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市场调查报告书
商品编码
1722973
2025 年至 2033 年生物反应器市场规模、份额、趋势及预测(按类型、用途、规模、控制类型和地区)Bioreactors Market Size, Share, Trends, and Forecast by Type, Usage, Scale, Control Type, and Region, 2025-2033 |
2024 年全球生物反应器市场规模价值 80 亿美元。展望未来, IMARC Group估计到 2033 年市场规模将达到 196 亿美元,2025-2033 年期间的复合年增长率为 10.4%。北美目前占据市场主导地位,到 2024 年将占据超过 39.1% 的显着市场。有效治疗药物的采用率不断提高,以及对预防性疫苗的需求不断增长,主要推动了生物反应器市场份额的成长。
由于对单株抗体和疫苗等生物製剂的需求不断增长,全球生物反应器市场正在经历成长。这可以归因于生物製药生产的进步。同时,一次性生物反应器的日益普及(以降低污染风险和营运成本而闻名)进一步加速了市场成长。细胞和基因治疗研究的快速进步以及对个人化医疗日益增长的兴趣也在推动需求。除此之外,政府对生物製剂製造的支持和对生物相似药生产的有利规定也促进了市场的扩张。此外,自动化和控制系统的技术改进正在提高生物反应器的性能,满足生物技术和製药行业的需求,并推动市场发展。
由于对生物相似药生产的日益关注,美国成为关键市场。主要生物製剂的专利到期以及这些替代品的价格越来越便宜,都证明了这一点。此外,慢性病的日益普及也促进了生物製药的投资,从而推动了对可扩展、高效的生物反应器系统的需求。根据美国疾病管制与预防中心2024年的研究报告,美国有1.29亿人患有至少一种美国卫生与公众服务部定义的主要慢性疾病,如心臟病、癌症、糖尿病、肥胖症或高血压,其中42%的人患有两种或两种以上疾病,12%的人患有至少五种疾病。在十大死因中,慢性病占了五分之一。二十年来,其发生率稳定上升,预计还会进一步上升。除此之外,干细胞研究和组织工程等生物加工应用的扩展对专用生物反应器产生了巨大的需求。同时,学术机构和生技公司的合作正在加速生物製造技术的进步。此外,生物反应器在食品和农业生物技术中的作用日益增强,为生物反应器市场创造了积极的前景。
一次性生物反应器的使用
一次性生物反应器 (SUB) 因其灵活性、成本效益、降低污染风险等优点而越来越受欢迎。这反过来又刺激了市场的发展。根据 IMARC 的数据,2023 年全球一次性生物反应器市场规模达 34 亿美元。展望未来, IMARC Group预计到 2032 年市场规模将达到 111 亿美元,从而在 2024-2032 年期间的成长率 (CAGR) 为 13.8%。此外,与传统的不銹钢生物反应器不同,SUB 采用一次性袋子,这有助于消除批次之间进行大量清洁和消毒的需要。 2023 年 12 月,Cellexus 推出了气升式抛弃式生物反应器系统,为细胞的快速生长提供最佳通气。这种轻柔搅拌的方法通常适用于微生物发酵和细胞培养。除此之外,主要参与者也正在生产创新的 SUB 设计,以满足小规模研究和大规模生产的需求,这推动了生物反应器市场的发展。例如,2024 年 2 月,合约开发和製造组织 (CDMO) 药明生物宣布在爱尔兰投资约 3.4 亿美元建造一个一次性生物反应器容量约为 54,000 公升的一次性工厂。此外,2024 年 3 月,赛默飞世尔科技 (TM) 针对 HyPerforma (TM) 一次性生物反应器 (SUB) 产品平台推出了一系列针对特定应用的增强功能,每个功能都针对强化补料分批、灌注和贴壁细胞培养的独特要求进行客製化。同样,2024 年 3 月,Distek, Inc. 推出了用于哺乳动物细胞生长和重组蛋白生产的一次性生物反应器 (SUB) 系统。此外,预计未来几年知名公司之间的持续合作将扩大市场。例如,2024年6月,Aragen Bioscience与Getinge宣布后者的一次性生产反应器(SUPR)成功验证。为此,此次合作结合了 Getinge 的创新一次性技术与 Aragen 在生物製药製造方面的专业知识。
自动化的进步
生物反应器市场的一个重要趋势是自动化的不断进步。新型控制系统和自动化与生物反应器的广泛整合正在彻底改变生物加工,实现对关键参数(如 pH、温度、溶解氧等)的精确控制和即时监控。这是一个重要的成长诱导因素。例如,2023 年 8 月,Repligen Corporation 和 Sartorius 推出了一款整合式生物反应器系统,该系统包含完全相容的嵌入式 XCell ATF 软体和硬体模组,可提供预先定义的高级控製配方以及整合製程分析技术 (PAT)。 Gartner 预测,到 2026 年,30% 的企业将实现超过一半的网路活动自动化,高于 2023 年的 10%,因为包括 GenAI 在内的人工智慧驱动的自动化将提高营运效率和灵活性。这些进步越来越多地应用于生物反应器,增强了数据驱动的决策和流程优化。此外,该系统旨在为使用者提供一种简化的方法来控制细胞生长并增强灌注过程中的细胞保留,而无需使用单独的细胞保留控制塔。此外,2023 年 9 月,生物技术解决方案创新者之一 Automated Control Concepts (ACC) 发布了其尖端生物反应器控制和资料平台 Lab Owl,该平台允许调整多个过程参数和进行精确监控,从而获得一致且可重复的结果。除此之外,2023年12月,Cultzyme推出了配备人工智慧、硬体和云端运算的生物反应器智慧操作奈米技术(BION)系统,以控制生物製造过程,并以最低成本更有效率地实现一致的结果。此外,先进控制系统的需求不断增长,因为它们促进了从实验室到生产规模的无缝扩大,有助于确保多种生物反应器尺寸的一致性能,这也增加了生物反应器市场的收入。例如,2024 年 4 月,Culture Biosciences 创建了具有先进控制系统和即时监控功能的生物反应器,旨在容纳中国仓鼠卵巢 (CHO) 细胞。
永续生物加工的发展
永续性正成为市场的一个重要考量。知名企业正致力于最大限度地减少能源消耗和废物产生,这刺激了生物反应器市场的成长。 2023 年 10 月,奈良先端科学技术大学院大学和藤田大学的一组研究人员推出了一种混合电脑模拟/细胞内控制器 (HISICC),将计算机前馈控制与转基因活细胞无缝集成,为经济高效且环保的化学品和燃料生产提供了潜力。除此之外,2023 年 11 月,ADM 和 Solugen 建立战略合作伙伴关係,建造一个约 50 万平方英尺的生物製造工厂,开发分子以取代现有的化石燃料基材料并扩大其低碳有机酸产品线。例如,英国已在 21 个跨部门合作中投资约 1400 万美元,以推进可持续生物製造,重点关註生物反应器创新和生物催化过程,例如用于生产扑热息痛的可扩展连续流反应器。这些措施旨在提高生物技术过程的可持续性,并支持英国在2050年实现净零排放的目标。此外,生物反应器製造商正在投资生物反应器设计的多项创新,例如更高效的混合和曝气系统,这正在提升更环保的生物加工解决方案的普及度。例如,勃林格殷格翰在动物保健领域提供生物製程技术操作,并更加重视环境永续性。与此相符的是,从不断讨论和评估当前的实践到优化抗原生物製造的工艺链,该公司坚定地致力于最大限度地减少其对环境的影响。此外,2024 年 3 月,英国研究与创新署 (UKRI) 宣布 21 项跨部门合作,以推动全国永续生物製造的进步。
The global bioreactors market size was valued at USD 8.0 Billion in 2024. Looking forward, IMARC Group estimates the market to reach USD 19.6 Billion by 2033, exhibiting a CAGR of 10.4% during 2025-2033. North America currently dominates the market, holding a significant market share of over 39.1% in 2024. The increasing adoption of effective treatment drugs, along with the rising need for preventive vaccines, is primarily propelling the bioreactors market share.
The global bioreactors market is experiencing growth due to the rising demand for biologics, including monoclonal antibodies and vaccines. This can be attributed to the advancements in biopharmaceutical production. Along with this, the increasing adoption of single-use bioreactors, known for reduced contamination risks and operational costs, is further accelerating market growth. Rapid advancements in cell and gene therapy research, and growing interest in personalized medicine, are also propelling demand. Apart from this, government support for biologics manufacturing and favorable regulations for biosimilar production are contributing to the market's expansion. Moreover, technological improvements in automation and control systems are enhancing bioreactor performance, addressing the needs of the biotechnology and pharmaceutical industries, and fueling the market.
The United States stands out as a key market, driven by the growing focus on biosimilar production. This can be supported by the patent expirations of major biologics and the increasing affordability of these alternatives. In addition, the increasing prevalence of chronic diseases is encouraging biopharmaceutical investments, fueling the need for scalable and efficient bioreactor systems. As per 2024 research report by the CDC, in the United States, 129 million individuals have at least one major chronic disease defined by the US Department of Health and Human Services, such as heart disease, cancer, diabetes, obesity, or hypertension, with 42% having two or more and 12% having at least five. Chronic diseases account for five of the top 10 leading causes of death. Their prevalence has steadily increased over two decades and is expected to rise further. Besides this, expansion in bioprocessing applications, such as stem cell research and tissue engineering, is creating significant demand for specialized bioreactors. Concurrently, collaborations between academic institutions and biotech companies are accelerating advancements in biomanufacturing techniques. Furthermore, the increasing role of bioreactors in food and agricultural biotechnology is creating a positive bioreactors market outlook.
Usage of Single-Use Bioreactors
Single-use bioreactors (SUBs) are gaining extensive popularity, owing to their benefits, such as flexibility, cost-effectiveness, reduced risk of contamination, etc. This, in turn, is stimulating the market. According to the IMARC, the global single-use bioreactors market size reached USD 3.4 Billion in 2023. Looking forward, IMARC Group expects the market to reach USD 11.1 Billion by 2032, thereby exhibiting a growth rate (CAGR) of 13.8% during 2024-2032. Moreover, unlike traditional stainless-steel bioreactors, SUBs adopt disposable bags, which aids in eliminating the need for extensive cleaning and sterilization between batches. In December 2023, Cellexus introduced airlift single-use disposable bioreactor systems that offer optimal aeration for the rapid growth of cells. This method of gentle agitation is usually suitable for microbial fermentation and cell culture. Besides this, key players are also producing innovative SUB designs, catering to both small-scale research and large-scale production needs, which is fueling the bioreactors market outlook. For instance, in February 2024, the contract development and manufacturing organization (CDMO), WuXi Biologics, announced the construction of a single-use site with approximately 54,000 L of disposable bioreactor capacity via an investment of roughly approximately USD 340 Million in Ireland. Additionally, in March 2024, Thermo Fisher Scientific(TM) launched a series of application-specific enhancements to the HyPerforma(TM) single-use bioreactor (SUB) product platform, each tailored to the unique requirements of intensified fed-batch, perfusion, and adherent cell cultures. Similarly, in March 2024, Distek, Inc. unveiled a single-use bioreactor (SUB) system for mammalian cell growth and recombinant protein production. Furthermore, continuous collaborations among prominent companies are projected to augment the market in the coming years. For example, in June 2024, Aragen Bioscience and Getinge announced the successful validation of the latter's single-use production reactors (SUPR). In line with this, the collaboration combined Getinge's innovative single-use technology and Aragen's expertise in biopharmaceutical manufacturing.
Advancements in Automation
On of the significant bioreactors market trends is continual advancements in automation. The widespread integration of novel control systems and automation with bioreactors is revolutionizing bioprocessing by enabling precise control over critical parameters, such as pH, temperature, dissolved oxygen, etc., and real-time monitoring. This is acting as a significant growth-inducing factor. For instance, in August 2023, Repligen Corporation and Sartorius introduced an integrated bioreactor system that comprises a fully compatible embedded XCell ATF software and hardware module offering predefined advanced control recipes with integrated process analytical technology (PAT). According to Gartner, by 2026, 30% of enterprises will automate over half of network activities, up from 10% in 2023, as AI-driven automation, including GenAI, boosts operational efficiency and agility. These advancements are increasingly applied in bioreactors, enhancing data-driven decision-making and process optimization. Additionally, the system aims to provide users with a streamlined way to control cell growth and enhance cell retention in perfusion processes without utilizing a separate cell retention control tower. Besides this, in September 2023, Automated Control Concepts (ACC), one of the innovators in biotechnology solutions, released its cutting-edge bioreactor control and data platform, Lab Owl, that allows for adjustment of multiple process parameters and precise monitoring, resulting in consistent and reproducible outcomes. Apart from this, in December 2023, Cultzyme launched a bioreactor intelligent operative nanotechnology (BION) system equipped with AI, hardware, and cloud computing to control the biomanufacturing process and achieve consistent outcomes more efficiently and at minimal costs. Furthermore, the escalating demand for advanced control systems, as they facilitate seamless scale-up from laboratory to production scale, which aids in ensuring consistent performance across numerous bioreactor sizes, is also increasing the bioreactors market revenue. For instance, in April 2024, Culture Biosciences created bioreactors with advanced control systems and real-time monitoring capabilities designed to accommodate Chinese Hamster Ovary (CHO) cells.
Development of Sustainable Bioprocessing
Sustainability is becoming a critical consideration in the market. Prominent players are focusing on minimizing energy consumption and waste generation, which is stimulating the bioreactors market growth. In October 2023, a team of researchers at the Nara Institute of Science and Technology and Fujita University introduced a hybrid in silico/in-cell controller (HISICC) that seamlessly integrates computerized feedforward control with genetically modified living cells, offering the potential for cost-effective and eco-friendly chemical and fuel production. Besides this, in November 2023, ADM and Solugen formed a strategic partnership to build an approximately 500,000-ft2 biomanufacturing facility to develop molecules to replace existing fossil fuel-based materials and scale its line of lower-carbon organic acids. For instance, the UK has invested approximately USD 14 Million in 21 cross-sector collaborations to advance sustainable biomanufacturing, focusing on bioreactor innovations and biocatalytic processes, such as scalable continuous flow reactors for paracetamol production. These initiatives aim to enhance the sustainability profile of biotechnology processes and support the UK's goal of achieving Net Zero by 2050. Moreover, bioreactor manufacturers are investing in several innovations in bioreactor design, such as more efficient mixing and aeration systems, which is elevating the popularity of greener bioprocessing solutions. For example, Boehringer Ingelheim offers bioprocess technology operations in animal health with an improved focus on environmental sustainability. In line with this, from continuously discussing and evaluating current practices to optimizing process chains for antigenic biological manufacturing, the company is strongly committed to minimizing its environmental footprint. Additionally, in March 2024, the UK Research and Innovation (UKRI) announced 21 cross-sector collaborations to drive advancements in sustainable biomanufacturing across the country.
Multi-use stands as the largest component in 2024, holding around 65.9% of the market. Multi-use bioreactors are the most versatile, cost-effective, and efficient bioreactors for diverse bioproduction processes. They are used in a wide range of pharmaceutical, biotechnology, and research applications because they can accommodate various cell culture and fermentation processes. Their design is robust, reusable, and scalable, making them ideal for large-scale manufacturing and experimental applications. Multi-use bioreactors are in line with the industry's demand for high-quality production and sustainable practices, as they reduce operational costs and ensure consistent performance. Their adaptability to advanced technologies further reinforces their position as the largest and most impactful segment in the bioreactors market.
Pilot-scale production leads the market with around 49.1% of market share in 2024. Pilot-scale production in bioreactors serves as a crucial intermediary step between laboratory research and full-scale manufacturing in the biopharmaceutical industry. This phase allows for the optimization of bioprocesses on a scale that closely mimics commercial production, providing valuable insights into process performance, scalability, and reproducibility. Pilot-scale bioreactors typically range from 50 to 500 liters in capacity. For instance, in January 2024, San Francisco-based SciFi Foods announced the successful completion of its first commercial bioreactor facility in San Leandro, California. They are used to test and refine production parameters such as cell growth, nutrient consumption, and product yield under conditions that replicate those of large-scale operations. Additionally, pilot-scale production facilitates regulatory compliance by generating data required for process validation and quality assurance. Companies like GE Healthcare and Sartorius offer advanced pilot-scale bioreactor systems equipped with sophisticated monitoring and control technologies, enabling precise control over critical process parameters and ensuring a seamless transition to large-scale manufacturing.
200L-1500L leads the market with around 47.8% of market share in 2024. Bioreactors are designed in various scales to meet the needs of different stages of bioprocessing, from research and development to full-scale commercial production. Bioreactors in the 200L to 1500L range are used for pilot-scale production, providing a realistic simulation of commercial-scale operations and facilitating the validation of production processes. These bioreactors hold significant prominence in the biopharmaceutical sector due to their versatility and scalability. These systems bridge the gap between laboratory-scale research and large-scale manufacturing, enabling efficient process optimization and technology transfer. Their adoption is driven by the rising demand for biologics, including monoclonal antibodies and vaccines, which require consistent and reproducible production environments.
Automated leads the market with around 65.9% of market share in 2024. Automated bioreactors are revolutionizing bioprocessing by integrating advanced control systems that enhance precision, efficiency, and scalability. They allow for real-time monitoring and control of critical parameters, including temperature, pH, dissolved oxygen, etc. The system's automation capabilities minimize human intervention, thereby reducing the risk of contamination and errors while optimizing cell growth and product yield. For example, in May 2024, a team of researchers at Florida International University developed an automated 3D-printed bioreactor to grow bone in the lab. Additionally, biopharmaceutical manufacturers offer versatile and robust solutions to enhance productivity and maintain high standards of quality and compliance. For instance, in September 2023, Automated Control Concepts (ACC), one of the leading innovators in biotechnology solutions, announced the development of its cutting-edge bioreactor control and data platform, Lab Owl, to redefine the landscape of bioprocessing.
In 2024, North America accounted for the largest market share of over 39.1%. The North America bioreactors market is witnessing robust growth, fueled by the region's strong emphasis on biopharmaceutical research, development, and manufacturing. Additionally, advancements in bioprocessing technologies, such as single-use bioreactors and automation, are enhancing the efficiency and scalability of biomanufacturing processes. The presence of major pharmaceutical and biotechnology companies, coupled with supportive government initiatives and funding, is further propelling the bioreactors market demand. In February 2024, Thermo Fisher Scientific expanded its manufacturing capacity at its Missouri, U.S. site to produce complex biologic treatments for a range of diseases, including cancer, autoimmune conditions, and rare disorders. Furthermore, the North America bioreactors market is poised for continued growth, driven by technological advancements and increasing biopharmaceutical production demands. For instance, in March 2023, Micro Digital Co. signed a formal contract to supply bioreactors to expand its presence in North America.
United States Bioreactors Market Analysis
In 2024, US accounted for around 87.6% of the total North America bioreactors market. The United States is at the forefront of adopting bioreactor technology, significantly advancing its position in biotechnology and pharmaceutical manufacturing. Bioreactors are streamlining the production of biologics, including vaccines, monoclonal antibodies, and regenerative medicine solutions, addressing both domestic and global healthcare needs. Key advantages include higher production efficiency, scalability, and enhanced process control, enabling faster responses to medical demands. Innovations such as single-use bioreactors are reducing costs and contamination risks while supporting sustainability goals. For instance, The United States, as the world's third-largest importer of bioreactors with 191 shipments, primarily sources from Mexico, India, and Canada. This strategic importation supports advancements in biotechnology and pharmaceuticals, bolstering the nation's innovation and economic growth. Major states like California, Massachusetts, and North Carolina, with robust biotechnology clusters, are hubs for bioreactor deployment, fostering collaborations and driving R&D. These advancements are further strengthening the U.S. position as a leader in life sciences, with companies and research centers contributing to breakthroughs in personalized medicine and cell-based therapies. Bioreactors are transforming industries beyond healthcare, including biofuels and agriculture, enhancing resource management and sustainability efforts across diverse sectors.
Asia Pacific Bioreactors Market Analysis
The Asia-Pacific region is emerging as a significant hub for bioreactor adoption, driven by advancements in biotechnology and the region's focus on pharmaceutical and biopharmaceutical development. Countries such as China, India, Japan, and South Korea are leveraging bioreactor technologies to enhance vaccine production, biologics manufacturing, and regenerative medicine. These innovations are enabling cost-effective and scalable production processes, crucial for meeting the demands of growing healthcare markets. For instance, India imported 2,480 bioreactor shipments from March 2023 to February 2024, primarily from the United States, Switzerland, and Germany. This significant import activity underscores India's commitment to advancing its biotechnology sector, enhancing research capabilities, and fostering economic growth. The region's favorable regulatory frameworks and substantial investments in research hubs, particularly in cities like Shanghai, Hyderabad, and Tokyo, are positioning Asia-Pacific as a leader in bioprocessing. The adoption of single-use bioreactors in South Korea's biopharmaceutical industry and China's focus on monoclonal antibody production exemplify the region's dynamic advancements. With strategic location advantages, including proximity to raw materials and skilled labor, Asia-Pacific is fostering sustainable biotechnology growth, meeting global supply demands, and addressing critical healthcare challenges.
Europe Bioreactors Market Analysis
The adoption of bioreactors in Europe is significantly transforming industries like pharmaceuticals and biotechnology by advancing production efficiency and sustainability. Bioreactors enable precise environmental control, enhancing the yield of biologics and biofuels while reducing waste and resource consumption. Europe, particularly Germany and Switzerland, leads in bioreactor innovation, leveraging advancements in automation and sensor technologies to optimize processes. Germany's pharmaceutical hubs utilize bioreactors to streamline vaccine production, meeting global health demands rapidly. Similarly, Switzerland's biotechnology sector has integrated bioreactors to enhance monoclonal antibody manufacturing, positioning the country as a leader in therapeutic advancements. Switzerland's export of bioreactors and effluent treatment equipment significantly benefits Europe by enhancing wastewater management and environmental sustainability. In 2024, Switzerland exported 2,474 shipments of MBR bioreactor treatment plant sections and related equipment, indicating robust trade activity in this sector. The widespread adoption across European countries, including the Netherlands and France, emphasizes the region's commitment to green technology and reduced carbon footprints. By fostering innovation hubs and research centers, Europe strengthens its position in global biotechnology, offering scalable solutions that address industrial and environmental challenges while maintaining a competitive edge in life sciences.
Latin America Bioreactors Market Analysis
The adoption of bioreactors in Latin America is revolutionizing biotechnology and sustainable production. Advancements in scalable cell culture and fermentation technologies enable efficient vaccine development and bio-based manufacturing. Countries like Brazil are leveraging bioreactors for ethanol production from sugarcane, enhancing renewable energy output. Similarly, Mexico utilizes bioreactors in pharmaceutical innovation, improving drug manufacturing. According to reports, The Mexico small-scale bioreactors market is projected to grow from USD 36.9 Million in 2018 to USD 154.1 Million by 2032, driven by increasing adoption in medical, food, agriculture, and energy sectors. These innovations position Latin America as a global hub for biotechnological progress. Strategically located near global trade routes, the region fosters economic growth through exports. States such as Sao Paulo and Jalisco exemplify leadership, driving technological adoption to support environmental sustainability and economic development.
Middle East and Africa Bioreactors Market Analysis
The Middle East and Africa are rapidly embracing bioreactors, revolutionizing biotechnology, and healthcare sectors. Bioreactors offer advantages such as enhanced cell growth, scalability, and precise environmental control, fostering innovation in pharmaceutical production and wastewater treatment. According to reports, the United Arab Emirates imported 12 bioreactor shipments, ranking 22nd globally. India led with 2,480 shipments, followed by Vietnam with 225, and the United States with 209. Advancements in single-use bioreactors and automation have streamlined operations, making them accessible to emerging markets. For instance, Saudi Arabia is utilizing bioreactors for vaccine manufacturing, ensuring local supply chains, while South Africa is employing them in biofuel production to address energy sustainability. Strategic positioning in these regions promotes economic diversification and self-reliance, making bioreactors a pivotal tool for regional growth.
The bioreactors market forecast indicates strong competition in the market, as key players iare focusing on innovation to enhance efficiency and scalability in bioprocessing. They are investing in advanced technologies such as single-use systems to meet the growing demand for flexible and cost-effective solutions. Companies are also expanding their portfolios to include modular and custom bioreactors tailored to specific applications such as cell and gene therapy. Along with this, partnerships with biotech firms and research institutions are strengthening R&D efforts, fostering the development of next-generation bioreactors. Additionally, manufacturers are leveraging automation and digital monitoring tools to improve process control and product quality.