breakup and analysis of the market based on the end use. This includes pharmaceutical and biotechnology companies, hospital and diagnostic laboratories, and academic research institutes. According to the report, academic research institutes represented the largest segment.
The demand for oligonucleotide synthesis in academic research institutes is driven by a rise in genomics and molecular biology research, particularly studies related to gene expression, genetic disorders, and the development of novel therapeutic strategies. Additionally, advancements in technologies such as Next-Generation Sequencing (NGS) and CRISPR gene-editing, which rely on synthesized oligonucleotides, are stimulating demand. In addition, the rising trend of interdisciplinary studies involving bioinformatics and data science, which necessitate the use of oligonucleotides for data validation, further drives the need. Governmental and institutional funding for genomics and biotechnology research is another major driver, enabling academic institutes to invest in oligonucleotide synthesis for various projects. Academic research institutes, with their focus on fundamental research and discovery, often possess cutting-edge knowledge and innovative ideas. By partnering with industry, they can translate their scientific findings into practical applications and commercial products.
North America
United States
Canada
Asia-Pacific
China
Japan
India
South Korea
Australia
Indonesia
Others
Europe
Germany
France
United Kingdom
Italy
Spain
Russia
Others
Latin America
Brazil
Mexico
Others
Middle East and Africa
North America exhibits a clear dominance, accounting for the largest oligonucleotide synthesis market share
The report has also provided a comprehensive analysis of all the major regional markets, which include North America (the United States and Canada); Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Latin America (Brazil, Mexico, and others); and the Middle East and Africa.
The North American market for oligonucleotide synthesis is propelled by a robust pharmaceutical and biotech industry, with a strong focus on drug discovery and development. The region's emphasis on personalized medicine and targeted therapies further propels this need. Additionally, North America's sophisticated healthcare system with advanced diagnostic capabilities increases the demand for oligonucleotides in diagnostic assays. The region also hosts numerous top-tier academic and research institutes conducting extensive genomics and molecular biology research, which necessitates oligonucleotide synthesis. Moreover, strong governmental and private sector investment in healthcare and life sciences research, particularly in genomics and personalized medicine, fuels the growth of industry in North America. Moreover, the advancements in delivery systems and formulations for oligonucleotide-based therapeutics in North America demonstrate the region's commitment to pushing the boundaries of innovation in this field. These developments not only contribute to the growth of the market but also have the potential to revolutionize the treatment of various diseases, including genetic disorders, cancers, and rare diseases.
The global oligonucleotide synthesis market is experiencing significant growth due to the escalating investments in the development of new production facilities, upgrading existing ones, and implementing more efficient production processes. Therefore, Companies are heavily investing in research and development to innovate their offerings, including developing new synthesis techniques, improving the scale and accuracy of synthesis, and creating new types of oligonucleotide products to support various applications in diagnostics, therapeutics, and research. Along with this, companies are entering into strategic collaborations, partnerships, and acquisitions to co-develop oligonucleotide-based drugs, share technology and expertise, or expand into new markets. In addition, the introduction of therapeutics, such as antisense oligonucleotides, siRNAs, and miRNAs, offer new avenues for treating a wide range of diseases, including genetic disorders and cancers is positively influencing the market. Furthermore, key players are offering services for the custom synthesis of oligonucleotides. This allows researchers and developers to order specific oligonucleotide sequences tailored to their needs, which is particularly important in fields like genomics, molecular biology, and personalized medicine.
Agilent Technologies Inc.
Biolegio B.V.
Bio-Synthesis Inc
Eurofins Genomics
GenScript
Horizon Discovery Ltd
Integrated DNA Technologies Inc (Danaher Corporation)
Kaneka Eurogentec S.A. (Kaneka Corporation)
LGC Limited
Nitto Denko Avecia Inc (Nitto Denko Corporation)
Thermo Fisher Scientific Inc.
In May 2023, GenScript increased the size of its principal manufacturing plant in Zhenjiang, Jiangsu, China for the manufacture of oligonucleotides and peptides. The expansion builds on GenScript's history of providing top-notch oligo and peptides to scientists all across the world for 20 years.
In January 2023, Agilent Technologies Inc. announced to increase its production of therapeutic nucleic acids, also known as oligonucleotides. The initiative is the most recent in a series of investments done by the sector in response to rapid development. At Agilent's plant in Frederick, Colorado, where the installation of a line announced in 2020 is slated to commence operating later this year, the project will add two oligonucleotide production lines.
In February 2022, Kaneka Eurogentec S.A. (Kaneka Corporation) stated that a 25 g batch of mRNA for a US customer had been successfully manufactured at its mRNA synthesis facility. In its present facility in Belgium, Eurogentec's GMP mRNA production service provides in vitro transcription (IVT), purification, quality control, and batch release of GMP material up to 25 g scale.