Product Code: PM5247
The global targeted protein degradation market size is expected to reach USD 3547.91 million by 2034, according to a new study by Polaris Market Research. The report "Targeted Protein Degradation Market Size, Share, Trends, Industry Analysis Report: By Type, Therapeutic Area (Inflammatory Disorders, Neurological Disorders, Oncological Disorders, Respiratory Disorders, and Others), Route of Administration, and Region (North America, Europe, Asia Pacific, Latin America, and Middle East & Africa) - Market Forecast, 2025-2034" gives a detailed insight into current market dynamics and provides analysis on future market growth.
The targeted protein degradation (TPD) market is experiencing significant growth, driven by advances in precision medicine and increased investments in biotechnology. A key driver is the potential of TPD to target previously "undruggable" proteins, opening new therapeutic avenues for complex diseases such as cancer and neurodegenerative disorders.
Opportunities in this market are expected to rise during the forecast period as pharmaceutical companies collaborate with academic institutions and tech firms to develop novel degraders. The emerging trend toward personalized medicine and the growing focus on small-molecule therapeutics also fuel market demand. Overall, with increasing research activities and clinical trials, the TPD market is poised for rapid expansion.
Targeted Protein Degradation Market Report Highlights:
Based on type, the proteolysis-targeting chimeric molecules (PROTACs) segment dominates the market, being widely adopted due to their ability to degrade a broad range of proteins. Degronimids are expected to witness rapid growth, driven by advancements in small-molecule therapeutics.
In terms of therapeutic area, the oncological disorders segment holds the largest share, as cancer treatments heavily rely on targeted protein degradation. The neurological disorders segment is projected to grow rapidly, with increasing research on neurodegenerative diseases such as Alzheimer's.
By route of administration, the intravenous segment dominates the market; the IV route is especially used for therapies requiring direct and controlled delivery.
North America leads the TPD market, owing to strong R&D activities and pharmaceutical investments. Asia Pacific is the fastest-growing region, driven by rising healthcare expenditure, growing biotechnology sectors, and an increasing focus on innovative therapies.
Some of the key players in the market are Arvinas, Kymera Therapeutics, and Nurix Therapeutics.
Polaris Market Research has segmented the targeted protein degradation market report on the basis of type, therapeutic area, route of administration, and region:
By Type Outlook (Revenue - USD Million, 2020-2034)
- Degronimids
- Immunomodulatory Drugs (IMiDs)
- Proteolysis-Targeting Chimeric Molecules (PROTACs)
- Sudden Acquired Retinal Degeneration Syndrome (SARDs)
- Selective Estrogen Receptor Degraders (SERDs)
- Others
By Therapeutic Area Outlook (Revenue - USD Million, 2020-2034)
- Inflammatory Disorders
- Neurological Disorders
- Oncological Disorders
- Respiratory Disorders
- Others
By Route of Administration Outlook (Revenue - USD Million, 2020-2034)
By Regional Outlook (Revenue - USD Million, 2020-2034)
- North America
- US
- Canada
- Europe
- Germany
- France
- UK
- Italy
- Spain
- Netherlands
- Russia
- Rest of Europe
- Asia Pacific
- China
- Japan
- India
- Malaysia
- South Korea
- Indonesia
- Australia
- Vietnam
- Rest of Asia Pacific
- Middle East & Africa
- Saudi Arabia
- UAE
- Israel
- South Africa
- Rest of Middle East & Africa
- Latin America
- Mexico
- Brazil
- Argentina
- Rest of Latin America
Table of Contents
1. Introduction
- 1.1. Report Description
- 1.1.1. Objectives of the Study
- 1.1.2. Market Scope
- 1.1.3. Assumptions
- 1.2. Stakeholders
2. Executive Summary
3. Research Methodology
- 3.1. Overview
- 3.2. Data Sources
- 3.2.1. Primary Sources
- 3.2.2. Secondary Sources
4. Global Targeted Protein Degradation Market Insights
- 4.1. Targeted Protein Degradation Market - Market Snapshot
- 4.2. Targeted Protein Degradation Market Dynamics
- 4.2.1. Drivers and Opportunities
- 4.2.1.1. Expansion in Oncology Applications
- 4.2.1.2. Rise in Neurological Disorder Treatments
- 4.2.2. Restraints and Challenges
- 4.2.2.1. Complexity of Drug Development and Clinical Validation
- 4.3. Porter's Five Forces Analysis
- 4.3.1. Bargaining Power of Suppliers (Moderate)
- 4.3.2. Threats of New Entrants: (Low)
- 4.3.3. Bargaining Power of Buyers (Moderate)
- 4.3.4. Threat of Substitute (Moderate)
- 4.3.5. Rivalry among existing firms (High)
- 4.4. PESTEL Analysis
- 4.5. Targeted Protein Degradation Market Application Trends
- 4.6. Value Chain Analysis
- 4.7. COVID-19 Impact Analysis
5. Global Targeted Protein Degradation Market, by Type
- 5.1. Key Findings
- 5.2. Introduction
- 5.2.1. Global Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 5.3. Degronimids
- 5.3.1. Global Targeted Protein Degradation Market, by Degronimids, by Region, 2020-2034 (USD Million)
- 5.4. Immunomodulatory Drugs (IMiDs)
- 5.4.1. Global Targeted Protein Degradation Market, by Immunomodulatory Drugs (IMiDs), by Region, 2020-2034 (USD Million)
- 5.5. Proteolysis-Targeting Chimeric Molecules (PROTACs)
- 5.5.1. Global Targeted Protein Degradation Market, by Proteolysis-Targeting Chimeric Molecules (PROTACs), by Region, 2020-2034 (USD Million)
- 5.6. Sudden Acquired Retinal Degeneration Syndrome (SARDs)
- 5.6.1. Global Targeted Protein Degradation Market, by Sudden Acquired Retinal Degeneration Syndrome (SARDs), by Region, 2020-2034 (USD Million)
- 5.7. Selective Estrogen Receptor Degraders (SERDs)
- 5.7.1. Global Targeted Protein Degradation Market, by Selective Estrogen Receptor Degraders (SERDs), by Region, 2020-2034 (USD Million)
- 5.8. Others
- 5.8.1. Global Targeted Protein Degradation Market, by Others, by Region, 2020-2034 (USD Million)
6. Global Targeted Protein Degradation Market, by Therapeutic Area
- 6.1. Key Findings
- 6.2. Introduction
- 6.2.1. Global Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 6.3. Inflammatory Disorders
- 6.3.1. Global Targeted Protein Degradation Market, by Inflammatory Disorders, by Region, 2020-2034 (USD Million)
- 6.4. Neurological Disorders
- 6.4.1. Global Targeted Protein Degradation Market, by Neurological Disorders, by Region, 2020-2034 (USD Million)
- 6.5. Oncological Disorders
- 6.5.1. Global Targeted Protein Degradation Market, by Oncological Disorders, by Region, 2020-2034 (USD Million)
- 6.6. Respiratory Disorders
- 6.6.1. Global Targeted Protein Degradation Market, by Respiratory Disorders, by Region, 2020-2034 (USD Million)
- 6.7. Others
- 6.7.1. Global Targeted Protein Degradation Market, by Others, by Region, 2020-2034 (USD Million)
7. Global Targeted Protein Degradation Market, by Route of Administration
- 7.1. Key Findings
- 7.2. Introduction
- 7.2.1. Global Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 7.3. Oral
- 7.3.1. Global Targeted Protein Degradation Market, by Oral, by Region, 2020-2034 (USD Million)
- 7.4. Intravenous
- 7.4.1. Global Targeted Protein Degradation Market, by Intravenous, by Region, 2020-2034 (USD Million)
- 7.5. Others
- 7.5.1. Global Targeted Protein Degradation Market, by Others, by Region, 2020-2034 (USD Million)
8. Global Targeted Protein Degradation Market, by Geography
- 8.1. Key Findings
- 8.2. Introduction
- 8.2.1. Targeted Protein Degradation Market Assessment, By Geography, 2020-2034 (USD Million)
- 8.3. Targeted Protein Degradation Market - North America
- 8.3.1. North America: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.3.2. North America: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.3.3. North America: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.3.4. Targeted Protein Degradation Market - US
- 8.3.4.1. US: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.3.4.2. US: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.3.4.3. US: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.3.5. Targeted Protein Degradation Market - Canada
- 8.3.5.1. Canada: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.3.5.2. Canada: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.3.5.3. Canada: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.4. Targeted Protein Degradation Market - Europe
- 8.4.1. Europe: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.4.2. Europe: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.4.3. Europe: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.4.4. Targeted Protein Degradation Market - UK
- 8.4.4.1. UK: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.4.4.2. UK: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.4.4.3. UK: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.4.5. Targeted Protein Degradation Market - France
- 8.4.5.1. France: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.4.5.2. France: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.4.5.3. France: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.4.6. Targeted Protein Degradation Market - Germany
- 8.4.6.1. Germany: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.4.6.2. Germany: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.4.6.3. Germany: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.4.7. Targeted Protein Degradation Market - Italy
- 8.4.7.1. Italy: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.4.7.2. Italy: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.4.7.3. Italy: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.4.8. Targeted Protein Degradation Market - Spain
- 8.4.8.1. Spain: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.4.8.2. Spain: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.4.8.3. Spain: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.4.9. Targeted Protein Degradation Market - Netherlands
- 8.4.9.1. Netherlands: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.4.9.2. Netherlands: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.4.9.3. Netherlands: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.4.10. Targeted Protein Degradation Market - Russia
- 8.4.10.1. Russia: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.4.10.2. Russia: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.4.10.3. Russia: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.4.11. Targeted Protein Degradation Market - Rest of Europe
- 8.4.11.1. Rest of Europe: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.4.11.2. Rest of Europe: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.4.11.3. Rest of Europe: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.5. Targeted Protein Degradation Market - Asia Pacific
- 8.5.1. Asia Pacific: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.5.2. Asia Pacific: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.5.3. Asia Pacific: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.5.4. Targeted Protein Degradation Market - China
- 8.5.4.1. China: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.5.4.2. China: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.5.4.3. China: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.5.5. Targeted Protein Degradation Market - India
- 8.5.5.1. India: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.5.5.2. India: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.5.5.3. India: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.5.6. Targeted Protein Degradation Market - Malaysia
- 8.5.6.1. Malaysia: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.5.6.2. Malaysia: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.5.6.3. Malaysia: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.5.7. Targeted Protein Degradation Market - Japan
- 8.5.7.1. Japan: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.5.7.2. Japan: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.5.7.3. Japan: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.5.8. Targeted Protein Degradation Market - Indonesia
- 8.5.8.1. Indonesia: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.5.8.2. Indonesia: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.5.8.3. Indonesia: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.5.9. Targeted Protein Degradation Market - South Korea
- 8.5.9.1. South Korea: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.5.9.2. South Korea: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.5.9.3. South Korea: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.5.10. Targeted Protein Degradation Market - Australia
- 8.5.10.1. Australia: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.5.10.2. Australia: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.5.10.3. Australia: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.5.11. Targeted Protein Degradation Market - Rest of Asia Pacific
- 8.5.11.1. Rest of Asia Pacific: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.5.11.2. Rest of Asia Pacific: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.5.11.3. Rest of Asia Pacific: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.6. Targeted Protein Degradation Market - Middle East & Africa
- 8.6.1. Middle East & Africa: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.6.2. Middle East & Africa: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.6.3. Middle East & Africa: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.6.4. Targeted Protein Degradation Market - Saudi Arabia
- 8.6.4.1. Saudi Arabia: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.6.4.2. Saudi Arabia: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.6.4.3. Saudi Arabia: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.6.5. Targeted Protein Degradation Market - UAE
- 8.6.5.1. UAE: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.6.5.2. UAE: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.6.5.3. UAE: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.6.6. Targeted Protein Degradation Market - Israel
- 8.6.6.1. Israel: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.6.6.2. Israel: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.6.6.3. Israel: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.6.7. Targeted Protein Degradation Market - South Africa
- 8.6.7.1. South Africa: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.6.7.2. South Africa: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.6.7.3. South Africa: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.6.8. Targeted Protein Degradation Market - Rest of Middle East & Africa
- 8.6.8.1. Rest of Middle East & Africa: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.6.8.2. Rest of Middle East & Africa: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.6.8.3. Rest of Middle East & Africa: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.7. Targeted Protein Degradation Market - Latin America
- 8.7.1. Latin America: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.7.2. Latin America: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.7.3. Latin America: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.7.4. Targeted Protein Degradation Market - Mexico
- 8.7.4.1. Mexico: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.7.4.2. Mexico: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.7.4.3. Mexico: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.7.5. Targeted Protein Degradation Market - Brazil
- 8.7.5.1. Brazil: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.7.5.2. Brazil: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.7.5.3. Brazil: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.7.6. Targeted Protein Degradation Market - Argentina
- 8.7.6.1. Argentina: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.7.6.2. Argentina: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.7.6.3. Argentina: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
- 8.7.7. Targeted Protein Degradation Market - Rest of Latin America
- 8.7.7.1. Rest of Latin America: Targeted Protein Degradation Market, by Type, 2020-2034 (USD Million)
- 8.7.7.2. Rest of Latin America: Targeted Protein Degradation Market, by Therapeutic Area, 2020-2034 (USD Million)
- 8.7.7.3. Rest of Latin America: Targeted Protein Degradation Market, by Route of Administration, 2020-2034 (USD Million)
9. Competitive Landscape
- 9.1. Expansion and Acquisition Analysis
- 9.1.1. Expansion
- 9.1.2. Acquisitions
- 9.2. Partnerships/Collaborations/Agreements/Exhibitions
10. Company Profiles
- 10.1. Arvinas
- 10.1.1. Company Overview
- 10.1.2. Financial Performance
- 10.1.3. Product Benchmarking
- 10.1.4. Recent Development
- 10.2. Kymera Therapeutics
- 10.2.1. Company Overview
- 10.2.2. Financial Performance
- 10.2.3. Product Benchmarking
- 10.2.4. Recent Development
- 10.3. Nurix Therapeutics
- 10.3.1. Company Overview
- 10.3.2. Financial Performance
- 10.3.3. Product Benchmarking
- 10.3.4. Recent Development
- 10.4. C4 Therapeutics
- 10.4.1. Company Overview
- 10.4.2. Financial Performance
- 10.4.3. Product Benchmarking
- 10.4.4. Recent Development
- 10.5. Foghorn Therapeutics
- 10.5.1. Company Overview
- 10.5.2. Financial Performance
- 10.5.3. Product Benchmarking
- 10.5.4. Recent Development
- 10.6. Zymeworks
- 10.6.1. Company Overview
- 10.6.2. Financial Performance
- 10.6.3. Product Benchmarking
- 10.6.4. Recent Development
- 10.7. Bristol-Myers Squibb
- 10.7.1. Company Overview
- 10.7.2. Financial Performance
- 10.7.3. Product Benchmarking
- 10.7.4. Recent Development
- 10.8. Pfizer
- 10.8.1. Company Overview
- 10.8.2. Financial Performance
- 10.8.3. Product Benchmarking
- 10.8.4. Recent Development
- 10.9. AbbVie
- 10.9.1. Company Overview
- 10.9.2. Financial Performance
- 10.9.3. Product Benchmarking
- 10.9.4. Recent Development
- 10.10. Molteni Farmaceutici
- 10.10.1. Company Overview
- 10.10.2. Financial Performance
- 10.10.3. Product Benchmarking
- 10.10.4. Recent Development