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癌症抗体联合治疗的全球市场:市场机会和临床试验分析(2028)Global Cancer Antibody Combinations Market Opportunity & Clinical Trials Insight 2028 |
本报告分析结果及摘要如下:
近年来,随着抗体联合疗法的出现,癌症治疗领域发生了典范转移。 这是一种动态方法,结合了针对特定分子的抗体的精确性与不同抗体的协同效应。 透过将不同类型的单株抗体与其他治疗药物结合,可以同时靶向涉及癌症发展的许多途径,从而可能产生相加或协同效应。 理论上,抗体联合疗法有助于限制多余的毒性,并且缺乏药物动力学(PK)相互作用,使得抗体联合疗法成为癌症治疗的可行选择,这是一种非常合适的方法。
将抗体与其他治疗药物结合的假说最早于20 世纪90 年代末提出,当时研究人员和科学家合作解决癌症恶性肿瘤中观察到的抗药性菌株的出现和逃脱机制。单株抗体的临床前测试(单株抗体)与化疗、放疗和其他治疗药物合併使用。 这些研究的主要目的是扩大单株抗体的治疗指数和潜力。 在临床前研究中,已观察到抗体组合具有诸如提高治疗效率、降低毒性、延迟治疗和抗药性起效以及减少剂量等优点。
化学疗法和放射疗法等传统疗法有可能损害健康细胞,但抗体联合疗法的出现彻底改变了标靶医学的模式。 目前,多种抗体联合疗法如Phesgo、赫赛汀和帕妥珠单抗、雷莫芦单抗和多西他赛、阿特珠单抗、贝伐单抗和化疗、阿特珠单抗和贝伐单抗、伊匹单抗和纳武单抗等已被FDA、EMA、NICE等批准用于多种癌症的治疗。它一直。
在癌症治疗领域,抗体联合治疗领域的初步临床开发重点是抗PD-1、抗CTLA-4、抗PD-L1单株抗体的打造(mAb)联合疗法。化疗以及针对血管内皮生长因子受体(VEGFR)和血小板源性生长因子受体(PDGFR)的各种治疗已被用作多种癌症的一线治疗,包括晚期实体瘤和血液癌。在利用单株抗体与口服小分子多激□抑制剂联合使用的潜力方面,已经观察到了改进。 中国浙江大学正在进行一项临床试验,以评估抗 PD-1 抗体与多激□抑制剂多纳非尼联合治疗方案的安全性和有效性。
另一家中国製药公司Chia Tai Tianqing Pharmaceutical Group推出了抗PD-1抗体penplimab与多靶点受体TKI安罗替尼的联合疗法,用于治疗肝细胞癌(HCC)患者。我报道过。 本研究的主要目的是评估合併疗法作为辅助疗法的疗效。 该研究为随机、双盲、安慰剂对照、多中心 3 期研究,预计于 2023 年 5 月开始,于 2026 年 12 月完成。
迄今为止,用于癌症治疗的抗体联合疗法的临床管线主要由CTLA-4、PD-1、PD-L1等免疫检查点抑制剂、PP2A抑制剂、CDK4/6抑制剂、单株抗体组成标靶 HER 2、TIGIT mAb、双特异性抗体、CAR-T 细胞疗法和抗体/药物组合。 我们当然可以期望在不久的将来见证用于治疗癌症恶性肿瘤的创新抗体联合疗法,製药业日益增长的兴趣以及 FDA 对新型联合疗法的指定推广就证明了这一点。 例如,2023年8月,Agenas 因其用于治疗结直肠癌患者的创新抗体组合 botencilimab (AGEN1181) 和 balstilimab (AGEN2034) 获得快速通道指定。
随着癌症类型数量以惊人的速度增加,世界各地的癌症患者都在寻求更好的治疗方法,这些治疗方法除了治疗之外还能带来意想不到的益处,越来越需要开发创新的抗体组合疗法。 此外,利用抗体联合疗法领域将涉及各种利益相关者,包括Pfizer、Bristol-Myers Squibb、AstraZeneca、Daiichi Sankyo、Agenus、Novartis、Celldex Therapeutics、Merck等製药和生物技术公司,这一趋势正在不断增长。 在目前的市场情况下,抗体药物组合市场的未来是充满希望的,临床试验数量的增加、研发活动的增加以及各利益相关者对该领域的参与都证明了这一点,预计将扩大。
“Global Cancer Antibody Combinations Market Opportunity & Clinical Trials Insight 2028” Report Findings & Highlights:
In recent years, the landscape of cancer therapeutics has witnessed a paradigm shift with the emergence of antibody combination therapies, a dynamic approach that intertwines the precision of antibodies to target specific molecules with the synergistic benefits of different types of antibodies. By merging different types of monoclonal antibodies with other therapeutic agents, numerous pathways that are involved in the pathogenesis of cancer may be targeted simultaneously, thereby, possibly leading to additive or else synergistic effects. Theoretically, the combinations of antibodies are very suitable approach that can be employed for the treatment of cancer modalities because of the fact that the antibody combination therapy aids to limit overlapping toxicity along with lack of pharmacokinetic (PK) interactions.
The hypothesis of combining antibodies with other therapeutic agents began in the late 1990s when the researchers together with scientists amplified the preclinical testing that includes a combinations of monoclonal antibodies (mAb) with chemotherapy, radiotherapy or any other therapeutic agents in order to address the occurrence of drug resistant strains or the escape mechanism for observed in cancer malignancies. The main purpose of these investigations was to expand the therapeutic index as well as the potential of mAbs. Advantages such as amended efficiency, diminished toxicities, delayed development of therapy or drug resistances in addition dose reduction were observed in the preclinical studies that come along with antibody combinations.
In dichotomy with the conventional treatments such as chemotherapy and radiotherapy, which clenches the possibility to damage healthy cells, with the arrival of antibody combination therapies has transformed the landscape of targeted medicine. As of now, multiple antibody combination therapies such as Phesgo, Herceptin with Perjeta, Ramucirumab with docetaxel, atezolizumab, Bevacizumab with chemotherapy, atezolizumab and bevacizumab, and ipilimumab and nivolumab etc have been approved by the FDA, EMA, NICE and others for the treatment of diverse type of cancers.
In the realm of cancer therapy, the preliminary clinical development for the domain of antibody combinations were focused on creating anti-PD-1, anti-CTLA-4 and anti-PD-L1 monoclonal antibody (mAb) combinations, there has been modern improvement observed in harnessing the potential of mAb in conjugation with chemotherapy or with various oral small molecule multikinase inhibitor of vascular endothelial growth factor receptor (VEGFR) or platelet derived growth factor receptor (PDGFR) as the first-line treatment for multiple types of cancer like advanced solid tumors, hematological cancer, etc. Zhejiang University based in China is conducting clinical studies in which the combination of anti-PD-1 antibody with Donafenib, multikinase inhibitor, is ongoing to evaluate the safety and efficacy of the treatment regimen.
Another pharmaceutical company based in China, Chia Tai Tianqing Pharmaceutical Group reported another combination of anti-PD-1 antibody, Penpulimab with multi targeted receptor TKI, Anlotinib for the treatment of patients suffering from hepatocellular cancer (HCC). The primary goal of this study is to assess the effectiveness of combined treatment regimen for adjuvant therapy. It is a randomized, double-blind, placebo-controlled, multicenter phase 3 study which was initiated in May 2023 and is expected to be complete by December 2026.
Hitherto, the clinical pipeline for the domain of antibody combination therapy for treating cancer modalities majorly consists of immune checkpoint inhibitors, such as CTLA-4, PD-1 and PD-L1, PP2A inhibitors, CDK4/6 inhibitors, mAbs targeting HER 2, TIGIT mAbs, bispecific antibodies, CAR T cell therapies, antibody drug conjugates, and others. It is expected that the imminent years will certainly witness innovative antibody combinations for the treatment of cancer malignancies as evident from augmenting interest in pharmaceutical sectors and fostering FDA designations to novel combination therapy. For instance, in August 2023, Agenus was granted the Fast Track Designation for its innovative antibody combination, botensilimab (AGEN1181) and balstilimab (AGEN2034) for the treatment of colorectal cancer patients.
With the increasing prevalence of cancer types at an alarming gait urges the need to develop better as well as innovative antibody combination therapies which could provide cure in addition to anticipation amidst the populace suffering from cancer across the globe. Furthermore, an inclining market trend towards utilizing the realm of antibody combination has been observed due to involvement of various stakeholders from pharmaceutical and biotech companies such as Pfizer, Bristol-Myers Squibb, AstraZeneca, Daiichi Sankyo, Agenus, Novartis, Celldex Therapeutics and Merck. With the current market scenario, the future of the antibody combination market looks promising and is expected to multiple further as evident from the growing clinical trials, rising research and development and involvement of various stakeholders in the domain.