市场调查报告书
商品编码
1439214
全球老年黄斑部病变(AMD)市场评估:按疾病,药物类型,给药途径,最终用户,分销管道,地区,机会和预测(2017-2031)Age Related Macular Degeneration Market Assessment, By Disease, By Drug Type, By Route of Administration, By End-user, By Distribution Channel By Region, Opportunities and Forecast, 2017-2031F |
全球老年黄斑部病变(AMD)市场规模将从2023年的101.9亿美元增至2031年的212.2亿美元,预计2024-2031年预测期间内复合年增长率为9.6%。近年来,该市场呈现显着成长,预计在预测期内将进一步扩大。
根据Journal Cureus发表的一篇文章,预计到 2022 年 9 月,将有 2 亿人患有 AMD。到 2040 年,这一数字预计将增加至约 3 亿。年龄相关性黄斑部病变 (AMD) 市场的成长归功于世界各地各个卫生组织和非政府组织不断努力,以提高人们对适当治疗过程和这种疾病影响的认识。Masu。
市场公司加大投资支持市场扩张
老年黄斑部病变(AMD)在世界各地的盛行率不断上升,促使多个市场参与者和研究机构开发治疗方案和早期诊断解决方案来对抗这种疾病。我们正在投资。例如,Adverum Biotechnologies, Inc. 正在开发 Ixoberogene soroparvovec (Ixo-vec) 作为湿性 AMD 的治疗方法。此临床阶段基因治疗候选产品采用专有载体 AAV.7m8。AAV.7m8 在其自身表达盒的控制下携带阿柏西普的编码序列。目前湿性AMD的治疗需要频繁地眼内注射抗VEGF药物,这对护理人员和患者都造成了负担。Adverum 有潜力提供一种经济高效、持久且安全的眼内治疗选择,满足全球视网膜专家、医疗保健系统以及患者及其照护者的需求。一项患者研究表明,Ixoberogene soroparvovec 对湿性 AMD 受试者俱有一致且持续的治疗水平。
人口老化加剧推动市场发展
由于老年人口不断增加,预计预测期内对 AMD 治疗药物的需求将会增加。由于老年人口黄斑部病变的风险较高,预计市场将随着老年人口的增加而扩大。据世界卫生组织 (WHO) 称,到 2030 年,全球六分之一的人口将超过 60 岁。到2050年,全球60岁以上人口将达21亿,80岁以上人口将达4.26亿。
美国疾病管制与预防中心 (CDC) 估计,美国有 730 万人因老年黄斑部病变 (AMD) 而面临视力丧失的高风险,其中 180 万人患有这种疾病。这些因素正在推动黄斑部病变治疗市场的成长。
北美占有很大的市场份额
老年人口的增加、多个市场参与者的存在以及年龄相关性黄斑部病变 (AMD) 患者数量的增加正在支持该地区的市场扩张。据估计,美国约有 2000 万成年人患有某种形式的黄斑部病变。据Canadian Ophthalmological Society称,年龄相关性黄斑部病变 (AMD) 是加拿大失明的主要原因之一,截至 2022 年 2 月,约有 200 万加拿大人受到影响。
会议将透过重点介绍加拿大眼科医生进行的研究来提高人们对不同治疗方法的认识,这些研究致力于创新旨在增强湿性 AMD 治疗的新疗法。我们致力于传播这一讯息。老年黄斑部病变 (AMD) 研究已在多个领域显示出前景。各种新疗法的化学试验正在进行中,旨在增加 AMD 的治疗选择。这些针对老年性黄斑部病变(AMD)治疗方法的持续投资和努力进一步推动了北美老年黄斑部病变(AMD)市场的扩张。
本报告研究和分析了全球年龄相关性黄斑部病变(AMD)市场,提供市场规模和预测、市场动态以及主要参与者的现状和前景。
Global age related macular degeneration market is projected to witness a CAGR of 9.6% during the forecast period 2024-2031, growing from USD 10.19 billion in 2023 to USD 21.22 billion in 2031F. The market witnessed significant growth in the recent years and is expected to further expand over the forecast period.
Age related macular degeneration (AMD) occur because of damage caused to macula due to aging. Macula is a part of retina, which is responsible for translating the light, that enters the eye, into images. It is responsible for central vision, allowing individuals to view objects directly in front of them. AMD is one of the leading causes of vision loss for older population. The different types of age related macular degeneration include dry AMD and wet AMD. Dry AMD occurs in three stages that include early, intermediate, and late. Wet AMD usually causes faster loss of vision, dry AMD can turn into wet AMD. It occurs due to abnormal blood vessel growth at the back of the eye, which causes damage to macula. According to an article published in Journal Cureus, in September 2022, it is estimated that 200 million people suffer from AMD. The number is projected to increase to roughly 300 million by 2040. The age related macular degeneration market growth can be attributed to the increased initiatives by various health agencies and NGOs across the globe to spread awareness about the adequate course of treatment and impact of the disease.
Increasing Investments by Market Players is Supporting Market Expansion
Owing to increasing prevalence of age-related macular degeneration in various regions across the globe, several market players and research institutions are investing towards the development of treatment options and early diagnostic solutions to combat the disease. For instance, Adverum Biotechnologies, Inc. is developing Ixoberogene soroparvovec (Ixo-vec) for the treatment of wet AMD. The clinical-stage gene therapy product candidate utilizes AAV.7m8, a propriety vector. Under the control of proprietary expression cassette, it carries an aflibercept coding sequence. Current care methods for wet AMD care require frequent anti-VEGF injections in the eyes, causing burden for both caregivers and patients. Adverum believes that Ixoberogene soroparvovec has the potential for providing cost effective, durable, and safe in-office treatment options that will address the requirements of retina specialists and healthcare systems across the globe as well as patients and their caregivers. The study conducted in patients demonstrated consistent and continuous therapeutic levels from Ixoberogene soroparvovec in study subjects with wet AMD.
Growing Prevalence in Aging Population to Boost the Market
The demand for AMD drugs is anticipated to increase over the forecast period, owing to rising aging population. As the risk for macular degeneration amongst the geriatric population is high, the market is expected to grow with the increasing number of older people. According to the World Health Organization, by 2030, 1 in 6 people living across the globe will age 60 and above. By 2050, the world's population aged 60 and above will reach 2.1 billion and by 2050 the number of individuals aging 80 years or older will reach 426 million.
The Centers for Disease Control and Prevention projects that 7.3 million individuals in America are at a heightened risk of loss of vision from age related macular degeneration and 1.8 million people suffer from the disease. These factors are bolstering the growth of the macular degeneration treatment market.
North America to Hold a Significant Share of the Market
The growth of geriatric population, strong presence of several market players, and increasing cases of age-related macular degeneration is supporting the expansion of the market in the region. It is estimated that approximately 20 million adults in the United States suffer from some sort of macular degeneration. As per Canadian Ophthalmological Society, age related macular disorder is one of the leading causes of blindness in Canada and as of February 2022, affects approximately 2 million Canadians.
The society is dedicated towards spreading awareness about the different treatments by highlighting the research conducted by Canadian ophthalmologists that are dedicated towards innovating new therapies that aim at enhancing the treatment for wet AMD. Promising age-related macular degeneration research is being conducted on several fronts. Various chemical trials are underway with novel therapies that aim at enhancing the treatment options for AMD. Such continuous investments and initiatives towards development of therapies for age related macular degeneration are further supporting the expansion of North America age related macular degeneration market.
Wet AMD Anticipated to Hold Significant Market Share
Wet age-related macular degeneration roughly accounts for 10% of cases, however, it results in 90% of cases of legal blindness. This disease is an advanced form of the AMD condition and can cause severe and rapid loss of vision. It occurs due to abnormal growth of blood vessels at the back of the eye, causing damage to macula. The current standard of care to aid the prevention of vision loss progression are anti-vascular endothelial growth factor (VEGF) therapies, however, these therapies require repeated intravitreal injections for the remainder of the patient's life. The highly demanding treatment schedule that requires injections every four to twelve weeks is expected to add to the overall demand in the market. Recently, an ophthalmologist at Mayo Clinic in Minnesota, the United States, performed the first subretinal gene therapy as a potential one-time treatment for wet age related macular degeneration as part of a clinical study of RGX-314.
New Developments in Eylea Injections
Eylea blocks the leakage of fluid caused by abnormal growth of blood vessels on the backside of the eye. In 2024, Molecular Therapeutics, linked their gene therapy to a reduction of wet AMD treatment burden by 90%, encouraging the organization to initiate planning for entry in phase 3 next year. An adeno-associated virus vector is used by 4D-150 for delivering transgenes encoding aflibercept. The aim is to eliminate the requirement for frequent injections of Eylea. In phase 2, 51 wet age-related macular degeneration patients at random, for eight weeks received injections of aflibercept or a shot of one of two doses of 4D-150. The patients on an average received 10 anti-VEGF injections in the previous year. By the twenty-four-week analysis, two-thirds of the patients that were on high dose, were injection free.
Future Market Scenario (2024 - 2031F)
Researchers from Anglia Ruskin University (ARU), have been working on developing a way to grow healthy retinal pigment epithelial (RPE) cells that can remain viable for up to 150 days. Retinal pigment epithelial cells are present outside the neural part of retina. The replacement of retinal pigment epithelial cells is one of the various promising therapeutic options available for effective treatment of age-related macular degeneration. Researchers are actively working on finding effective ways for transplanting these cells in eyes.
Recently Adverum Biotechnologies, Inc. released data from their optic extension study on patients suffering from wet age-related macular degeneration during the Retina Subspecialty Day at the American Academy of Ophthalmology (AAO) annual meeting. The patients continued to experience long term benefits including reduction in anti-VEGF treatment burden and maintenance of vision.
Key Players Landscape and Outlook
Key participants in the age-related macular degeneration market include Bausch Health Companies Inc., REGENXBIO Inc., F. Hoffmann-La Roche Ltd, 4D Molecular Therapeutics, and Adverum Biotechnologies, Inc. The expansion of the aging population and increasing prevalence of age-related macular degeneration are providing lucrative growth opportunities to the market.
In 2023, Bausch+ Lomb Corporation, a subsidiary of Bausch Health Companies Inc., launched PreserVision AREDS 2 Formula eye vitamins plus coenzyme Q10 that combine the nutrient formula recommended by the NEI to aid in reducing the risk of moderate to advanced AMD progression. The global eye health company is dedicated towards helping their customers to live better lives.
All segments will be provided for all regions and countries covered
Companies mentioned above DO NOT hold any order as per market share and can be changed as per information available during research work