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市场调查报告书
商品编码
1819882
寡核苷酸合成市场报告(按产品、应用(PCR 引子、PCR 检测和组合、定序、DNA 微阵列、萤光原位杂交、反义寡核苷酸等)、最终用途和地区划分,2025 年至 2033 年)Oligonucleotide Synthesis Market Report by Product, Application (PCR Primers, PCR Assays and Panels, Sequencing, DNA Microarrays, Fluorescence In-Situ Hybridization, Antisense Oligonucleotides, and Others), End Use, and Region 2025-2033 |
2024年,全球寡核苷酸合成市场规模达33亿美元。展望未来, IMARC Group预计到2033年,市场规模将达到86亿美元,2025-2033年期间的复合年增长率(CAGR)为10.55%。遗传性疾病在人群中的日益流行、新型治疗策略的不断发展以及小干扰RNA (siRNA)和反义寡核苷酸疗法的广泛应用,是推动市场发展的主要因素。
寡核苷酸合成是指依预定序列建构短DNA或RNA分子(称为寡核苷酸)的过程。这些分子的长度范围从几个碱基到大约200个核苷酸不等。该过程在受控的实验室环境中以化学方式完成,通常使用固相亚磷酰胺化学。在该方法中,核苷酸被依次添加到不断增长的链中,每次添加都涉及一系列化学反应。这项技术使科学家能够产生客製化的寡核苷酸,用于各种应用,包括基因合成、聚合酶炼式反应 (PCR)、基因编辑工具(例如 CRISPR-Cas9)以及分子诊断测试。寡核苷酸合成的进展大大加速了基因组学和分子生物学的研究,为医学和生物学研究的许多突破奠定了基础。
群体中遗传疾病的发生率不断上升,是全球市场的主要驱动力。这促使人们开发新的治疗策略,而寡核苷酸疗法在其中扮演重要角色。例如,使用小干扰RNA (siRNA) 和反义寡核苷酸的疗法正在被研究并用于治疗杜氏肌肉营养不良症和脊髓性肌肉萎缩症等遗传疾病。因此,遗传疾病的日益普及推动了全球范围内的需求。同时,生物资讯学和资料科学的发展对寡核苷酸合成产业产生了直接影响。分析大型基因组资料集的能力不断提升也对市场产生了正面的影响。因此,运算能力的提升正在推动对新型寡核苷酸合成的需求成长。此外,寡核苷酸,特别是反义寡核苷酸,已被证明是表观遗传学研究和治疗的有效工具,有助于调节基因表达,这创造了积极的市场前景。
医疗保健和製药行业需求不断增长
全球对个人化医疗和疗法的需求正在迅速增长,这导致寡核苷酸合成市场空前扩张。这些合成序列是开发针对各种遗传疾病(包括癌症)的标靶疗法的重要组成部分。同时,反义寡核苷酸、适体、siRNA 和免疫刺激性寡核苷酸等治疗性寡核苷酸的进步,透过特异性抑製或改变基因表达,正在彻底改变疾病治疗。此外,客製化寡核苷酸的合成对于疫苗的生产至关重要,包括基于 mRNA 的 COVID-19 疫苗,这些疫苗已被证明有效并已被广泛使用。随着製药公司和研究人员不断探索寡核苷酸在疾病治疗和预防方面的新应用,寡核苷酸合成的需求也有望上升。
技术进步与创新
寡核苷酸合成技术的稳定发展和完善正在推动市场成长。此外,包括高通量和自动化合成系统在内的合成製程创新,提高了寡核苷酸生产的效率、准确性和可扩展性。此外,生物资讯学和合成生物学的发展,包括DNA定序和基因编辑(例如CRISPR-Cas9),在很大程度上依赖精确合成寡核苷酸的能力。这些进步使得创建具有更高复杂性和多样性的客製化序列成为可能,并促进了合成生物学的快速原型测试,从而促进了更高效的研发。这些持续的技术进步和发展也为市场做出了贡献。
不断增长的合作与伙伴关係
製药公司、生技公司和研究机构之间的合作与伙伴关係已成为推动遗传疾病寡核苷酸疗法开发和商业化的重要驱动力。这些合作汇集了多元化的专业知识、资源和资金,创造了协同增效的环境,加速了科学发现转化为实用有效的治疗方法。製药公司凭藉其在药物开发、临床试验和监管流程方面的经验,为合作贡献了至关重要的专业知识。他们拥有必要的基础设施、知识和资源,能够应对复杂的药物开发环境,并确保寡核苷酸疗法符合安全性和有效性的监管标准。他们的参与有助于利用现有的网路、製造能力和分销管道,简化商业化路径。
The global oligonucleotide synthesis market size reached USD 3.3 Billion in 2024. Looking forward, IMARC Group expects the market to reach USD 8.6 Billion by 2033, exhibiting a growth rate (CAGR) of 10.55% during 2025-2033. The growing prevalence of genetic diseases among the masses, the development of novel therapeutic strategies, and the widespread adoption of therapies using small interfering RNAs (siRNAs), and antisense oligonucleotides are some of the major factors propelling the market.
Oligonucleotide synthesis refers to the process of constructing short DNA or RNA molecules, called oligonucleotides, in a predetermined sequence. These can range from just a few bases to around 200 nucleotides in length. The process is accomplished chemically in a controlled laboratory environment, typically using solid phase phosphoramidite chemistry. In this method, nucleotides are sequentially added to a growing chain, each addition involving a series of chemical reactions. This technology enables scientists to generate custom-made oligonucleotides for various applications including gene synthesis, polymerase chain reaction (PCR), gene editing tools, such as CRISPR-Cas9, and molecular diagnostic tests. Advances in oligonucleotide synthesis have dramatically accelerated research in genomics and molecular biology, underpinning many breakthroughs in medical and biological research.
The rising prevalence of genetic diseases among the masses majorly drives the global market. This necessitates the development of novel therapeutic strategies, where oligonucleotide-based therapies play a significant role. For instance, therapies using small interfering RNAs (siRNAs) and antisense oligonucleotides are being investigated and utilized in the treatment of genetic disorders, such as Duchenne muscular dystrophy and spinal muscular atrophy. As such, the growing prevalence of genetic diseases drives the demand on the global level. Along with this, the growth of bioinformatics and data science has a direct impact on the oligonucleotide synthesis industry. The escalating capacity to analyze large genomic datasets is also positively influencing the market. Therefore, the rising computational capability is driving an increased demand for the synthesis of novel oligonucleotides. Furthermore, oligonucleotides particularly antisense oligonucleotides, have been shown to be effective tools in epigenetic research and therapy, helping to modulate gene expression, which is creating a positive market outlook.
Rising Demand in the Healthcare and Pharmaceutical Industries
The global demand for personalized medicine and therapeutics is rapidly increasing, leading to an unprecedented expansion in the oligonucleotide synthesis market. These synthesized sequences are integral components in developing targeted therapies for various genetic disorders and diseases, including cancer. Along with this, the advancement of therapeutic oligonucleotides, such as antisense oligonucleotides, aptamers, siRNAs, and immunostimulatory oligonucleotides, is revolutionizing disease treatment by specifically inhibiting or altering gene expression. Furthermore, the synthesis of custom oligonucleotides is fundamental to the production of vaccines, including mRNA-based COVID-19 vaccines, which have proven effective and are now widely used. As pharmaceutical companies and researchers continue to discover novel applications for oligonucleotides in the treatment and prevention of diseases, the demand for oligonucleotide synthesis is poised to rise.
Technological Advancements and Innovation
The steady development and refinement of oligonucleotide synthesis technologies are driving market growth. In addition, innovations in the synthesis process, including high-throughput and automated synthesis systems, have increased the efficiency, accuracy, and scalability of oligonucleotide production. Moreover, developments in bioinformatics and synthetic biology, including DNA sequencing and gene editing (e.g., CRISPR-Cas9), heavily rely on the ability to synthesize oligonucleotides accurately. These advancements allow for the creation of custom sequences with greater complexity and diversity and facilitate rapid prototype testing in synthetic biology, thereby fostering more efficient research and development. These continuous technological advancements and developments are also contributing to the market.
Growing Collaborations and Partnerships
Collaborations and partnerships between pharmaceutical companies, biotechnology firms, and research institutions have become essential drivers in advancing the development and commercialization of oligonucleotide therapies for genetic diseases. These collaborations bring together diverse expertise, resources, and funding, creating a synergistic environment that accelerates the translation of scientific discoveries into practical and effective treatments. Pharmaceutical companies, with their experience in drug development, clinical trials, and regulatory processes, contribute vital expertise to the collaboration. They have the infrastructure, knowledge, and resources necessary to navigate the complex landscape of drug development and ensure that oligonucleotide therapies meet regulatory standards for safety and efficacy. Their involvement helps streamline the path to commercialization by leveraging existing networks, manufacturing capabilities, and distribution channels.
Synthesized oligonucleotide products dominate the market
The market for synthesized oligonucleotide products in the oligonucleotide synthesis industry is being driven by the ever-increasing demand from pharmaceutical and biotechnological companies for drug discovery and development, especially for personalized medicine and targeted therapeutics. Along with this, the rise in genomics and molecular research, fueled by significant advancements in technologies such as Next Generation Sequencing (NGS) and CRISPR gene-editing, is enhancing the requirement for synthesized oligonucleotides. Additionally, the growth in diagnostic applications of oligonucleotides, such as in PCR and microarray assays for genetic and infectious diseases, is propelling the market forward. The expanding field of epigenetics also represents a key driver, with oligonucleotides playing a crucial role in gene expression studies. Moreover, the increasing prevalence of genetic disorders and the resultant demand for novel therapeutic strategies involving oligonucleotides further accelerates the market growth for synthesized oligonucleotide products.
PCR primers dominate the market
The demand for PCR primers in the oligonucleotide synthesis industry is driven by the ongoing global health crisis necessitating extensive viral testing, in which PCR is a primary method. Furthermore, the increasing application of PCR in medical diagnostics, forensics, and research to detect genetic mutations and infectious diseases fuels the demand for primers. In the field of genomics and molecular biology, PCR is considered a crucial tool for DNA sequencing, cloning, and genetic manipulation, and this broad utilization further drives the need for PCR primer synthesis. Apart from this, technological advancements in PCR techniques, such as real-time PCR and digital PCR, are also playing a role in boosting demand. Moreoevr, the growing funding for research in healthcare and life sciences has resulted in expanded use of PCR, thus driving the demand for PCR primers in the overall industry.
Academic research institutes dominate the market
The demand for oligonucleotide synthesis in academic research institutes is driven by a rise in genomics and molecular biology research, particularly studies related to gene expression, genetic disorders, and the development of novel therapeutic strategies. Additionally, advancements in technologies such as Next-Generation Sequencing (NGS) and CRISPR gene-editing, which rely on synthesized oligonucleotides, are stimulating demand. In addition, the rising trend of interdisciplinary studies involving bioinformatics and data science, which necessitate the use of oligonucleotides for data validation, further drives the need. Governmental and institutional funding for genomics and biotechnology research is another major driver, enabling academic institutes to invest in oligonucleotide synthesis for various projects. Academic research institutes, with their focus on fundamental research and discovery, often possess cutting-edge knowledge and innovative ideas. By partnering with industry, they can translate their scientific findings into practical applications and commercial products.
North America exhibits a clear dominance, accounting for the largest oligonucleotide synthesis market share
The report has also provided a comprehensive analysis of all the major regional markets, which include North America (the United States and Canada); Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Latin America (Brazil, Mexico, and others); and the Middle East and Africa.
The North American market for oligonucleotide synthesis is propelled by a robust pharmaceutical and biotech industry, with a strong focus on drug discovery and development. The region's emphasis on personalized medicine and targeted therapies further propels this need. Additionally, North America's sophisticated healthcare system with advanced diagnostic capabilities increases the demand for oligonucleotides in diagnostic assays. The region also hosts numerous top-tier academic and research institutes conducting extensive genomics and molecular biology research, which necessitates oligonucleotide synthesis. Moreover, strong governmental and private sector investment in healthcare and life sciences research, particularly in genomics and personalized medicine, fuels the growth of industry in North America. Moreover, the advancements in delivery systems and formulations for oligonucleotide-based therapeutics in North America demonstrate the region's commitment to pushing the boundaries of innovation in this field. These developments not only contribute to the growth of the market but also have the potential to revolutionize the treatment of various diseases, including genetic disorders, cancers, and rare diseases.
The global oligonucleotide synthesis market is experiencing significant growth due to the escalating investments in the development of new production facilities, upgrading existing ones, and implementing more efficient production processes. Therefore, Companies are heavily investing in research and development to innovate their offerings, including developing new synthesis techniques, improving the scale and accuracy of synthesis, and creating new types of oligonucleotide products to support various applications in diagnostics, therapeutics, and research. Along with this, companies are entering into strategic collaborations, partnerships, and acquisitions to co-develop oligonucleotide-based drugs, share technology and expertise, or expand into new markets. In addition, the introduction of therapeutics, such as antisense oligonucleotides, siRNAs, and miRNAs, offer new avenues for treating a wide range of diseases, including genetic disorders and cancers is positively influencing the market. Furthermore, key players are offering services for the custom synthesis of oligonucleotides. This allows researchers and developers to order specific oligonucleotide sequences tailored to their needs, which is particularly important in fields like genomics, molecular biology, and personalized medicine.